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TAR DNA Binding Protein (TARDBP) ELISA Kits

Bezeichnung:
TAR DNA Binding Protein ELISA Kits (TARDBP)
Auf www.antikoerper-online.de finden Sie aktuell 31 TAR DNA Binding Protein (TARDBP) ELISA Kits von 11 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen TAR DNA Binding Protein Antikörper (236) und TAR DNA Binding Protein Proteine (14) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 296 TAR DNA Binding Protein Produkte verfügbar.
Synonyme:
1190002A23Rik, ALS10, C85084, DKFZp459I2127, tardbp, TDP-43, Tdp43, wu:fb77f02, wu:fc52g10

Weitere ELISA Kits für TAR DNA Binding Protein Interaktionspartner

Human TAR DNA Binding Protein (TARDBP) Interaktionspartner

  1. These findings suggest that TDP-43 promotes tau exon 10 inclusion and 4R-tau expression and that disease-related changes of TDP-43, truncations and mutations, affect its function in tau exon 10 splicing, possibly because of TDP-43 mislocalization to the cytoplasm.

  2. Mutant C9ORF72 impairs mitochondria activity in a different and opposite manner compared to mutant TDP-43. TARDBP and C9ORF72 mutations might trigger cell death by impairing not only RNA metabolism, but also mitochondria activity in ALS (zeige IGFALS ELISA Kits)/FTD (zeige FTL ELISA Kits) neurons since their mitochondrial energetic metabolism depends mainly on oxidative phosphorylation.

  3. 14-3-3 eta (zeige YWHAH ELISA Kits) isoform colocalizes TDP-43 on the coarse granules in the anterior horn cells of patients with sporadic amyotrophic lateral sclerosis.

  4. Pathological TAR-DNA binding protein 43 (TDP-43) is cleaved into two major groups of fragments of approximately 35-, approximately 25-kDa, and the truncation at Arg208 completely eliminates the intrinsic ability of RNA recognition motif RRM2 (zeige RRM2 ELISA Kits) to fold.

  5. TDP-43 dual phosphorylation by MEK, at threonine 153 and tyrosine 155 (p-T153/Y155), was dramatically increased by the heat shock response (HSR) in human cells.

  6. Taken together, inhibition of nuclear import of TDP-43 by cytoplasmic poly-GA inclusions causally links the two main aggregating proteins in C9orf72 amyotrophic lateral sclerosis /lobar degeneration pathogenesis.

  7. The aim of this review will be to provide a general overview of TDP-43 and FUS/TLS (zeige FUS ELISA Kits) proteins and to highlight their physiological functions--{REVIEW}

  8. Increased cytoplasmic TARDBP mRNA in affected spinal motor neurons in amyotrophic lateral sclerosis is caused by abnormal autoregulation of TDP-43.

  9. Findings suggest a mechanism in which retrotransposable element (RTE) activity contributes to neurodegeneration in TAR DNA-binding protein 43 (TDP-43)-mediated diseases such as Amyotrophic lateral sclerosis (ALS (zeige IGFALS ELISA Kits)) and frontotemporal lobar degeneration (FTLD).

  10. Possible role of deregulated DNA binding function of TDP-43 in ALS.

Mouse (Murine) TAR DNA Binding Protein (TARDBP) Interaktionspartner

  1. These findings suggest that TDP-43 promotes tau exon 10 inclusion and 4R-tau expression and that disease-related changes of TDP-43, truncations and mutations, affect its function in tau exon 10 splicing, possibly because of TDP-43 mislocalization to the cytoplasm.

  2. this study suggests hemizygous TDP-43(M337V) mice as a useful animal model to study TDP-43 toxicity and further consolidates mitochondrial TDP-43 as a novel therapeutic target for TDP-43-linked neurodegenerative diseases.

