anti-MDM2 (MDM2) Antikörper

Bezeichnung:
anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) Antikörper (MDM2)
Auf www.antikoerper-online.de finden Sie aktuell 392 Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) Antikörper von 25 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MDM2 Proteine (21) und MDM2 Kits (10) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 459 MDM2 Produkte verfügbar.
Synonyme:
1700007J15Rik, AA415488, ACTFS, hdm2, HDMX, Mdm-2, zgc:109834

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Am meisten referenzierte anti-MDM2 Antikörper

  1. Human Polyclonal MDM2 Primary Antibody für EIA - ABIN358421 : Burch, Scott, Pohler, Meek, Hupp: Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1. in Journal of molecular biology 2004 (PubMed)
    Zeige alle 5 Referenzen für 358421

  2. Human Polyclonal MDM2 Primary Antibody für EIA, IHC (p) - ABIN356776 : Schon, Friedler, Freund, Fersht: Binding of p53-derived ligands to MDM2 induces a variety of long range conformational changes. in Journal of molecular biology 2004 (PubMed)
    Zeige alle 5 Referenzen für 356776

  3. Human Polyclonal MDM2 Primary Antibody für DB, EIA - ABIN358505 : Balass, Kalef, Maya, Wilder, Oren, Katchalski-Katzir: Characterization of two peptide epitopes on Mdm2 oncoprotein that affect p53 degradation. in Peptides 2002 (PubMed)
    Zeige alle 3 Referenzen für 358505

  4. Human Monoclonal MDM2 Primary Antibody für IHC (fro), IHC (p) - ABIN180331 : Gueven, Becherel, Birrell, Chen, DelSal, Carney, Grattan-Smith, Lavin: Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype. in Cancer research 2006 (PubMed)
    Zeige alle 3 Referenzen für 180331

  5. Human Polyclonal MDM2 Primary Antibody für IHC (p), WB - ABIN388068 : Xia, Paik, Li: p53 activation in chronic radiation-treated breast cancer cells: regulation of MDM2/p14ARF. in Cancer research 2004 (PubMed)
    Zeige alle 3 Referenzen für 388068

  6. Human Monoclonal MDM2 Primary Antibody für BI, IHC (f) - ABIN967511 : Martin, Trouche, Hagemeier, Sørensen, La Thangue, Kouzarides: Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein. in Nature 1995 (PubMed)
    Zeige alle 2 Referenzen für 967511

  7. Human Polyclonal MDM2 Primary Antibody für IF, IHC (p) - ABIN388067 : Lei, Velez, Kazlauskas: Pathological signaling via platelet-derived growth factor receptor {alpha} involves chronic activation of Akt and suppression of p53. in Molecular and cellular biology 2011 (PubMed)
    Zeige alle 2 Referenzen für 388067

  8. Human Polyclonal MDM2 Primary Antibody für ELISA, WB - ABIN185508 : Bond, Hu, Bond, Robins, Lutzker, Arva, Bargonetti, Bartel, Taubert, Wuerl, Onel, Yip, Hwang, Strong, Lozano, Levine: A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. in Cell 2004 (PubMed)

Weitere Antikörper gegen MDM2 Interaktionspartner

Human Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) Interaktionspartner

  1. a novel molecular mechanism which, in silico, is capable of triggering p53 (zeige TP53 Antikörper) oscillations. The mechanism that is based on Mdm2's dual regulation of p53 (zeige TP53 Antikörper) can provide mechanistic insights into an excitability of the p53 (zeige TP53 Antikörper) network, thus it contributes to understanding of variability of p53 (zeige TP53 Antikörper) dynamics in response to single and double strand breaks.

  2. Histologically low-grade and relatively low-grade cases of extraskeletal osteosarcoma are not always associated with MDM2 amplification. ESOS cases with MDM2 amplification could be high grade.

  3. Disturbed p53 (zeige TP53 Antikörper)-MDM2 feedback loop contributing to the pathogenesis of thoracic aortic dissection may be linked to TRIM25 (zeige TRIM25 Antikörper) overexpression.

