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these results identify the PI3K-GSK3-SMAD1 (zeige SMAD1 Proteine) axis as a central node integrating multiple signaling networks that govern bone formation and homeostasis.
Data suggest a critical role for KDM3A (zeige KDM3A Proteine) in the PI3K/AP-1 (zeige JUN Proteine) oncogenic axis and propose a novel strategy for inhibition of KDM3A (zeige KDM3A Proteine) against liver tumor development under PI3K pathway activation.
Data show that tumors lacking PSMA had less than half the abundance of type 1 insulin-like growth factor receptor (IGF-1R), less activity in the survival pathway mediated by PI3K-AKT signaling, and more activity in the proliferative pathway mediated by MAPK-ERK1/2 signaling.
Both PIK3CA mutants H1047R and E545K are able to activate the AKT/mTOR pathway. An intact AKT2/mTOR complex 1 cascade is required for tumourigenesis induced by H1047R/c-Met or E545K/c-Met in the liver in mice.
Loss of HDAC (zeige HDAC3 Proteine)-mediated repression and gain of NF-kappaB (zeige NFKB1 Proteine) activation underlie cytokine induction in ARID1A- and PIK3CA-mutation-driven ovarian cancer.
We further demonstrate that loss of one allele of PTEN is sufficient to shift isoform dependency from p110alpha to p110beta in vivo. These results provide insight into the molecular mechanism by which ErbB2 (zeige ERBB2 Proteine)-positive breast cancer escapes p110alpha inhibition.
Studies indicate that the Pten+/- genotype displayed neoplasia in multiple organs, including the endometrium and that the Pten is a key regulatory player in the PI3K/PTEN/AKT (zeige AKT1 Proteine) pathway.
our results offer significant insight into how PIK3CA overexpression drives squamous cell carcinoma (HNSCC) invasion and metastasis, providing a rationale for targeting PI3K/PDK1 (zeige PDPK1 Proteine) and TGFb (zeige TGFB1 Proteine) signaling in advanced HNSCC patients with PIK3CA amplification
Data show that docetaxel, rapamycin and tanespimycin multi-drug loaded micelles targeted against HSP90 (zeige HSP90 Proteine) and the PI3K/AKT (zeige AKT1 Proteine)/mTOR (zeige FRAP1 Proteine) pathway in prostate cancer.
Data indicate that chlorogenic acid (CGA (zeige CGA Proteine)) protected osteoblast MC3T3-E1 cells against oxidative damage via PI3K/Akt (zeige AKT1 Proteine)-mediated activation of Nrf2 (zeige NFE2L2 Proteine)/HO-1 (zeige HMOX1 Proteine) pathway, which may be an effective drug in treatment of osteoporosis.
Concomitant inhibition of PIM (zeige PIM1 Proteine) kinase and p110alpha activities inhibits glioma stem cell function and survival.
Study shows that PIK3CA is required for the proliferation, migration, invasion and clone formation of gallbladder carcinoma (GBC) cells in vitro and that the E545K mutation of PIK3CA promotes GBC progression through its enhanced binding to EGFR (zeige EGFR Proteine).
Our findings suggest that PIK3CA mutation has the neutral prognostic effects on colorectal cancers (CRC (zeige CALR Proteine)) OS and progression-free survival. Evidence was accumulating for the establishment of CRC (zeige CALR Proteine) survival between PIK3CA mutations and patient-specific clinical or molecular profiles.
Sixteen of 20 patients treated at the MTD had reduced (18)FDG-PET uptake; 7 (33%) had a reduction >25%. One patient achieved a complete response (CR; endometrial carcinoma exhibiting both PIK3CA and PTEN mutations and complete PTEN loss) and two had a partial response (PR; both metastatic breast cancer).
Ehrlichia chaffeensis infection activated the phosphatidylinositol 3-kinase (PI3K)-Akt (zeige AKT1 Proteine)-mTOR (mechanistic target of rapamycin (zeige FRAP1 Proteine)) pathway, and activation was induced by three ehrlichial tandem repeat protein (TRP (zeige TBPL1 Proteine)) effectors, with TRP120 inducing the strongest activation.
Overexpression of KAT6A or TRIM24 (zeige TRIM24 Proteine) promoted PIK3CA expression, AKT (zeige AKT1 Proteine) phosphorylation, and cell proliferation.
Combined PI3Kalpha and CDK4/6 (zeige CDK4 Proteine) inhibition significantly improved disease control in human xenograft models compared with either monotherapy.
Data show that cancer-associated fibroblasts (CAFs (zeige TBX1 Proteine))-derived hepatocyte growth factor (HGF (zeige HGF Proteine)) or recombinant HGF (zeige HGF Proteine) activated c-Met/phosphoinositide 3-kinase (PI3K)/Akt (zeige AKT1 Proteine) and glucose-regulated protein 78 (GRP78 (zeige HSPA5 Proteine)) signalling pathways in ovarian cancer cells.
Compared to single-gene-targeted cells and parental controls, cells with both a PIK3CA mutation and TP53 (zeige TP53 Proteine) alteration had increased cancerous phenotypes including cell proliferation, soft agar colony formation, aberrant morphology in acinar formation assays, and genomic heterogeneity.
Data indicate that PIK3CA copy number gain was an independent poor prognostic factor for disease-free survival (DFS (zeige FST Proteine)).
There are multiple conformations in equilibrium during the course of PI3K SH3 domain unfolding.
PI3K has a role in activation of 5'-AMP (zeige TMPRSS5 Proteine)-activated kinase during hypoxia-reoxygenation of bovine aortic endothelial cells
Production of PtdIns3P by PI3K-C2alpha (zeige PIK3C2A Proteine) is required for acquisition of fusion competence in neurosecretion.
crystallographic and biochemical approaches used to gain insight into activating mutations in two noncatalytic p110alpha domains-the adaptor-binding and the helical domains
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.
phosphoinositide-3-kinase, catalytic, alpha polypeptide
, Phosphoinositide-3-kinase, catalytic, alpha polypeptide
, PI3-kinase subunit alpha
, phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha
, phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
, phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha
, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
, phosphoinositide-3-kinase catalytic alpha polypeptide
, ptdIns-3-kinase subunit alpha
, ptdIns-3-kinase subunit p110-alpha
, serine/threonine protein kinase PIK3CA
, PI3-kinase p110 subunit alpha
, phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha
, phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform
, ptdIns-3-kinase p110
, phosphoinositide 3-kinase catalytic subunit