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Mouse (Murine) IL1B Protein expressed in Escherichia coli (E. coli) - ABIN1305081
Gray, Glaister, Chen, Goeddel, Pennica: Two interleukin 1 genes in the mouse: cloning and expression of the cDNA for murine interleukin 1 beta. in Journal of immunology (Baltimore, Md. : 1950) 1986
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Human IL1B Protein expressed in Escherichia coli (E. coli) - ABIN413480
Kahlenberg, Thacker, Berthier, Cohen, Kretzler, Kaplan: Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus. in Journal of immunology (Baltimore, Md. : 1950) 2011
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Human IL1B Protein expressed in Escherichia coli (E. coli) - ABIN1589581
Hollborn, Vogler, Reichenbach, Wiedemann, Bringmann, Kohen: Regulation of the hyperosmotic induction of aquaporin 5 and VEGF in retinal pigment epithelial cells: involvement of NFAT5. in Molecular vision 2015
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Rat (Rattus) IL1B Protein expressed in Escherichia coli (E. coli) - ABIN809718
Yang, Poon, Luo, Cheung, Ho, Lo, Fan: Up-regulation of vascular endothelial growth factor (VEGF) in small-for-size liver grafts enhances macrophage activities through VEGF receptor 2-dependent pathway. in Journal of immunology (Baltimore, Md. : 1950) 2004
Mouse (Murine) IL1B Protein expressed in Escherichia coli (E. coli) - ABIN804033
Tiwari, Wang, Brochetta, Ke, Vita, Qi, Rivera, Soranzo, Zabucchi, Hong, Blank: VAMP-8 segregates mast cell-preformed mediator exocytosis from cytokine trafficking pathways. in Blood 2008
Human IL1B Protein expressed in Escherichia coli (E. coli) - ABIN1305079
Kitamura, Tange, Terasawa, Chiba, Kuwaki, Miyagawa, Piao, Miyazono, Urabe, Takaku: Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin. in Journal of cellular physiology 1989
Mouse (Murine) IL1B Protein expressed in Escherichia coli (E. coli) - ABIN988112
Zhang, Bennett, Verkman: Ex vivo spinal cord slice model of neuromyelitis optica reveals novel immunopathogenic mechanisms. in Annals of neurology 2011
Leukocyte expression of IL-1beta was detectable only following injury, which activated leukocytes throughout zebrafish embryos in a caspase (zeige CASP3 Proteine) dependent manner.
Embryo and larva leukocytes upregulate IL-1beta expression proportional to the dose of ultraviolet radiation exposure in an immune response at the organismal level.
findings reveal that the Il-1beta-Myd88 (zeige MYD88 Proteine) axis and NADPH oxidase (zeige NOX1 Proteine)-mediated ROS (zeige ROS1 Proteine) signaling are two independent pathways that differentially regulate neutrophil migration during sterile inflammation.
the expression levels of IL-1beta and TNF-alpha in high cholesterol diet (HCD)-fed zebrafish larvae
These results represent the first demonstration of processing and secretion of zebrafish IL-1beta in response to a pathogen.
Following vasectomy, IL1alpha (zeige IL1A Proteine), IL1beta, IL1ra (zeige IL1RN Proteine), IL10 (zeige IL10 Proteine), and TNF-alpha (zeige TNF Proteine) may mediate immune reaction in whole epididymis, whereas IL6 (zeige IL6 Proteine) and TGF-beta1 (zeige TGFB1 Proteine) may mediate regionally different immune response primarily in the lower part of epididymis.
Elevations of CO2 cause oligomerization of the inflammasome components ASC (zeige STS Proteine), NLRP3 (zeige NLRP3 Proteine), caspase 1 (zeige CASP1 Proteine), thioredoxin interacting protein (zeige TXNIP Proteine), and calreticulin (zeige CALR Proteine) - a protein from endoplasmic reticulum, leading to IL-1beta synthesis. An increased production rate of MPs containing elevated amounts of IL-1beta persists for hours after short-term exposures to elevated CO2
dimerized or endogenous caspase-8 (zeige CASP8 Proteine) can also directly cleave IL-1beta into its biologically active form, in the absence of canonical inflammasome components.
In this newborn mouse lung hypoxia-reoxygenation model, we found downregulation of genes of mediators of inflammation, an antiapoptotic gene expression pattern, and downregulation of DNA glycosylases. Sod1 (zeige SOD1 Proteine) and Il1b were significantly differentially expressed when comparing reoxygenation using 60% O2 with air.
