Integrin beta 2 Proteine (ITGB2)

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Synonyme:
2E6, AI256028, AI528527, CD18, D12S370, ITGB2, LAD, LCAMB, LFA-1, Lfa1, LT-BETA-R, Ltar, LTbetaR, MAC-1, MF17, MFI7, TNF-R-III, Tnfbr, TNFCR, TNFR-RP, TNFR2-RP, TNFR3, TNFRrp, TNFRSF3
alle Proteine anzeigen Gen GeneID UniProt
ITGB2 16414 P11835
ITGB2 309684  
ITGB2 3689 P05107

Integrin beta 2 Proteine (ITGB2) nach Spezies

Weitere Proteine zu Integrin beta 2 Interaktionspartnern

Mouse (Murine) Integrin beta 2 (ITGB2) Interaktionspartner

  1. Coro1A (zeige CORO1A Proteine) represents an important novel player in integrin biology, with key functions in polymorphonuclear neutrophils trafficking during innate immunity.

  2. EAE induced by weak activation of innate immunity requires the NLRP3 inflamma (zeige CXCR4 Proteine)some and (zeige CXCR2 Proteine)is sensitive to interferon-beta treatment

  3. These results identify CD47 (zeige CD47 Proteine) as an important regulator of LFA-1 (zeige ITGAL Proteine) and VLA-4 integrin-adhesive functions in T cell proliferation.

  4. lymphatic vessel expansion occurs in two distinct phases; the first wave of expansion is dependent on IL-7 (zeige IL7 Proteine); the second phase, responsible for leukocyte exit from the glands, is regulated by lymphotoxin (zeige LTB Proteine) (LT)betaR signaling

  5. both GDF-15 (zeige GDF15 Proteine) and TGF-beta1 (zeige TGFB1 Proteine) counteract chemokine (zeige CCL1 Proteine)-induced integrin activation on neutrophils via the ALK-5 (zeige TGFBR1 Proteine)/TGF-betaRII heterodimer.

  6. the Slam (zeige SLAMF1 Proteine) locus has an overall inhibitory role during NK cell activation that is solely dependent on 2B4 (zeige CD244 Proteine). This effect is influenced by cytokines and leads to suppression of LFA-1 (zeige ITGAL Proteine) activity.

  7. Wild-type C57BL/6 mice with pristane-induced lupus developed a strong IFN signature, which was absent in immunoglobulin-deficient (muMT), C3(-/-) , and CD18(-/-) mice.

  8. Study suggest an important impact of NKT (zeige CTSL1 Proteine) cells and postulate a critical function for LFA-1 (zeige ITGAL Proteine) during processes of liver regeneration.

  9. NDR1 (zeige STK38 Proteine) kinase, activated by the Rap1 (zeige TERF2IP Proteine) signaling cascade through RAPL (zeige RASSF5 Proteine) and Mst1 (zeige MST1 Proteine)/Mst2 (zeige STK3 Proteine), associated with and recruited kindlin-3 (zeige FERMT3 Proteine) to the immunological synapses, which was required for high-affinity LFA-1 (zeige ITGAL Proteine)/ICAM-1 (zeige ICAM1 Proteine) binding.

  10. LTbetaR is essential for efficient liver regeneration and cooperates with TNFRp55 (zeige TNFRSF1A Proteine) in this process. Differences in survival kinetics strongly suggest distinct functions for these two cytokine receptors in liver regeneration.

