EGFR Proteine (EGFR)

Epidermal Growth Factor Receptor Proteine (EGFR)
Auf finden Sie aktuell 136 Epidermal Growth Factor Receptor (EGFR) Proteine von 18 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen EGFR Antikörper (2360) und EGFR Kits (145) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 2714 EGFR Produkte verfügbar.
9030024J15Rik, AI552599, C-erb, c-erbB, CG10079, D-Egf, d-egf-r, D-EGFR, dEgfr, dEGFR1, der, DER/EGFR, DER/faint little ball, DER/top, DER/torpedo, DER1, DER flb, Dmel\\CG10079, DmHD-33, EFG-R, Egf, Egf-r, egfr, egfr1, EGFR12, EGFR15, EK2-6, El, Elp, Elp-1, Elp-B1, Elp-B1RB1, Erbb, ErbB-1, ERBB1, Erbb2, Errb1, Errp, flb, HD-33, HER1, l(2)05351, l(2)09261, l(2)57DEFa, l(2)57Ea, l(2)57EFa, mENA, mor1, PIG61, top, top/DER, top/flb, Torpedo/DER, torpedo/egfr, wa-2, wa2, Wa5
alle Proteine anzeigen Gen GeneID UniProt
EGFR 1956 P00533
EGFR 24329  
EGFR 13649 Q01279

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Am meisten referenzierte EGFR Proteine

  1. Rat (Rattus) EGFR Protein expressed in Human Cells - ABIN2009151 : Schlessinger: Cell signaling by receptor tyrosine kinases. in Cell 2000 (PubMed)
    Zeige alle 2 Referenzen für 2009151

  2. Human EGFR Protein expressed in Baculovirus infected Insect Cells - ABIN2001846 : Yarden, Sliwkowski: Untangling the ErbB signalling network. in Nature reviews. Molecular cell biology 2001 (PubMed)
    Zeige alle 2 Referenzen für 2001846

  3. Human EGFR Protein expressed in Insect cells (Sf9) - ABIN2720019 : Chaudhary, Thamake, Shetty, Vishwanatha: Inhibition of triple-negative and Herceptin-resistant breast cancer cell proliferation and migration by Annexin A2 antibodies. in British journal of cancer 2014 (PubMed)

  4. Human EGFR Protein expressed in Wheat germ - ABIN1352437 : Zheng, Zhang, Croucher, Soliman, St-Denis, Pasculescu, Taylor, Tate, Hardy, Colwill, Dai, Bagshaw, Dennis, Gingras, Daly, Pawson: Temporal regulation of EGF signalling networks by the scaffold protein Shc1. in Nature 2013 (PubMed)

  5. Human EGFR Protein expressed in HEK-293 Cells - ABIN2181000 : Singer, Fazekas, Wang, Weichselbaumer, Matz, Mader, Steinfellner, Meitz, Mechtcheriakova, Sobanov, Willmann, Stockner, Spillner, Kunert, Jensen-Jarolim: Generation of a canine anti-EGFR (ErbB-1) antibody for passive immunotherapy in dog cancer patients. in Molecular cancer therapeutics 2014 (PubMed)

Weitere Proteine zu EGFR Interaktionspartnern

Horse (Equine) Epidermal Growth Factor Receptor (EGFR) Interaktionspartner

  1. Results indicated that most periocular squamous cell carcinomas of horses expressed epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2 (zeige ERBB2 Proteine)).

Fruit Fly (Drosophila melanogaster) Epidermal Growth Factor Receptor (EGFR) Interaktionspartner

  1. The activity of Gro (zeige CXCL1 Proteine) is antagonized by EGFR signaling, which inhibits Gro (zeige CXCL1 Proteine)-dependent repression via p-ERK (zeige MAPK1 Proteine) mediated phosphorylation.

  2. These results reveal that ESCRT-0 (ESCRT-0 components stam (zeige STAM Proteine) and hrs)mutants inhibit EGFR signaling by disrupting Rhomboid endosomal trafficking in the ligand-producing cells.

  3. we find that EGFR regulates the apical determinant Crb and the extracellular matrix regulator Serp, two factors previously known to control tube length. EGFR regulates the organisation of endosomes in which Crb and Serp proteins are loaded

  4. Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr) pathway in the lateral epidermis for sustained dpp (zeige TGFb Proteine) expression in the LE. Specifically, we demonstrate that Egfr pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK (zeige MAPK8 Proteine) signaling

  5. Loss of Usp5 (zeige USP5 Proteine) results in upregulation of Notch (zeige NOTCH1 Proteine) signaling and downregulation of RTK signaling by EGF receptor (EGFR) and Sevenless (Sev), leading to impaired photoreceptor development.

