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Human TGFA Protein expressed in Escherichia coli (E. coli) - ABIN2667579
DeglInnocenti, Alberti, Castellano, Greco, Miranda, Pierotti, Seregni, Borrello, Canevari, Tomassetti: Integrated ligand-receptor bioinformatic and in vitro functional analysis identifies active TGFA/EGFR signaling loop in papillary thyroid carcinomas. in PLoS ONE 2010
Zeige alle 6 Referenzen für ABIN2667579
Human TGFA Protein expressed in Escherichia coli (E. coli) - ABIN2666940
Juanes, Ferreira, Montero, Arribas, Pandiella: N-terminal cleavage of proTGFalpha occurs at the cell surface by a TACE-independent activity. in The Biochemical journal 2005
Zeige alle 6 Referenzen für ABIN2666940
c-Myc (zeige MYC Proteine) and transforming growth factor alpha enhance the development of hepatic lesions due to mutant beta-catenin (zeige CTNNB1 Proteine) in transgenic mice.
Reverse transcriptase polymerase chain reaction studies showed that three members, Tgfa, Hbegf,and Nrg1 of the EGF family were expressed in the epithelium cultured with FGF7 + LPA as well as in the epithelium freshly isolated from the rudiments.
findings suggest that elevated PHD4 (zeige P4HTM Proteine) levels disturb the angiogenic balance in osteosarcoma via induction of the TGF-alpha pathway and inhibit tumor growth by reducing the expression of HIF-2alpha (zeige EPAS1 Proteine)
Interaction between IRF6 (zeige IRF6 Proteine) and TGFA genes contribute to the risk of nonsyndromic cleft lip/palate.
These results imply that TGFalpha stimulates proliferation of endometrial stromal cells through multiple mechanisms, including its regulation of Igfbp3 (zeige IGFBP3 Proteine) and Mmp3 (zeige MMP3 Proteine) transcription.
ADAM-17 (zeige ADAM17 Proteine) and TGF-alpha are strongly and locally upregulated following adult mice cortical damage.
Different mechanisms regulate neurogenesis in neonatal and adult olfactory epithelium; fibroblast growth factor (FGF)2 (zeige FGF2 Proteine) and TGFalpha may have different roles throughout development.
beta-catenin (zeige CTNNB1 Proteine) controlled both cell-autonomous and non-cell-autonomous hepatocyte proliferation, through direct transcriptional and complex control of cyclin D1 (zeige CCND1 Proteine) gene expression and of the expression of a new target gene, Tgfalpha.
variable TGF-alpha expression may explain, in part, the genetic susceptibility to chronic kidney disease (CKD) progression.
This may be the first report of the expression of carcinogenesis-related molecules such as EGFR (zeige EGFR Proteine), K-ras (zeige HRAS Proteine), Cox2 and TGFalpha during chronic pancreatitis.
In conclusion, we identified four novel loci (TGFA, PIK3R1, FGFR3 (zeige FGFR3 Proteine) and TREH (zeige TREH Proteine)) and confirmed two loci known to be associated with cartilage thickness.The identified associations were not caused by rare exonic variants. This is the first report linking TGFA to human Osteoarthritis, which may serve as a new target for future therapies.
Our study showed that TGFA/TGFB3 (zeige TGFB3 Proteine)/MSX1 (zeige MSX1 Proteine) gene polymorphisms were associated with congenital NSHI. The distribution of genotype frequencies and allele frequencies of TGFA rs3771494, TGFB3 (zeige TGFB3 Proteine) rs3917201 and rs2268626, and MSX1 (zeige MSX1 Proteine) rs3821949 and rs62636562 were significantly different between the case and the control groups
TGFA gene expression is regulated by MiR (zeige MLXIP Proteine)-374a in lung adenocarcinoma.TGFA plays role in lung adenocarcinoma cell proliferation and invasion.
Overall, our findings indicated that intratumoral administration of TGFalphaL3-SEB effectively inhibited the growth of breast tumors through induction of necrosis and suppressing proliferation and angiogenesis without systemic toxicity.
TGFA expression decreased after 10 and 30min of treatment even when transcription was not inhibited. We found that activation of PI3K (zeige PIK3CA Proteine) was necessary for triiodothyronine to modulate HIF1A (zeige HIF1A Proteine) and TGFA expression
This is the first demonstration that miR (zeige MLXIP Proteine)-490-3P might act as a suppressor in endometrial cancer tumorigenesis and progression by targeting TGFalpha.
miR (zeige MLXIP Proteine)-505 acts as tumor suppressor in endometrial cancer by regulating TGF-alpha.
findings strongly suggest that phosphorylated HSP20 (zeige HSPB6 Proteine) inhibits TGF-alpha-induced HCC (zeige FAM126A Proteine) cell migration and invasion via suppression of the JNK (zeige MAPK8 Proteine) signaling pathway
miR (zeige MLXIP Proteine)-205 may function as a tumor suppressor via targeting TGF-alpha in Osteosarcoma
our data suggest that the anti-inflammatory actions of paricalcitol in tubular cells could depend on the inhibition of TGF-a/ADAM17 (zeige ADAM17 Proteine)/EGFR (zeige EGFR Proteine) pathway in response to aldosterone, showing an important mechanism of VDRAs action.
upregulation of TGFalpha or FGF2 (zeige FGF2 Proteine) expression is not a pre-requisite for enhanced testicular growth and increased Sertoli cell proliferation that occurs subsequent to hemicastration in the neonatal boar
This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
transforming growth factor, alpha
, transforming growth factor alpha
, protransforming growth factor alpha
, transforming growth factor-alpha
, waved 1
, TGF alpha