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Human TRAF6 ELISA Kit für Sandwich ELISA - ABIN578203
Bilir, Engin, Can, Temi, Demirtas: The prognostic role of inflammation and hormones in patients with metastatic cancer with cachexia. in Medical oncology (Northwood, London, England) 2015
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we found that reactive oxygen species-induced autophagy acts as a negative feedback regulator of JNK (zeige MAPK8 ELISA Kits) activity by dissociating Atg9 (zeige ATG9A ELISA Kits)/mAtg9 (zeige ATG9A ELISA Kits) from dTRAF2/TRAF6 in Drosophila.
null mutant of DTRAF2 showed immune deficiencies in which NF-kappaB nuclear translocation and antimicrobial gene transcription against microbial infection were severely impaired
this study shows that TRAF6 is necessary for the nontranscriptional priming of NLRP3 (zeige NLRP3 ELISA Kits) inflammasome by TLR/IL-1R derived signals
work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (zeige TRAF1 ELISA Kits)/NF-kappaB (zeige NFKB1 ELISA Kits)-regulated apoptosis and the p53 (zeige TP53 ELISA Kits)/PCNA (zeige PCNA ELISA Kits)- and ATM (zeige ATM ELISA Kits)/ATR (zeige ATR ELISA Kits)-Chk1 (zeige CHEK1 ELISA Kits)/2-controlled DNA-damage response pathways.
TRAF6 prevents the mitochondrial translocation of p53 (zeige TP53 ELISA Kits) and spontaneous apoptosis by promoting lysine63-linked ubiquitination of p53 (zeige TP53 ELISA Kits) in cytosol.
TRAF6 mediates lysine-63 ubiquitination within the SH2 domain of STAT3 (zeige STAT3 ELISA Kits), which is an essential step for STAT3 (zeige STAT3 ELISA Kits) membrane recruitment and phosphorylation in response to S Typhimurium infection; results reveal a strategy in which S Typhimurium T3SS effectors broaden their functions through the activation of host proteins in a ubiquitination-dependent manner to manipulate host cells into becoming a Salmonella-friendly zone
this study shows that an interaction of TRAF6 with cullin-5 (zeige CUL5 ELISA Kits) promotes TRAF6 polyubiquitination and lipopolysaccharide signaling
Consistent with cellular studies, icaritin downregulated TRAF6 and NFATc1 protein expression in CD11b(+) /Gr-1(-/low) osteoclast precursors
Data (including data from studies using knockout mice) suggest that RANKL (zeige TNFSF11 ELISA Kits) enhances TNF (zeige TNF ELISA Kits)-induced osteoclast formation from precursor spleen cells and enhances bone resorption independently of Traf6 by degrading Traf3 (zeige TRAF3 ELISA Kits), a known inhibitor of osteoclastogenesis. (RANKL (zeige TNFSF11 ELISA Kits) = osteoclast differentiation factor (zeige TNFSF11 ELISA Kits); TNF (zeige TNF ELISA Kits) = tumor necrosis factor (zeige TNF ELISA Kits); Traf (zeige TRAF1 ELISA Kits) = TNF (zeige TNF ELISA Kits) receptor-associated factor)
the SH3 domain (zeige ITSN1 ELISA Kits) of NOSTRIN (zeige NOSTRIN ELISA Kits) is involved in the NOSTRIN (zeige NOSTRIN ELISA Kits)-TRAF6 interaction and is required for NOSTRIN (zeige NOSTRIN ELISA Kits)-induced down-regulation of endothelial cell proteins
this study shows that TRAF6 overexpression in hematopoietic stem/progenitor cells results in impaired hematopoiesis and bone marrow failure
TRAF6 and H2AX (zeige H2AFX ELISA Kits) overexpression and gammaH2AX (zeige H2AFX ELISA Kits)-mediated HIF1alpha (zeige HIF1A ELISA Kits) enrichment in the nucleus of cancer cells lead to overactivation of HIF1alpha (zeige HIF1A ELISA Kits)-driven tumorigenesis, glycolysis and metastasis.
we have now analyzed the in vivo function of Traf6 in the innate immune response without interference of adaptive immunity
Full-length traf6 was functionally characterized.
Taken together, these results define a novel role for miR (zeige MLXIP ELISA Kits)-146a as a negative regulator of dengue virus-induced autophagy and identify TRAF6 as a key target of this microRNA in modulating the dengue virus-autophagy interaction.
These data define that YOD1 (zeige YOD1 ELISA Kits) antagonizes TRAF6/p62 (zeige GTF2H1 ELISA Kits)-dependent IL-1 (zeige IL1A ELISA Kits) signaling to NF-kappaB (zeige NFKB1 ELISA Kits).
high expression of TRAF6 is significant for esophageal cancer progression, and TRAF6 indicates poor prognosis in esophageal cancer patients.
CRBN (zeige CRBN ELISA Kits) negatively regulates TLR4 (zeige TLR4 ELISA Kits) signaling via attenuation of TRAF6 and TAB2 (zeige TAB2 ELISA Kits) ubiquitination.
the polymorphisms in TLR-MyD88 (zeige MYD88 ELISA Kits)-NF-kappaB (zeige NFKB1 ELISA Kits) signaling pathway confer genetic susceptibility to Type 2 diabetes mellitus and diabetic nephropathy.
The E3 ligase TRAF6 binds to DCP1a (zeige DCP1A ELISA Kits) and indirectly regulates DCP1a (zeige DCP1A ELISA Kits) phosphorylation, expression of decapping factors, and gene-specific mRNA decay.
Study showed that patients without a history of atrial fibrillation who develop postoperative atrial fibrillation have a higher percentage of left atrial fibrosis, increased expression of TRAF6, higher serum Ang II (zeige AGT ELISA Kits) levels, and changes in the activities of the MAPKs/TGF-beta1 (zeige TGFB1 ELISA Kits)/TRAF6 pathway.
Low TRAF6 expression is associated with graft-versus-host disease.
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported.
TNF receptor-associated factor 6-B
, E3 ubiquitin-protein ligase TRAF6
, TNF-receptor-associated factor 2
, TNF receptor-associated factor 6
, TNF receptor-associated factor 6-like
, RING finger protein 85
, interleukin-1 signal transducer
, TNF-receptor associated factor 6