MAP3K14 Proteine (MAP3K14)

Mitogen-Activated Protein Kinase Kinase Kinase 14 Proteine (MAP3K14)
Auf finden Sie aktuell 9 Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14) Proteine von 5 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MAP3K14 Antikörper (132) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 153 MAP3K14 Produkte verfügbar.
aly, F23F1.4, F23F1_4, FLH21957, FTDCR1B, HGK, HS, HSNIK, MEKKK4, mitogen-activated protein kinase kinase kinase 14, Nik
alle Proteine anzeigen Gen GeneID UniProt
MAP3K14 9020 Q99558
MAP3K14 360640  
MAP3K14 53859 Q9WUL6

Weitere Synonyme anzeigen

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Weitere Proteine zu MAP3K14 Interaktionspartnern

Human Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14) Interaktionspartner

  1. OLFM1 (zeige OLFM1 Proteine) is a negative regulator of non-canonical NF-kappaB (zeige NFKB1 Proteine) signalling by interacting with and inhibiting NIK. Thus, OLFM1 (zeige OLFM1 Proteine) may serve as a valuable biomarker and therapeutic target for colorectal cancer (CRC (zeige CALR Proteine)) patients.

  2. The expression of OTUD7B (zeige OTUD7B Proteine) and NIK were negatively correlated in non-small cell lung cancer tumor samples. the higher expression of NIK was related to more lymph node metastasis and later TNM (zeige ODZ1 Proteine) stage. high OTUD7B (zeige OTUD7B Proteine)/low NIK index can predict an good prognosis.

  3. NIK expression was significantly increased in the tumor tissue of patients with breast carcinoma, which may be an important factor that affects the prognosis of these patients.

  4. This study identified two novel independent loci (MAP3K14 and CARD9 (zeige CARD9 Proteine)) strongly associated with joint damage in Mexican Americans and European Americans and a few shared loci showing suggestive evidence for association.

  5. The forced expression of NDRG2 (zeige NDRG2 Proteine) in ATL cells down-regulates not only the canonical pathway by inhibiting AKT (zeige AKT1 Proteine) signaling but also the non-canonical pathway by inducing NF-kappaB (zeige NFKB1 Proteine)-inducing kinase (NIK) dephosphorylation via the recruitment of PP2A (zeige PPP2R4 Proteine)

  6. NIK(+) endothelial cells may play an important role in the persistence of synovitis

  7. Data suggest microRNA302c, but not microRNA520e, promotes replication of influenza A virus H3N2 although the two microRNAs target same site of NFkappaB (zeige NFKB1 Proteine)-inducing kinase (MAP3K14) 3prime untranslated region; studies were conducted in lung epithelial cells.

  8. TWEAK (zeige TNFSF12 Proteine) induces noncanonical NF-kappaB (zeige NFKB1 Proteine) signaling and signal-specific regulation of NIK mRNA expression.

  9. by demonstrating a critical role of NIK in mediating NF-kappaB (zeige NFKB1 Proteine) activation and BAG3 (zeige BAG3 Proteine) induction upon ST80/Bortezomib cotreatment, our study provides novel insights into mechanisms of resistance to proteotoxic stress in RMS

  10. Loss-of-function mutations in NIK can cause B-cell lymphopenia, hypogammaglobulinemia, impaired ICOSL (zeige ICOSLG Proteine) expression, and disordered T helper cell and NK cell function.

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14) Interaktionspartner

  1. this study demonstrates that although NIK (zeige MAP4K4 Proteine) is dispensable for thymocyte development, it has a cell-intrinsic role in regulating the homeostasis and function of peripheral T cells

  2. Using a novel conditional mutant of NIK (zeige MAP4K4 Proteine), the authors could show in vivo that NIK (zeige MAP4K4 Proteine) signaling in thymic epithelial cells is essential for the thymic hardwiring of gammadelta T cell cytokine production.

  3. NIK (zeige MAP4K4 Proteine) not only contributes to lymphoid organogenesis, inflammation and cell survival but also to TNFR1 (zeige TNFRSF1A Proteine)/RIP1 (zeige RALBP1 Proteine)-dependent cell death independently of the alternative NF-kappaB (zeige NFKB1 Proteine) pathway.

  4. This study demonstrated that NFkappaB-inducing kinase inhibits NFkappaB activity specifically in neurons of the CNS.

  5. results assign NIK (zeige MAP4K4 Proteine)-induced alternative NF-kappaB (zeige NFKB1 Proteine) signaling a master regulatory role in B-cells, starting from the T1 stage and also show that B-1 B cells are less dependent on this pathway, presumably owing to the existence of alternative pathways yet to be determined

  6. NIK (zeige MAP4K4 Proteine), and thus probably the noncanonical NF-kappaB (zeige NFKB1 Proteine) pathway, is critical to allow DCs to acquire the capacity to cross-present antigen and prime CD8 (zeige CD8A Proteine) T cells after exposure to licensing stimuli.

  7. Deletion of NIK (zeige MAP4K4 Proteine) in adult mice results in decreases in B cell populations in lymph nodes and spleen, similar to what is observed upon blockade of BAFF (zeige TNFSF13B Proteine).

  8. We identify NIK (zeige MAP4K4 Proteine) as a critical negative regulator of beta cell function, as pharmacological NIK (zeige MAP4K4 Proteine) activation results in impaired glucose-stimulated insulin (zeige INS Proteine) secretion in mouse and human islets.

  9. the NIK (zeige MAP4K4 Proteine) in thymic stroma may be critically involved in the differentiation of most NKT (zeige CTSL1 Proteine) cell subsets (although the level of NIK (zeige MAP4K4 Proteine) dependence may vary among the subsets), and also the NIK (zeige MAP4K4 Proteine) in NKT (zeige CTSL1 Proteine)-alphabeta cells may be dispensable for their effector function.

  10. CHIP/TRAF3 (zeige TRAF3 Proteine)/NIK (zeige MAP4K4 Proteine) interactions recruit NIK (zeige MAP4K4 Proteine) to E3 ligase complexes for ubiquitination and degradation, thus maintaining NIK (zeige MAP4K4 Proteine) at low levels

MAP3K14 Protein Überblick

Protein Überblick

This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.

Alternative names and synonyms associated with MAP3K14

  • mitogen-activated protein kinase kinase kinase 14 (MAP3K14)
  • mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4)
  • mitogen-activated protein kinase kinase kinase 14 (Map3k14)
  • mitogen-activated protein kinase kinase kinase 14 (MAPKKK14)
  • aly Protein
  • F23F1.4 Protein
  • F23F1_4 Protein
  • FLH21957 Protein
  • FTDCR1B Protein
  • HGK Protein
  • HS Protein
  • HSNIK Protein
  • MEKKK4 Protein
  • mitogen-activated protein kinase kinase kinase 14 Protein
  • Nik Protein

Bezeichner auf Proteinebene für MAP3K14

NF-kappa-beta-inducing kinase , serine/threonine protein-kinase , serine/threonine-protein kinase NIK , HPK/GCK-like kinase HGK , MAPK/ERK kinase kinase kinase 4 , MEK kinase kinase 4 , Ste20 group protein kinase HGK , hepatocyte progenitor kinase-like/germinal center kinase-like kinase , nck-interacting kinase , NF kappa B-inducing kinase , Nfkb inducing kinase , alymphoplasia , protein kinase

9020 Homo sapiens
9448 Homo sapiens
360640 Rattus norvegicus
817555 Arabidopsis thaliana
53859 Mus musculus
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