anti-PRKACA (PRKACA) Antikörper

Bezeichnung:
anti-Protein Kinase A, alpha Antikörper (PRKACA)
Auf www.antikoerper-online.de finden Sie aktuell 113 Protein Kinase A, alpha (PRKACA) Antikörper von 15 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PRKACA Proteine (18) und PRKACA Kits (12) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 150 PRKACA Produkte verfügbar.
Synonyme:
Calpha, Cs-PKA, PKA, PKACA, PKCA1, PKCD, PRKAR1
Alle Antikörper anzeigen Gen GeneID UniProt
PRKACA 18747 P05132
PRKACA 5566 P17612
PRKACA 25636  

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Meistgesuchte Reaktivitäten zu anti-PRKACA (PRKACA) Antikörper

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anti-Mouse (Murine) PRKACA Antikörper:

anti-Human PRKACA Antikörper:

anti-Rat (Rattus) PRKACA Antikörper:

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Am meisten referenzierte anti-PRKACA Antikörper

  1. Human Polyclonal PRKACA Primary Antibody für EIA, IHC (p) - ABIN359056 : Tateyama, Rivolta, Clancy, Kass: Modulation of cardiac sodium channel gating by protein kinase A can be altered by disease-linked mutation. in The Journal of biological chemistry 2003 (PubMed)
    Zeige alle 5 Referenzen für 359056

  2. Human Monoclonal PRKACA Primary Antibody für WB - ABIN238374 : Beebe, Oyen, Sandberg, Frøysa, Hansson, Jahnsen: Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase. in Molecular endocrinology (Baltimore, Md.) 1990 (PubMed)
    Zeige alle 5 Referenzen für 238374

  3. Human Polyclonal PRKACA Primary Antibody für EIA, WB - ABIN453298 : Sugiyama, Chen, Hunter, Taffs, Sitkovsky: The dual role of the cAMP-dependent protein kinase C alpha subunit in T-cell receptor-triggered T-lymphocytes effector functions. in The Journal of biological chemistry 1993 (PubMed)

  4. Human Polyclonal PRKACA Primary Antibody für ICC, IF - ABIN408069 : Enns, Morton, Mangalindan, McKnight, Schwartz, Kaeberlein, Kennedy, Rabinovitch, Ladiges: Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A. in The journals of gerontology. Series A, Biological sciences and medical sciences 2009 (PubMed)

  5. Human Polyclonal PRKACA Primary Antibody für ELISA, WB - ABIN562366 : Adachi, Kano, Saido, Murata: Visual screening and analysis for kinase-regulated membrane trafficking pathways that are involved in extensive beta-amyloid secretion. in Genes to cells : devoted to molecular & cellular mechanisms 2009 (PubMed)

Weitere Antikörper gegen PRKACA Interaktionspartner

Mouse (Murine) Protein Kinase A, alpha (PRKACA) Interaktionspartner

  1. study identifies a new role of Dual-AKAP1 (zeige AKAP1 Antikörper) in regulating mitochondrial trafficking through Miro-2 (zeige RHOT2 Antikörper), and supports a model in which PINK1 (zeige PINK1 Antikörper) and mitochondrial PKA participate in a similar neuroprotective signaling pathway to maintain dendrite connectivity

  2. Data suggest that enzyme activation by cAMP involves highly stable conformation of Prkar1a as it binds to Prkaca; glycine residue, G235, appears to function as hinge in B/C helix conserved in Prkar1a; this "Flipback" conformation plays role in cAMP association to A domain of Prkar1a. (Prkar1a = cyclic AMP-dependent protein kinase RIalpha subunit; Prkaca = cyclic AMP-dependent protein kinase catalytic subunit)

  3. cAMP dependent protein kinase A (PKA) is a key intracellular factor mediating SHH (zeige SHH Antikörper) signaling through regulation of GLI3 (zeige GLI3 Antikörper) processing.