  6. These data demonstrate a strong genetic link between dG9a and the EGFR signaling pathway.

  7. Avermectin directly interacts with EGFR and leads to the activation of the EGFR/AKT (zeige AKT1 Proteine)/ERK (zeige MAPK1 Proteine) pathway.

  8. The dorsoventral patterning and EGFR signaling genes play essential roles in correct identity determination and differentiation of lateral glia in the Drosophila nervous system.

  9. Data suggest that OSCP1 (organic solute carrier partner 1 (zeige OSCP1 Proteine)) plays multiple roles during eye development in D. melanogaster; OSCP1 (zeige OSCP1 Proteine) regulates developmental gene expression and epidermal growth factor receptor signaling pathway in imaginal discs of eye.

  10. The vector of cell movement is regulated by localised epidermal growth factor (EGF (zeige EGF Proteine)) signalling from the distally placed tip cell lineage and the acquisition of planar polarity leads to asymmetric pulsatile Myosin II accumulation.

Zebrafish Epidermal Growth Factor Receptor (EGFR) Interaktionspartner

  1. Study demonstrated that IGF-I (zeige IGF1 Proteine) can stimulate egfr expression in both follicles cell culture and intact follicles promoting oocyte maturation.

  2. These results indicate that maintenance of Pgrmc1 signaling is required for Egfr expression on zebrafish oocyte cell membranes and for conserving the functions of Egfr in maintaining meiotic arrest through estrogen activation of Gper.

  3. EGFR signaling in vertebrate oocytes can prevent meiotic progression.

  4. the expression of EGFR was mainly restricted to the follicle cells with little expression in the oocytes

Human Epidermal Growth Factor Receptor (EGFR) Interaktionspartner

  1. EGFR and C/EBP-beta (zeige CEBPB Proteine) oncogenic signaling is bidirectional in human glioma and varies with the C/EBP-beta (zeige CEBPB Proteine) isoform

  2. Studies indicate that positive PD-L1 (zeige CD274 Proteine) expression was significantly correlated with KRAS mutation and EGFR mutation.

  3. Piccolo contributes to tumor aggressiveness in esophageal squamous cell carcinoma, likely by stabilizing EGFR and promoting EGFR-dependent signaling.

  4. Finally, the authors show that EGFR-ERK1/2 and beta1-integrin signaling are the main pathways used for bacteria-mediated EGR1 (zeige EGR1 Proteine) upregulation.

  5. Two new signals were observed at genome-wide significance (P < 5 x 10-8), namely, rs7216064 (17q24.3, BPTF), for overall lung adenocarcinoma risk, and rs3817963 (6p21.3, BTNL2 (zeige BTNL2 Proteine)) which is specific to cases with EGFR mutations. In further sub-analyses by EGFR status, rs9387478 (ROS1 (zeige ROS1 Proteine)/DCBLD1) and rs2179920 (HLA-DPB1 (zeige HLA-DPB1 Proteine)) showed stronger estimated associations in EGFR-positive compared to EGFR-negative cases

  6. Study shows that EGFR negatively regulates POPDC1 (zeige BVES Proteine) expression in breast cancer cell lines and that overexpression of POPDC1 (zeige BVES Proteine) can reduce EGFR-mediated cell migration and proliferation in breast cancer cells.

  7. The present findings indicate that genetic variation in EGFR may contribute to the attainment of extreme old age in Japanese.

  8. developed a simulator to accurately calculate the dynamic sensitivity of extracellular-signal-regulated kinase (ERK (zeige EPHB2 Proteine)) activity (ERK (zeige EPHB2 Proteine)*) and Akt (zeige AKT1 Proteine) activity (Akt (zeige AKT1 Proteine)*), downstream of the ErbB receptors stimulated with epidermal growth factor (EGF (zeige EGF Proteine)) and heregulin (HRG (zeige NRG1 Proteine))

  9. EGFR amplification/EGFRvIII mutation can repress the expression of Pri-miR (zeige MLXIP Proteine)-524 by histone modification. MiR (zeige MLXIP Proteine)-524-3p and miR (zeige MLXIP Proteine)-524-5p inhibited TGF/beta (zeige TGFB1 Proteine), Notch (zeige NOTCH1 Proteine) and the Hippo pathway by targeting Smad2 (zeige SMAD2 Proteine), Hes1 and Tead1 (zeige TEAD1 Proteine), respectively; these pathways repressed their common downstream transcription factor, C-myc (zeige MYC Proteine).

