anti-BIM (BCL2L11) Antikörper

Bezeichnung:
anti-BCL2-Like 11 (Apoptosis Facilitator) Antikörper (BCL2L11)
Auf www.antikoerper-online.de finden Sie aktuell 339 BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) Antikörper von 30 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen BIM Kits (19) und BIM Proteine (12) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 390 BIM Produkte verfügbar.
Synonyme:
1500006F24Rik, BAM, Bim, BIMEL, BimL, Bod

Meistgesuchte Reaktivitäten zu anti-BIM (BCL2L11) Antikörper

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anti-Human BIM Antikörper:

anti-Mouse (Murine) BIM Antikörper:

anti-Rat (Rattus) BIM Antikörper:

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Am meisten referenzierte anti-BIM Antikörper

  1. Human Polyclonal BIM Primary Antibody für ELISA, IHC - ABIN4284640 : Zhang, Gillespie, Borrow, Hersey: The histone deacetylase inhibitor suberic bishydroxamate regulates the expression of multiple apoptotic mediators and induces mitochondria-dependent apoptosis of melanoma cells. in Molecular cancer therapeutics 2004 (PubMed)
    Zeige alle 7 Referenzen für 4284640

  2. Human Polyclonal BIM Primary Antibody für WB - ABIN967649 : Adams, Cory: The Bcl-2 protein family: arbiters of cell survival. in Science (New York, N.Y.) 1998 (PubMed)
    Zeige alle 6 Referenzen für 967649

  3. Human Polyclonal BIM Primary Antibody für IHC (p), WB - ABIN388101 : Chen, Zhou: Caspase cleavage of BimEL triggers a positive feedback amplification of apoptotic signaling. in Proceedings of the National Academy of Sciences of the United States of America 2004 (PubMed)
    Zeige alle 6 Referenzen für 388101

  4. Human Polyclonal BIM Primary Antibody für WB - ABIN222941 : Chen, Huang, Wang: Deficiency of Bim in dendritic cells contributes to overactivation of lymphocytes and autoimmunity. in Blood 2007 (PubMed)
    Zeige alle 3 Referenzen für 222941

  5. Human Polyclonal BIM Primary Antibody für IHC (p), WB - ABIN197552 : Fukazawa, Noguchi, Masumi, Murakami, Uehara: BimEL is an important determinant for induction of anoikis sensitivity by mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitors. in Molecular cancer therapeutics 2004 (PubMed)
    Zeige alle 2 Referenzen für 197552

  6. Human Polyclonal BIM Primary Antibody für IF, IHC (p) - ABIN197056 : Luciano, Jacquel, Colosetti, Herrant, Cagnol, Pages, Auberger: Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function. in Oncogene 2003 (PubMed)
    Zeige alle 2 Referenzen für 197056

  7. Human Polyclonal BIM Primary Antibody für EIA, WB - ABIN453531 : Putcha, Le, Frank, Besirli, Clark, Chu, Alix, Youle, LaMarche, Maroney, Johnson: JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis. in Neuron 2003 (PubMed)
    Zeige alle 2 Referenzen für 453531

  8. Human Polyclonal BIM Primary Antibody für ELISA, WB - ABIN250248 : Jiang, Lucas, Avery-Kiejda, Wade, deBock, Thorne, Allen, Hersey, Zhang: Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress. in Cancer research 2008 (PubMed)
    Zeige alle 2 Referenzen für 250248

  9. Human Polyclonal BIM Primary Antibody für FACS, IHC (p) - ABIN652493 : Hippe, Weber, Zhou, Chang, Häcker, Lüder: Toxoplasma gondii infection confers resistance against BimS-induced apoptosis by preventing the activation and mitochondrial targeting of pro-apoptotic Bax. in Journal of cell science 2009 (PubMed)
    Zeige alle 2 Referenzen für 652493

  10. Human Polyclonal BIM Primary Antibody für IF (p), IHC (p) - ABIN682873 : Gogada, Yadav, Liu, Tang, Zhang, Schneider, Seshadri, Sun, Aldaz, Tang, Chandra: Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer. in The Journal of biological chemistry 2013 (PubMed)

Weitere Antikörper gegen BIM Interaktionspartner

Zebrafish BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) Interaktionspartner

  1. Cloning and functional analysis of the bim gene.

Human BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) Interaktionspartner

  1. BIM is associated with favorable prognostic markers for prediction of disease-free survival and overall survival in cervical cancer.

  2. this study shows that BIM deletion polymorphisms are associated with a poor clinical response to erlotinib and represents an independent prognostic factor for patients with EGFR (zeige EGFR Antikörper) positive non-small-cell lung cancer

  3. The Bim deletion polymorphism was found to be associated with primary resistance to crizotinib in patients with ALK (zeige ALK Antikörper) fusion-positive NSCLC.

  4. increased apoptosis resistance was associated with significantly reduced up-regulation of proapoptotic Bim in T cells from patients with primary sclerosing cholangitis.

  5. Results suggest that valproic acid (VPA) reduces paraoxonase 2 (PON2 (zeige PON2 Antikörper)) expression in glioblastoma multiforme (GBM) cells, which in turn increases reactive oxygen species (ROS (zeige ROS1 Antikörper)) production and induces Bim protein production that inhibits cancer progression via the PON2 (zeige PON2 Antikörper)-Bim cascade.

  6. Little difference in Bim expression among CD20 (zeige MS4A1 Antikörper)+ cells was seen between tonsil primary follicles, tonsil germinal centers, and lupus nephritis renal tissue. The frequency of Bim-positive cells among CD4 (zeige CD4 Antikörper)+ lymphocytes was significantly lower in lupus nephritis kidneys compared to tonsil controls.