Report direct role of pleural cells in the pathogenesis of bleomycin-induced pulmonary fibrosis via caspase-1 (zeige CASP1 Proteine)/IL-1beta pathway.
the senescence associated secretory phenotype was also increased significantly in the kidney of Sod1 (zeige SOD1 Proteine)(-/)(-) mice compared to WT mice as measured by the expression of transcripts for IL-6 (zeige IL6 Proteine) and IL-1b
These studies elucidate an important role for neutrophils and IL-1beta in lung carcinogenesis.
PLCd1 (zeige PLCD1 Proteine) negatively regulates lipopolysaccharide-induced production of IL-1b and Fc gamma receptor (zeige FCGR1A Proteine)-mediated phagocytosis in macrophages.
these data are the first to show dramatic posttranscriptional control of inflammatory cytokine production by a relevant tissue-derived macrophage population and proteasomal degradation of proIL-1beta and NLRP3 (zeige NLRP3 Proteine) as a mechanism to control inflammasome activation
data provide evidence that the NLRC4 (zeige NLRC4 Proteine) inflammasome contributes to resistance through regulation of caspase-1 (zeige CASP1 Proteine), IL-1beta and IL-18 (zeige IL18 Proteine) in a CD11blowLy6Glow population of cells
These data suggest that in aged skin, IL-1beta signalling is diminished due to altered expression of IL1B and decoy receptor gene IL1R2 (zeige IL1R2 Proteine).
High glucose triggers IL-1beta synthesis in retinal endothelial cells. The produced IL-1beta induces increased FoxO1 (zeige FOXO1 Proteine) expression, and interacts with the IL-1 (zeige IL1A Proteine) receptor to activate MAPK (zeige MAPK1 Proteine) signaling, thereby inducing IL-1beta autostimulation.
Several studies to date clearly show that in diseased joints, SDC4 (zeige SDC4 Proteine) and inflammatory cytokines IL-1beta and TNF-alpha (zeige TNF Proteine) form a positive feedback loop, wherein they control each other's expression and/or activity. [review]
Elevated breast milk IL-1beta level was associated with decreased risk of early childhood eczema suggesting either a direct protective effect of IL-1beta or IL-1b acting as a proxy for a healthy maternal immune system protecting high-risk offspring from eczema.
Data show that Cx43 (zeige GJA1 Proteine) was inhibited predominantly via IL-1beta-activated ERK1/2 and p38 MAP kinase (zeige MAPK14 Proteine) cascades.
study provides the status of SNPs at IL-1beta promoter in Saudi population. As per our information, ours is the first article that shows the genetic diversity in IL-1beta promoters and its level in the Saudi Coronary Artery Disease patients.
these results indicate that AMBN (zeige AMBN Proteine) enhances IL-1beta production in LPS (zeige IRF6 Proteine)-treated U937 cells through ERK1/2 phosphorylation and caspase-1 (zeige CASP1 Proteine) activation, suggesting that AMBN (zeige AMBN Proteine) upregulates the inflammatory response in human macrophages and plays an important role in innate immunity.
Effects of pro-inflammatory cytokines, lipopolysaccharide and COX-2 mediators on human colonic neuromuscular function and epithelial permeability
Levels of IL-1beta and TNF-alpha (zeige TNF Proteine) in conjunctival biopsy specimens were increased in diabetic patients with dry eye
Serum and seminal levels of TNF-alpha (zeige TNF Proteine), IL-1beta, IL6 (zeige IL6 Proteine) and IL8 (zeige IL8 Proteine) were all significantly increased in the metabolic syndrome group.
This study showed that classical swine fever virus and p7 protein induced IL-1beta secretion and that p7 protein was a short-lived protein degraded by the proteasome.
local expression of IL-1beta and IL-8 (zeige IL8 Proteine) in non-bacterial thrombotic endocarditis, Staphylococcus aureus infective endocarditis, animals with S. aureus sepsis without endocarditis and controls
IL1B regulates expression of IL1R1 (zeige IL1RN Proteine) and IL1RAP (zeige IL1RAP Proteine) and stimulates expression of PTGS1 (zeige PTGS1 Proteine) and PTGS2 (zeige PTGS2 Proteine) that are considered to be the most rate-limiting enzymes for endometrial synthesis of prostaglandins during the peri (zeige PLIN1 Proteine)-implantation period of pregnancy in pigs.
the results presented here strongly suggest IL-1beta as a key molecule guiding tissue remodelling events after myocardial infarction.
