NNT Proteine (NNT)

Bezeichnung:
Nicotinamide Nucleotide Transhydrogenase Proteine (NNT)
Auf www.antikoerper-online.de finden Sie aktuell 7 Nicotinamide Nucleotide Transhydrogenase (NNT) Proteine von 2 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen NNT Antikörper (48) und NNT Kits (1) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 64 NNT Produkte verfügbar.
Synonyme:
4930423F13Rik, Afu5g02780, AI323702, BB168308, GCCD4, wu:fa20d10, wu:fc86a04, zgc:76979
alle Proteine anzeigen Gen GeneID UniProt
NNT 23530 Q13423
NNT 18115  
Ratte NNT NNT 310378  

Weitere Synonyme anzeigen

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Weitere Proteine zu NNT Interaktionspartnern

Caenorhabditis elegans (C. elegans) Nicotinamide Nucleotide Transhydrogenase (NNT) Interaktionspartner

  1. nnt-1 is important in the defense against mitochondrial oxidative stress

Human Nicotinamide Nucleotide Transhydrogenase (NNT) Interaktionspartner

  1. NNT should be sequenced in all primary adrenal insufficiencies for which the most frequent etiologies have been ruled out. As NNT is involved in oxidative stress, careful follow-up is needed to evaluate mineralocorticoid biosynthesis extent, and gonadal, heart and thyroid function.

  2. identified a 6.67 Mb homozygous region harboring the NNT gene in a Dutch patient presenting with familial glucocorticoid deficiency (FGD (zeige FGD1 Proteine)); a novel homozygous mutation (NM_012343.3: c.1259dupG) in NNT was revealed; reviewed the literature for all the reported NNT mutations and their clinical presentation

  3. This report of a novel NNT mutation, p.G200S, expands the phenotype of NNT mutations to include mineralocorticoid deficiency. It provides the first evidence that NNT mutations can cause oxidative stress and mitochondrial defects.

  4. Data suggest mutations in nicotinamide nucleotide transhydrogenase (NNT) as contributory to left ventricular noncompaction (LVNC).

  5. NNT mRNA expression is significantly higher in visceral fat of obese patients and correlates with body weight, BMI, % body fat, visceral and sc fat area, waist and hip circumference, and fasting plasma insulin (zeige INS Proteine).

  6. Results suggest that NNT may have a role in ROS (zeige ROS1 Proteine) detoxification in human adrenal glands.

  7. In the failing heart a partial loss of Nnt activity adversely impacts NADPH (zeige NQO1 Proteine)-dependent enzymes and the capacity to maintain membrane potential, thus contributing to a decline in bioenergetic capacity, redox regulation and antioxidant defense.

Mouse (Murine) Nicotinamide Nucleotide Transhydrogenase (NNT) Interaktionspartner

  1. this study demonstrates that the respiratory state and/or substrates that sustain energy metabolism markedly influence the relative contribution of NNT (i.e. varies between nearly 0 and 100%) to NADPH (zeige FDXR Proteine)-dependent mitochondrial peroxide metabolism.

  2. Pathologic workload reverses Nnt to deplete NADPH (zeige FDXR Proteine) and antioxidative capacity. Reverse Nnt induces mitochondrial oxidative stress and necrosis.

  3. In mitochondria, genetic or pharmacological disruptions in the PDHC-NNT redox circuit negate counterbalance changes in energy expenditure

  4. Data conclude that Herpud1 (zeige HERPUD1 Proteine) regulates insulin (zeige INS Proteine) secretion via control of Nnt expression.

  5. our data suggest that NNT functions as a high-capacity source of mitochondrial NADPH (zeige FDXR Proteine) and that its functional loss due to the Nnt mutation results in mitochondrial redox abnormalities

  6. the role of NNT in regulating central carbon metabolism via redox balance, calling for other mechanisms that coordinate substrate preference to maintain a functional TCA cycle.

  7. Our results demonstrate a novel role for NNT as a regulator of macrophage-mediated inflammatory responses

  8. A normal Nnt allele can help with better cardiac function in MnSOD (zeige SOD2 Proteine)-deficient mice during fetal development.

  9. The presence of a truncated Nnt did not affect insulin (zeige INS Proteine) secretion or glucose tolerance on the C57BL/6 background.

  10. Nnt was identified as a novel candidate gene for contribution to glucose intolerance through reduced beta cell activity.

NNT Protein Überblick

Protein Überblick

This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification. Two alternatively spliced variants, encoding the same protein, have been found for this gene.

Alternative names and synonyms associated with NNT

  • Nicotinamide Nucleotide Transhydrogenase (nnt-1)
  • nicotinamide nucleotide transhydrogenase (AFUA_5G02780)
  • nicotinamide nucleotide transhydrogenase (nnt)
  • nicotinamide nucleotide transhydrogenase (NNT)
  • nicotinamide nucleotide transhydrogenase (Nnt)
  • 4930423F13Rik Protein
  • Afu5g02780 Protein
  • AI323702 Protein
  • BB168308 Protein
  • GCCD4 Protein
  • wu:fa20d10 Protein
  • wu:fc86a04 Protein
  • zgc:76979 Protein

Bezeichner auf Proteinebene für NNT

Nicotinamide Nucleotide Transhydrogenase family member (nnt-1) , nicotinamide nucleotide transhydrogenase , NAD(P) transhydrogenase, mitochondrial , pyridine nucleotide transhydrogenase , Nicotinamide nucleotide transhydrogenase (NAD(P)+ transhydrogenase)

GENE ID SPEZIES
180884 Caenorhabditis elegans
3505502 Aspergillus fumigatus Af293
100158572 Xenopus (Silurana) tropicalis
23530 Homo sapiens
18115 Mus musculus
310378 Rattus norvegicus
406619 Danio rerio
447528 Xenopus laevis
427196 Gallus gallus
280878 Bos taurus
479342 Canis lupus familiaris
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