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These results suggest that Z-360 exerts an anti-tumor effect through a reduction in anti-apoptosis factors by blocking CCK2R
High CCK-BR expression is associated with Gastric Cancer.
There is no identifiable link between nuclear CCK2R expression and all the clinicopathological characteristics examined in a cohort of Taiwanese colon cancer patients.
Our study showed significantly higher expression of CCKAR and down regulation of CCKBR in pancreatic cancer as compared to control while CCKBR/GR was detected in majority of stomach cancer samples. Thus, our study suggests that CCK (zeige CCK Proteine) and Gs receptors may have diagnostic and therapeutic implications.
Data indicate that variant c.811+32C>A in cholecystokinin-B receptor gene (CCKBR) does not have a significant impact on pancreatic cancer risk or survival in a Hungarian cohort.
The neurotransmitter cholecystokinin (CCK (zeige CCK Proteine)), along with its receptors, CCKAR and CCKBR, have been previously associated with psychiatric disorders, suggesting that variants near these genes may play a role in the pre-pulse/startle response in this cohort
There is functional synergy between cholecystokinin (zeige CCK Proteine) receptors CCKAR and CCKBR in mammalian brain development.
CCK-BR SNP predicts survival and should be studied as a candidate genetic biomarker for those at risk of pancreatic cancer.
treatment with gastrin (zeige GAST Proteine), a CCK2R agonist, stimulated the secretion of GLP-1 (zeige GCG Proteine), and that this effect was likely due to increased expression of proglucagon (zeige GCG Proteine) and PCSK1 (zeige PCSK1 Proteine) (also known as prohormone convertase 3 (PC3 (zeige PCSK1 Proteine) gene)).
Our results indicate a promoting role of CCK2R on GIST tumourigenesis, particularly in tumours of gastric origin.
CCKBR and D5R synergistically interact in the kidney, which may contribute to the maintenance of normal sodium balance following an increase in sodium intake
findings provide novel evidence that Cnr1 (zeige CNR1 Proteine) contributes to cued fear expression via an interaction with the CCKB receptor.
mice lacking CCK (zeige CCK Proteine) receptors exhibited a functional shift from the gastrin (zeige GAST Proteine)-CCK (zeige CCK Proteine) pathways to the neuronal pathway in control of the ECL (zeige APOC4 Proteine) cells and eventually the acid secretion
CCK2R labels +4 antral stem cells that can be activated and expanded by progastrin, thus identifying one hormonal trigger for gastric stem cell interconversion and a potential target for gastric cancer chemoprevention and therapy.
CCK-1 (zeige CCL28 Proteine) and -2 receptors may function synergistically in single PaPo neurons and deletion of CCK-1 (zeige CCL28 Proteine) receptors may facilitate CCK (zeige CCK Proteine)-2 receptor signaling.
cholecystokinin receptor-2 has a role in stress-triggered fear memory and anxiety in the mouse
shift of breakpoint on Arrhenius plot established in CCK (zeige CCK Proteine)(2) receptor-deficiency confirms that such kind of alteration in Na(+),K(+)-ATPase (zeige ATP1A1 Proteine) temperature dependence is likely related to the homeostatic adjustment of altered function of the sodium pump.
Environmental enrichment has beneficial effects in neuropathic conditions and reinforce the causal link between CCK(2) receptors, mechanical sensitivity and the development of CCI-induced hypersensitivity.
The gastrin receptor promotes pancreatic growth in transgenic mice.
This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors.
cholecystokinin B receptor
, gastrin/cholecystokinin type B receptor
, CCK-B receptor
, CCK2 receptor
, cholecystokinin-2 receptor
, gastrin receptor
, CCK(B) receptor
, CCK-B/gastrin receptor
, CCK2/gastrin receptor
, Cholecystokinin-2 receptor
, gastrin/CCK-B receptor
, cholecystokinin receptor