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anti-CHEK1 (CHEK1) Antikörper

anti-Checkpoint Kinase 1 Antikörper (CHEK1)
Auf finden Sie aktuell 486 Checkpoint Kinase 1 (CHEK1) Antikörper von 29 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen CHEK1 Kits (25) und CHEK1 Proteine (16) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 567 CHEK1 Produkte verfügbar.
An08g10320, AO090003000441, C85740, CHEK1, Chk1, id:ibd2720, rad27, zgc:56093

Meistgesuchte Reaktivitäten zu anti-CHEK1 (CHEK1) Antikörper

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anti-Human CHEK1 Antikörper:

anti-Mouse (Murine) CHEK1 Antikörper:

anti-Rat (Rattus) CHEK1 Antikörper:

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Am meisten referenzierte anti-CHEK1 Antikörper

  1. Human Polyclonal CHEK1 Primary Antibody für EIA, IHC (p) - ABIN358109 : Krämer, Mailand, Lukas, Syljuåsen, Wilkinson, Nigg, Bartek, Lukas: Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase. in Nature cell biology 2004 (PubMed)
    Zeige alle 5 Referenzen für ABIN358109

  2. Human Polyclonal CHEK1 Primary Antibody für EIA, WB - ABIN357628 : Chen, Ryan, Piwnica-Worms: Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding. in Molecular and cellular biology 2003 (PubMed)
    Zeige alle 5 Referenzen für ABIN357628

  3. Human Polyclonal CHEK1 Primary Antibody für EIA, IHC (p) - ABIN358108 : Xu, Lee, Stern: Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. in The Journal of biological chemistry 2004 (PubMed)
    Zeige alle 5 Referenzen für ABIN358108

  4. Human Polyclonal CHEK1 Primary Antibody für DB, IHC (p) - ABIN389543 : Ng, Lee, Ho, Arooz, Siu, Lau, Poon: Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains. in The Journal of biological chemistry 2004 (PubMed)
    Zeige alle 3 Referenzen für ABIN389543

  5. Human Polyclonal CHEK1 Primary Antibody für IF, ELISA - ABIN1531555 : Sanchez, Wong, Thoma, Richman, Wu, Piwnica-Worms, Elledge: Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. in Science (New York, N.Y.) 1997 (PubMed)
    Zeige alle 2 Referenzen für ABIN1531555

  6. Human Polyclonal CHEK1 Primary Antibody für IF, ELISA - ABIN1531554 : Matsuoka, Ballif, Smogorzewska, McDonald, Hurov, Luo, Bakalarski, Zhao, Solimini, Lerenthal, Shiloh, Gygi, Elledge: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. in Science (New York, N.Y.) 2007 (PubMed)
    Zeige alle 2 Referenzen für ABIN1531554

  7. Chicken Polyclonal CHEK1 Primary Antibody für WB - ABIN2779737 : Bennett, Larkin, Gillespie, Clarke: Claspin is phosphorylated in the Chk1-binding domain by a kinase distinct from Chk1. in Biochemical and biophysical research communications 2008 (PubMed)

Weitere Antikörper gegen CHEK1 Interaktionspartner

Human Checkpoint Kinase 1 (CHEK1) Interaktionspartner

  1. High CHK1 expression is associated with increased radioresistance of non-small cell lung cancer.

  2. CHEK1 loss-of-function mutations have not been found in human tumors, and transgenic expression of Chek1 in mice promotes oncogene (zeige RAB1A Antikörper)-induced transformation. [review]

  3. persistence of CHK1 levels in response to DNA damage in p53 (zeige TP53 Antikörper)-deficient cancer cells, leads to CHK1-mediated activation of NF-kappaB (zeige NFKB1 Antikörper) and induction of NF-kappaB (zeige NFKB1 Antikörper)-regulated genes in cells and in associated tumor-derived microvesicles, both of which are abrogated by loss or inhibition of CHK1.

  4. Chk1's expression is controlled by p53 (zeige TP53 Antikörper) and RB/E2F1 (zeige E2F1 Antikörper) at the transcriptional level.

