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Data indicate that jagged 1 protein (JAG1)-mediated Notch (zeige NOTCH1 Proteine) signaling regulates differentiation of basal cells (BC) into secretory cells.
these results show that the Notch (zeige NOTCH1 Proteine) signaling pathway in T cells is crucial for the induction of TH2-mediated allergic airway inflammation in an house dust mite -driven asthma model but that expression of Jagged 1 or Jagged 2 (zeige JAG2 Proteine) on DCs is not required
Bruceine D inhibits hepatocellular carcinoma growth by targeting beta-catenin/jagged1 signaling pathways.
Results showed that JAG1 was significantly downregulated in miR (zeige MLXIP Proteine)-26a-overexpressing osteosarcoma cells and is a direct target of miR (zeige MLXIP Proteine)-26a.
the effects of two Notch (zeige NOTCH1 Proteine) ligands, i.e., Jagged1 and DLL1 (zeige DLL1 Proteine), on murine and human hematopoiesis in vitro. Our observations indicate that the stromal expression of Notch (zeige NOTCH1 Proteine) ligands increases the production of both the total and phenotypically early murine and human hematopoietic cells in the co-culture.
Specific Notch3 (zeige NOTCH3 Proteine) and Jag1 subcellular localization patterns may provide clues for the behavior of the corresponding tumors and could potentially be applied in the clinic for Jag1 targeting in triple-negative breast cancer patients.
there is a cross-talk between Jagged1/Notch3 (zeige NOTCH3 Proteine) and VEGF (zeige VEGFA Proteine) in TNBC angiogenesis. Jagged1/Notch3 (zeige NOTCH3 Proteine) is expected to be an important signaling pathway for TNBC progression and a potential target for TNBC neovascularization therapy.
Low levels of Notch pathway genes Notch1, Notch2, Notch4 and Jagged1 correlated with poor prognostic factors such as larger tumor size, positive lymph-node status, tumor phenotype and infiltrating tumor Treg cells.
Human Jagged-1 induced the proliferation and differentiation of CD133+ cord blood progenitors compared with hDll-1. Thus, hJagged-1 signaling in the bone marrow niche may be used to expand EPCs for therapeutic angiogenesis
By studying leprosy as a model, we provide evidence that upregulation of JAG1 on endothelium instructs monocytes to differentiate into M1 macrophages with antimicrobial activity.
Epidermal stem cells accelerate diabetic wound healing via the Notch1 (zeige NOTCH1 Proteine) signaling pathway; Jag1 overexpression improves diabetic wound healing in vivo.
Notch (zeige NOTCH1 Proteine) signaling in ECs was induced by cocultures of ECs with tumor cells expressing the Notch (zeige NOTCH1 Proteine) ligands DLL4 (zeige DLL4 Proteine) and JAG1 in vitro, and NICD (zeige NOTCH1 Proteine) expression was induced in ECs by tumor-infiltrating myeloid cells in vivo
pre-coated Notch1 (zeige NOTCH1 Proteine) protein promotes Notch1 (zeige NOTCH1 Proteine)-knocked down B cells to produce antibody in LPS (zeige TLR4 Proteine)-stimulated B cells suggesting that Notch1 (zeige NOTCH1 Proteine) in other cells may promote antibody production by binding its ligands Dll1 (zeige DLL1 Proteine) and Jag1 in B cells.
JAG1 is the main activator of NOTCH signaling and GDNF expression in Sertoli cells.
Fringe modifications at EGF8 and EGF12 enhanced Notch1 binding to and activation from Delta-like 1, while modifications at EGF6 and EGF36 (added by Manic and Lunatic but not Radical) inhibited Notch1 activation from Jagged1.
A Jagged1-Hey1 (zeige HEY1 Proteine) signal might mediate the impairment of angiogenesis induced by Ang II (zeige AGT Proteine) during cardiac hypertrophy.
Data show that Rac1 induced nuclear import of STAT3 (zeige STAT3 Proteine) by physical binding, and nuclear STAT3 (zeige STAT3 Proteine) directly activated the transcription of essential oocyte-specific genes, including Jagged1, GDF9 (zeige GDF9 Proteine) and BMP15 (zeige BMP15 Proteine).
Diabetes mellitus induces Jagged1 overexpression and suppresses Notch signaling in endothelial cells. Blocking Jagged1 prevented diabetes-induced microvasculopathy and could reverse it even after 4 weeks.
Jagged1 intracellular domain-mediated inhibition of Notch1 (zeige NOTCH1 Proteine) signalling regulates cardiac homeostasis in the postnatal heart.
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
jagged 1 (Alagille syndrome)
, jagged 1
, protein jagged-1-like
, protein jagged-1