CDK2 Proteine (CDK2)

Bezeichnung:
Cyclin-Dependent Kinase 2 Proteine (CDK2)
Auf www.antikoerper-online.de finden Sie aktuell 38 Cyclin-Dependent Kinase 2 (CDK2) Proteine von 10 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen CDK2 Antikörper (470) und CDK2 Kits (43) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 591 CDK2 Produkte verfügbar.
Synonyme:
A630093N05Rik, cdk2L, CDKN2, CINP, eg1, MGC84068, p33(CDK2), wu:fa10c02, zgc:56598, zgc:77684
alle Proteine anzeigen Gen GeneID UniProt
CDK2 362817  
CDK2 1017 P24941
CDK2 12566 P97377

Weitere Synonyme anzeigen

CDK2 Proteine (CDK2) nach Spezies

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Am meisten referenzierte CDK2 Proteine

  1. Human CDK2 Protein expressed in Baculovirus infected Insect Cells - ABIN2003156 : Gu, Rosenblatt, Morgan: Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. in The EMBO journal 1992 (PubMed)
    Zeige alle 5 Referenzen für 2003156

  2. Human CDK2 Protein expressed in Escherichia coli (E. coli) - ABIN667950 : Hannon, Casso, Beach: KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases. in Proceedings of the National Academy of Sciences of the United States of America 1994 (PubMed)
    Zeige alle 2 Referenzen für 667950

  3. Human CDK2 Protein expressed in Wheat germ - ABIN1348936 : Molatore, Marinoni, Lee, Pulz, Ambrosio, degli Uberti, Zatelli, Pellegata: A novel germline CDKN1B mutation causing multiple endocrine tumors: clinical, genetic and functional characterization. in Human mutation 2010 (PubMed)

Weitere Proteine zu CDK2 Interaktionspartnern

Xenopus laevis Cyclin-Dependent Kinase 2 (CDK2) Interaktionspartner

  1. evidence that cyclin A1 (zeige CCNA1 Proteine)-associated activity is a mediator of apoptosis and that cyclin A1 (zeige CCNA1 Proteine)/Cdk2 is sufficient to induce apoptosis

Human Cyclin-Dependent Kinase 2 (CDK2) Interaktionspartner

  1. Here, we introduce a transcriptional signature to specifically track CDK2 activity. It responds to genetic and chemical perturbations in the CDK (zeige CDK4 Proteine)-RB-E2F (zeige E2F1 Proteine) axis, correlates with mitotic rate in vitro and in vivo and reacts rapidly to changes in CDK2 activity during cell cycle progression

  2. Here, we found that centrosomal protein of 76 kDa (Cep76 (zeige Cep76 Proteine)), previously shown to restrain centriole amplification, interacts with cyclin-dependent kinase 2 (CDK2) and is a bona fide substrate of this kinase. Cep76 (zeige Cep76 Proteine) is preferentially phosphorylated by cyclin A (zeige CCNA2 Proteine)/CDK2 at a single site S83, and this event is crucial to suppress centriole amplification in S phase

  3. The authors find that Spy1 (zeige SPDYA Proteine) confers structural changes to Cdk2 that obviate the requirement of Cdk (zeige CDK4 Proteine) activation loop phosphorylation.

  4. CDK2 serves as an important nexus linking primary beta-cell dysfunction to progressive beta-cell mass deterioration in diabetes

  5. Date show that when Wee1 (zeige WEE1 Proteine) alone is inhibited, Chk1 (zeige CHEK1 Proteine) suppresses CDC45 (zeige CDC45 Proteine) loading and thereby limits the extent of unscheduled replication initiation and subsequent S-phase DNA damage, despite very high CDK (zeige CDK4 Proteine)-activity.

  6. Results show that cyclin E1 (zeige CCNE1 Proteine) and CDK2 participate in STC1 (zeige STC1 Proteine) promoting cell proliferation of prostate neoplasm cells.

  7. The data presented here suggest that the temporal separation of pro- and anti-apoptotic pathways by selective inhibition of CDK2 disrupts coherent signaling modules and may synergize with anti-proliferative drugs, averting toxic side effects from CDK1 (zeige CDK1 Proteine) inhibition.

  8. periodic phosphorylation of Ku70 (zeige XRCC6 Proteine) by cyclin-cyclin (zeige PCNA Proteine) dependent kinases prevents the interaction of Ku with replication origin after initiation events in S-phase.

  9. a SUMO-deficient Rb mutant results in reduced SUMOylation and phosphorylation, weakened CDK2 binding, and attenuated E2F-1 (zeige E2F1 Proteine) sequestration.

