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Human EGFR Protein expressed in Human Cells - ABIN2001843
Schlessinger: Cell signaling by receptor tyrosine kinases. in Cell 2000
Show all 4 Pubmed References
Human EGFR Protein expressed in HEK-293 Cells - ABIN2181000
Singer, Fazekas, Wang, Weichselbaumer, Matz, Mader, Steinfellner, Meitz, Mechtcheriakova, Sobanov, Willmann, Stockner, Spillner, Kunert, Jensen-Jarolim: Generation of a canine anti-EGFR (ErbB-1) antibody for passive immunotherapy in dog cancer patients. in Molecular cancer therapeutics 2014
Human EGFR Protein expressed in Insect cells (Sf9) - ABIN2720019
Chaudhary, Thamake, Shetty, Vishwanatha: Inhibition of triple-negative and Herceptin-resistant breast cancer cell proliferation and migration by Annexin A2 antibodies. in British journal of cancer 2014
Human EGFR Protein expressed in Wheat germ - ABIN1352437
Zheng, Zhang, Croucher, Soliman, St-Denis, Pasculescu, Taylor, Tate, Hardy, Colwill, Dai, Bagshaw, Dennis, Gingras, Daly, Pawson: Temporal regulation of EGF signalling networks by the scaffold protein Shc1. in Nature 2013
Results indicated that most periocular squamous cell carcinomas of horses expressed epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2 (zeige ERBB2 Proteine)).
Data show that EGFR controls the proper formation of brain neuroblasts by regulating the number, survival and proneural gene expression of neuroectodermal progenitor cells which suggest that EGFR signalling is crucially important for patterning and early neurogenesis of the brain.
The activity of Gro (zeige CXCL1 Proteine) is antagonized by EGFR signaling, which inhibits Gro (zeige CXCL1 Proteine)-dependent repression via p-ERK (zeige MAPK1 Proteine) mediated phosphorylation.
These results reveal that ESCRT-0 (ESCRT-0 components stam (zeige STAM Proteine) and hrs)mutants inhibit EGFR signaling by disrupting Rhomboid endosomal trafficking in the ligand-producing cells.
we find that EGFR regulates the apical determinant Crb and the extracellular matrix regulator Serp, two factors previously known to control tube length. EGFR regulates the organisation of endosomes in which Crb and Serp proteins are loaded
Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr) pathway in the lateral epidermis for sustained dpp (zeige TGFb Proteine) expression in the LE. Specifically, we demonstrate that Egfr pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK (zeige MAPK8 Proteine) signaling
Loss of Usp5 (zeige USP5 Proteine) results in upregulation of Notch (zeige NOTCH1 Proteine) signaling and downregulation of RTK signaling by EGF receptor (EGFR) and Sevenless (Sev), leading to impaired photoreceptor development.
These data demonstrate a strong genetic link between dG9a and the EGFR signaling pathway.
Avermectin directly interacts with EGFR and leads to the activation of the EGFR/AKT (zeige AKT1 Proteine)/ERK (zeige MAPK1 Proteine) pathway.
The dorsoventral patterning and EGFR signaling genes play essential roles in correct identity determination and differentiation of lateral glia in the Drosophila nervous system.
Data suggest that OSCP1 (organic solute carrier partner 1 (zeige OSCP1 Proteine)) plays multiple roles during eye development in D. melanogaster; OSCP1 (zeige OSCP1 Proteine) regulates developmental gene expression and epidermal growth factor receptor signaling pathway in imaginal discs of eye.
Study demonstrated that IGF-I (zeige IGF1 Proteine) can stimulate egfr expression in both follicles cell culture and intact follicles promoting oocyte maturation.
These results indicate that maintenance of Pgrmc1 signaling is required for Egfr expression on zebrafish oocyte cell membranes and for conserving the functions of Egfr in maintaining meiotic arrest through estrogen activation of Gper.
EGFR signaling in vertebrate oocytes can prevent meiotic progression.
the expression of EGFR was mainly restricted to the follicle cells with little expression in the oocytes
the activation of EGFR plays a critical role in the switch between cell survival and cell death induced by autophagy in hypoxia.
ALK/EGFR mutational co-alterations are associated with response to chemotherapy in Non-Small Cell Lung Cancer.
EGFR mutations are associated with Resistance to chemptherapy in Lung cancer.
The authors have characterized ligand-induced dimerization and multimerization of EGFR using single-molecule analysis, and show that multimerization can be blocked by mutations in a specific region of Domain IV of the extracellular module.
Here the authors show that suppressor of cytokine signaling (SOCS (zeige CISH Proteine)) five has a pivotal role in restricting influenza A virus in the airway epithelium, through the regulation of epidermal growth factor receptor (EGFR).
Overexpression of LAMC2 (zeige LAMC2 Proteine) and knockdown of CD82 (zeige CD82 Proteine) markedly promoted GC cell invasion and activated EGFR/ERK1/2-MMP7 (zeige MMP7 Proteine) signaling via upregulation of the expression of phosphorylated (p)-EGFR, p-ERK1/2 and MMP7 (zeige MMP7 Proteine).
Data indicate a role for AXL receptor tyrosine kinase (AXL (zeige AXL Proteine)) in regulating the nuclear translocation of epidermal growth factor receptor (EGFR) and suggest that AXL (zeige AXL Proteine)-mediated SRC (zeige SRC Proteine) family kinases (SFKs) and neuregulin-1 (NRG1 (zeige NRG1 Proteine)) expression promote this process.
EGFR and/or HER2 (zeige ERBB2 Proteine) transactivation is involved in cell adhesion, cell migration and VEGF (zeige VEGFA Proteine) secretion produced by GHRH (zeige GHRH Proteine).