  5. High CHK1 expression correlates with urinary bladder cancer.

  6. Inappropriate activation of CDK2 (zeige CDK2 Antikörper) in S phase underlies the sensitivity of a subset of cell lines to Chk1 inhibitors.

  7. In conclusion, this study exemplifies cancer-specific synthetic lethality between two proteins in the same pathway and raises the prospect of combining ATR (zeige ANTXR1 Antikörper) and CHK1 inhibitors as promising cancer therapy.

  8. This study shows that Chk1 indeed maintains a closed conformation in the absence of DNA damage through an intramolecular interaction between a region (residues 31-87) at the N-terminal kinase domain and the distal C terminus. A highly conserved Leu-449 at the C terminus is important for this intramolecular interaction.

  9. Avoiding damage formation through invalidation of Mus81 (zeige MUS81 Antikörper)-Eme2 (zeige EME2 Antikörper) and Mre11 (zeige MRE11A Antikörper), or preventing damage signaling by turning off the ATM (zeige ATM Antikörper) pathway, suppresses the replication phenotypes of Chk1-deficient cells.

  10. Chk1 is a predictive biomarker of radiotherapy resistance and early local recurrence.

Xenopus laevis Checkpoint Kinase 1 (CHEK1) Interaktionspartner

  1. The study analyzes the role of Chk1 in the replication program in sperm nuclei replicating in Xenopus egg extracts by a combination of experimental and modelling approaches.

  2. ATR-Chk1 DDR pathway appears to be dispensable for the preferential association of REV1 to MMC-damaged chromatin.

  3. Results show that Chk1 negatively regulates the Treslin-mediated loading of Cdc45 (zeige CDC45 Antikörper) onto chromatin and thereby serves to antagonize the initiation of replication.

  4. The MRN complex, in particular the nuclease (zeige DCLRE1C Antikörper) activity of Mre11 (zeige MRE11A Antikörper), plays an important role in the activation of Chk1 in response to stalled replication forks.

  5. DNA polymerase kappa (zeige POLK Antikörper)-dependent DNA synthesis at stalled replication forks is important for CHK1 activation.

  6. APE2 (zeige APEX2 Antikörper) associates with Chk1; a serine residue (S86) in the Chk1-binding motif of APE2 (zeige APEX2 Antikörper) is essential for Chk1 phosphorylation, indicating a Claspin (zeige CLSPN Antikörper)-like but distinct role for APE2 (zeige APEX2 Antikörper) in ATR (zeige ATR Antikörper)-Chk1 signaling.

  7. Data show that the death pathway is independent of ERK (zeige MAPK1 Antikörper) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (zeige CDK1 Antikörper) and JNK (zeige MAPK8 Antikörper).

  8. Findings reveal that XH2AX has a specific role in anterior neural formation of Xenopus, which is mediated through phosphorylation of XH2AX at Thr (zeige TRH Antikörper)(16) by Chk1.

  9. mechanism of Chk1 activation at the DNA replication checkpoint

  10. Cdc25A (zeige CDC25A Antikörper) is essential for the Chk1-induced cell cycle arrest and the DNA replication checkpoint in early embryos

Mouse (Murine) Checkpoint Kinase 1 (CHEK1) Interaktionspartner

  1. RAD9 (zeige RAD9A Antikörper) has a prominent role in the ATR (zeige ATR Antikörper)-Chk1 pathway that is necessary for successful formation of the damage-sensing complex and DNA damage checkpoint signaling.

  2. Acute inactivation of E4F1 (zeige E4F1 Antikörper) in these cells results in CHK1-dependent checkpoint deficiency and multiple mitochondrial dysfunctions that lead to increased ROS (zeige ROS1 Antikörper) production, energy stress, and inhibition of de novo pyrimidine synthesis

  3. Altogether, our results classify E4F1 (zeige E4F1 Antikörper) as a master regulator of CHK1 activity that ensures high fidelity of DNA replication, thus safeguarding genome stability.

  4. Heterozygous loss of Chk1 in a Wnt (zeige WNT2 Antikörper)-driven background resulted in an increase in DNA damage and apoptosis and accelerated both tumour development and progression.