Human Integrin beta 2 (ITGB2) Interaktionspartner

  1. membrane-bound lymphotoxin-beta receptor (LTbetaR) and CXC chemokine receptor (zeige CXCR4 Proteine) 2 (CXCR2 (zeige CXCR2 Proteine)), is involved in type B EAE development

  2. data suggest that regulation of LFA-1 (zeige ITGAL Proteine) is one reason for the different activity of NK cells during differentiation

  3. The single nucleotide polymorphism rs1143678 substitutes Pro(1146) for Ser (zeige SIGLEC1 Proteine) in the integrin alphaM cytoplasmic tail generates a noncanonical 14-3-3zeta (zeige YWHAZ Proteine) binding site that modulates integrin alphaM(PS)beta2 outside-in signaling

  4. this study shows that cross-talk between LFA-1 (zeige ITGAL Proteine) and Notch1 (zeige NOTCH1 Proteine) through the Akt (zeige AKT1 Proteine)/ERK (zeige EPHB2 Proteine)-GSK3beta signaling enhances T cell differentiation toward Th1 (zeige TH1L Proteine)

  5. FRbeta (zeige FOLR2 Proteine) as a novel CD11b/CD18 (zeige ITGAM Proteine) regulator for trafficking and homing of a subset of macrophages on collagen.

  6. The results show that with LFA-1 (zeige ITGAL Proteine) antibodies, we can activate LFA-1 (zeige ITGAL Proteine) and inhibit alpha4beta1, inhibit both LFA-1 (zeige ITGAL Proteine) and alpha4beta1, inhibit LFA-1 (zeige ITGAL Proteine) but not alpha4beta1, or not affect LFA-1 (zeige ITGAL Proteine) or alpha4beta1

  7. K152 and D120 within the PH domain of SKAP55 (zeige SKAP1 Proteine) regulate plasma membrane targeting and T cell receptor-mediated activation of LFA-1 (zeige ITGAL Proteine).

  8. LIGHT and LTBR (zeige LTBR Proteine) interaction increases the survival and proliferation of human bone marrow-derived mesenchymal stem cells, and therefore, LIGHT might play an important role in stem cell therapy.

  9. Genetic inactivation and blockade studies revealed that homophilic interactions between intercellular adhesion molecule 1 (ICAM-1 (zeige ICAM1 Proteine)) expressed on tumor cells and MSCs, respectively, regulate the competition between tumor cells and HSPCs for binding to MSCs. Moreover, tumor cell-secreted soluble ICAM-1 (zeige ICAM1 Proteine)(sICAM-1) also impaired HSPC (zeige PSMA7 Proteine) adhesion via blocking CD18-ICAM-1 (zeige ICAM1 Proteine) binding between HSPCs and MSCs

  10. The ability of simvastatin to target CR3 (zeige ITGAM Proteine) in its ligand binding-activated conformation is a novel mechanism to explain the known anti-inflammatory effects of this compound, in particular because this CR3 (zeige ITGAM Proteine) conformation is found in pro-inflammatory environments.

Cow (Bovine) Integrin beta 2 (ITGB2) Interaktionspartner

  1. Identification of numerous variations in exonic and intronic regions within the ITGB2 gene in Bos taurus and indicus screened for bovine leukocyte adhesion deficiency.

  2. intramammarily administered lipopolysaccharides seem to play an important role in modulating L-selectin (zeige SELL Proteine) and beta2 integrin expression on circulating bovine polymorphonuclear leukocytes

  3. A delay in apoptosis was demonstrated in CD18-deficient bovine neutrophils and this appeared to be closely associated with lowered signalling via [Ca2 (zeige CA2 Proteine)+]i, diminished annexin V (zeige ANXA5 Proteine) expression on the cell surface, and decreased caspase 3 (zeige CASP3 Proteine) activity in lysates

  4. The I-EGF (zeige EGF Proteine)-3 domain of bovine CD18 (amino acid residues 541-581) is critical for conferring species-specific susceptibility to Mannheimia haemolytica leukotoxin.

  5. These results clearly indicate that the bovine CD18 subunit of beta(2)-integrins is the functional receptor for M. haemolytica Lkt.[ruminant-specific leukotoxin]

  6. study provides evidence that the expression of CD18 was downregulated by the plasma glycoforms of alpha-1 acid glycoprotein (zeige ORM1 Proteine) and inhibited the chemotaxis of monocytes

  7. Loss of CD18 is associated with bovine leukocyte adhesion deficiency.

  8. Intact signal peptide of CD18, the beta-subunit (zeige POLG Proteine) of beta2-integrins, renders ruminants susceptible to Mannheimia haemolytica leukotoxin.