  10. The searched for functional interactions between EGFR and D2-like receptors, focusing on the molecular mechanisms involved in the EGFR-mediated regulation of dopamine receptor signaling.

Mouse (Murine) Epidermal Growth Factor Receptor (EGFR) Interaktionspartner

  1. EGFR signaling in macrophages, but not in colonic epithelial cells, has a significant role in colitis-associated carcinogenesis.

  2. KrasG12D-driven proliferation of pancreatic ductal epithelial cells (PDECs) depends on an EGFR signaling loop engaging the oncogenic transcription factor c-MYC (zeige MYC Proteine).

  3. Detecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor

  4. High expression of EGFR is associated with lung carcinogenesis.

  5. our results suggest that NeuGcGM3 and EGFR may coordinately contribute to the tumor cell biology and that therapeutic combinations against these two targets might be a valid strategy to explore.

  6. In FGF9-overexpressing colorectal cancer cell lines, FGF9 overexpression induced strong resistance to anti-EGFR therapies via the enforced FGFR (zeige FGFR2 Proteine) signal, and this resistance was cancelled by the application of an FGFR (zeige FGFR2 Proteine) inhibitor.

  7. Although EGFR activation promotes wound healing, released exosomes may antagonize EGFR activation and wound healing.

  8. opposing signals generated by different ErbB dimer combinations function in the same cardiac cushion mesenchymal cells for proper cardiac valve formation.

  9. Combined targeting of TGF-beta (zeige TGFB1 Proteine), EGFR and HER2 (zeige ERBB2 Proteine) signaling suppresses lymphangiogenesis and metastasis in a pancreatic ductal adenocarcinoma model.

  10. The conjugation of benzylguanine-modified auristatin F to EGFR-specific 425(scFv)-SNAP and HER2 (zeige ERBB2 Proteine)-specific alphaHER2(scFv)-SNAP resulted in two potent recombinant antibody-drug conjugates that specifically killed breast cancer cell lines by inducing apoptosis when applied at nanomolar concentrations.

Pig (Porcine) Epidermal Growth Factor Receptor (EGFR) Interaktionspartner

  1. this study shows that anemonin may ameliorate LPS (zeige IRF6 Proteine)-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR signaling pathways

  2. Syndecan-4 (zeige SDC4 Proteine) mediates porcine respiratory and reproductive syndrome virus entry by interacting with EGFR.

  3. These results indicate that cAMP and oocyte-secreted factors cooperate to promote EGF receptor functionality in developing cumulus oocyte complexes, representing a key component of the acquisition of oocyte developmental competence.

  4. patients experiencing gefitinib dose reduction or short-term treatment interruption due to toxicities did not show inferior survival, compared to those receiving full dose of gefitinib in non-small cell lung cancer patients with EGFR mutation

  5. Report EGFR expression in the normal pancreas.

  6. Injury and activation of purinergic receptors and direct activation of EGFR via EGF (zeige EGF Proteine) induce distinct downstream pathways.

  7. Data suggest that the mechanism of hypoxia-induced increased activation of EGFR kinase is mediated by nNOS (zeige NOS1 Proteine)-derived nitric oxide.

  8. EGFR, VEGFR (zeige KDR Proteine) and FGFR (zeige FGFR2 Proteine) are expressed in porcine oviduct and endometrium during the time of implantation [review]

  9. the restricted presence of the functional full-size receptor to the epithelial layer indicates a specific role during early embryonic development, whereas truncated EGF-R forms may potentially regulate contractions and blood flow in the oviduct

  10. The phase-related expression of EGF (zeige EGF Proteine) and EGFR in the endothelium of the uterine artery and its branches suggest the modulatory effect of EGF (zeige EGF Proteine) and its receptor on the uterine artery and the region supplying these vessels.

Cow (Bovine) Epidermal Growth Factor Receptor (EGFR) Interaktionspartner

  1. Stimulation of bovine oviduct epithelial cell EGFR with EGF (zeige EGF Proteine) (human recombinant EGF (zeige EGF Proteine)) alone or with EGF (zeige EGF Proteine) in postovulatory/follicular phases (not luteal phase) up-regulates phosphorylation of MAPKs; heat blocks effects of EGF (zeige EGF Proteine) on phosphorylation of MAPKs.

  2. Expression of the erbB/HER receptor family in the bovine uterus during the sexual cycle and the relation of this family to serum sex steroids.

  3. Regulation of the sperm EGFR by ouabain leads to initiation of the acrosome reaction.

  4. EGFR may simultaneously activate c-Src (zeige SRC Proteine) and PI3K to amplify the oxytocin signaling to increase the output of PGF (zeige PGF Proteine)(2 alpha) in endometrial epithelial cells.

