PIK3CA Proteine (PIK3CA)

Bezeichnung:
Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide Proteine (PIK3CA)
Auf www.antikoerper-online.de finden Sie aktuell 4 Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) Proteine von 2 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PIK3CA Antikörper (163) und PIK3CA Kits (10) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 186 PIK3CA Produkte verfügbar.
Synonyme:
6330412C24Rik, C-P3K, caPI3K, CLOVE, CWS5, MCAP, MCM, MCMTC, p110, p110-alpha, p110alpha, pi3-k, PI3-kinase, PI3K, PI3K-alpha
alle Proteine anzeigen Gen GeneID UniProt
PIK3CA 18706 P42337
PIK3CA 5290 P42336
Ratte PIK3CA PIK3CA 170911  

Weitere Synonyme anzeigen

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Weitere Proteine zu PIK3CA Interaktionspartnern

Mouse (Murine) Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) Interaktionspartner

  1. Studies indicate that the Pten+/- genotype displayed neoplasia in multiple organs, including the endometrium and that the Pten is a key regulatory player in the PI3K/PTEN/AKT (zeige AKT1 Proteine) pathway.

  2. our results offer significant insight into how PIK3CA overexpression drives squamous cell carcinoma (HNSCC) invasion and metastasis, providing a rationale for targeting PI3K/PDK1 (zeige PDPK1 Proteine) and TGFb (zeige TGFB1 Proteine) signaling in advanced HNSCC patients with PIK3CA amplification

  3. Data show that docetaxel, rapamycin and tanespimycin multi-drug loaded micelles targeted against HSP90 (zeige HSP90 Proteine) and the PI3K/AKT (zeige AKT1 Proteine)/mTOR (zeige FRAP1 Proteine) pathway in prostate cancer.

  4. Data indicate that chlorogenic acid (CGA (zeige CGA Proteine)) protected osteoblast MC3T3-E1 cells against oxidative damage via PI3K/Akt (zeige AKT1 Proteine)-mediated activation of Nrf2 (zeige NFE2L2 Proteine)/HO-1 (zeige HMOX1 Proteine) pathway, which may be an effective drug in treatment of osteoporosis.

  5. Data show that macrophage M2 polarization was mediated through PTEN/PI3k/AKT (zeige AKT1 Proteine) pathway activation.

  6. Constitutive Activation of PI3K is associated with Ovarian Granulosa Cell Tumors.

  7. Together with recent identification of somatic mutations in p110a (encoded by PIK3CA), our data establish a potential mechanistic link between AGGF1 (zeige AGGF1 Proteine) and PIK3CA, the two genes identified for Klippel-Trenaunay syndrome (KTS)

  8. p110beta has a role in mediating skeletal muscle metabolic signaling by regulating expression of AMP-activated protein kinase (zeige PRKAA2 Proteine)

  9. The mRNA levels of leptin (zeige LEP Proteine) and of 17-beta-dehydrogenase 3, and enzyme important for testosterone production, were significantly higher in the testis of adult alpha-/- males( PI3K catalytic subunit p110alpha deletion).

  10. Results suggest a role of ST6GalNAc I (zeige ST6GALNAC1 Proteine) in promoting the growth and invasion of hepatocarcinoma cells through regulating PI3K/AKT (zeige AKT1 Proteine)/NF-kappa B (zeige NFKB1 Proteine) signaling, and ST6GalNAc I (zeige ST6GALNAC1 Proteine) might be a marker for the prognosis and therapy of hepatocarcinoma.

Human Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) Interaktionspartner

  1. MicroRNA miR (zeige MLXIP Proteine)-155-5p promoted proliferation, invasion and migration, but inhibited apoptosis in hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) by directly targeting the 3'-UTR of PTEN through the PI3K/Akt (zeige AKT1 Proteine) pathway.

  2. Mosaic mutations in PIK3CA or PIK3R2 which activate class 1A PI3K cause severe non-ketotic hypoglycaemia in a subset of patients, with the metabolic phenotype presumably related to the extent of mosaicism within the liver.

  3. KRAS and PIK3CA genetic variants are associated with aggressive clinicopathological features in colorectal adenocarcinoma.

  4. Inducible expression of mutant PIK3CA resulted in a robust activation of phosphatidylinositol-3-kinase (PI3K)/AKT (zeige AKT1 Proteine) signaling but attenuation of Her2 (zeige ERBB2 Proteine)/Her3 (zeige ERBB3 Proteine) signaling, and this can be reversed by deinduction of PIK3CAH1047R expression.