Pig (Porcine) Integrin beta 2 (ITGB2) Interaktionspartner

  1. CR3 (zeige ITGAM Proteine) plays a cardinal (zeige CARD8 Proteine) role in beta-glucan signalling in porcine neutrophils, while macrophages use a more diverse receptor array to detect and respond towards beta-glucans.

  2. The expression of zona pellucida glycoprotein 3 (zeige ZP3 Proteine) and integrin beta-2 in oocytes after brilliant cresyl blue staining is reported.

  3. early CD18 downregulation is profitable for the host in a situation with an intense LPS (zeige IRF6 Proteine) stimulus

  4. It is concluded that porcine CD18 is necessary to mediate A. pleuropneumoniae ApxIIIA toxin-induced leukolysis.

Goat Integrin beta 2 (ITGB2) Interaktionspartner

  1. Integrin CD11c (zeige ITGAX Proteine)/CD18 alpha-chain (zeige FCGRT Proteine) phosphorylation is functionally important.

Integrin beta 2 (ITGB2) Protein Überblick

Protein Überblick

This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed.

Alternative names and synonyms associated with Integrin beta 2 (ITGB2)

  • integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) (ITGB2)
  • integrin, beta 2 (ITGB2)
  • integrin beta 2 (Itgb2)
  • integrin, beta 2 (Itgb2)
  • integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) (CD18)
  • lymphotoxin B receptor (Ltbr)
  • lymphotoxin beta receptor (TNFR superfamily, member 3) (LTBR)
  • 2E6 Protein
  • AI256028 Protein
  • AI528527 Protein
  • CD18 Protein
  • D12S370 Protein
  • ITGB2 Protein
  • LAD Protein
  • LCAMB Protein
  • LFA-1 Protein
  • Lfa1 Protein
  • LT-BETA-R Protein
  • Ltar Protein
  • LTbetaR Protein
  • MAC-1 Protein
  • MF17 Protein
  • MFI7 Protein
  • TNF-R-III Protein
  • Tnfbr Protein
  • TNFCR Protein
  • TNFR-RP Protein
  • TNFR2-RP Protein
  • TNFR3 Protein
  • TNFRrp Protein
  • TNFRSF3 Protein

Bezeichner auf Proteinebene für Integrin beta 2 Proteine (ITGB2)

integrin beta-2 , Mac-1 beta , cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta , complement receptor C3 subunit beta , lymphocyte function associated antigen 1 , macrophage antigen-1 beta , CD18 leukocyte adhesion molecule , integrin beta 2 , integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1 , integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit) , macrophage antigen 1 (mac-1) beta subunit) , cell surface adhesion glycoprotein LFA-1/CR3/P150,959 beta subunit precursor) , complement receptor C3 beta-subunit , integrin beta chain, beta 2 , leukocyte cell adhesion molecule CD18 , leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C , CD18 subunit , Leu-CAM receptor , integrin, beta 2 (antigen CD18 subunit (p95), lymphocyte function-associated antigen 1, integrin B2) , integrin beta 2 subunit , Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta , Complement receptor C3 subunit beta , Integrin beta-2 , antigen CD18 , integrin beta-2 chain , LT beta-R , LT-beta receptor , TNF receptor-related protein , lymphotoxin-beta receptor , tumor necrosis factor receptor superfamily member 3 , tumor necrosis factor receptor superfamily, member 3 , lymphotoxin B receptor , tumor necrosis factor C receptor , tumor necrosis factor receptor 2-related protein , tumor necrosis factor receptor type III

GENE ID SPEZIES
458607 Pan troglodytes
710577 Macaca mulatta
16414 Mus musculus
309684 Rattus norvegicus
3689 Homo sapiens
281877 Bos taurus
396943 Sus scrofa
396181 Gallus gallus
100861185 Capra hircus
494433 Ovis aries
17000 Mus musculus
4055 Homo sapiens
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