  4. this study shows illustrates for the first time the ability of protein kinase A to increase colony-stimulating factor 1 receptor (zeige CSF1R Antikörper) DNA methylation (zeige HELLS Antikörper) resulting in macrophage maturation

  5. these results suggest that the activation of 5-HT1D receptors selectively enhanced IA via the Gbetagamma of the Go-protein, PKA, and the sequential B-Raf (zeige SNRPE Antikörper)-dependent p38 MAPK (zeige MAPK14 Antikörper) signaling cascade.

  6. These data indicate that LPA increases CCN2 (zeige CTGF Antikörper) expression through the activation of PKC (zeige PKC Antikörper) and PKA. Thus, the regulatory functions of the PKC (zeige PKC Antikörper) and PKA pathways are implicated in the LPA-induced increase in CCN2 (zeige CTGF Antikörper) expression

  7. PKA phosphorylates the ATPase inhibitory factor 1 (zeige ATPIF1 Antikörper) and inactivates its capacity to bind and inhibit the mitochondrial H(+)-ATP synthase.

  8. Data suggest PRKAR1A (zeige PRKAR1A Antikörper) contains two structurally homologous cAMP-binding domains that exhibit marked differences in dynamic profiles in activation/inhibition of Prkaca; conservation of structure does not necessarily imply conservation of dynamics.

  9. Data (including data from studies in transgenic mice) suggest that constitutive activation of Prkaca in osteoblasts is sufficient to increase bone mass, favorably modify bone architecture, and improve mechanical properties of bone.

  10. Lin28a (zeige LIN28A Antikörper) protects against DCM through PKA/ROCK2 (zeige ROCK2 Antikörper) dependent pathway.

Human Protein Kinase A, alpha (PRKACA) Interaktionspartner

  1. PRKACA mutations are present in cortisol-producing adenomas and bilateral adrenal macronodular hyperplasia. PRKACA mutation is associated with more severe autonomous cortisol secretion.

  2. Dual co-expression of human fetal Tau with PKA in Escherichia coli results in multisite Tau phosphorylation including also naturally occurring sites which were not previously considered in the context of 14-3-3 (zeige YWHAQ Antikörper) binding. Tau protein co-expressed with PKA displays tight functional interaction with 14-3-3 (zeige YWHAQ Antikörper) isoforms of a different type.

  3. This review will discuss the effects of PKA phosphorylation on wild-type CFTR (zeige CFTR Antikörper), the consequences of cystic fibrosis (zeige S100A8 Antikörper) mutations on PKA phosphorylation, and the development of therapies that target PKA-mediated signaling. [review]

  4. This interaction is promoted by EPAC1 (zeige RAPGEF3 Antikörper) activation, triggering its translocation to the plasma membrane and binding to NHERF1 (zeige SLC9A3R1 Antikörper). Our findings identify a new CFTR (zeige CFTR Antikörper)-interacting protein and demonstrate that cAMP activates CFTR (zeige CFTR Antikörper) through two different but complementary pathways - the well-known PKA-dependent channel gating pathway and a new mechanism regulating endocytosis that involves EPAC1 (zeige RAPGEF3 Antikörper).

  5. The inhibitory effects of BMP4 (zeige BMP4 Antikörper) on PDGF (zeige PDGFA Antikörper)-induced cell proliferation, collagen synthesis, and calpain-2 (zeige CAPN2 Antikörper) activation are impaired in pulmonary artery smooth muscle cells from pulmonary arterial hypertension patient.

  6. description of PRKACA mutations in 2 cases of primary aldosteronism (PA) patients: a novel variant (p.His88Asp) in a case of sudden onset of PA and a mutation (p.Leu206Arg) in context of hypokalemic aggravation of long-term hypertension; these genetic alterations were not found in a subsequent series of 120 aldosterone-producing adenomas and thereby appear to be very rare events

  7. PKA signaling is pivotal in pigmentation process itself in cultured melanoma cells, while the importance of Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling should be emphasized in the context of development and differentiation

  8. Studies indicate a functional interaction between leucine-rich repeat kinase 2 (LRRK2 (zeige LRRK2 Antikörper)) and protein kinase A (PKA) cross-talk in neuron and microglia.