The presence of embryos increased endometrial IL1B protein locally, while no differences regarding IL1R1 (zeige IL1RN Proteine) protein and IL1B and IL1R1 (zeige IL1RN Proteine) mRNA were detected.
For the inflammasome-dependent IL-1beta release, bovine monocytes require ATP in addition to a primary stimulus. This IL-1beta release depends on potassium efflux, but, in contrast to human and murine monocytes, does not require calcium influx or generation of reaction oxygen and is independent of the P2X7 receptor (zeige P2RX7 Proteine).
Role of TGF-beta1 (zeige TGFB1 Proteine) and TNF-alpha (zeige TNF Proteine) in IL-1beta mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease.
Testicular IL-1 alpha (zeige IL1A Proteine) and IL-1 beta concentrations were highest in the early post-natal period; however, IL-1 (zeige IL1A Proteine) bioactivity and IL-6 (zeige IL6 Proteine) concentrations were greatest in the immediate pre-pubertal period.
Data describe the expression of IL-8, IL-1beta and their respective receptors, CXCR1 and IL-1R1 in bovine theca cells, and suggest that VEGF is associated with the IL system in theca cells in ovary.
Genes for IL-1alpha and IL-1beta are expressed and a functional IL-1R is present in bovine corpora lutea throughout luteal phase. IL-1alpha and IL-1beta may have different roles as regulating PGF (zeige PGF Proteine)(2alpha) and PGE (zeige LIPF Proteine)(2) production during luteal phase.
non-metalloproteinase mechanisms participate in IL-1 (zeige IL1A Proteine)-induced matrix degradation and loss of tissue material properties
dynamic compression stimulates cell proliferation and proteoglycan (zeige Vcan Proteine) synthesis in the presence of IL-1beta and/or inhibitors of the MAPKs and NFkappaB and AP-1 (zeige JUN Proteine) signalling pathways
These results indicate that activation of the intrinsic antistaphylococcal response in bovine endothelial cells (BEC), enhanced by TNF-alpha (zeige TNF Proteine) and IL-1beta, is effective to eliminate S. aureus and S. epidermidis.
the low friction of articular cartilage can be modified by TGF-beta1 (zeige TGFB1 Proteine) and IL-1beta treatment and that the friction coefficient depends on multiple factors, including superficial zone protein localization and surface roughness
Mild heat shock increased the production of inflammatory cytokines, IL-1beta and IL-6 (zeige IL6 Proteine) in rabbit cornea cells.
IL-1beta and TNF-alpha (zeige TNF Proteine) expression increases significantly during acute lung injury. Ambroxol combined with low-dose heparin inhibits teh release of IL-1beta and TNF-alpha (zeige TNF Proteine).
IL-1beta induced a significant reduction in the relative intrinsic activity of GLUT5 and in this decrease are involved NO signal pathways; blockage of D-fructose intestinal uptake by IL-1beta may play an essential role in the pathophysiology of septic shock.
The inhibitory effect of IL-1beta on D-galactose absorption across mucosal side of enterocyte could be mediated by the activation of several kinases and nuclear factor kappa B.
Glucosamine hydrochloride treatment can can partially decrease the expression levels of IL-1 beta and increase the expression levels of TGF-beta 1 (zeige TGFB1 Proteine), which delays the development of osteoarthritis.
In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of IL1B transcripts depending on luteal stage.
results revealed that a transient episode of raised-intensity phonation causes a significant increase in vocal fold inflammatory mRNA expression - IL-1beta,COX-2, and TGFbeta1 (zeige TGFB1 Proteine)
Increased PGE2 production led to reduction in 5-LO (zeige ALOX5 Proteine) products in LPS (zeige IRF6 Proteine)-treated equine whole blood via IL-1b.
Results suggested that chemokine (zeige CCL1 Proteine) expression by cultured equine BECs following exposure to pulmonary hemorrhage conditions may contribute to the development of inflammatory airway disease in horses.
IL-1beta-induced up-regulation of matrix metalloproteinase 13 (zeige MMP13 Proteine) mRNA was blocked by all concentrations of geldanamycin tested
This study examined effects of in vitro exposure to solutions of hay (zeige GTF2H5 Proteine) dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
, IL-1 beta
, interleukin-1 beta
, preinterleukin 1 beta
, prointerleukin-1 beta
, Interleukin-1 beta
, precursor interleukin-1beta
, interleukin-1 beta proprotein
, interleukin 1 beta
, lymphocyte proliferation-potentiating factor