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anti-Human HRAS Antikörper:
anti-Rat (Rattus) HRAS Antikörper:
anti-Mouse (Murine) HRAS Antikörper:
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Human Polyclonal HRAS Primary Antibody für IF, IHC (p) - ABIN392183
Ma, Liu, Wu, Terada: p66(Shc) restrains Ras hyperactivation and suppresses metastatic behavior. in Oncogene 2010
Show all 2 Pubmed References
Human Polyclonal HRAS Primary Antibody für ELISA, WB - ABIN561363
Ambrosini, Khanin, Carvajal, Schwartz: Overexpression of DDX43 mediates MEK inhibitor resistance through RAS Upregulation in uveal melanoma cells. in Molecular cancer therapeutics 2014
Data demonstrate that H-Ras activation is important in the activation of the specific signaling events leading to the accelerated retinal capillary cell apoptosis in hyperglycemic conditions.
Activation of H-Ras and its downstream signaling pathway in the retina and its vasculature could be under the control of superoxide, and H-Ras activation in diabetes can be prevented by inhibiting superoxide accumulation.
Thrombospondin 1 (zeige THBS1 Antikörper), fibronectin (zeige FN1 Antikörper), and vitronectin (zeige VTN Antikörper) are differentially dependent upon RAS, ERK1/2 (zeige MAPK1/3 Antikörper), and p38 (zeige MAPK14 Antikörper) for induction of vascular smooth muscle cell chemotaxis.
Kita driven expression of oncogenic HRAS leads to early onset and highly penetrant melanoma in zebrafish
Analysis of HRAS mutations and their respiratory phenotype revealed that the common p.Gly12Ser mutation is more often associated with transient respiratory distress and other respiratory diagnoses.
we found that H-Ras proteins and particularly the G12V and G13D variants are significantly more flexible than their K-Ras counterparts.while most of the simulated proteins sampled the effector-interacting state 2 conformational state, G12V and G13D H-Ras adopted an open switch state 1 conformation that is defective in effector interaction
The HRAS mutation p.T58I could manifest with severe early-onset but stabilizing cardiomyopathy. The dysmorphic features are mild compared with the features of Costello syndrome. The phenotypic variability makes the diagnosis challenging, suggesting that this variant of Costello syndrome might go undiagnosed.
Age at diagnosis of follicular thyroid cancer (FTC (zeige FUT2 Antikörper)) and frequency of extrathyroidal extension have changed over four decades; prevalence of RAS mutations has decreased; HRAS/NRAS (codon 61) and TERT (zeige TERT Antikörper) (promoter) mutations may be associated with poor clinical outcomes in FTC (zeige FUT2 Antikörper), especially when two mutations coexist; this retrospective study was conducted in Seoul.
Knockdown of forkhead Box M1 (FoxM1 (zeige FOXM1 Antikörper)) reduced Prx (zeige PRDX6 Antikörper) II levels in H-ras(G12V)-hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)) cells, indicating FoxM1 (zeige FOXM1 Antikörper) as a direct transcription factor of Prx (zeige PRDX6 Antikörper) II in HCC (zeige FAM126A Antikörper).
we found that ectopic expression of oncogenic KRas and HRas in cells resulted in elevated CIB1 (zeige CIB1 Antikörper) expression. We previously described the Ca(2 (zeige CA2 Antikörper)+)-myristoyl switch function of CIB1 (zeige CIB1 Antikörper), and its ability to facilitate agonist-induced plasma membrane localisation of sphingosine kinase 1 (SK1 (zeige SPHK1 Antikörper)), a location where SK1 (zeige KCNN1 Antikörper) is known to elicit oncogenic signalling.
Data suggest that isoform-specific sequences in the allosteric lobes of HRAS, KRAS, and NRAS (zeige NRAS Antikörper) have an impact on biocatalysis (kinetics of GTP (zeige AK3 Antikörper) hydrolysis) and interaction with c-Raf (zeige RAF1 Antikörper) kinase, which must be due to allosteric effects on dynamics and conformational states, given the identical active sites of these isoenzymes.