  5. High PI3K expression is associated with melanoma.

  6. Data indicate that PI3K pathway mutation predicts longer time to local progression after radioembolization of colorectal liver metastases.

  7. Oncogenic beta-catenin (zeige CTNNB1 Proteine) and PI3K activities interact in the acquisition of multiple cancer-related phenotypes in organoids grown in Matrigel.

  8. Results indicate that p110alpha primarily mediates PI3K/AKT (zeige AKT1 Proteine) signaling in HER2 (zeige ERBB2 Proteine)+ PTEN deficient breast tumors whereas p110beta conditionally mediates HER2 (zeige ERBB2 Proteine)/PI3K signaling in the absence of p110alpha.

  9. Cytokines IL-2 (zeige IL2 Proteine)/7/9 stimulation activates PI3K/Akt (zeige AKT1 Proteine) pathways downstream of Ras in RasGRP1 (zeige RASGRP1 Proteine) T-cell acute lymphoblastic leukemia (T-ALL).

  10. This study revealed that (1) PIK3CA hotspot mutations occurred with low frequency in gastric cancer; (2) PIK3CA hotspot mutations were not directly associated with PI3K pathway activation; and (3) p-AKT (zeige AKT1 Proteine) (+) may be a biomarker for better outcomes for gastric cancer patients undergoing gastrectomy regardless of the PIK3CA mutation status.

Cow (Bovine) Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) Interaktionspartner

  1. There are multiple conformations in equilibrium during the course of PI3K SH3 domain unfolding.

  2. PI3K has a role in activation of 5'-AMP (zeige TMPRSS5 Proteine)-activated kinase during hypoxia-reoxygenation of bovine aortic endothelial cells

  3. Production of PtdIns3P by PI3K-C2alpha (zeige PIK3C2A Proteine) is required for acquisition of fusion competence in neurosecretion.

  4. crystallographic and biochemical approaches used to gain insight into activating mutations in two noncatalytic p110alpha domains-the adaptor-binding and the helical domains

PIK3CA Protein Überblick

Protein Überblick

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.

Alternative names and synonyms associated with PIK3CA

  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA)
  • Phosphoinositide-3-kinase, catalytic, alpha polypeptide (GL50803_14855)
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (pik3ca)
  • phosphoinositide-3-kinase, catalytic, alpha polypeptide (LOC100337822)
  • phosphatidylinositol 3-kinase, catalytic, alpha polypeptide (Pik3ca)
  • phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (Pik3ca)
  • phosphoinositide-3-kinase, catalytic, alpha polypeptide (PIK3CA)
  • 6330412C24Rik Protein
  • C-P3K Protein
  • caPI3K Protein
  • CLOVE Protein
  • CWS5 Protein
  • MCAP Protein
  • MCM Protein
  • MCMTC Protein
  • p110 Protein
  • p110-alpha Protein
  • p110alpha Protein
  • pi3-k Protein
  • PI3-kinase Protein
  • PI3K Protein
  • PI3K-alpha Protein

Bezeichner auf Proteinebene für PIK3CA

phosphoinositide-3-kinase, catalytic, alpha polypeptide , Phosphoinositide-3-kinase, catalytic, alpha polypeptide , PI3-kinase subunit alpha , PI3K-alpha , PI3Kalpha , phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha , phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform , phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha , phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform , phosphoinositide-3-kinase catalytic alpha polypeptide , ptdIns-3-kinase subunit alpha , ptdIns-3-kinase subunit p110-alpha , serine/threonine protein kinase PIK3CA , PI3-kinase p110 subunit alpha , phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha , phosphatidylinositol 3-kinase, catalytic, alpha polypeptide , phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform , PI3K , p110alpha , ptdIns-3-kinase p110 , phosphoinositide 3-kinase catalytic subunit

GENE ID SPEZIES
460858 Pan troglodytes
5702156 Giardia lamblia ATCC 50803
100144924 Xenopus (Silurana) tropicalis
100229768 Taeniopygia guttata
100337822 Oryctolagus cuniculus
18706 Mus musculus
5290 Homo sapiens
282306 Bos taurus
170911 Rattus norvegicus
488084 Canis lupus familiaris
424971 Gallus gallus
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