Opsin 1 (Cone Pigments), Medium-Wave-Sensitive Proteine (OPN1MW)

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Synonyme:
CBBM, CBD, CHK-1, COD5, GCP, GOP, grops1, grops2, OPN1LW, OPN1MW, OPN1MW1, PRA1, RH2-2, RH2-3, si:zc263a23.3, si:zc263a23.4, wu:fk57c11
alle Proteine anzeigen Gen GeneID UniProt
OPN1MW 728458 P04001
OPN1MW 14539 O35599
Ratte OPN1MW OPN1MW 89810 O35476

Opsin 1 (Cone Pigments), Medium-Wave-Sensitive Proteine (OPN1MW) nach Spezies

Weitere Proteine zu Opsin 1 (Cone Pigments), Medium-Wave-Sensitive Interaktionspartnern

Human Opsin 1 (Cone Pigments), Medium-Wave-Sensitive (OPN1MW) Interaktionspartner

  1. Findings show that mutation in OPN1MW underlie the cone dysfunction in all of the subjects tested, the color vision defect can be caused either by the same mutation or a gene rearrangement at the same locus.

  2. Data suggest that OPN1MW exhibits a conserved Pro-Pro motif in extracellular loop 2 as observed in monostable visual G-protein-coupled receptors; comparison of deuterium uptake between inactive and active states of OPN1MW suggests a reduced solvent accessibility of the extracellular N-terminal region and an increased accessibility of the chromophore binding site.

  3. Data suggest that insights into dimerization interface of red cone opsin should aid investigations of the structure and function of GPCR cell signaling.

  4. Identification of one single red-green OPN1LW/MW hybrid gene harboring a point mutation that associates with blue cone monochromatism.

  5. The photoreceptor phenotype associated with OPN1LW and OPN1MW mutations is highly variable. These findings have implications for the potential restoration of visual function in subjects with opsin mutations.

  6. Missense mutatin in both OPN1LW and OPN1MW cause X-linked cone dystrophy.

  7. Mutations in the LW/MW cone opsin gene array can, therefore, lead to a spectrum of disease, ranging from color blindness to progressive cone dystrophy (XLCOD5).

  8. Immunoreactivity to anti-OPN1LW antibodies was seen in the basal layer of human epidermis & reconstructed skin. The opsin mRNA was seen in total RNA from human skin. Neither immunoreactivity nor mRNA expression was seen in cultured human keratinocytes.

  9. In Japanese males with congenital red/green color blindness the mutation Asn94Lys (AAC-->AAA) occurred in the single green gene of a deutan subject (A155); and Arg330Gln (CGA-->CAA) in both green genes of another, affecting protein folding and function

  10. Abnormal distribution of cone green opsin is associated with autosomal dominant cone dystrophy

Mouse (Murine) Opsin 1 (Cone Pigments), Medium-Wave-Sensitive (OPN1MW) Interaktionspartner

  1. quantitative FRET analysis in acutely isolated cone OS revealed that the cone degeneration-causing V268I mutation in peripherin-2 selectively reduced binding to M-opsin without affecting the peripherin-2 interaction to S-opsin or rhodopsin

  2. Luciferase expression driven by the midwavelength sensitive opsin intron 3-4 region was only slightly increased by THRB2 (zeige THRB Proteine), and rather enhanced by COUP-TFII (zeige NR2F2 Proteine).

  3. ectopically expressed cTalpha 1) forms a heterotrimeric complex with rod Gbeta(1)gamma(1), and substitutes equally for rTalpha in generating photoresponses initiated by either rhodopsin or S-cone opsin

  4. results show that UV-opsin suppression successively ceases in presence of the M-opsin activating background light, which implies that cone light adaptation is controlled at the opsin stage, before activation of transducin (zeige GNAT1 Proteine).

  5. Thus, the three types of mouse opsin appear distinctive in the degree to which their bleached, unregenerated opsins generate "dark light."

  6. alpha transducin and opsin have roles in mouse photoreceptor cell responses to light and dark

Guinea Pig Opsin 1 (Cone Pigments), Medium-Wave-Sensitive (OPN1MW) Interaktionspartner

  1. The apparent decline in opsin 1 opponency from superior to inferior retina is consistent with the dual gradient and a model where photoreceptor signals in both superior and inferior retina

Opsin 1 (Cone Pigments), Medium-Wave-Sensitive (OPN1MW) Protein Überblick

Protein Überblick

This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called green cone photopigment or medium-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. The long-wavelength opsin gene and multiple copies of the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of deutanopic colorblindness.

Alternative names and synonyms associated with Opsin 1 (Cone Pigments), Medium-Wave-Sensitive (OPN1MW)

  • opsin 1 (cone pigments), medium-wave-sensitive 2 (OPN1MW2)
  • opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan) (Opn1mw)
  • rhodopsin (opsin 2, rod pigment) (retinitis pigmentosa 4, autosomal dominant) (RHO)
  • opsin 1 (cone pigments), medium-wave-sensitive, 2 (opn1mw2)
  • opsin 1 (cone pigments), medium-wave-sensitive, 3 (opn1mw3)
  • KFH-G protein (kfh-g)
  • opsin 1 (cone pigments), medium-wave-sensitive (OPN1MW)
  • opsin 1 (cone pigments), medium-wave-sensitive (Opn1mw)
  • CBBM Protein
  • CBD Protein
  • CHK-1 Protein
  • COD5 Protein
  • GCP Protein
  • GOP Protein
  • grops1 Protein
  • grops2 Protein
  • OPN1LW Protein
  • OPN1MW Protein
  • OPN1MW1 Protein
  • PRA1 Protein
  • RH2-2 Protein
  • RH2-3 Protein
  • si:zc263a23.3 Protein
  • si:zc263a23.4 Protein
  • wu:fk57c11 Protein

Bezeichner auf Proteinebene für OPN1MW

green cone photoreceptor pigment , green-sensitive opsin , medium-wave-sensitive opsin 1 , MWS opsin , green LWS photopigment , green long wavelength sensitive cone opsin , medium wavelength-sensitive cone opsin , midwavelength sensitive opsin , green sensitive cone opsin , opsin CHK-1 , green-sensitive opsin-2 , opsin RH2-2 , opsin-1, medium-wave-sensitive 2 , green cone photoreceptor pigment 2 , green-sensitive opsin-3 , opsin RH2-3 , opsin-1, medium-wave-sensitive 3 , green cone photoreceptor pigment 3 , cone dystrophy 5 (X-linked) , green cone pigment , photopigment apoprotein , opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan), green opsin , opsin 1, long-wave-sensitive , green opsin , opsin 1 (cone pigments), medium-wave-sensitive , green-sensitive opsin-like

GENE ID SPEZIES
728458 Homo sapiens
14539 Mus musculus
396486 Gallus gallus
360151 Danio rerio
360152 Danio rerio
100049180 Oryzias latipes
2652 Homo sapiens
89810 Rattus norvegicus
100008674 Oryctolagus cuniculus
100135586 Cavia porcellus
100445186 Pongo abelii
100595592 Nomascus leucogenys
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