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Human NR5A2 + LRH1 Protein expressed in Wheat germ - ABIN1312989
Khan, Narayanan, Lu, Choo, Du, Wiradharma, Yang, Wan: Delivery of reprogramming factors into fibroblasts for generation of non-genetic induced pluripotent stem cells using a cationic bolaamphiphile as a non-viral vector. in Biomaterials 2013
NR5A2 may be important in the pathophysiology of preterm birth and exploring noncoding regulators of NR5A2 is warranted
Our study suggests that miR (zeige MLXIP Proteine)-219-5p regulated the proliferation, migration, and invasion of human gastric cancer cells by suppressing LRH-1.
Liver receptor homolog-1 was identified as a direct target gene of miR (zeige MLXIP Proteine)-136
miR (zeige MLXIP Proteine)-27b-3p levels were found to be significantly negatively correlated with both NR5A2 and CREB1 (zeige CREB1 Proteine) levels in breast cancer tissues.
The fusion transcript NR5A2-KLHL29FT was identified in normal and cancerous colonic epithelia. It is due to an uncharacterized polymorphic germline insertion of the NR5A2 sequence from chromosome 1 into the KLHL29 locus at chromosome 2, rather than a chromosomal rearrangement. NR5A2-KLH29FT expression levels were significantly lower in colon cancers than in matched normal colonic epithelia.
Additionally, the authors solved the structure of the human LRH-1 DNA-binding domain bound to a DR0 motif located within the Oct4 (zeige POU5F1 Proteine) promoter.
miR (zeige MLXIP Proteine)-376c inhibits non-small-cell lung cancer cell growth and invasion by targeting LRH-1
The first crystal structure of the LRH-1-PGC1alpha complex , which depicts hydrophobic contacts is identified and described.
The dramatic repositioning is influenced by a differential ability to establish stable face-to-face pi-pi-stacking with the LRH-1 residue His-390, as well as by a novel polar interaction mediated by the RJW100 hydroxyl group. The differing binding modes result in distinct mechanisms of action for the two agonists.
The role of NR5A2 in regulating pancreatic cancer stem cell properties and epithelial-mesenchymal transition of pancreatic carcinoma cells
results suggest that Sod2 (zeige SOD2 Proteine) is a target gene of LRH-1, and that LRH-1 agonists can mediate a reduction in ROS (zeige ROS1 Proteine) production and oxidative stress driven by an excess of fatty acids, as exhibited in nonalcoholic fatty liver disease
These findings suggest that compromised SUMOylation of LRH-1 promotes the development of nonalcoholic fatty liver disease under lipogenic conditions through regulation of OSBPL3 (zeige OSBPL3 Proteine).
these data show for the first time LRH-1 expression in T cells, its role in FASLG (zeige FASL Proteine) transcription and the potential of pharmacological inhibition of LRH-1 in the treatment of FasL (zeige FASL Proteine)-mediated immunopathologies
highlight the importance of LRH-1 in coordinating glutamine-induced metabolism and signaling to promote hepatocellular carcinogenesis.
Mice carrying a mutation on lysine 289 of LRH-1 (Lrh1 K289R mice) display reduced LRH-1 SUMOylation and increased expression of genes regulating cholesterol transport.
Results identify LRH-1 as a critical component of the anti-inflammatory and fungicidal response of alternatively activated macrophages that acts upstream from the IL-13 (zeige IL13 Proteine)-induced 15-HETE/PPARgamma (zeige PPARG Proteine) axis.
The authors conclude that LRH-1 initiates a novel pathway of endoplasmic reticulum stress resolution that is independent of the unfolded protein response, yet equivalently required.
study demonstrates for the first time that LRH-1 has a CRT (zeige SLC6A8 Proteine)-dependent NES (zeige NES Proteine) which is not only required for cytoplasmic trafficking, but also essential for correct protein folding to avoid misfolding-induced aggregation.
Heterozygous gene deletion of LRH-1 causes body weight gains without any apparent worsening of glucose and lipid metabolism.
NR5A2 has a role in controlling aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis
GATA4 (zeige GATA4 Proteine) and GATA6 (zeige GATA6 Proteine) mRNA and proteins could be detected in bovine corpus luteum (CL). GATA6 (zeige GATA6 Proteine) showed a marked decrease at the regressed luteal stage, like NR5A1 (zeige NR5A1 Proteine), NR5A2, and the other steroidogenic markers.
NR5A2 (LRH-1, SF2 (zeige SRSF1 Proteine)) mRNA is upregulated in granulosa cells of dominant and hCG (zeige CGA Proteine)-induced ovulatory ovarian follicles.
Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
nuclear receptor subfamily 5, group A, member 2
, Ftz-F1-related orphan receptor A
, FTZ-F1-related nuclear orphan receptor
, Ftz-F1-related orphan receptor
, liver receptor-like protein 1
, CYP7A promoter-binding factor
, alpha-1-fetoprotein transcription factor
, b1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virus
, fetoprotein-alpha 1 (AFP) transcription factor
, hepatocytic transcription factor
, liver nuclear receptor homolog-1 variant 2
, liver receptor homolog 1
, liver receptor homolog-1
, nuclear receptor NR5A2
, nuclear receptor subfamily 5 group A member 2
, Ftz-F1-related orphan receptor B
, fetoprotein transcription factor
, FTZ-F1 beta
, FTZ-F1 beta2 protein