Adducin 2 (Beta) Proteine (ADD2)

Adducin 2 (Beta) Proteine (ADD2)
Auf finden Sie aktuell 7 Adducin 2 (Beta) (ADD2) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Adducin 2 (Beta) Antikörper (58) und Adducin 2 (Beta) Kits (3) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 77 Adducin 2 (Beta) Produkte verfügbar.
2900072M03Rik, add97, ADDB, beta-ADD, si:dkey-202n14.5
alle Proteine anzeigen Gen GeneID UniProt
ADD2 119 P35612
ADD2 11519 Q9QYB8
ADD2 24171 Q05764

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Human Adducin 2 (Beta) (ADD2) Interaktionspartner

  1. Aberrant DNA methylation (zeige HELLS Proteine) of ADD2 could be potential screening markers of colorectal cancer.

  2. Study evaluated effects of ADD genetic variability on cognitive functions in a sample of patients with schizophrenia, known to show a wide and heterogeneous neuropsychological deficit and found that ADD2 C1797T polymorphism showed diffuse effects on almost every cognitive domain.

  3. ADD2 and NCX1 (zeige SLC8A1 Proteine) variants influence the risk and the clinical features of systemic lupus erythematosus and lupus nephritis.

  4. Taken together, these results show that beta-adducin is a pivotal lipid raft-associated protein in PSGL-1 (zeige SELPLG Proteine)-mediated neutrophil rolling on P-selectin (zeige SELP Proteine).

  5. chorein interacts with beta-adducin and beta-actin (zeige ACTB Proteine).

  6. phosphorylation of beta-adducin by GSK3 promotes efficient neurite outgrowth in neurons.


  8. there was significant heterogeneity between Slavic and Italian subjects in the phenotype-genotype relationships with beta-adducin

  9. Expression of the hypertensive rat or human variant of adducin into normal renal epithelial cells recreates the hypertensive phenotype with higher Na+,K+-ATPase (zeige ATP1A1 Proteine) activity, mu2 (zeige AP2M1 Proteine)-subunit hyperphosphorylation, and impaired Na+,K+-ATPase (zeige ATP1A1 Proteine) endocytosis.

  10. Polymorphisms in the ADD2 and ADD3 (zeige ADD3 Proteine) genes taken alone were not associated with blood pressure and renin (zeige REN Proteine) activity

Mouse (Murine) Adducin 2 (Beta) (ADD2) Interaktionspartner

  1. Darpp32 (zeige PPP1R1B Proteine) interaction with beta-adducin may be the molecular pathway by which environmental changes may rapidly alter responsiveness of striatal neurons involved in the reward system.

  2. Calcium plays a role in regulating the expression and function of beta-adducin to sustain normal organization of the spectrin-based cytoskeleton and the differentiation properties in keratinocytes through the calmodulin/EGFR/cadherin signaling pathway.

  3. study identified novel long-distance upstream non-canonical polyadenylation-regulatory elements that enhance or silence 3'end processing of the Add2 PAS4 (zeige CD36 Proteine)

  4. chorein interacts with beta-adducin and beta-actin (zeige ACTB Proteine).

  5. mice lacking beta-Adducin fail to assemble new synapses upon enhanced plasticity and exhibit diminished long-term hippocampal memory upon environmental enrichment.

  6. Analysis of 3 new alleles reveals previously unknown consequences of red blood cell (RBC (zeige CACNA1C Proteine)) spectrin deficiency, resulting in markedly reduced RBC (zeige CACNA1C Proteine) membrane spectrin content, decreased band 3 (zeige SLC4A1 Proteine), and absent beta-adducin.

  7. Further analysis based on antibody staining of central and peripheral nerves revealed beta-adducin, septin 2 (zeige SEPT2 Proteine), and sh3p8 (zeige SH3GL1 Proteine) as putative paranodal proteins.

  8. beta-Adducin may play an important role in the cellular mechanisms underlying activity-dependent synaptic plasticity associated with learning and memory.

  9. Beta-adducin plays an essential role in the maintenance of erythrocyte shape and membrane stability.

  10. Targeted deletion of alpha-adducin (zeige ADD1 Proteine) results in absent beta- and gamma-adducin (zeige ADD3 Proteine), compensated hemolytic anemia, and lethal hydrocephalus in mice

Adducin 2 (Beta) (ADD2) Protein Überblick

Protein Überblick

Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described.

Alternative names and synonyms associated with Adducin 2 (Beta) (ADD2)

  • adducin 2 (beta) (ADD2)
  • adducin 2 (beta) (add2)
  • adducin 2 (beta) (Add2)
  • 2900072M03Rik Protein
  • add97 Protein
  • ADDB Protein
  • beta-ADD Protein
  • si:dkey-202n14.5 Protein

Bezeichner auf Proteinebene für Adducin 2 (Beta) Proteine (ADD2)

adducin 2 (beta) , beta-adducin , erythrocyte adducin subunit beta , beta-adducin-like , snoRNA MBII-396 , adducin beta , adducin-63

459305 Pan troglodytes
570147 Danio rerio
702939 Macaca mulatta
100125042 Xenopus (Silurana) tropicalis
100174677 Pongo abelii
100348972 Oryctolagus cuniculus
100402289 Callithrix jacchus
100483326 Ailuropoda melanoleuca
100032839 Monodelphis domestica
100050348 Equus caballus
100564223 Anolis carolinensis
100607928 Nomascus leucogenys
100624449 Sus scrofa
119 Homo sapiens
610670 Canis lupus familiaris
518896 Bos taurus
11519 Mus musculus
24171 Rattus norvegicus
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