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Human RNF8 Protein expressed in Wheat germ - ABIN1318397
Delker, Zhou, Strikoudis, Stebbins, Papavasiliou: Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase. in Proceedings of the National Academy of Sciences of the United States of America 2013
Show all 2 Pubmed References
RNF8-promoted Twist ubiquitination is required for Twist localization to the nucleus for subsequent epithelial-mesenchymal transition and cancer stem cells functions, thereby conferring chemoresistance.
Structure-guided separation-of-function mutations show that the RNF8 E2 stimulating activity is essential for DSB signaling in mammalian cells and is necessary for downstream recruitment of 53BP1 and BRCA1.
RNF8(-/-) mice exhibit neuronal degeneration and reactive astrocytosis. Neurons from RNF8(-/-) mice appear to be more susceptible to X-ray-induced DNA damage
Altogether, the data in this study highlight the importance of p53 (zeige TP53 Proteine)-pathway activation upon loss of Rnf8, suggesting that Rnf8 and p53 (zeige TP53 Proteine) functionally interact to protect against genomic instability and tumorigenesis.
The identification of RNF8 allows new insights into the integration of the control of p12 (zeige CDK2AP1 Proteine) degradation by different DNA damage signaling pathways.
RNF8-dependent ubiquitination of histone H2A during meiosis establishes active epigenetic modifications, including dimethylation of H3K4 on the sex chromosomes
A new mechanism of chromatin remodelling-assisted ubiquitylation was shown, which involves cooperation between CHD4 (zeige CHD4 Proteine) and RNF8 to create a local chromatin environment permissive to the assembly of checkpoint and repair machineries at DNA lesions.
Rnf8 physically interacts with Tpp1 (zeige TPP1 Proteine) to generate Ubc13 (zeige UBE2N Proteine)-dependent Lys63 polyubiquitin (zeige UBB Proteine) chains that stabilize Tpp1 (zeige TPP1 Proteine) at telomeres.
RNF8 and Chfr (zeige CHFR Proteine), function together to activate ATM (zeige ATM Proteine) and maintain genomic stability in vivo.
53BP1 (zeige TP53BP1 Proteine) protein binds to Rnf8, suggesting DNA damage involves RNF8 dependent ubiquitylation, which allows its accumulation at damaged chromatin.
RNF8 expression was elevated in patients with advanced breast cancer and was correlated with reduced metastasis-free survival. Collectively, these results indicate that RNF8 activates TWIST to promote EMT (zeige ITK Proteine) and chemoresistance and suggest the potential for therapeutic targeting of RNF8 to indirectly target TWIST.
The present findings indicate that WRAP53beta and RNF8 are rate-limiting factors in the repair of DNA double-strand breaks and raise the possibility that upregulation of WRAP53beta may contribute to genomic stability in and survival of cancer cells.
The study identifies a previously unrecognized role for RNF8 in the negative regulation of NF-kappaB (zeige NFKB1 Proteine) activation by targeting and deactivating the IKK (zeige CHUK Proteine) complex.
the role of RNF8-mediated histone H3 (zeige HIST3H3 Proteine) polyubiquitylation in the regulation of histone H3 (zeige HIST3H3 Proteine) stability and chromatin modification, is reported.
RNF8- and Ube2S-dependent Lys11-linkage ubiquitin conjugation plays an important role in regulating DNA damage-induced transcriptional silencing, distinct from the role of Lys63-linkage ubiquitin in the recruitment of DNA damage repair proteins 53BP1 and BRCA1.
The attenuated DNA damage localization of RNF8 resulting from INT6 (zeige EIF3E Proteine) depletion could be attributed to the defective retention of ATM (zeige ATM Proteine).
In late S/G2 (zeige STRN3 Proteine) phase, the DNA damage-responsive E3 ligase RNF8 conjugates K63-linked ubiquitin chains to tankyrase 1 (zeige TNKS Proteine), while in G1 phase such ubiquitin chains are removed by BRISC, an ABRO1 (zeige FAM175B Proteine)/BRCC36 (zeige BRCC3 Proteine)-containing deubiquitinase complex.
Findings indicate direct interaction of dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) with ring finger protein (C3HC4 type) 8 (RNF8) in regulating response to DNA damage.
High RNF8 expression is associated with bladder cancer.
The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants.
E3 ubiquitin-protein ligase RNF8
, ActA binding protein 2
, actA-interacting protein 37
, C3HC4-type zinc finger protein
, UBC13/UEV-interacting ring finger protein
, ring finger protein (C3HC4 type) 8
, E3 ubiquitin-protein ligase RNF8 A
, E3 ubiquitin-protein ligase RNF8-A
, RING finger protein 8 A
, RING finger protein 8-A