  10. These two states are separated by different metastable states that share hybrid structural features with both forms of the kinase. In contrast, the CDK2/ANS complex landscape is compatible with a conformational selection picture where the binding of ANS in proximity of the alphaC helix causes a population shift toward the inactive conformation

Mouse (Murine) Cyclin-Dependent Kinase 2 (CDK2) Interaktionspartner

  1. CDK2 serves as an important nexus linking primary beta-cell dysfunction to progressive beta-cell mass deterioration in diabetes

  2. data indicate that the essential meiotic functions of Cdk2 depend on its kinase activity, without which the generation of haploid cells is disrupted, resulting in sterility of otherwise healthy animals

  3. Testosterone is the positive regulator of hepatocyte cell cycle via cyclin E (zeige CCNE1 Proteine)/cdk2 promoting hepatocarcinogenesis.

  4. This approach allowed us to determine the identity of cyclin E (zeige CCNE1 Proteine) protein partners, as well as phosphorylation substrates of cyclins E (cyclin (zeige PCNA Proteine) E1and cyclin E2 (zeige CCNE2 Proteine))and its associated kinase, Cdk2, in different mouse organs.

  5. RingoA (zeige SPDYA Proteine) is an important activator of Cdk2 at meiotic telomeres.

  6. Foxo3 (zeige FOXO3 Proteine) circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2.

  7. Results identify phosphorylation of CDK2 at tyrosine 160 as a gate-keeping mechanism for hepatocyte proliferation.

  8. Sox2 (zeige SOX2 Proteine) phosphorylation by Cdk2 promotes the establishment but not the maintenance of the pluripotent state.

  9. Our data indicate that Cdk2 and Cdk4 (zeige CDK4 Proteine) play important overlapping roles in homeostatic and stress hematopoiesis, which need to be considered when using broad-spectrum cyclin-dependent kinase (zeige CDK1 Proteine) inhibitors for cancer therapy.

  10. ablation of the kinase CDK2 alters the nuclear envelope in mouse spermatocytes, and that the proteins SUN1, KASH5 (also known as CCDC155) and lamin C2 show an abnormal cap-like distribution facing the centrosome.

Zebrafish Cyclin-Dependent Kinase 2 (CDK2) Interaktionspartner

  1. intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (zeige CDK1 Proteine), wee1 (zeige WEE1 Proteine), p21 (zeige CDKN1A Proteine), PCNA (zeige PCNA Proteine) and cdk2, but only weakly influences cyclin B1 (zeige CCNB1 Proteine), cyclin B2 (zeige CCNB2 Proteine) and cyclin E1 (zeige CCNE1 Proteine) expression.

  2. PI3-kinase (zeige PIK3CA Proteine) and Akt (zeige AKT1 Proteine) participate in insulin (zeige INS Proteine) stimulation of p34cdc2 (zeige CDK1 Proteine) activation in zebrafish oocyte with phosphodiesterase 3 as a potential downstream target.

  3. an essential role for UHRF1 (zeige UHRF1 Proteine) phosphorylation by cyclin-dependent kinase 2/cyclin A2 (zeige CCNA2 Proteine) during early vertebrate development

Cow (Bovine) Cyclin-Dependent Kinase 2 (CDK2) Interaktionspartner

  1. cyclin D1 (zeige CCND1 Proteine), CDK2 and CDK4 (zeige CDK4 Proteine) are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation

CDK2 Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported.

Alternative names and synonyms associated with CDK2

  • MGC84068 protein (MGC84068)
  • cyclin-dependent kinase 2 interacting protein (CINP)
  • Cyclin-dependent kinase 2-interacting protein (cinp)
  • cyclin dependent kinase 2 (Cdk2)
  • cyclin-dependent kinase 2 (CDK2)
  • cyclin-dependent kinase 2 (Cdk2)
  • cyclin-dependent kinase 2 (cdk2)
  • cyclin-dependent kinase 2 (CDK2) (Cdk2)
  • cyclin-dependent kinase-2 alpha (LOC100154715)
  • A630093N05Rik Protein
  • cdk2L Protein
  • CDKN2 Protein
  • CINP Protein
  • eg1 Protein
  • MGC84068 Protein
  • p33(CDK2) Protein
  • wu:fa10c02 Protein
  • zgc:56598 Protein
  • zgc:77684 Protein

Bezeichner auf Proteinebene für CDK2

MGC84068 protein , Cyclin-dependent kinase 2-interacting protein , cyclin-dependent kinase 2 interacting protein , cyclin-dependent kinase 2-interacting protein , cell division protein kinase 2 , cyclin dependent kinase 2-alpha , cyclin-dependent kinase 2 , cdc2-related protein kinase , cell devision kinase 2 , p33 protein kinase , CDC2 homolog Eg1 protein kinase , Cell division protein kinase 2

GENE ID SPEZIES
444599 Xenopus laevis
744050 Pan troglodytes
100196126 Salmo salar
362817 Rattus norvegicus
1017 Homo sapiens
12566 Mus musculus
406715 Danio rerio
399314 Xenopus laevis
100529062 Gallus gallus
606931 Canis lupus familiaris
519217 Bos taurus
100134865 Oryctolagus cuniculus
100127490 Sus scrofa
100714324 Cavia porcellus
100860751 Capra hircus
100216433 Ovis aries
101844411 Mesocricetus auratus
100689039 Cricetulus griseus
100154715 Sus scrofa
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