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The bromodomain and extraterminal domain (BET) family consists of BRDT (zeige BRDT Proteine), BRD2 (zeige BRD2 Proteine), BRD3 (zeige BRD3 Proteine), and BRD4 (zeige BRD4 Proteine), each containing 2 bromodomains located N-terminal to extraterminal domain, which is located near C-terminus. Data suggest that 10 distinct acylations participate in binding of BET family proteins to histone 4 (oligopeptide fragments used here); C-terminal bromodomains do not cooperatively bind multiple acylation sites.
The identification of RNF43 (zeige RNF43 Proteine) mutations in a distinct subset of intraductal papillary neoplasm of the bile ducts revealed a new molecular role in the pathogenesis of this disease
LRP1B (zeige LRP1B Proteine), BRD2 (zeige BRD2 Proteine) and CACNA1D (zeige CACNA1D Proteine) are new candidate genes in fetal metabolic programming of newborns exposed to maternal hyperglycemia.
This study implicates BET Brds as important regulators of IkappaB kinase (zeige CHUK Proteine)/NF-kappaB (zeige NFKB1 Proteine)-mediated synovial inflammation of RA and identifies BET proteins as novel therapeutic targets in inflammatory arthritis.
An unexpected role for the bromodomain and extraterminal domain (BET) proteins BRD2 (zeige BRD2 Proteine) and BRD4 (zeige BRD4 Proteine) in maintaining oncogenic IKK (zeige CHUK Proteine) activity in activated B-cell-like diffuse large B-cell lymphoma.
BET proteins, particularly Brd2 (zeige BRD2 Proteine) and Brd4 (zeige BRD4 Proteine), may play a key role in the regulation of Nrf2 (zeige GABPA Proteine)-dependent antioxidant gene transcription and are hence an important target for augmenting antioxidant responses in oxidative stress-mediated diseases.
The C-terminal domain of Brd2 (zeige BRD2 Proteine) is important for chromatin interaction and regulation of transcription and alternative splicing.
A structural basis for BRD2 (zeige BRD2 Proteine)/4-mediated host chromatin interaction and oligomer assembly of Kaposi sarcoma-associated herpesvirus and murine gammaherpesvirus LANA proteins.
The SNP alleles in BRD2 (zeige BRD2 Proteine), Cx-36 (zeige GJD2 Proteine), and ME2 and microdeletions in 15q13.3, 15q11.2, and 16p13.11 also contribute risk to juvenile myoclonic epilepsy'
BRD2 (zeige BRD2 Proteine), BRD3 (zeige BRD3 Proteine), and BRD4 (zeige BRD4 Proteine) interact with gammaretroviral INs (zeige INS Proteine) and serve as cofactors for murine leukemia virus integration.
the in vivo bioactivities of FSH (zeige BRD2 Proteine) glycoforms in Fshb (zeige FSHB Proteine) null mice using a pharmacological rescue approach, was investigated.
These mice showed an increase in FSH (zeige BRD2 Proteine) levels, but they remained in a prepubertal state. Together with previous findings, our data indicate that leptin (zeige LEP Proteine)-selective action in gonadotropes serves a role in adult reproductive physiology but is not sufficient to allow pubertal maturation in mice.
GnRH (zeige GNRH1 Proteine) stimulated the secretion of the VGF (zeige VGF Proteine)-derived peptide NERP1 (zeige VGF Proteine). NERP1 (zeige VGF Proteine) caused a concentration-dependent decrease in Fshb (zeige FSHB Proteine) gene induction.
the signaling pathways mediating GnRH activation of CREB and ICER are distinct, contributing to the decoding of the pulsatile GnRH to regulate FSHbeta expression.
Data show that estradiol or bisphenol A decreased expression of luteinizing hormone beta (Lhb (zeige LHB Proteine)), follicle stimulating hormone beta (Fshb (zeige FSHB Proteine)), and intracellular adhesion molecule (zeige NCAM1 Proteine)-5 (Icam5 (zeige ICAM5 Proteine)) in females but only decreased expression of Icam5 (zeige ICAM5 Proteine) in males.
GnRH (zeige GNRH1 Proteine) stimulation of Fshb (zeige FSHB Proteine) expression is dependent on miR (zeige MLXIP Proteine)-132/212 and involves a SIRT1 (zeige SIRT1 Proteine)-FOXO1 (zeige FOXO1 Proteine) pathway.
results suggest that FOXO1 (zeige FOXO1 Proteine) binding to the proximal Fshb (zeige FSHB Proteine) promoter as well as FOXO1 (zeige FOXO1 Proteine) interaction with SMAD3 (zeige SMAD3 Proteine)/4 proteins may result in decreased activin induction of Fshb (zeige FSHB Proteine) in gonadotropes
SCGB3A2 (zeige SCGB3A2 Proteine) regulates FSH (zeige BRD2 Proteine)/LH production in the anterior pituitary lobe.
Data suggest that the BMP2 (zeige BMP2 Proteine)-like Activin A (zeige INHBA Proteine)/BMP2 (zeige BMP2 Proteine) chimera AB215 regulates follicle stimulating hormone beta (FSHbeta) induction in LbetaT2 gonadotroph cells due to its ability to block activin A (zeige INHBA Proteine) signaling.
Two regions of the proximal Fshb (zeige FSHB Proteine) promoter (-50/-41 and -30/-21) appear to be necessary for FOXO1 (zeige FOXO1 Proteine) suppression of GnRH (zeige GNRH1 Proteine)-induced Fshb (zeige FSHB Proteine) transcription.
Report changes in hormone secretion and response of isolated ovarian tissue from transgenic animals to FSH (zeige BRD2 Proteine) and ghrelin (zeige GHRL Proteine).
This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene.
, bromodomain-containing 2
, bromodomain-containing protein 2
, female sterile homeotic-related gene 1
, really interesting new gene 3 protein
, follicle-stimulating hormone beta subunit
, follitropin beta chain
, follitropin subunit beta