Data suggest HRas activates both p110alpha and p110delta isoforms; membrane-resident HRas, not soluble HRas, increases membrane recruitment of both p110alpha and p110delta. (HRas = v-Ha-ras Harvey rat sarcoma viral oncogene homolog; p110alpha = class IA phosphoinositide 3-kinases, subunit p110alpha; p110delta = class IA phosphoinositide 3-kinases, subunit p110delta)
Our data suggest that testing for any RAS mutation is unlikely to change the clinical management of thyroid nodules that have indeterminate cytology
Equilibrium dissociation constants were determined for the binding of HRAS, KRAS, NRAS and RRAS2 to the RAS binding (RB) domain of binding proteins.
It has been concluded that VMP1-mediated autophagy cooperated with Kras to promote pancreatic ductal adenocarcinoma initiation.
High KRAS expression is associated with Gastric Tumorigenesis.
Study underscores genomic alterations that represent early events in the development of Kras mutant LUAD following Gprc5a (zeige GPRC5A Antikörper) loss and tobacco carcinogen exposure.
High HRAS expression is associated with hepatocarcinogenesis.
In the absence of TP53, chronic imflammaiton leads to the development of several rare K-ras-independent forms of PC, with infrequent PDAC.
KrasG12D-driven proliferation of pancreatic ductal epithelial cells (PDECs) depends on an EGFR (zeige EGFR Antikörper) signaling loop engaging the oncogenic transcription factor c-MYC (zeige MYC Antikörper).
median survival of KPIC mice was longer than that of LSL-KrasG12D; Ink4flox/flox; Ptf1/p48 (zeige PTF1A Antikörper)-Cre mice (KIC) (89 vs 62 days) and shorter than that of KRAS (KrasG12D), TP53 (zeige TP53 Antikörper) (Trp53R172H/+) and Ptf1/p48 (zeige PTF1A Antikörper)-Cre (KPC) mice
Loss of N-cadherin in the context of oncogenic K-ras leads to increased pancreatic intraepithelial neoplasia (PanIN) incidence and progression.
p21 (zeige D4S234E Antikörper)-associated inhibition of early-stage malignant progression and the intense expression in papilloma outgrowths, identifies a novel, significant antagonism between p21 (zeige D4S234E Antikörper) and ras(Ha)/ROCK2 (zeige ROCK2 Antikörper)/NF-kappaB (zeige NFKB1 Antikörper) signalling in skin carcinogenesis.these data show that ROCK2 (zeige ROCK2 Antikörper) activation induces malignancy in ras(Ha)-initiated/promoted papillomas in the context of p53 (zeige TP53 Antikörper) loss and novel NF-kappaB (zeige NFKB1 Antikörper) expression
activating mutations in GNAS and Kras cooperatively promote murine pancreatic tumorigenesis
This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.
GTP- and GDP-binding peptide B
, GTPase HRas
, Ha-Ras1 proto-oncoprotein
, Ras family small GTP binding protein H-Ras
, c-has/bas p21 protein
, c-ras-Ki-2 activated oncogene
, p19 H-RasIDX protein
, transformation gene: oncogene HAMSV
, transforming protein p21
, v-Ha-ras Harvey rat sarcoma viral oncogene homolog
, Transforming protein p21
, neuroblastoma ras oncogene
, v-Ha-ras Harvey rat sarcoma viral oncogene-like protein
, Harvey ras1 protein
, Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog
, ras p21
, small G-protein H-Ras
, GTPase HRas (Transforming protein p21) (H-Ras-1) (c-H-ras)
, Harvey ras 1
, H-ras 1 protein
, c-Ha-ras p21 protein
, c-Ha-ras transgene
, transforming protein P21