  5. PAR, supplied by PARP1, interacts with Chk1 via a novel PAR-binding regulatory (PbR) motif in Chk1, independent of ATR and its activity

  6. ATM (zeige ATM Antikörper) (pSer-1981)-Chk1 (pSer-345) cascade might have mediated G2/M cell cycle arrest to allowed time to facilitate sperm-derived DNA damage repair in mouse zygotes fertilized with oxygen-stressed sperm.

  7. High level of phospho-Chk1 is associated with skin tumors.

  8. Chk1 is essential for the developmental formation of murine epidermal melanocytes but hemizygosity has little permanent developmental consequence in this cell type

  9. activated Akt1 (zeige AKT1 Antikörper) in Brca1 (zeige BRCA1 Antikörper)-deficient cells impairs Chk1 nuclear localization and subsequently disrupts interaction of Chk1 and Rad51 (zeige RAD51 Antikörper) leading to homologous recombination defects.

  10. Our results uncover a novel p53 (zeige TP53 Antikörper)-independent function for p21 (zeige D4S234E Antikörper) in protecting cells from the lethal effects of DNA damage followed by Chk1 inhibition

Cow (Bovine) Checkpoint Kinase 1 (CHEK1) Interaktionspartner

  1. The Chk1 directly phosphorylates eNOS (zeige NOS3 Antikörper) Ser (zeige SIGLEC1 Antikörper)(1179) in response to UV irradiation, which is dependent on Hsp90 (zeige HSP90 Antikörper) interaction.

CHEK1 Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with CHEK1

  • checkpoint kinase 1 (CHEK1) Antikörper
  • serine/threonine-protein kinase chk1 (ANI_1_2436074) Antikörper
  • serine/threonine-protein kinase chk1 (AOR_1_768154) Antikörper
  • serine/threonine-protein kinase Chk1 (PTRG_04183) Antikörper
  • serine/threonine-protein kinase chk1 (SJAG_01680) Antikörper
  • serine/threonine-protein kinase chk1 (PAAG_04978) Antikörper
  • serine/threonine-protein kinase chk1 (MCYG_03290) Antikörper
  • serine/threonine-protein kinase chk1 (VDBG_03742) Antikörper
  • checkpoint kinase 1 (chek1) Antikörper
  • checkpoint kinase 1 (Chek1) Antikörper
  • CHK1 checkpoint homolog (S. pombe) (chek1) Antikörper
  • CHK1 checkpoint homolog (S. pombe) (CHEK1) Antikörper
  • STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) (STT3A) Antikörper
  • An08g10320 Antikörper
  • AO090003000441 Antikörper
  • C85740 Antikörper
  • CHEK1 Antikörper
  • Chk1 Antikörper
  • id:ibd2720 Antikörper
  • rad27 Antikörper
  • zgc:56093 Antikörper

Bezeichner auf Proteinebene für CHEK1

CHK1 checkpoint homolog , Serine/threonine-protein kinase Chk1-like protein , serine/threonine-protein kinase Chk1 , serine/threonine-protein kinase chk1 , Checkpoint, S. pombe, homolog of, 1 , Chk1-S , cell cycle checkpoint kinase , checkpoint kinase-1 , Chk1 checkpoint kinase , xChk1 , checkpoint kinase 1 homolog , rad27 homolog , 2720 , integral membrane protein 1

100064353 Equus caballus
4983346 Aspergillus niger CBS 513.88
5991605 Aspergillus oryzae RIB40
6342420 Pyrenophora tritici-repentis Pt-1C-BFP
7049849 Schizosaccharomyces japonicus yFS275
9096078 Paracoccidioides sp. 'lutzii' Pb01
9230546 Arthroderma otae CBS 113480
9532482 Verticillium alfalfae VaMs.102
1111 Homo sapiens
398191 Xenopus laevis
609767 Canis lupus familiaris
12649 Mus musculus
140583 Rattus norvegicus
100511709 Sus scrofa
393162 Danio rerio
513678 Bos taurus
374260 Gallus gallus
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