E2F1 Proteine (E2F1)

Bezeichnung:
E2F Transcription Factor 1 Proteine (E2F1)
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Synonyme:
ATE2FB, CG6376, dE2f, de2f1, def21, DmE2F-1, Dmel\\CG6376, Dp, drosE2F1, DRTF1/E2F, E(Sev-CycE)3A, E(var)3-93E, E(var)3-95E, E(var)93E, e2f, E2F-1, e2f1, E2FB, E2FB TRANSCRIPTION FACTOR, E2F TRANSCRIPTION FACTOR-1 E2F1, E2F transcription factor 1, Evar(3)164, l(3)07172, l(3)j3B1, l(3)j3C2, l(3)rM729, mKIAA4009, RBAP1, RBBP3, RBP3, xE2F
alle Proteine anzeigen Gen GeneID UniProt
E2F1 1869 Q01094
E2F1 13555 Q61501
E2F1 399489  

Weitere Synonyme anzeigen

E2F1 Proteine (E2F1) nach Spezies

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Am meisten referenzierte E2F1 Proteine

  1. Human E2F1 Protein expressed in HEK-293 Cells - ABIN2719894 : Tarangelo, Lo, Teng, Kim, Le, Watson, Furth, Raman, Ehmer, Viatour: Recruitment of Pontin/Reptin by E2f1 amplifies E2f transcriptional response during cancer progression. in Nature communications 2015 (PubMed)

Weitere Proteine zu E2F1 Interaktionspartnern

Fruit Fly (Drosophila melanogaster) E2F Transcription Factor 1 (E2F1) Interaktionspartner

  1. specific alternate transcripts of activator E2F (zeige E2F2 Proteine), dE2F1, may have a dual function on cell cycle progression and cannot simply be viewed as a pro-proliferative transcription factor

  2. These findings identify a key function of E2F in skeletal muscle required for animal viability, and illustrate how the cell cycle regulator is repurposed in post-mitotic cells.

  3. Mechanistically, miR (zeige MYLIP Proteine)-998 operates by repressing dCbl, a negative regulator of EGFR (zeige EGFR Proteine) signaling. Significantly, dCbl is a critical target of miR (zeige MYLIP Proteine)-998 since dCbl phenocopies the effects of miR (zeige MYLIP Proteine)-998 on dE2f1-dependent apoptosis in rbf (zeige ATP5I Proteine) mutants

  4. also demonstrated that an optimum level of dLin52 is needed for dE2F1/2 activity on the hid promoter

  5. Results show that regulation of e2f1 and PCNA (zeige PCNA Proteine) by DREF (zeige ZBED1 Proteine) in vivo is complex and the regulation mechanism may differ with the tissue and/or positions in the tissue.

  6. Loss of dE2F compromises mitochondrial function.

  7. Data propose that the interaction between ORC5 (zeige ORC5 Proteine) and dE2F1 may reflect a feedback mechanism between replication initiation proteins and dE2F1 that ensures that proliferating cells maintain a robust level of replication proteins for the next cell cycle.

  8. results suggest that E2F/DP complexes are essential for all genomic targeting of RBF1

  9. Inappropriate accumulation of E2f1 protein during S phase triggers the elimination of potentially hyperplastic cells via apoptosis in order to ensure normal development of rapidly proliferating tissues.

  10. endocycles of Drosophila are driven by a molecular oscillator in which the E2F1 transcription factor promotes CycE (zeige CCNE1 Proteine) expression and S-phase initiation, S-phase then activates the CRL4(CDT2) ubiquitin ligase, and this in turn mediates the destruction of E2F1

Human E2F Transcription Factor 1 (E2F1) Interaktionspartner

  1. These data suggest a model in which cells experiencing oncogene (zeige RAB1A Proteine)-induced replication stress through deregulation of E2F-dependent transcription.

  2. Describe a regulatory loop miR (zeige MLXIP Proteine)-218-CDK6 (zeige CDK6 Proteine)/CyclinD1-E2F1 whose disruption may contribute to cell cycle progression in gastric cancer.

  3. Results demonstrated that somatic mutation within E2F1:MIR136-5p target site impairs miRNA-mediated regulation and leads to increased gene activity.

  4. Specific E2Fs also have prognostic value in breast cancer, independent of clinical parameters. We discuss here recent advances in understanding of the RB-E2F pathway in breast cancer. We also discuss the application of genome-wide genetic screening efforts to gain insight into synthetic lethal interactions of CDK4/6 (zeige CDK4 Proteine) inhibitors in breast cancer for the development of more effective combination therapies.

  5. Here, we introduce a transcriptional signature to specifically track CDK2 (zeige CDK2 Proteine) activity. It responds to genetic and chemical perturbations in the CDK (zeige CDK4 Proteine)-RB-E2F axis, correlates with mitotic rate in vitro and in vivo and reacts rapidly to changes in CDK2 (zeige CDK2 Proteine) activity during cell cycle progression

  6. E2F transcription factor 1 (E2F1) downregulated micrRNA miR (zeige MLXIP Proteine)-519d directly and miR (zeige MLXIP Proteine)-519d downregulated Ras homolog gene family member C (RhoC (zeige RHOC Proteine)) directly.

  7. REVIEW: the data available so far indicate that the proliferative and apoptotic functions of E2F1 in Hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) may coexist but the proliferative effect seems to be more pronounced than the apoptotic one

  8. our results established the significance of activating the KLF6 (zeige KLF6 Proteine)-E2F1 axis in aggressive primary metastatic clear cell renal cell carcinoma (zeige MOK Proteine)

  9. High E2F1 expression is associated with glioma.

  10. H19 (zeige NCKAP1 Proteine) is overexpressed and plays oncogenic role in PDAC through promoting cancer cell proliferation via the upregulation of E2F-1.

