PKC iota Proteine (PRKCI)

Protein Kinase C, iota Proteine (PRKCI)
Auf finden Sie aktuell 14 Protein Kinase C, iota (PRKCI) Proteine von 9 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PKC iota Antikörper (54) und PKC iota Kits (12) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 85 PKC iota Produkte verfügbar.
2310021H13Rik, AI427505, aPKClambda, aPKC[l], DXS1179E, hal, has, mKIAA4165, nPKC-iota, PKC, PKCI, Pkcl, PKClambda, Prkci, Prkcl
alle Proteine anzeigen Gen GeneID UniProt
PRKCI 690660 P62959
PRKCI 5584 P41743
PRKCI 18759 Q62074

Weitere Synonyme anzeigen

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Weitere Proteine zu PKC iota Interaktionspartnern

Human Protein Kinase C, iota (PRKCI) Interaktionspartner

  1. Polarity signaling via CDC42 (zeige CDC42 Proteine)/atypical protein kinase C (zeige PRKCZ Proteine) can affect the dynamic turnover of the intermediate filament network to promote the polarization of the network itself.

  2. a PI3K (zeige PIK3CA Proteine)/PKCiota/cyclin E (zeige CCNE1 Proteine) signaling pathway as a therapeutic target during ovarian tumorigenesis

  3. results identify a novel role of PHLPP in regulating aPKC and cell polarity.

  4. the polarity function of PRKCI during cavitation

  5. 14-3-3zeta (zeige YWHAZ Proteine)-mediated invasion of cancer cells was found to upregulate Snail (zeige SNAI1 Proteine) through the activation of atypical protein kinase C (zeige PRKCZ Proteine) (aPKC).

  6. Upregulated expression of PRKCI and interaction with CDK7 (zeige CDK7 Proteine) is associated with esophageal squamous cell carcinoma.

  7. the results revealed that PRKCI rs546950 variant decreased the risk of prostate cancer in an Iranian population

  8. effects. Further studies indicated that PRKCI knockdown-mediated autophagy was associated with the inactivation of phosphatidylinositol 3-kinase alpha/AKT (zeige AKT1 Proteine)-mammalian target of rapamycin (zeige FRAP1 Proteine) (PIK3CA (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine)-MTOR (zeige FRAP1 Proteine)) signaling.

  9. the knockdown of aPKC increases and extends TGFbeta (zeige TGFB1 Proteine)-induced p38 MAPK (zeige MAPK14 Proteine) activation, which sensitizes NSCLC cells to undergo apoptosis.

  10. PKCiota binds to Rab14 (zeige RAB14 Proteine) and that PKCiota requires Rab14 (zeige RAB14 Proteine) for its correct distribution in cells. As with Rab14 (zeige RAB14 Proteine), PKCiota protects claudin-2 (zeige CLDN2 Proteine) from lysosomal degradation and, in consequence, modulates epithelial barrier.

Mouse (Murine) Protein Kinase C, iota (PRKCI) Interaktionspartner

  1. Selective deletion of the aPKC isoform Pkc-lambda in proopiomelanocortin (POMC (zeige POMC Proteine)) neurons disrupts leptin (zeige LEP Proteine) action, reduces melanocortin content in the paraventricular nucleus, and markedly increases susceptibility to obesity, glucose intolerance, and insulin (zeige INS Proteine) resistance specifically in HFD-fed male mice.

  2. results identify a novel role of PHLPP in regulating aPKC and cell polarity.

  3. Prkci and its downstream partners direct polarized cell division of luminal myocardial cells to drive trabeculation in the nascent heart.

  4. Prkci regulates expansion of various stem cells via Notch (zeige NOTCH1 Proteine)-dependent pathway.

  5. PKClambda/iota could be a crucial regulator of mitochondrial function and energy metabolism in stem cells and other cellular contexts

  6. Asymmetric division and CD8+ T lymphocyte fate specification is regulated by protein kinase Czeta and protein kinase Clambda.

  7. adenoviral-mediated supplementation of hepatic PKC-lambda induced a diabetic state in heterozygous PKC-lambda knockout mice.

  8. Data indicate that pseudosubstrate arginine residues are key regulators of atypical protein kinase C (zeige PRKCZ Proteine)-lambda and atypical protein kinase C-zeta (zeige PRKCZ Proteine).

  9. Loss of aPKClambda in differentiated neurons disrupts the polarity complex but does not induce obvious neuronal loss or disorientation in mouse brains.

  10. PKClambda/iota was identified as an important factor for actin cytoskeletal regulation in podocytes and Def-6 as a specific downstream target of PKClambda/iota that regulates the activity of small GTPases and subsequently the actin cytoskeleton of podocytes.

Zebrafish Protein Kinase C, iota (PRKCI) Interaktionspartner

  1. Zebrafish pronephros tubulogenesis and epithelial identity maintenance are reliant on the polarity proteins Prkc iota and zeta.

  2. a loss of zBves affects the proteins involved in the pathway of the PAR (zeige AFG3L2 Proteine) junctional complex, especially aPKC, and both aPKC and Bves (zeige BVES Proteine) are indispensable to claudin expression.

  3. Heart and soul/PRKCi and nagie oko/Mpp5 regulate myocardial coherence and remodeling during cardiac morphogenesis.

  4. PrkCi function and planar divisions are necessary for asymmetric, self-renewing division of spinal cord precursors.

Cow (Bovine) Protein Kinase C, iota (PRKCI) Interaktionspartner

  1. These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.

PKC iota (PRKCI) Protein Überblick

Protein Überblick

This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.

Alternative names and synonyms associated with PKC iota (PRKCI)

  • protein kinase C, iota (PRKCI)
  • histidine triad nucleotide binding protein 1 (Hint1)
  • protein kinase C, iota (Prkci)
  • protein kinase C, iota (LOC100348584)
  • protein kinase C, iota (prkci)
  • 2310021H13Rik Protein
  • AI427505 Protein
  • aPKClambda Protein
  • aPKC[l] Protein
  • DXS1179E Protein
  • hal Protein
  • has Protein
  • mKIAA4165 Protein
  • nPKC-iota Protein
  • PKC Protein
  • PKCI Protein
  • Pkcl Protein
  • PKClambda Protein
  • Prkci Protein
  • Prkcl Protein

Bezeichner auf Proteinebene für Protein Kinase C, iota Proteine (PRKCI)

protein kinase C, iota , protein kinase C iota , nPKC-iota , protein kinase C iota type , 17 kDa inhibitor of protein kinase C , PKCI-1 , adenosine 5'-monophosphoramidase , histidine triad nucleotide-binding protein 1 , protein kinase C inhibitor 1 , protein kinase C-interacting protein 1 , PRKC-lambda/iota , aPKC-lambda/iota , atypical protein kinase C-lambda/iota , protein kinase C, lambda , heart and soul protein

450143 Pan troglodytes
574352 Macaca mulatta
100063737 Equus caballus
100166344 Acyrthosiphon pisum
100173964 Pongo abelii
690660 Rattus norvegicus
5584 Homo sapiens
18759 Mus musculus
100348584 Oryctolagus cuniculus
100731983 Cavia porcellus
100174945 Sus scrofa
117507 Danio rerio
478686 Canis lupus familiaris
528478 Bos taurus
424991 Gallus gallus
101118322 Ovis aries
84006 Rattus norvegicus
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