  7. Inhibition of mTORC1-mediated 4EBP1 (zeige EIF4EBP1 Antikörper) phosphorylation leads to decreased expression of c-MYC (zeige MYC Antikörper) and subsequent upregulation of the proapoptotic BCL2 (zeige BCL2 Antikörper) family member PUMA (zeige BBC3 Antikörper), whereas inhibition of mTORC2 (zeige CRTC2 Antikörper) results in nuclear factor-kappaB-mediated expression of the Early Growth Response 1 (EGR1 (zeige EGR1 Antikörper)) gene, which encodes a transcription factor that binds and transactivates the proapoptotic BCL2L11 locus encoding BIM.

  8. miR (zeige MLXIP Antikörper)-423-3p activates oncogenic and Beclin-1 (zeige BECN1 Antikörper)-dependent autophagy and promotes GC progression by reducing the expression of Bim. The newly identified miR (zeige MLXIP Antikörper)-423-3p-Bim axis might be a potential therapeutic target in GC.

  9. activation of the PI3K (zeige PIK3CA Antikörper) pathway does not suppress activation of the ARF (zeige CDKN2A Antikörper) or BIM gene by over-expressed E2F1 (zeige E2F1 Antikörper)

  10. have shown that Bim protein expression in CM is an independent predictor for advanced disease confirming that this pro-apoptotic BH3-only (zeige BBC3 Antikörper) protein might be a potent biomarker and promising therapeutic target

Mouse (Murine) BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) Interaktionspartner

  1. understanding the cell autonomous role Bim plays in the retinal vascular homeostasis will give us new insight into how to modulate pathological retinal neovascularization and vessel regression to preserve vision

  2. The central role of Bim-dependent apoptosis in Buruli Ulcer pathogenesis

  3. we found a temporal and tissue-specific role for Bim in limiting thymic agonist selection of CD8alphaalpha precursors and their TCRbeta repertoire, but not in the maintenance of CD8alphaalpha intraepithelial lymphocytes in the intestine.

  4. loss of the BH3-only (zeige BBC3 Antikörper) protein BIM accelerated lymphoma development in p53 (zeige TP53 Antikörper)-deficient mice. This process was negated by concomitant loss of RAG1 (zeige RAG1 Antikörper)/2-mediated antigen receptor gene rearrangement.

  5. Overexpression of miR (zeige MLXIP Antikörper)-29 or miR (zeige MLXIP Antikörper)-24 is sufficient to inhibit the induction of Bim and Puma (zeige BBC3 Antikörper) in young sympathetic neurons.

  6. the activation of ERK5 (zeige MAPK7 Antikörper)-AKT (zeige AKT1 Antikörper)-FoxO3a (zeige FOXO3 Antikörper) signaling pathways by fluid shear stress resulted in a decreased expression of FasL (zeige FASL Antikörper) and Bim and an inhibition of caspase-3 (zeige CASP3 Antikörper) activation, which exerts a protective effect that prevents osteoblasts from apoptosis.

  7. long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan

  8. Results indicate that upregulation of miR (zeige MLXIP Antikörper)-124 could regulate apoptosis and impaired autophagy process in the MPTP (zeige PTPN2 Antikörper) model of Parkinson's disease, thus reducing the loss of dopaminergic neurons

  9. Rapid activation of AMPK (zeige PRKAA1 Antikörper) was detected after exposure of cortical neuronal cultures to zinc, which was induced by LKB1 (zeige STK11 Antikörper) activation but not increased intracellular AMP (zeige TMPRSS5 Antikörper) levels or CaMKKbeta activation.

  10. Fluorizoline bind to prohibitin (zeige PHB Antikörper), inducing mitochondrial apoptotic pathway through NOXA (zeige PMAIP1 Antikörper) and BIM upregulation.

Pig (Porcine) BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) Interaktionspartner

  1. Pseudorabies virus glycoprotein gE-mediated ERK 1 (zeige MAPK3 Antikörper)/2 phosphorylation also occurs in epithelial cells and in these cells, gE-mediated ERK 1 (zeige MAPK3 Antikörper)/2 signaling is associated with degradation of the pro-apoptotic protein Bim.

  2. BIMEL expression is regulated in porcine cumulus cells by oocyte secreted factor GDF9 (zeige GDF9 Antikörper).

  3. It was concluded that apoptotic cumulus cells, in which BIM(EL) up-regulation was involved, accelerated oocyte aging and degeneration in vitro via a paracrine action.

BIM (BCL2L11) Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.

Alternative names and synonyms associated with BIM (BCL2L11)

  • BCL2-like 11 (bcl2l11) Antikörper
  • BCL2-like 11 (LOC100345483) Antikörper
  • BCL2-like 11 (apoptosis facilitator) (BCL2L11) Antikörper
  • BCL2-like 11 (apoptosis facilitator) (Bcl2l11) Antikörper
  • 1500006F24Rik Antikörper
  • BAM Antikörper
  • Bim Antikörper
  • BIMEL Antikörper
  • BimL Antikörper
  • Bod Antikörper

Bezeichner auf Proteinebene für BCL2L11

BCL2-like 11 , Bcl-2 interacting mediator of cell death , bcl-2 interacting mediator of cell death , bcl-2 interacting protein Bim , bcl-2-like protein 11 , bcl-2-related ovarian death agonist , Bcl2 interacting mediator of cell death , bcl2-L-11 , bcl2-interacting mediator of cell death , Bcl-2 related apoptotic gene product BimL , bcl-2-related ovarian death protein

GENE ID SPEZIES
100190951 Danio rerio
100345483 Oryctolagus cuniculus
10018 Homo sapiens
12125 Mus musculus
64547 Rattus norvegicus
507390 Bos taurus
396632 Sus scrofa
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