  3. demonstrated that the levels of HSF1 (zeige HSF1 ELISA Kits) and heat shock proteins are significantly reduced in affected neuronal tissues from a TDP-43 transgenic mouse model of amyotrophic lateral sclerosis and patients with sporadic amyotrophic lateral sclerosis.

  4. The present study identified USP7 (zeige USP7 ELISA Kits) and TDP-43 as the regulators of CRY1 (zeige CRY1 ELISA Kits) and CRY2 (zeige CRY2 ELISA Kits), underscoring the significance of the stability control process of CRY (zeige CRY2 ELISA Kits) proteins for period determination in the mammalian circadian clockwork.

  5. TDP-43 functions within a network of hnRNP (zeige HNRNPH2 ELISA Kits) proteins to inhibit the production of a truncated human SORT1 (zeige SORT1 ELISA Kits) receptor.

  6. Data demonstrate the existence of a physiological decrease of TDP-43/TBPH levels with aging in brain tissue both in wild-type mice and flies, showing that it is an evolutionary conserved phenomenon

  7. This study demonistrated that proprioceptive nerve endings in muscles revealed early and alterations at Ia/II proprioceptive nerve endings in muscle spindles and in the absence of alterations in alpha-motor axons in TDP43(A315T) transgenic mice.

  8. UBQLN2 (zeige UBQLN2 ELISA Kits) dysregulation in neurons can drive NF-kappaB (zeige NFKB1 ELISA Kits) activation and cytosolic TDP-43 aggregation.

  9. These findings demonstrate a role for PABPN1 (zeige PABPN1 ELISA Kits) in rescuing several cytopathological features of TDP-43 proteinopathy by increasing the turnover of pathologic proteins.

  10. identifies DDX58 (zeige DDX58 ELISA Kits) and MTHFSD as two TDP-43 targets that are misregulated in amyotrophic lateral sclerosis. 1

Zebrafish TAR DNA Binding Protein (TARDBP) Interaktionspartner

  1. Data indicate a method for site-directed single nucleotide editing in two disease-related genes, DNA binding protein (zeige CNBP ELISA Kits) tardbp and RNA binding protein fus (zeige FUS ELISA Kits).

  2. Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth.

  3. TARDBP and FUS (zeige FUS ELISA Kits) act in a pathogenic pathway that is independent of SOD1 (zeige SOD1 ELISA Kits).

TAR DNA Binding Protein (TARDBP) Antigen-Profil

Beschreibung des Gens

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.

Alternative names and synonyms associated with TAR DNA Binding Protein (TARDBP)

  • TAR DNA binding protein (TARDBP) Elisa Kit
  • Tardbp protein (tardbp) Elisa Kit
  • TAR DNA binding protein (tardbp) Elisa Kit
  • TAR DNA binding protein (Tardbp) Elisa Kit
  • TAR DNA-binding protein 43-like (LOC100621383) Elisa Kit
  • 1190002A23Rik Elisa Kit
  • ALS10 Elisa Kit
  • C85084 Elisa Kit
  • DKFZp459I2127 Elisa Kit
  • tardbp Elisa Kit
  • TDP-43 Elisa Kit
  • Tdp43 Elisa Kit
  • wu:fb77f02 Elisa Kit
  • wu:fc52g10 Elisa Kit

Bezeichner auf Proteinebene für TARDBP

TAR DNA binding protein , TAR DNA-binding protein 43 , Tardbp protein , TDP-43 , TAR DNA-binding protein-43

GENE ID SPEZIES
100174676 Pongo abelii
457942 Pan troglodytes
713860 Macaca mulatta
778772 Ciona intestinalis
100051482 Equus caballus
100602228 Nomascus leucogenys
380329 Xenopus laevis
419453 Gallus gallus
23435 Homo sapiens
478234 Canis lupus familiaris
540632 Bos taurus
230908 Mus musculus
298648 Rattus norvegicus
325052 Danio rerio
100718595 Cavia porcellus
101114038 Ovis aries
100621383 Sus scrofa
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