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dOgg1 and RpS3 in mitochondria increase cell survival after exposure to the nitric oxide donor SNAP
Short 5'UTR mRNAs are enriched with TISU (translation initiator of short 5'UTR), a 12-nucleotide element directing efficient scanning-independent translation. This study demonstrate that TISU is particularly dependent on eukaryotic initiation factor (zeige EIF4G1 Proteine) 1A (eIF1A (zeige EIF1AX Proteine)) which interacts with both RPS3 and RPS10e.
Data show that ribosomal protein S3 (RPS3) knockdown decreased mitochondrial calcium uptake 1 (zeige MICU1 Proteine) protein (MICU1 (zeige MICU1 Proteine)) expression.
a novel cell fate determination mechanism to ensure cells undergo programed cell death through interfering with RPS3/NF-kappaB (zeige NFKB1 Proteine)-conferred anti-apoptotic transcription by the fragment from partial p65 (zeige GORASP1 Proteine) cleavage by activated Caspase-3 (zeige CASP3 Proteine)
Increased RPS3 expression is associated with osteosarcoma invasion.
RPS3, a component of basic translation machinery operates at initiation and most probably elongation of protein synthesis, is also implicated in various events of the cell life as an extraribosomal player. [Review]
IkappaBalpha (zeige NFKBIA Proteine) sequesters not only p65 (zeige GORASP1 Proteine) but also RPS3 in the cytoplasm.
These findings suggest that the secreted rpS3 protein is an indicator of malignant tumors.
rpS3 accumulates in the mitochondria to repair damaged DNA due to the decreased interaction between rpS3 and HSP90 (zeige HSP90 Proteine) in the cytosol.
rpS3 acts as a microtubule associated protein and regulates spindle dynamics during mitosis.
A novel radioresistance mechanism through functional orchestration of rpS3, TRAF2 (zeige TRAF2 Proteine), and NF-kappaB (zeige NFKB1 Proteine) in non-small cell lung cancer cells, is reported.
The RPS3 gene silencing ameliorates experimental asthma, probably by disrupting NF-kappaB (zeige NFKB1 Proteine) activity. RPS3 could be a novel therapeutic target for allergic airway inflammation.
a novel cell fate determination mechanism to ensure cells undergo programed cell death through interfering with RPS3/NF-kappaB (zeige NFKB1 Proteine)-conferred anti-apoptotic transcription by the fragment from partial p65 (zeige NFkBP65 Proteine) cleavage by activated Caspase-3 (zeige CASP3 Proteine)
Rps3 knockdown increased the radiation sensitivity of FDC-P1, confirming that the mechanism of action of Lxn (zeige LXN Proteine) is mediated by Rps3 pathway.
RpS3 is expressed only in activated microglia after lipopolysaccharide treatment; strong rpS3 immunoreactivity is shown in non-pyramidal and non-granule cells.
oxidative stress regulates the phosphorylation status of nonribosomal rpS3 by both activating PKCdelta (zeige PKCd Proteine) and blocking the PP2A (zeige PPP2R2B Proteine) interaction with rpS3
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
40S ribosomal protein S3-A
, ribosomal protein S3
, rps3 gene
, 40S ribosomal protein S3
, IMR-90 ribosomal protein S3