POFUT1 Proteine (POFUT1)

Bezeichnung:
Protein O-Fucosyltransferase 1 Proteine (POFUT1)
Auf www.antikoerper-online.de finden Sie aktuell 11 Protein O-Fucosyltransferase 1 (POFUT1) Proteine von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen POFUT1 Antikörper (65) und POFUT1 Kits (6) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 90 POFUT1 Produkte verfügbar.
Synonyme:
DDD2, Fut12, mKIAA0180, O-Fuc-T, O-FucT-1, O-FUT, OFUCT1, pofut1, zgc:110472
alle Proteine anzeigen Gen GeneID UniProt
POFUT1 23509 Q9H488
POFUT1 140484 Q91ZW2
POFUT1 311551 Q6EV70

Weitere Synonyme anzeigen

POFUT1 Proteine (POFUT1) nach Spezies

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Am meisten referenzierte POFUT1 Proteine

  1. Human POFUT1 Protein expressed in Escherichia coli (E. coli) - ABIN1098747 : Luo, Haltiwanger: O-fucosylation of notch occurs in the endoplasmic reticulum. in The Journal of biological chemistry 2005 (PubMed)
    Zeige alle 2 Referenzen für 1098747

Weitere Proteine zu POFUT1 Interaktionspartnern

Human Protein O-Fucosyltransferase 1 (POFUT1) Interaktionspartner

  1. Our findings suggested that overexpression of Pofut1 and activated Notch1 (zeige NOTCH1 Proteine) signaling may be associated with a poor prognosis in breast cancer.

  2. POFUT1 gene expression in gastric cancer

  3. POFUT1, POGLUT1 (zeige POGLUT1 Proteine) and ADAM10 (zeige ADAM10 Proteine) are processing enzymes that are involved in different steps of Notch (zeige NOTCH1 Proteine) receptor activation in the epidermis[10]; the roles of these unique enzymes in a single pathway may explain both the overlapping and distinct clinical features of DDD (zeige KRT5 Proteine) and RAK (zeige FRK Proteine) patients

  4. High expression of POFUT1 correlates with aggressive clinicopathological characteristics and poor prognosis of hepatocellular carcinoma patients.

  5. The upregulation of poFUT1 by LIF (zeige LIF Proteine) facilitated trophoblast cell migration and invasion through activating the PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) signaling pathway.

  6. Silencing of Pofut1 expression exerted antiproliferative and antiadhesive effects on hepatocytes.

  7. Only a novel 1-bp deletion (c.246+5delG) in POFUT1 was found in a Chinese family with Dowling-Degos disease (DDD (zeige KRT5 Proteine)). No other novel mutation or this deletion was detected in POFUT1 in a second DDD (zeige KRT5 Proteine) family and a sporadic DDD (zeige KRT5 Proteine) case by Sanger Sequencing.

  8. Identification of six pathogenic POFUT1 mutations in Dowling-Degos disease patients of different ethnic origin.

  9. POFUT1 expression can contribute to cancer progression and that POFUT1 may serve as a diagnostic marker and a therapeutic target for OSCCs.

  10. The protein product of POFUT1 plays a significant and conserved role in melanin synthesis and transport.

Mouse (Murine) Protein O-Fucosyltransferase 1 (POFUT1) Interaktionspartner

  1. The POFUT1 binds EGF (zeige EGF Proteine)-like domains of the hEGF type and that the highly correlated presence of POFUT1 and fucosylatable hEGFs has accompanied animal evolution.

  2. Loss of Pofut1 expression is associated with Muscle Aging-Related Phenotypes.

  3. results demonstrated that POFUT1-mediated O-fucosylation of NOTCH (zeige NOTCH1 Proteine) receptors regulates myogenic cell differentiation and affects postnatal muscle growth in mice

  4. results establish the critical role of Pofut1 on Notch (zeige NOTCH1 Proteine) pathway activation during myogenic differentiation

  5. mDLL1 O-fucosylation by POFUT1 is dispensable for ligand function

  6. Loss of Pofut1 is associated with myeloid hyperplasia and impaired lymphopoiesis.

  7. Pofut1 and O-fucose have roles in mammalian Notch (zeige NOTCH1 Proteine) signaling

  8. Pofut1 is required for Notch (zeige NOTCH1 Proteine) signaling upstream of NICD1.

  9. These data are consistent with a role for Pofut1 in AChR aggregation during synaptogenesis via the regulation of the synaptogenic activity of muscle agrin (zeige AGRN Proteine).

  10. Reduced POFUT1 levels might affect Notch (zeige NOTCH1 Proteine) trafficking or overall O-fucosylation.

POFUT1 Protein Überblick

Protein Überblick

This gene encodes a member of the glycosyltransferase O-Fuc family. This enzyme adds O-fucose through an O-glycosidic linkage to conserved serine or threonine residues in the epidermal growth factor-like repeats of a number of cell surface and secreted proteins. O-fucose glycans are involved in ligand-induced receptor signaling. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Alternative names and synonyms associated with POFUT1

  • protein O-fucosyltransferase 1 (POFUT1)
  • protein O-fucosyltransferase 1 (pofut1)
  • protein O-fucosyltransferase 1 (Pofut1)
  • DDD2 Protein
  • Fut12 Protein
  • mKIAA0180 Protein
  • O-Fuc-T Protein
  • O-FucT-1 Protein
  • O-FUT Protein
  • OFUCT1 Protein
  • pofut1 Protein
  • zgc:110472 Protein

Bezeichner auf Proteinebene für POFUT1

GDP-fucose protein O-fucosyltransferase 1 , putative protein-O-fucosyltransferase , O-FucT-1 , peptide-O-fucosyltransferase 1 , protein-O-fucosyltransferase 1 , protein-O-fucosyltransferase , protein O-fucosyltransferase 1 , o-fucosyltransferase protein

GENE ID SPEZIES
395070 Gallus gallus
397627 Sus scrofa
403029 Danio rerio
449504 Pan troglodytes
496411 Xenopus (Silurana) tropicalis
589493 Strongylocentrotus purpuratus
609881 Canis lupus familiaris
100125467 Oryzias latipes
100294553 Pongo abelii
23509 Homo sapiens
140484 Mus musculus
311551 Rattus norvegicus
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