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TAR DNA Binding Protein Proteine (TARDBP)

TAR DNA Binding Protein Proteine (TARDBP)
Auf finden Sie aktuell 14 TAR DNA Binding Protein (TARDBP) Proteine von 7 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen TAR DNA Binding Protein Antikörper (236) und TAR DNA Binding Protein Kits (31) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 296 TAR DNA Binding Protein Produkte verfügbar.
1190002A23Rik, ALS10, C85084, DKFZp459I2127, tardbp, TDP-43, Tdp43, wu:fb77f02, wu:fc52g10
alle Proteine anzeigen Gen GeneID UniProt
TARDBP 23435 Q13148
TARDBP 230908 Q921F2
Ratte TARDBP TARDBP 298648  

Weitere Synonyme anzeigen

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Am meisten referenzierte TAR DNA Binding Protein Proteine

  1. Human TARDBP Protein expressed in HEK-293 Cells - ABIN2733240 : Yang, Lin, Robertson, Wang: Dual vulnerability of TDP-43 to calpain and caspase-3 proteolysis after neurotoxic conditions and traumatic brain injury. in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2014 (PubMed)
    Zeige alle 3 Referenzen für ABIN2733240

  2. Human TARDBP Protein expressed in Escherichia coli (E. coli) - ABIN1098222 : Ou, Wu, Harrich, García-Martínez, Gaynor: Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs. in Journal of virology 1995 (PubMed)

Weitere Proteine zu TAR DNA Binding Protein Interaktionspartnern

Human TAR DNA Binding Protein (TARDBP) Interaktionspartner

  1. We directly link TDP-43 loss of function toxicity to two genes with rare amyotrophic lateral sclerosis and frontotemporal lobar degeneration-causing mutations, CHMP2B (zeige CHMP2B Proteine) and ErbB4 (zeige ERBB4 Proteine).

  2. We report that overexpression of HSPB8 (zeige HSPB8 Proteine) in immortalized motor neurones decreased the accumulation of TDP-25 and TDP-35 and that protection against mislocalized/truncated TDP-43 was observed for HSPB8 (zeige HSPB8 Proteine) in Drosophila melanogaster Overexpression of HSP67Bc, the functional ortholog of human HSPB8 (zeige HSPB8 Proteine), suppressed the eye degeneration caused by the cytoplasmic accumulation of a TDP-43 variant

  3. The extreme N-terminus of TDP-43 mediates the cytoplasmic aggregation of TDP-43 and associated toxicity in vivo. Study provides further evidence confirming the critical role of the extreme N-terminus of TDP-43 in regulating protein structure as well as mediating toxicity associated with its aggregation.

  4. This animal disease model of TDP-43 Proteinopathy mice in which mutant human TDP-43 expression causes progressive neuron loss. Also show that these rNLS8 mice have a pattern of axonal dieback and cell death that mirrors that often observed in human patients.

  5. we analyzed fast axonal transport in larval motor neurons of Drosophila models of TARDBP (TDP-43), FUS (zeige FUS Proteine) and C9orf72 (zeige C9ORF72 Proteine). We also analyzed the effect of loss-of-function mutants of the Drosophila orthologs of TDP-43 and FUS (zeige FUS Proteine), TBPH and caz, respectively. The motor activities of larvae and adults in these models were assessed to correlate potential defects in axonal transport with locomotor deficits

  6. These findings suggest that TDP-43 promotes tau exon 10 inclusion and 4R-tau expression and that disease-related changes of TDP-43, truncations and mutations, affect its function in tau exon 10 splicing, possibly because of TDP-43 mislocalization to the cytoplasm.

  7. Mutant C9ORF72 (zeige C9ORF72 Proteine) impairs mitochondria activity in a different and opposite manner compared to mutant TDP-43. TARDBP and C9ORF72 (zeige C9ORF72 Proteine) mutations might trigger cell death by impairing not only RNA metabolism, but also mitochondria activity in ALS (zeige IGFALS Proteine)/FTD (zeige FTL Proteine) neurons since their mitochondrial energetic metabolism depends mainly on oxidative phosphorylation.

  8. 14-3-3 eta (zeige YWHAH Proteine) isoform colocalizes TDP-43 on the coarse granules in the anterior horn cells of patients with sporadic amyotrophic lateral sclerosis.

  9. Pathological TAR-DNA binding protein 43 (TDP-43) is cleaved into two major groups of fragments of approximately 35-, approximately 25-kDa, and the truncation at Arg208 completely eliminates the intrinsic ability of RNA recognition motif RRM2 (zeige RRM2 Proteine) to fold.