  4. These results identify a novel function for FKBP12 (zeige FKBP1A PLURAL_@30317@) in downregulating MDM2, which directly enhances sensitivity of cancer cells to chemotherapy and nutlin-3 treatment.

  5. Although uncommon, MDM2 labeling is seen in a subset of fat-predominant angiolipomas and is a potential diagnostic pitfall in the evaluation of fatty tumors of the retroperitoneum.

  6. high-level MDM2 expression is needed in order to perform a critical p53 (zeige TP53 Antikörper)-independent function and may obviate the need for genomic alterations to the p53 (zeige TP53 Antikörper) pathway during retinoblastoma tumorigenesis.

  7. p16 (zeige CDKN2A Antikörper) in combination with MDM2 and CDK4 (zeige CDK4 Antikörper) immunohistochemistry may help in the differential diagnosis of atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma.

  8. MDM2 gene single nucleotide polymorphism are associated with apoptotic signaling and smoking-related emphysematous changes in lungs.

  9. we determined the molecular mechanism responsible for IER3 (zeige IER3 Antikörper) degradation, involving a ternary complex of IER3 (zeige IER3 Antikörper), MDM2 and FHL2 (zeige FHL2 Antikörper), which may contribute to cervical tumor growth. Furthermore, we demonstrated that FHL2 (zeige FHL2 Antikörper) serves as a scaffold for E3 ligase and its substrate during the ubiquitination reaction, a function that has not been previously reported for this protein

  10. NPM1 (zeige NPM1 Antikörper) downregulation by P-STAT5 (zeige STAT5A Antikörper) is mediated by impairing the BRCA1-BARD1 (zeige BARD1 Antikörper) ubiquitin ligase, which controls the stability of NPM1 (zeige NPM1 Antikörper). In turn, decreased NPM1 (zeige NPM1 Antikörper) levels led to suppression of p53 (zeige TP53 Antikörper) expression, resulting in enhanced cell survival.

Cow (Bovine) Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) Interaktionspartner

  1. results suggest overexpression of MDM2 is closely linked to inhibition of p53 (zeige TP53 Antikörper)-dependent apoptosis of Theileria parva (zeige PARVA Antikörper)-infected lymphocytes; aberrant expression of host lymphocyte MDM2 induced by cytoplasmic existence of T. parva (zeige PARVA Antikörper), directly and/or indirectly, is associated with aspects of this type of transformation of T. parva (zeige PARVA Antikörper)-infected lymphocytes

Zebrafish Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) Interaktionspartner

  1. Data indicate that knockdown of the Mdm2 and Mdm4 (zeige MDM4 Antikörper) caused dramatic accumulation of mutant p53 protein (zeige TP53 Antikörper).

  2. Together with p53 (zeige TP53 Antikörper), provides an experimental model for characterizing drugs and genes that affect p53 (zeige TP53 Antikörper) signaling.

  3. Data show that liver-specific expression of p53 (zeige TP53 Antikörper)-negative regulator mdm2 leads to growth retardation and fragile liver in zebrafish.

Mouse (Murine) Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) Interaktionspartner

  1. In Fmr1 (zeige FMR1 Antikörper) KO neurons, Mdm2 is hyperphosphorylated, nuclear localized basally, and unaffected by MEF2 (zeige MEF2C Antikörper) activation, which our data suggest due to an enhanced interaction with Eukaryotic Elongation Factor (zeige TSFM Antikörper) 1alpha (EF1alpha), whose protein levels are elevated in Fmr1 (zeige FMR1 Antikörper) KO. Expression of a dephosphomimetic of Mdm2 rescues PSD-95 (zeige DLG4 Antikörper) ubiquitination, degradation and synapse elimination in Fmr1 (zeige FMR1 Antikörper) KO neurons.

  2. MDM2 is a non-redundant survival factor for proximal tubular cells by protecting them from spontaneous p53 (zeige TP53 Antikörper) overexpression-related cell death.

