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a comprehensive model of CCL19 and CCL21 (zeige CCL21 Proteine) transport and gradient formation in the lymph nodes (LNs) was built; predicts that ACKR4 in LNs prevents CCL19/CCL21 (zeige CCL21 Proteine) accumulation in efferent lymph, but does not control intranodal gradients; instead, it attributes the disrupted interfollicular CCL21 (zeige CCL21 Proteine) gradients observed in Ackr4-deficient LNs to ACKR4 loss upstream
The beneficial effects of epicatechin in ameriorating diet-induced obesity and insulin (zeige INS Proteine) resistance could be mediated, at least in part, by marked suppression of CCL19 expression.
Results suggest that baicalin exerts an inhibitory effect on airway inflammation, and this effect may be associated with the inhibition of CCR7 (zeige CCR7 Proteine) and its ligands, CCL19 and CCL21 (zeige CCL21 Proteine), as well as on the nuclear factor-Kappa B (NF-kappaB (zeige NFKB1 Proteine)) pathway in a mouse model of asthma.
Interferon-gamma (IFN-gamma (zeige IFNG Proteine)) and interleukin-12 (IL-12 (zeige IL12A Proteine)) levels in the tumors and plasma were significantly enhanced after processing with recombinant mouse CCL19.
Modulation of the chemokines CCL19 and CCL21 (zeige CCL21 Proteine) represents a potent immunoregulatory treatment approach, and thus represents a novel therapeutic target to stabilize atherosclerotic lesions.
CCL19 (ELC) improves TH1 (zeige HAND1 Proteine)-polarized immune responses and protective immunity in a murine Her2/neu (zeige ERBB2 Proteine) DNA vaccination model.
study shows that CCL19/21 and its possible signaling through CXCR3 (zeige CXCR3 Proteine) are required for the development of thymic metallophilic macrophages
CCL19 and CCL21 (zeige CCL21 Proteine) induce prompt Ab responses to antigen, and negatively regulate helper T cell responses in vivo.
CCX-CKR (zeige CCRL1 Proteine)(-/-) have a 5-fold increase in the level of CCL21 (zeige CCL21 Proteine) protein in blood, and 2- to 3-fold increases in CCL19 and CCL21 (zeige CCL21 Proteine) in peripheral lymph nodes.
findings connect NOTCH1 (zeige NOTCH1 Proteine), DUSP22 (zeige DUSP22 Proteine), and CCL19-driven chemotaxis within a single functional network, suggesting that modulation of the homing process may provide a relevant contribution to the unfavorable prognosis associated with NOTCH1 (zeige NOTCH1 Proteine) mutations in CLL.
Deletion of this extended C-terminus reduces CCL21 (zeige CCL21 Proteine)'s affinity for heparin and transferring the CCL21 (zeige CCL21 Proteine) C-terminus to CCL19 enhances heparin binding mainly through non-specific, electrostatic interactions
CCL19 is significantly overexpressed in patients with unstable carotid atherosclerotic plaques and may be a possible novel biomarker for identifying high-risk patients in whom more urgent intervention may be indicated.
CrkL (zeige CRKL Proteine) regulates CCL19 and CCR7 (zeige CCR7 Proteine)-induced epithelial-to-mesenchymal transition via ERK (zeige EPHB2 Proteine) signaling pathway in epithelial ovarian carcinoma patients.
observed significantly higher concentrations of IL-8 (zeige IL8 Proteine) (p < 0.001), MCP-1 (zeige CCL2 Proteine) (p = 0.014), and MIP (zeige TNPO1 Proteine)-3beta (p = 0.022) in the PF of women with endometriosis than in the controls.
The solution structure of CCL19 is reported. It contains a canonical chemokine (zeige CCL1 Proteine) domain. Chemical shift mapping shows the N-termini of PSGL-1 (zeige SELPLG Proteine) and CCR7 (zeige CCR7 Proteine) have overlapping binding sites for CCL19 and binding is competitive.
Our findings serve to elucidate the molecular mechanisms underlying the resistin (zeige RETN Proteine) induction of CCL19 expression in ECs and the shear-stress protection against this induction.
The mRNA levels of CCL19/CCL21 (zeige CCL21 Proteine) in ankylosing spondylitis hip ligament were significantly higher than in osteoarthritis ligament.
Serum CCL19 and CCL21 (zeige CCL21 Proteine) were up-regulated during Rickettsia conorii infection.
CCL19 promoted monocyte adhesion to HUVEC cells. CCL19 rs2227302 was associated with coronary artery disease in a Chinese Han population.
This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7.
C-C motif chemokine 19
, chemokine (C-C motif) ligand 19
, CCL19 chemokine
, CC chemokine ligand 19
, small inducible cytokine A19
, chemokine CCL19/MIP-3BETA
, CK beta-11
, EBI1 ligand chemokine
, EBI1-ligand chemokine
, beta chemokine exodus-3
, beta-chemokine exodus-3
, epstein-Barr virus-induced molecule 1 ligand chemokine
, macrophage inflammatory protein 3 beta
, macrophage inflammatory protein 3-beta
, small inducible cytokine subfamily A (Cys-Cys), member 19
, small-inducible cytokine A19
, EBI-1 ligand chemokine
, EBV-induced molecule 1 ligand chemokine
, chemokine CCL19