  5. results indicate that arginase induction depends in part on epidermal growth factor (EGF (zeige EGF Proteine)) receptor activity, and that EGFR inhibitors may attenuate vascular remodeling without affecting nitric oxide release

  6. Data suggest that epidermal growth factor (EGF (zeige EGF Proteine)) and EGF (zeige EGF Proteine) receptors are important paracrine and/or autocrine regulators of spermatogenesis in bovine.

  7. MT1-MMP (zeige MMP14 Proteine) has a role in signaling events mediating EGFR transactivation

  8. possible cooperative role of the EGF (zeige EGF Proteine) and HGF (zeige HGF Proteine) pathways and indicate that cross-talk between their respective receptors may modulate mammary gland development in the cow

  9. EGFR is stimulated during capacitation via PKA activation. More activation induces the acrosome reaction, which is induced by GPCR via EGFR transactivation by a signaling pathway involving PKA, SRC & metalloproteinase & effectors PI3K, PLC & PKC.

EGFR Protein Überblick

Protein Überblick

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.

Alternative names and synonyms associated with EGFR

  • epidermal growth factor receptor (EGFR)
  • Epidermal growth factor receptor (Egfr)
  • epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) (egfra)
  • epidermal growth factor receptor (egfr1)
  • epidermal growth factor receptor (AaeL_AAEL004319)
  • epidermal growth factor receptor (Egfr)
  • epidermal growth factor receptor (LOC100008806)
  • 9030024J15Rik Protein
  • AI552599 Protein
  • C-erb Protein
  • c-erbB Protein
  • CG10079 Protein
  • D-Egf Protein
  • d-egf-r Protein
  • D-EGFR Protein
  • dEgfr Protein
  • dEGFR1 Protein
  • der Protein
  • DER/EGFR Protein
  • DER/faint little ball Protein
  • DER/top Protein
  • DER/torpedo Protein
  • DER1 Protein
  • DER flb Protein
  • Dmel\\CG10079 Protein
  • DmHD-33 Protein
  • EFG-R Protein
  • Egf Protein
  • Egf-r Protein
  • egfr Protein
  • egfr1 Protein
  • EGFR12 Protein
  • EGFR15 Protein
  • EK2-6 Protein
  • El Protein
  • Elp Protein
  • Elp-1 Protein
  • Elp-B1 Protein
  • Elp-B1RB1 Protein
  • Erbb Protein
  • ErbB-1 Protein
  • ERBB1 Protein
  • Erbb2 Protein
  • Errb1 Protein
  • Errp Protein
  • flb Protein
  • HD-33 Protein
  • HER1 Protein
  • l(2)05351 Protein
  • l(2)09261 Protein
  • l(2)57DEFa Protein
  • l(2)57Ea Protein
  • l(2)57EFa Protein
  • mENA Protein
  • mor1 Protein
  • PIG61 Protein
  • top Protein
  • top/DER Protein
  • top/flb Protein
  • Torpedo/DER Protein
  • torpedo/egfr Protein
  • wa-2 Protein
  • wa2 Protein
  • Wa5 Protein

Bezeichner auf Proteinebene für EGFR

CG10079-PA , CG10079-PB , DER-Ellipse , EGF-receptor , EGFR , Egf receptor , Egfr-PA , Egfr-PB , drosophila epidermal growth factor receptor homologue , ellipse , ellipse torpedo , epidermal growth factor receptor , faint little ball , morphological defects 1 , torpedo , torpedo/DER , erbb1a , avian erythroblastic leukemia viral (v-erb-b) oncogene homolog , cell growth inhibiting protein 40 , cell proliferation-inducing protein 61 , proto-oncogene c-ErbB-1 , receptor tyrosine-protein kinase erbB-1 , EGFR-related peptide , Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1) , avian erythroblastic leukemia viral (v-erbB) oncogene homolog , epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1) , waved 2 , CER , epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) , egf receptor , receptor tyrosine kinase ErbB1

100067755 Equus caballus
37455 Drosophila melanogaster
378478 Danio rerio
778955 Ciona intestinalis
5564544 Aedes aegypti
1956 Homo sapiens
24329 Rattus norvegicus
13649 Mus musculus
396494 Gallus gallus
397070 Sus scrofa
404306 Canis lupus familiaris
407217 Bos taurus
100008806 Oryctolagus cuniculus
100725363 Cavia porcellus
780479 Ovis aries
613027 Macaca mulatta
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