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Frame-shift mutation in TWIST1 is associated with type 2 scurs syndrome.
Interaction with Snail1/2, and Twist function more generally, is regulated by GSK-3-beta-mediated phosphorylation of conserved sites in the WR domain.
Results have shown that the formation of a TWIST1- RELA (zeige NFkBP65 Proteine) complex is partially dependent on the well conserved W190, R191, and E193 residues of the TWIST1 WR domain, and that mutations at these positions reduce binding and downstream IL-8 (zeige IL8 Proteine) promoter activation.
In urothelial bladder carcinoma, TWIST1 expression positively correlated with KLF4 (zeige KLF4 Proteine). Metastasis-free survival was poorest in those with KLF4 (zeige KLF4 Proteine)/TWIST1 coexpression. KLF4 (zeige KLF4 Proteine) knockdown suppressed TWIST1 expression. KLF4 (zeige KLF4 Proteine) overexpression activated TWIST1 expression and restored EMT (zeige ITK Proteine) and metastatic phenotype. TWIST1 knockdown abolished KLF4 (zeige KLF4 Proteine)-faciliated EMT (zeige ITK Proteine) and metastatic feature without affecting KLF4 (zeige KLF4 Proteine) expression.
data provide the first evidence that T17M rhodopsin (zeige RHO Proteine) mutant disrupts C3 secretion via the induction of ROS (zeige ROS1 Proteine) and the suppression of TWIST1.
C-ROS-1 (zeige ROS1 Proteine) is involved in Bone marrow-derived mesenchymal stem/stromal cell fate switching between osteogenesis and adipogenesis, mediated via PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine)/mTORC1 signalling.
Data show that twist-related protein 1 (Twist1) requires TGF-beta type-I receptor (TGFBR1 (zeige TGFBR1 Proteine))-activation for activation for epithelial-mesenchymal transition (EMT (zeige ITK Proteine))-induction.
High Twist1 expression is associated with mesenchymal to epithelial transition of breast cancer.
FGFR2 (zeige FGFR2 Proteine), TWIST1, and FGFR3 (zeige FGFR3 Proteine) mutations were identified in children with tracheal cartilaginous sleeve (TCS). All five children with a W290C mutation in FGFR2 (zeige FGFR2 Proteine) had TCS, and most previously reported children with W290C had identification of TCS or early death
Data show that miR (zeige MLXIP Proteine)-26b-5p suppresses Twist1-induced EMT (zeige ITK Proteine), invasion, and metastasis of HCC (zeige FAM126A Proteine) cells by targeting SMAD1 (zeige GARS Proteine).
DNMT3 mutation in OCI-AML3 (zeige RUNX2 Proteine) strain enhances leukemic aggressiveness by promoting extramedullary infiltration process, which is partially through upregulating TWIST1.
By analyzing the expression levels of miR (zeige MLXIP Proteine)-497, Twist was found inversely correlated with miR (zeige MLXIP Proteine)-497 in pancreatic cancer tissues, and a positive correlation was found between Twist and VEGFA (zeige VEGFA Proteine) levels in pancreatic cancer specimens
molecular and cellular processes that regulate dural Cerebral vein development in mammals and describe venous malformations in humans with craniosynostosis and TWIST1 mutations that are recapitulated in mouse models, are reported.
Methyltransferase G9A (zeige EHMT2 Proteine) Regulates Osteogenesis via Twist Gene Repression in mice.
this study shows that loss of Twist1 in collagen-producing cells leads to increased bleomycin-induced pulmonary fibrosis, which is mediated by increased expression of CXCL12 (zeige CXCL12 Proteine)
RNF8 (zeige RNF8 Proteine)-promoted Twist ubiquitination is required for Twist localization to the nucleus for subsequent epithelial-mesenchymal transition and cancer stem cells functions, thereby conferring chemoresistance.
These results indicate that Twist1 Ser42 phosphorylation contributes to the pathogenesis of bleomycin-induced pulmonary fibrosis through angiopoietin-Tie2 (zeige TEK Proteine) signaling.
the mesenchymal properties of the cranial mesoderm are likely to be regulated by a network of TWIST1 targets that influences the extracellular matrix and cell-matrix interactions, and collectively they are required for the morphogenesis of the craniofacial structures.
TWIST1 expression promotes developmental angiogenesis by inducing endothelial cell proliferation and migration.
There was a possible regulatory link between Twist 1 and PPARgamma (zeige PPARG Proteine) in 3T3-L1 mature adipocytes. This regulatory link enhanced the regulation of PPARgamma (zeige PPARG Proteine) and may be a functional mechanism of Twist 1 regulation of adipocyte physiology and pathology
ur study revealed the dynamic Twist localization within the early stage of embryo. The results are discussed in terms of potential roles of Twist1 in the processes of lineage segregation, hatching, and implantation in post-compaction embryos and in blastocysts.
findings demonstrate that Twist-1, which maintains BMSC at an immature state, endows them with an increased capacity for supporting hematopoiesis via direct activation of CXCL12 (zeige CXCL12 Proteine) gene expression.
the ventral migration of Cranial neural crest cells (CNCCs) away from a source of Bmps in the dorsal ectoderm promotes ectomesenchyme development by relieving Id2a-dependent repression of Twist1 function.
twist1a and twist1b control skeletal development and dorsoventral patterning by regulating runx2b in zebrafish
These observations are consistent with a role for twist1 in craniofacial, vertebral, and early renal development.
Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Dermo1. The strongest expression of this mRNA is in placental tissue\; in adults, mesodermally derived tissues express this mRNA preferentially. Mutations in this gene have been found in patients with Saethre-Chotzen syndrome.
twist homolog 1
, twist transcription factor
, twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome)
, hypothetical protein
, twist-like protein
, twist-related protein 1
, twist-related protein
, B-HLH DNA binding protein
, TWIST homolog of drosophila
, class A basic helix-loop-helix protein 38
, charlie chaplin
, polydactyly EMS
, twist gene homolog 1
, twist 1
, twist homolog 1 (Drosophila)