Mouse (Murine) E2F Transcription Factor 1 (E2F1) Interaktionspartner

  1. The evidence has been presented that the retinoblastoma protein utilizes a cell-cycle-independent interaction with E2F1 to recruit EZH2 (zeige EZH2 Proteine) to diverse repeat sequences.

  2. germ-line loss of E2f1 or E2f3b, but not E2f3a, protected mice against hepatocellular carcinoma

  3. E2F1 hinders skin wound healing by suppressing VEGF (zeige VEGFA Proteine) expression, neovascularization, and macrophage recruitment. Strategies that target E2F1 may enhance wound healing.

  4. systems-level control of cell cycle arrest by pRB (zeige PGR Proteine)-E2F and p27 (zeige CDKN1B Proteine)-CDK (zeige CDK4 Proteine) regulation, is reported.

  5. TERT (zeige TERT Proteine) has a role in neointima formation through epigenetic regulation of proliferative E2F1 target gene expression in smooth muscle cells.

  6. inhibition of PDK4 (zeige PDK4 Proteine) activity in Hepatocellular carcinoma cells increased cyclin E1 (zeige CCNE1 Proteine), cyclin A2 (zeige CCNA2 Proteine), and E2F1 proteins.

  7. Data indicate that adenosine and CGS21680 upregulate CD39 (zeige ENTPD1 Proteine) and CD73 via E2F-1 and CREB (zeige CREB1 Proteine).

  8. Expression of Kv10.1 (zeige KCNG3 Proteine) driven by phosphorylated Rb/E2F1 contributes to G2/M progression of cancer and non-transformed cells.

  9. Spinal cord injury-induced activation of E2F1-2 mediates cell cycle activation, contributing to gliopathy and neuronal/tissue loss associated with motor impairments and post-traumatic hyperesthesia.

  10. In the initial stage of myocyte differentiation, transcription of the YB-1 (zeige YBX1 Proteine) gene was regulated by E2F1 and Sp1 (zeige SP1 Proteine), and was then gradually replaced under the control of both MyoD (zeige MYOD1 Proteine) and myogenin (zeige MYOG Proteine).

Xenopus laevis E2F Transcription Factor 1 (E2F1) Interaktionspartner

  1. Xphb1 represses E2F1 activity.

Arabidopsis thaliana E2F Transcription Factor 1 (E2F1) Interaktionspartner

  1. SIM (zeige SIM2 Proteine) and SMR1 are involved in hyperphosphorylation of the cell-cycle regulator RBR1 and overexpression of E2F target genes.

  2. S6K1 interacts with retinoblastoma protein RBR via its N-terminal RBR binding motif, promotes its nuclear localization and consequent RBR-dependent repression of cell cycle genes through transcription factor E2FB.

  3. The Arabidopsis (Arabidopsis thaliana) DEL1 gene was identified as a transcriptional target of the classical E2Fb and E2Fc transcription factors.

  4. The authors found that S6K1 associates with the Retinoblastoma-related 1 (RBR1)-E2FB complex and this is partly mediated by its N-terminal LVxCxE motif.

  5. Results suggest that E2FB is one of the key targets for auxin to determine whether cells proliferate or whether they exit the cell cycle, enlarge, and endoreduplicate their DNA.

  6. AtE2Fa and AtE2Fb have specific expression patterns and may play similar but distinct roles during cell cycle progression.

E2F1 Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.

Alternative names and synonyms associated with E2F1

  • E2F transcription factor (E2f)
  • E2F transcription factor 1 (E2F1)
  • E2F transcription factor 1 (E2f1)
  • E2F transcription factor 1 (e2f1)
  • ATE2FB Protein
  • CG6376 Protein
  • dE2f Protein
  • de2f1 Protein
  • def21 Protein
  • DmE2F-1 Protein
  • Dmel\\CG6376 Protein
  • Dp Protein
  • drosE2F1 Protein
  • DRTF1/E2F Protein
  • E(Sev-CycE)3A Protein
  • E(var)3-93E Protein
  • E(var)3-95E Protein
  • E(var)93E Protein
  • e2f Protein
  • E2F-1 Protein
  • e2f1 Protein
  • E2FB Protein
  • E2FB TRANSCRIPTION FACTOR Protein
  • E2F TRANSCRIPTION FACTOR-1 E2F1 Protein
  • E2F transcription factor 1 Protein
  • Evar(3)164 Protein
  • l(3)07172 Protein
  • l(3)j3B1 Protein
  • l(3)j3C2 Protein
  • l(3)rM729 Protein
  • mKIAA4009 Protein
  • RBAP1 Protein
  • RBBP3 Protein
  • RBP3 Protein
  • xE2F Protein

Bezeichner auf Proteinebene für E2F1

CG6376-PA , CG6376-PB , CG6376-PC , CG6376-PD , E2-promoter binding factor , E2f-PA , E2f-PB , E2f-PC , E2f-PD , PBR3 , PRB-binding protein E2F-1 , RBAP-1 , RBBP-3 , retinoblastoma-associated protein 1 , retinoblastoma-binding protein 3 , transcription factor E2F1 , E2F-1 transcription factor , E2F-1

GENE ID SPEZIES
42550 Drosophila melanogaster
100069192 Equus caballus
1869 Homo sapiens
13555 Mus musculus
485839 Canis lupus familiaris
535369 Bos taurus
458184 Pan troglodytes
100036852 Xenopus laevis
396142 Gallus gallus
399489 Rattus norvegicus
100729531 Cavia porcellus
832283 Arabidopsis thaliana
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