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Human RNF8 Protein expressed in Wheat germ - ABIN1318397
Delker, Zhou, Strikoudis, Stebbins, Papavasiliou: Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase. in Proceedings of the National Academy of Sciences of the United States of America 2013
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Structure-guided separation-of-function mutations show that the RNF8 E2 stimulating activity is essential for DSB signaling in mammalian cells and is necessary for downstream recruitment of 53BP1 and BRCA1.
RNF8(-/-) mice exhibit neuronal degeneration and reactive astrocytosis. Neurons from RNF8(-/-) mice appear to be more susceptible to X-ray-induced DNA damage
Altogether, the data in this study highlight the importance of p53 (zeige TP53 Proteine)-pathway activation upon loss of Rnf8, suggesting that Rnf8 and p53 (zeige TP53 Proteine) functionally interact to protect against genomic instability and tumorigenesis.
The identification of RNF8 allows new insights into the integration of the control of p12 (zeige CDK2AP1 Proteine) degradation by different DNA damage signaling pathways.
RNF8-dependent ubiquitination of histone H2A during meiosis establishes active epigenetic modifications, including dimethylation of H3K4 on the sex chromosomes
A new mechanism of chromatin remodelling-assisted ubiquitylation was shown, which involves cooperation between CHD4 (zeige CHD4 Proteine) and RNF8 to create a local chromatin environment permissive to the assembly of checkpoint and repair machineries at DNA lesions.
Rnf8 physically interacts with Tpp1 (zeige TPP1 Proteine) to generate Ubc13 (zeige UBE2N Proteine)-dependent Lys63 polyubiquitin (zeige UBB Proteine) chains that stabilize Tpp1 (zeige TPP1 Proteine) at telomeres.
RNF8 and Chfr (zeige CHFR Proteine), function together to activate ATM (zeige ATM Proteine) and maintain genomic stability in vivo.
53BP1 (zeige TP53BP1 Proteine) protein binds to Rnf8, suggesting DNA damage involves RNF8 dependent ubiquitylation, which allows its accumulation at damaged chromatin.
RNF8 deficint mice exhibit increased genomic instability and elevated risks for tumorigenesis indicating that Rnf8 is a novel tumor suppressor.
Findings indicate direct interaction of dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) with ring finger protein (C3HC4 type) 8 (RNF8) in regulating response to DNA damage.
High RNF8 expression is associated with bladder cancer.
The interaction of MDC1 with RNF8, but not with ATM (zeige ATM Proteine) requires WRAP53beta, suggesting that WRAP53beta facilitates the former interaction without altering phosphorylation of MDC1 by ATM (zeige ATM Proteine).
These findings elucidate deeply and extensively the mechanism of RNF8/RNF168 (zeige RNF168 Proteine) and USP11 to maintain the proper status of ubiquitylation gammaH2AX (zeige H2AFX Proteine) to repair double strand breaks.
define a novel function for ATDC (zeige TRIM29 Proteine) in the RNF8-mediated DNA damage response and implicate RNF8 binding as a key determinant of the radioprotective function of ATDC (zeige TRIM29 Proteine)
Results indicate that RNF8 recruits and ubiquitinates many factors to repair DNA damage thereby conferring radioresistance to nasopharyngeal cancer cells.
Significantly restored tolerance of RAD18 (zeige RAD18 Proteine)-/- and RNF8-/- cells to camptothecin and olaparib without affecting Rad51 (zeige RAD51 Proteine) focus formation.
considered potential associations of 14 single nucleotide polymorphisms (SNPs) in RNF8 and BRDT (zeige BRDT Proteine) genes in Chinese patients with non-obstructive azoospermia
our results indicate that down-regulation of RNF8 mediated by miR (zeige MLXIP Proteine)-214 impedes DNA damage response to induce chromosomal instability in ovarian cancers, which may facilitate the understanding of mechanisms underlying chromosomal instability.
Finding that RNF8 is less abundant than RNF168 (zeige RNF168 Proteine) identifies RNF8 as a rate-limiting determinant of focal repair complex assembly.
The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants.
E3 ubiquitin-protein ligase RNF8
, ActA binding protein 2
, actA-interacting protein 37
, C3HC4-type zinc finger protein
, UBC13/UEV-interacting ring finger protein
, ring finger protein (C3HC4 type) 8
, E3 ubiquitin-protein ligase RNF8 A
, E3 ubiquitin-protein ligase RNF8-A
, RING finger protein 8 A
, RING finger protein 8-A