EGFR mutations were frequently seen in histologically low- and intermediate-grade tumors but not a prognostic factor
EGFR mutation is associated with lung adenocarcinoma.
OLIG2 (zeige OLIG2 Proteine) modulates growth factor signaling in two distinct populations of glioma stem cells, characterized by expression of either the epidermal growth factor receptor (EGFR) or platelet-derived growth factor receptor alpha (zeige PDGFRA Proteine).
Data indicate that interleukin-33 (IL-33 (zeige IL33 Proteine))-induced Interleukin-13 (IL-13 (zeige IL13 Proteine)) production by type-2 helper T cells (Th2 cells) Is dependent on epidermal growth factor receptor (EGFR) expression.
The EGFR-mediated control of beta-cell differentiation via apical polarity is also conserved in human neurogenin3 (zeige NEUROG3 Proteine)(+) cells.
Epiregulin (zeige EREG Proteine) and EGFR interactions have roles in pain processing
HB-EGF (zeige HBEGF Proteine) stimulates Prss56 expression via EGFR-ERK (zeige EPHB2 Proteine) pathway.
provides definitive evidence that sustained activation of EGFR in proximal epithelia is sufficient to cause spontaneous, progressive renal tubulointerstitial fibrosis, evident by epithelial dedifferentiation, increased myofibroblasts, immune cell infiltration, and increased matrix deposition
EGFR signaling is central to macrophage function in response to enteric bacterial pathogen
Overall there is a substantial sex difference in the Egfr pathways in mice. These data may have significant impact on drug target design, development, formulation, and dosage determinant for women and men in clinical trials.
Redox-dependent regulation of EGFR activation in airway epithelial cells was found to strongly depend on activation of either DUOX1 (zeige DUOX1 Proteine) or NOX2 (zeige CYBB Proteine).
EGFR signaling in macrophages, but not in colonic epithelial cells, has a significant role in colitis-associated carcinogenesis.
this study shows that anemonin may ameliorate LPS (zeige IRF6 Proteine)-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR signaling pathways
Syndecan-4 (zeige SDC4 Proteine) mediates porcine respiratory and reproductive syndrome virus entry by interacting with EGFR.
These results indicate that cAMP and oocyte-secreted factors cooperate to promote EGF receptor functionality in developing cumulus oocyte complexes, representing a key component of the acquisition of oocyte developmental competence.
patients experiencing gefitinib dose reduction or short-term treatment interruption due to toxicities did not show inferior survival, compared to those receiving full dose of gefitinib in non-small cell lung cancer patients with EGFR mutation
Report EGFR expression in the normal pancreas.
Injury and activation of purinergic receptors and direct activation of EGFR via EGF (zeige EGF Proteine) induce distinct downstream pathways.
Data suggest that the mechanism of hypoxia-induced increased activation of EGFR kinase is mediated by nNOS (zeige NOS1 Proteine)-derived nitric oxide.
EGFR, VEGFR (zeige KDR Proteine) and FGFR (zeige FGFR2 Proteine) are expressed in porcine oviduct and endometrium during the time of implantation [review]
the restricted presence of the functional full-size receptor to the epithelial layer indicates a specific role during early embryonic development, whereas truncated EGF-R forms may potentially regulate contractions and blood flow in the oviduct
The phase-related expression of EGF (zeige EGF Proteine) and EGFR in the endothelium of the uterine artery and its branches suggest the modulatory effect of EGF (zeige EGF Proteine) and its receptor on the uterine artery and the region supplying these vessels.
Stimulation of bovine oviduct epithelial cell EGFR with EGF (zeige EGF Proteine) (human recombinant EGF (zeige EGF Proteine)) alone or with EGF (zeige EGF Proteine) in postovulatory/follicular phases (not luteal phase) up-regulates phosphorylation of MAPKs; heat blocks effects of EGF (zeige EGF Proteine) on phosphorylation of MAPKs.
Expression of the erbB/HER receptor family in the bovine uterus during the sexual cycle and the relation of this family to serum sex steroids.
Regulation of the sperm EGFR by ouabain leads to initiation of the acrosome reaction.
EGFR may simultaneously activate c-Src (zeige SRC Proteine) and PI3K to amplify the oxytocin signaling to increase the output of PGF (zeige PGF Proteine)(2 alpha) in endometrial epithelial cells.
results indicate that arginase induction depends in part on epidermal growth factor (EGF (zeige EGF Proteine)) receptor activity, and that EGFR inhibitors may attenuate vascular remodeling without affecting nitric oxide release
Data suggest that epidermal growth factor (EGF (zeige EGF Proteine)) and EGF (zeige EGF Proteine) receptors are important paracrine and/or autocrine regulators of spermatogenesis in bovine.
MT1-MMP (zeige MMP14 Proteine) has a role in signaling events mediating EGFR transactivation
possible cooperative role of the EGF (zeige EGF Proteine) and HGF (zeige HGF Proteine) pathways and indicate that cross-talk between their respective receptors may modulate mammary gland development in the cow
EGFR is stimulated during capacitation via PKA activation. More activation induces the acrosome reaction, which is induced by GPCR via EGFR transactivation by a signaling pathway involving PKA, SRC & metalloproteinase & effectors PI3K, PLC & PKC.
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
, Egf receptor
, drosophila epidermal growth factor receptor homologue
, ellipse torpedo
, epidermal growth factor receptor
, faint little ball
, morphological defects 1
, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
, cell growth inhibiting protein 40
, cell proliferation-inducing protein 61
, proto-oncogene c-ErbB-1
, receptor tyrosine-protein kinase erbB-1
, EGFR-related peptide
, Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)
, avian erythroblastic leukemia viral (v-erbB) oncogene homolog
, epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)
, waved 2
, epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
, egf receptor
, receptor tyrosine kinase ErbB1