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Loss of SIVA1 expression is associated with nasopharyngeal carcinoma.
These findings collectively reveal a novel role for the p53 (zeige TP53 Proteine) target gene SIVA both in regulating metabolism and in enabling tumorigenesis, independently of p53 (zeige TP53 Proteine).
Functional test demonstrated that Siva1 significantly inhibited the invasion and migration of HCT116 cells.
electrical stimulation -inducible SIVA1 modulates p53 (zeige TP53 Proteine) activities in proliferating keratinocytes, and exogenous electrical stimulation affects p53 (zeige TP53 Proteine)/HDM2/SIVA1 axis leading to increased proliferation during re-epithelialization
SIVA1 interacts with RAD18 (zeige RAD18 Proteine) and serves as a molecular bridge between RAD18 (zeige RAD18 Proteine) and PCNA (zeige PCNA Proteine), thus targeting the E3 ligase activity of RAD18 (zeige RAD18 Proteine) onto PCNA (zeige PCNA Proteine).
Siva1 promotes the ubiquitination and degradation of ARF, which in turn affects the stability of p53 (zeige TP53 Proteine).
Upon stimulation of thromboxane A2, degradation of Siva1 is impeded, resulting in an accumulation of the protein, which translocates from the nucleus to the cytosol.
negative regulator of IL-2 gene expression in Treg cells
Data show that low levels of Siva1 and Ser16-phosphorylated stathmin (zeige STMN1 Proteine) correlate with high metastatic states of breast cancer cells.
These findings suggest that the caspase (zeige CASP3 Proteine)-dependent pathway for induction of apoptosis is involved in Siva-1-mediated influenza A virus replication.
Data indicate that p53 (zeige TP53 Proteine) target Siva is pivotal in regulating apoptosis in the pathology of renal ischemia reperfusion injury.
SIVA is a direct transcriptional target for the tumor suppressors p53 (zeige TP53 Proteine) and E2F1 (zeige E2F1 Proteine)
Siva's expression pattern suggests that it plays an instructive role in apoptosis, and accordingly, we demonstrate that Siva is essential for p53 (zeige TP53 Proteine)-dependent apoptosis in cerebellar granule neurons.
lysophosphatidic acid 2 (zeige PTOV1 Proteine) receptor mediates down-regulation of Siva-1 to promote cell survival
Data show that SLIMMER (zeige FHL1 Proteine) delayed Siva-1-dependent apoptosis in C2C12 myoblasts.
This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described.
CD27-binding (Siva) protein
, apoptosis regulatory protein Siva
, CD27-binding protein
, Cd27 binding protein