  10. TDP-43 dual phosphorylation by MEK, at threonine 153 and tyrosine 155 (p-T153/Y155), was dramatically increased by the heat shock response (HSR) in human cells.

Mouse (Murine) TAR DNA Binding Protein (TARDBP) Interaktionspartner

  1. These results establish that SMN overexpression in motor neurons slows disease onset and outcome by ameliorating pathological signs in this model of mutant TDP-43-mediated amyotrophic lateral sclerosis (ALS).

  2. These findings suggest that TDP-43 promotes tau exon 10 inclusion and 4R-tau expression and that disease-related changes of TDP-43, truncations and mutations, affect its function in tau exon 10 splicing, possibly because of TDP-43 mislocalization to the cytoplasm.

  3. this study suggests hemizygous TDP-43(M337V) mice as a useful animal model to study TDP-43 toxicity and further consolidates mitochondrial TDP-43 as a novel therapeutic target for TDP-43-linked neurodegenerative diseases.

  4. demonstrated that the levels of HSF1 (zeige HSF1 Proteine) and heat shock proteins are significantly reduced in affected neuronal tissues from a TDP-43 transgenic mouse model of amyotrophic lateral sclerosis and patients with sporadic amyotrophic lateral sclerosis.

  5. The present study identified USP7 (zeige USP7 Proteine) and TDP-43 as the regulators of CRY1 (zeige CRY1 Proteine) and CRY2 (zeige CRY2 Proteine), underscoring the significance of the stability control process of CRY (zeige CRY2 Proteine) proteins for period determination in the mammalian circadian clockwork.

  6. TDP-43 functions within a network of hnRNP (zeige HNRNPH2 Proteine) proteins to inhibit the production of a truncated human SORT1 (zeige SORT1 Proteine) receptor.

  7. Data demonstrate the existence of a physiological decrease of TDP-43/TBPH levels with aging in brain tissue both in wild-type mice and flies, showing that it is an evolutionary conserved phenomenon

  8. This study demonistrated that proprioceptive nerve endings in muscles revealed early and alterations at Ia/II proprioceptive nerve endings in muscle spindles and in the absence of alterations in alpha-motor axons in TDP43(A315T) transgenic mice.

  9. UBQLN2 (zeige UBQLN2 Proteine) dysregulation in neurons can drive NF-kappaB (zeige NFKB1 Proteine) activation and cytosolic TDP-43 aggregation.

  10. These findings demonstrate a role for PABPN1 (zeige PABPN1 Proteine) in rescuing several cytopathological features of TDP-43 proteinopathy by increasing the turnover of pathologic proteins.

Zebrafish TAR DNA Binding Protein (TARDBP) Interaktionspartner

  1. Data indicate a method for site-directed single nucleotide editing in two disease-related genes, DNA binding protein (zeige CNBP Proteine) tardbp and RNA binding protein fus (zeige FUS Proteine).

  2. Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth.

  3. TARDBP and FUS (zeige FUS Proteine) act in a pathogenic pathway that is independent of SOD1 (zeige SOD1 Proteine).

TAR DNA Binding Protein (TARDBP) Protein Überblick

Protein Überblick

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.

Alternative names and synonyms associated with TAR DNA Binding Protein (TARDBP)

  • TAR DNA binding protein (TARDBP)
  • Tardbp protein (tardbp)
  • TAR DNA binding protein (tardbp)
  • TAR DNA binding protein (Tardbp)
  • TAR DNA-binding protein 43-like (LOC100621383)
  • 1190002A23Rik Protein
  • ALS10 Protein
  • C85084 Protein
  • DKFZp459I2127 Protein
  • tardbp Protein
  • TDP-43 Protein
  • Tdp43 Protein
  • wu:fb77f02 Protein
  • wu:fc52g10 Protein

Bezeichner auf Proteinebene für TARDBP

TAR DNA binding protein , TAR DNA-binding protein 43 , Tardbp protein , TDP-43 , TAR DNA-binding protein-43

100174676 Pongo abelii
457942 Pan troglodytes
713860 Macaca mulatta
778772 Ciona intestinalis
100051482 Equus caballus
100602228 Nomascus leucogenys
380329 Xenopus laevis
419453 Gallus gallus
23435 Homo sapiens
478234 Canis lupus familiaris
540632 Bos taurus
230908 Mus musculus
298648 Rattus norvegicus
325052 Danio rerio
100718595 Cavia porcellus
101114038 Ovis aries
100621383 Sus scrofa
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