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Human CDK2 Protein expressed in Wheat germ - ABIN1348934
Bockstaele, Kooken, Libert, Paternot, Dumont, de Launoit, Roger, Coulonval: Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors". in Molecular and cellular biology 2006
Show all 2 Pubmed References
evidence that cyclin A1 (zeige CCNA1 Proteine)-associated activity is a mediator of apoptosis and that cyclin A1 (zeige CCNA1 Proteine)/Cdk2 is sufficient to induce apoptosis
The upregulation of miR (zeige MLXIP Proteine)-302b reduced the expression of CDK2, and inhibited ERK (zeige EPHB2 Proteine) signaling pathway, thereby inhibiting cell proliferation and G1/S phase conversion rate.
High CDK2 expression is associated with breast cancer.
Here, we introduce a transcriptional signature to specifically track CDK2 activity. It responds to genetic and chemical perturbations in the CDK (zeige CDK4 Proteine)-RB-E2F (zeige E2F1 Proteine) axis, correlates with mitotic rate in vitro and in vivo and reacts rapidly to changes in CDK2 activity during cell cycle progression
Here, we found that centrosomal protein of 76 kDa (Cep76 (zeige Cep76 Proteine)), previously shown to restrain centriole amplification, interacts with cyclin-dependent kinase 2 (CDK2) and is a bona fide substrate of this kinase. Cep76 (zeige Cep76 Proteine) is preferentially phosphorylated by cyclin A (zeige CCNA2 Proteine)/CDK2 at a single site S83, and this event is crucial to suppress centriole amplification in S phase
The authors find that Spy1 (zeige SPDYA Proteine) confers structural changes to Cdk2 that obviate the requirement of Cdk (zeige CDK4 Proteine) activation loop phosphorylation.
CDK2 serves as an important nexus linking primary beta-cell dysfunction to progressive beta-cell mass deterioration in diabetes
Date show that when Wee1 (zeige WEE1 Proteine) alone is inhibited, Chk1 (zeige CHEK1 Proteine) suppresses CDC45 (zeige CDC45 Proteine) loading and thereby limits the extent of unscheduled replication initiation and subsequent S-phase DNA damage, despite very high CDK (zeige CDK4 Proteine)-activity.
Results show that cyclin E1 (zeige CCNE1 Proteine) and CDK2 participate in STC1 (zeige STC1 Proteine) promoting cell proliferation of prostate neoplasm cells.
The data presented here suggest that the temporal separation of pro- and anti-apoptotic pathways by selective inhibition of CDK2 disrupts coherent signaling modules and may synergize with anti-proliferative drugs, averting toxic side effects from CDK1 (zeige CDK1 Proteine) inhibition.
periodic phosphorylation of Ku70 (zeige XRCC6 Proteine) by cyclin-cyclin (zeige PCNA Proteine) dependent kinases prevents the interaction of Ku with replication origin after initiation events in S-phase.
Ad-p21 inhibits RNV in OIR. A potential underlying mechanism for this may be that overexpression of p21 arrests the cell cycle at the G1- to S-phase transition via inhibition of CDK2 activity.
data indicate that the essential meiotic functions of Cdk2 depend on its kinase activity, without which the generation of haploid cells is disrupted, resulting in sterility of otherwise healthy animals
Testosterone is the positive regulator of hepatocyte cell cycle via cyclin E (zeige CCNE1 Proteine)/cdk2 promoting hepatocarcinogenesis.
This approach allowed us to determine the identity of cyclin E (zeige CCNE1 Proteine) protein partners, as well as phosphorylation substrates of cyclins E (cyclin (zeige PCNA Proteine) E1and cyclin E2 (zeige CCNE2 Proteine))and its associated kinase, Cdk2, in different mouse organs.
RingoA (zeige SPDYA Proteine) is an important activator of Cdk2 at meiotic telomeres.
Foxo3 (zeige FOXO3 Proteine) circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2.
Results identify phosphorylation of CDK2 at tyrosine 160 as a gate-keeping mechanism for hepatocyte proliferation.
Sox2 (zeige SOX2 Proteine) phosphorylation by Cdk2 promotes the establishment but not the maintenance of the pluripotent state.
Our data indicate that Cdk2 and Cdk4 (zeige CDK4 Proteine) play important overlapping roles in homeostatic and stress hematopoiesis, which need to be considered when using broad-spectrum cyclin-dependent kinase (zeige CDK1 Proteine) inhibitors for cancer therapy.
intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (zeige CDK1 Proteine), wee1 (zeige WEE1 Proteine), p21 (zeige CDKN1A Proteine), PCNA (zeige PCNA Proteine) and cdk2, but only weakly influences cyclin B1 (zeige CCNB1 Proteine), cyclin B2 (zeige CCNB2 Proteine) and cyclin E1 (zeige CCNE1 Proteine) expression.
PI3-kinase (zeige PIK3CA Proteine) and Akt (zeige AKT1 Proteine) participate in insulin (zeige INS Proteine) stimulation of p34cdc2 (zeige CDK1 Proteine) activation in zebrafish oocyte with phosphodiesterase 3 as a potential downstream target.
an essential role for UHRF1 (zeige UHRF1 Proteine) phosphorylation by cyclin-dependent kinase 2/cyclin A2 (zeige CCNA2 Proteine) during early vertebrate development
cyclin D1 (zeige CCND1 Proteine), CDK2 and CDK4 (zeige CDK4 Proteine) are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation
our results indicate that an ATM (zeige ATM Proteine)-P53 (zeige TP53 Proteine)-P21 (zeige CDKN1A Proteine) DNA damage checkpoint is intact in the absence of CDK2; however, CDK2 is important for proper repair of the damaged DNA by either directly or indirectly influencing DNA repair-related gene expression.
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported.
cdc2-related protein kinase
, cell devision kinase 2
, cell division protein kinase 2
, p33 protein kinase
, Cyclin-dependent kinase 2-interacting protein
, cyclin-dependent kinase 2 interacting protein
, cyclin-dependent kinase 2-interacting protein
, MGC84068 protein
, cyclin dependent kinase 2-alpha
, cyclin-dependent kinase 2
, CDC2 homolog Eg1 protein kinase
, Cell division protein kinase 2