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Human JAG1 Protein expressed in Human Cells - ABIN2004473
Li, Milner, Deng, Iwata, Banta, Graf, Marcovina, Friedman, Trask, Hood, Torok-Storb: The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1. in Immunity 1998
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Low levels of Notch pathway genes Notch1, Notch2, Notch4 and Jagged1 correlated with poor prognostic factors such as larger tumor size, positive lymph-node status, tumor phenotype and infiltrating tumor Treg cells.
Human Jagged-1 induced the proliferation and differentiation of CD133+ cord blood progenitors compared with hDll-1. Thus, hJagged-1 signaling in the bone marrow niche may be used to expand EPCs for therapeutic angiogenesis
By studying leprosy as a model, we provide evidence that upregulation of JAG1 on endothelium instructs monocytes to differentiate into M1 macrophages with antimicrobial activity.
High Jag1 expression is associated with metastasis in colorectal cancer.
amplification of Jagged1 contributed to mRNA expression that activates the Jagged1-Notch (zeige NOTCH1 Proteine) signaling pathway in liver cancer and led to poor outcome.
Our data revealed that MALAT1 inhibited tongue cancer cell growth and metastasis through miR-124-dependent JAG1 regulation. In conclusion, we revealed that MALAT1 may play an oncogenic role by increasing proliferation and metastasis of tongue cancer and is a potential therapeutic target in human tongue cancer.
Positive Jagged1 and DLL4 (zeige DLL4 Proteine) expression is closely correlated with severe clinicopathological characteristics and poor prognosis in patients with pancreatic ductal carcinoma.
miR (zeige MLXIP Proteine)-199a-3p targets YAP1 (zeige YAP1 Proteine), downregulates Jagged1 and suppresses the Notch (zeige NOTCH1 Proteine) signaling to inhibit hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) cell proliferation and promote apoptosis. These findings provide new insights into the mechanism by which miR (zeige MLXIP Proteine)-199a-3p suppresses HCC (zeige FAM126A Proteine) cell proliferation and induces apoptosis.
Jagged1 activation of Notch3 (zeige NOTCH3 Proteine) resulted in a significant decrease in cell proliferation while concomitantly promoting Hemangioma-pericyte maturation.
expression of JAG1 is regulated by various pathways and is associated with poor prognosis through promoting the epithelial to mesenchymal transition and cell proliferation or maintaining cell survival in colorectal cancer
Fringe modifications at EGF8 and EGF12 enhanced Notch1 binding to and activation from Delta-like 1, while modifications at EGF6 and EGF36 (added by Manic and Lunatic but not Radical) inhibited Notch1 activation from Jagged1.
A Jagged1-Hey1 (zeige HEY1 Proteine) signal might mediate the impairment of angiogenesis induced by Ang II (zeige AGT Proteine) during cardiac hypertrophy.
Data show that Rac1 induced nuclear import of STAT3 (zeige STAT3 Proteine) by physical binding, and nuclear STAT3 (zeige STAT3 Proteine) directly activated the transcription of essential oocyte-specific genes, including Jagged1, GDF9 (zeige GDF9 Proteine) and BMP15 (zeige BMP15 Proteine).
Diabetes mellitus induces Jagged1 overexpression and suppresses Notch signaling in endothelial cells. Blocking Jagged1 prevented diabetes-induced microvasculopathy and could reverse it even after 4 weeks.
Jagged1 intracellular domain-mediated inhibition of Notch1 (zeige NOTCH1 Proteine) signalling regulates cardiac homeostasis in the postnatal heart.
endothelial Jagged1 has a role in promoting solid tumor development
Jag1 expression in pulmonary capillary endothelial cells is upregulated after repeated lung injury and contributes to lung fibrosis.
On a C57BL/6 background, Jag1 haploinsufficiency results in bile duct paucity in mice
Jag1-induced Notch (zeige NOTCH1 Proteine) activity and the subsequent (or concomitant) downregulation of the Dll4 (zeige DLL4 Proteine)-mediated signalling are both required for generating haematopoietic stem cells in the embryo.
miR (zeige MLXIP Proteine)-34c overexpression inhibits the Notch (zeige NOTCH1 Proteine) signaling pathway by targeting Notch1 (zeige NOTCH1 Proteine) and Jaggged1 in high glucose-treated podocytes.
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
jagged 1 (Alagille syndrome)
, jagged 1
, protein jagged-1-like
, protein jagged-1