  3. The case emphasizes that MDM2 expression represents a possible pitfall in the diagnosis of spindle cell tumors. The differential diagnostic distinction between FDCS and a dedifferentiated liposarcoma is discussed.

  4. MDM2 is involved in fibroblast activation, mediating renal tubulointerstitial fibrosis via a p53 (zeige TP53 Antikörper)-independent pathway dependant on Notch1 (zeige NOTCH1 Antikörper) ubiquitination and proteasome degradation.

  5. These findings suggest that Mdm2 splice isoforms may play critical roles in the regulatory loop of p53 (zeige TP53 Antikörper)/Mdm2-Mdm4 (zeige MDM4 Antikörper) via a RING domain-mediated biochemical mechanism.

  6. both MDM2 and MDMX (zeige MDM4 Antikörper) deletion-caused pancreatic defects are completely rescued by loss of p53 (zeige TP53 Antikörper), verifying the crucial role of the MDM2 and/or MDMX (zeige MDM4 Antikörper) in regulating p53 (zeige TP53 Antikörper) in a spatio-temporal manner during the development, functional maintenance, and related disease progress of endocrine pancreas.

  7. Vif (zeige BTG1 Antikörper) stabilization by CBFbeta (zeige CBFB Antikörper) is mainly caused by impairing MDM2-mediated degradation.

  8. These results demonstrated a critical prosurvival role for MDM2 in the oocytes

  9. we failed to detect any increase in p53 (zeige TP53 Antikörper) level in mutant oocytes, nor any other apoptotic marker, introgression of this targeted invalidation in p53 (zeige TP53 Antikörper)-/- mice restored the fertility of females. This study is the first to show that Mdm2, but not Mdm4 (zeige MDM4 Antikörper), has a critical role in oocyte survival and would be involved in premature ovarian insufficiency phenotype.

  10. Inhibition of MDM2 re-sensitizes rapamycin resistant renal cancer cells via the activation of p53 (zeige TP53 Antikörper).

MDM2 Antigen-Profil

Beschreibung des Gens

This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.

Alternative names and synonyms associated with MDM2

  • MDM2 oncogene, E3 ubiquitin protein ligase (MDM2) Antikörper
  • MDM2 oncogene, E3 ubiquitin protein ligase (mdm2) Antikörper
  • MDM2 oncogene, E3 ubiquitin protein ligase (Mdm2) Antikörper
  • Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) (MDM2) Antikörper
  • p53 E3 ubiquitin protein ligase (Mdm2) Antikörper
  • transformed 3T3 cell double minute 2 homolog (mouse) (mdm2) Antikörper
  • transformed mouse 3T3 cell double minute 2 (Mdm2) Antikörper
  • 1700007J15Rik Antikörper
  • AA415488 Antikörper
  • ACTFS Antikörper
  • hdm2 Antikörper
  • HDMX Antikörper
  • Mdm-2 Antikörper
  • zgc:109834 Antikörper

Bezeichner auf Proteinebene für MDM2

E3 ubiquitin-protein ligase Mdm2 , Mdm2, p53 E3 ubiquitin protein ligase homolog , Mdm2, transformed 3T3 cell double minute 2, p53 binding protein , double minute 2, human homolog of; p53-binding protein , oncoprotein Mdm2 , Mdm2 p53 binding protein homolog , double minute 2 protein , p53-binding protein Mdm2 , xdm2 , MDM2 alpha , cdm2 , double minute 2 homolog , double minute 2 , MDM2-like protein , edm2 , transformed mouse 3T3 cell double minute 2 , etID309863.4 , murine double minute 2 homolog

GENE ID SPEZIES
4193 Homo sapiens
444499 Xenopus laevis
100724684 Cavia porcellus
403693 Canis lupus familiaris
493939 Felis catus
100125959 Sus scrofa
540378 Bos taurus
100033891 Equus caballus
395609 Gallus gallus
742141 Pan troglodytes
314856 Rattus norvegicus
30637 Danio rerio
17246 Mus musculus
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