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Human TNFSF13B Protein expressed in Escherichia coli (E. coli) - ABIN1344400
Bossen, Cachero, Tardivel, Ingold, Willen, Dobles, Scott, Maquelin, Belnoue, Siegrist, Chevrier, Acha-Orbea, Leung, Mackay, Tschopp, Schneider: TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts. in Blood 2008
Show all 2 Pubmed References
Human TNFSF13B Protein expressed in Escherichia coli (E. coli) - ABIN413043
Kern, Cornuel, Billard, Tang, Rouillard, Stenou, Defrance, Ajchenbaum-Cymbalista, Simonin, Feldblum, Kolb: Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway. in Blood 2004
Human TNFSF13B Protein expressed in HEK-293 Cells - ABIN1344293
Huard, Tran, Benkhoucha, Manzin-Lorenzi, Santiago-Raber: Selective APRIL blockade delays systemic lupus erythematosus in mouse. in PLoS ONE 2012
Equine adipose-derived stem cell (ASC (zeige PYCARD Proteine)) expresses BAFF (TNFSF13B) and its receptors, which may be associated with the differentiation process of ASC (zeige PYCARD Proteine) towards adipocyte.
Among the BAFF receptors in a cohort of rheumatoid arthritis (RA) patients, the AA have shown, by fluorescence activated cell sorter (FACS) analysis of median fluorescence intensity (MFI), that transmembrane activator and calcium-modulating cyclophilin ligand (zeige CAMLG Proteine) interactor (TACI (zeige TNFRSF13B Proteine)) and B cell maturation antigen (BCMA (zeige TNFRSF17 Proteine)) do not change
The BAFF promoter increased in response to TNF-alpha (zeige TNF Proteine) treatment or overexpression of HIF-1alpha (zeige HIF1A Proteine). However, TNF-alpha (zeige TNF Proteine)-induced BAFF expression and promoter activity decreased after treatment with the ERK (zeige EPHB2 Proteine) inhibitor PD98059.
This study indicates that orbital fibroblasts from Graves' orbitopathy can express BAFF and mediate the intraorbital survival of B cells via BAFF mechanism.
Inhibition of B cell plasmablast differentiation by reduction of Aiolos (zeige IKZF3 Proteine) and Ikaros (zeige IKZF1 Proteine) may have utility in the treatment of systemic lupus erythematosus , where elevated levels of BAFF and Aiolos (zeige IKZF3 Proteine) may prime CD27 (zeige CD27 Proteine)(+) memory and double negative memory-like B cells to become Ab-producing plasmablasts in the presence of BAFF and proinflammatory cytokines.
BCMA (zeige TNFRSF17 Proteine) has other contributors for ligands binding except DxL motif. The affinity of BCMA (zeige TNFRSF17 Proteine) for APRIL higher than for BAFF may be caused by the segment outside of the conservative DxL motif. Moreover, the exposition of new binding modes of BCMA2 interacting with APRIL may establish the foundation of designing novel drugs in the future
study demonstrated a high prevalence of endogenous antibodies to BAFF in a multi-ethnic Asian systemic lupus erythematosus (SLE) cohort; while levels of serum BAFF correlated positively with disease activity, levels of anti-BAFF antibody were correlated negatively with levels of its target cytokine, anti-dsDNA antibody and clinical disease activity
this study provides new useful information about the increased levels of BAFF observed during HIV-1 infection and highlights the importance of macrophages as a source of BAFF
The novel association between BAFF and inflammatory bowel disease (IBD) seems to identify that BAFF might regulate the inflammatory process in these diseases and it appears to be a potential marker of IBD.
In BAFF, rs2893321 may be a susceptible genetic variant for the development of GD and AITDs. Associations of rs2893321 with susceptibility to GD and AITDs and the correlation between rs2893321 and TAb exhibit a dimorphic pattern. Additional studies with larger sample sizes are required to confirm our findings.
BAFF and IL-17A (zeige IL17A Proteine) are associated with different subphenotypes of primary Sjogren's syndrome.
This study suggests that BAFF selects IL-10 (zeige IL10 Proteine)(-)B cells over IL-10 (zeige IL10 Proteine)(+) regulatory B cells via BAFF receptors in inflammatory responses
BAFF plays a previously unappreciated role in lupus nephritis by inducing renal tertiary lymphoid structures and regulating the position of T cells within the glomeruli.
this study shows that BAFF overexpression reduces hypercholesterolemia and atherosclerosis in hyperlipidemic mice via TACI (zeige TNFRSF13B Proteine)-dependent B cell activation (zeige BLNK Proteine)
B cell-activating factor (BAFF) upregulates CD28 (zeige CD28 Proteine)/B7 and CD40 (zeige CD40 Proteine)/CD154 (zeige CD40LG Proteine) expression, and promotes the interactions between T and B cells in a BAFF receptor (zeige TNFRSF13C Proteine)-dependent manner.
findings highlight a novel mechanism through which BAFF promotes humoral autoimmunity via direct, TACI (zeige TNFRSF13B Proteine)-dependent activation of transitional B cells
neutrophils secreted a B cell-activating factor that highly accelerated plasma cell generation and antigen-specific antibody production.
The enhanced thermogenic program was confirmed by higher protein levels of UCP1 (zeige UCP1 Proteine) and irisin (zeige FNDC5 Proteine) in female BAFF-/- than in WT mice.
Antibodies That Block or Activate Mouse B Cell Activating Factor of the Tumor Necrosis Factor (TNF (zeige TNF Proteine)) Family (BAFF), Respectively, Induce B Cell Depletion or B Cell Hyperplasia.
Increased B-cell activating factor (BAFF) induced B cell differentiation into germinal center (GC) B (zeige NPR2 Proteine) cells within the autoimmune target tissue.
The Tnfas13b in the hippocampus in the prefrontal cortex of the DBA (zeige RPS19 Proteine)/2 J strain were up-regulated.
study reports the molecular cloning, expression and bioactivity of the porcine homologue of human BAFF
This study demonstrated expression of BAFF on cultured monocyte-derived dendritic cells, which was further enhanced by interferon-alpha (zeige IFNA Proteine) or interferon-gamma (zeige IFNG Proteine) treatment.
Although BAFF expression is dispensable for B cell development in the bone marrow, it is required for B cell development in gut (zeige GUSB Proteine)-associated lymphoid tissue.
BAFF and its receptors during B-cell activation (zeige BLNK Proteine) and autoantibody production in rabbits derived from selective breeding to develop a reproducible rabbit model of Systemic Lupus Erythematosus, were investigated.
Cloning and expression analysis of B-cell activating factor (BAFF) provide the basis for investigation of its role in regulating rabbit B-lymphocyte (zeige AKAP17A Proteine) development and immune responses.
BAFF was detected in developing appendix of young rabbits by immunohistochemical staining suggesting that BAFF plays a role during the period following birth when rabbit B-cell development is occurring.
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
tumor necrosis factor ligand superfamily member 13B
, tumor necrosis factor (ligand) superfamily, member 13b
, B-cell activating factor
, B-lymphocyte stimulator
, TNF- and APOL-related leukocyte expressed ligand 1
, ApoL related ligand TALL-1
, B-cell-activating factor
, Delta4 BAFF
, TNF and ApoL-related leukocyte expressed ligand 1
, TNF homolog that activates apoptosis
, delta BAFF
, dendritic cell-derived TNF-like molecule
, tumor necrosis factor (ligand) superfamily, member 20
, tumor necrosis factor-like protein ZTNF4
, b cell-activating factor
, tumor necrosis factor superfamily member 13b