  9. Studies indicate the importance of the AKAP79 (zeige AKAP5 Antikörper)/PP2B/protein kinase A complex's role in synaptic long-term depression in the CA1 (zeige CA1 Antikörper) region of the hippocampus.

  10. GPER (zeige GPER Antikörper) enhances melanogenesis via PKA by upregulating microphthalmia-related transcription factor-tyrosinase (zeige TYR Antikörper) in melanoma

Pig (Porcine) Protein Kinase A, alpha (PRKACA) Interaktionspartner

  1. ceramide as a potent physiological modulator of the Na(+)-ATPase (zeige DNAH8 Antikörper), participating in a regulatory network in kidney cells and counteracting the stimulatory effect of PKA via PKCzeta (zeige PRKCZ Antikörper)

  2. we demonstrate that PKA, PKC (zeige FYN Antikörper) and PI3K pathways crosstalk in porcine male germ cells to crucially regulate GSK3A (zeige GSK3a Antikörper) phosphorylation which subsequently controls cell motility.

Cow (Bovine) Protein Kinase A, alpha (PRKACA) Interaktionspartner

  1. PKA and MEK (thus, also pERK) are the intracellular mediators downstream of GPR30 that induce the non-genomic suppression of GnRH-induced LH secretion from bovine AP cells by estradiol or G1

  2. Data indicate that mitochondrial cAMP-dependent protein kinase (PKA) activity is regulated by the protease calpain.

  3. structural basis of selectivity for protein kinase A in complex with Rho-kinase (zeige ROCK1 Antikörper) inhibitors by x-ray crystallography

  4. Purification and characterisation of protein kinase catalytic subunit (PKAcat) from bovine lens.

PRKACA Antigen-Profil

Beschreibung des Gens

Cyclic AMP-dependent protein kinase A (PKA) is an essential enzyme in the signaling pathway of the second messenger cAMP. Through phosphorylation of target proteins, PKA controls many biochemical events in the cell including regulation of metabolism, ion transport, and gene transcription. The PKA holoenzyme is composed of 2 regulatory and 2 catalytic subunits and dissociates from the regulatory subunits upon binding of cAMP.

Alternative names and synonyms associated with PRKACA

  • protein kinase, cAMP dependent, catalytic, alpha (Prkaca) Antikörper
  • protein kinase, cAMP-dependent, catalytic, alpha (PRKACA) Antikörper
  • protein kinase, cAMP-dependent, catalytic, alpha (Prkaca) Antikörper
  • protein kinase, cAMP-dependent, regulatory, type I, beta (PRKAR1B) Antikörper
  • Calpha Antikörper
  • Cs-PKA Antikörper
  • PKA Antikörper
  • PKACA Antikörper
  • PKCA1 Antikörper
  • PKCD Antikörper
  • PRKAR1 Antikörper

Bezeichner auf Proteinebene für PRKACA

PKA C-alpha , cAMP-dependent protein kinase catalytic subunit alpha , sperm cAMP-dependent protein kinase catalytic subunit , protein kinase A catalytic subunit , protein kinase, cAMP-dependent, catalytic, alpha , C-alpha subunit , protein kinase A , cAMP-dependent protein kinase catalytic subunit C alpha , protein kinase A alpha , cAMP-dependent protein kinase type I-beta regulatory subunit

GENE ID SPEZIES
18747 Mus musculus
5566 Homo sapiens
397652 Sus scrofa
282322 Bos taurus
443094 Ovis aries
25636 Rattus norvegicus
403556 Canis lupus familiaris
5575 Homo sapiens
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