SIRT4 Proteine (SIRT4)

Sirtuin 4 Proteine (SIRT4)
Auf finden Sie aktuell 11 Sirtuin 4 (SIRT4) Proteine von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen SIRT4 Antikörper (115) und SIRT4 Kits (13) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 150 SIRT4 Produkte verfügbar.
4930596O17Rik, im:7139453, SIR2L4, SIRT4
alle Proteine anzeigen Gen GeneID UniProt
SIRT4 23409 Q9Y6E7
SIRT4 75387 Q8R216
SIRT4 304539  

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Weitere Proteine zu SIRT4 Interaktionspartnern

Human Sirtuin 4 (SIRT4) Interaktionspartner

  1. we found that knock-out of mitochondrial sirtuin (zeige SIRT1 Proteine) sir-2.3, homologous to mammalian SIRT4, is protective in both chemical ischemia and hyperactive channel induced necrosis. This work suggests a deleterious role of SIRT4 during ischemic processes in mammals that must be further investigated

  2. This is the first study to identify an association between SIRT4 expression and decreased mitochondrial fission, which was driven by Drp1. SIRT4 inhibited Drp1 phosphorylation and weakened Drp1 recruitment to the mitochondrial membrane via an interaction with Fis-1.

  3. miR (zeige MLXIP Proteine)-15b is a negative regulator of stress-induced SIRT4 expression, thereby counteracting senescence associated mitochondrial dysfunction and regulating the SASP (zeige ASPRV1 Proteine) and possibly organ aging, such as photoaging of human skin.

  4. SIRT4 overexpression inhibits the proliferation of colorectal cancer cells in vitro and in vivo.

  5. Data indicate that compared to non-neoplastic endometria (NNE (zeige ENO1 Proteine)), endometrial cancer (EC) showed SIRT7 (zeige SIRT7 Proteine) mRNA overexpression, whereas SIRT1 (zeige SIRT1 Proteine), SIRT2 (zeige SIRT2 Proteine), SIRT4 and SIRT5 (zeige SIRT5 Proteine) were underexpressed, and no significant differences were observed for SIRT3 (zeige SIRT3 Proteine) and SIRT6 (zeige SIRT6 Proteine).

  6. Thus, these results suggest that SIRT4 has essential roles in stress resistance and may be an important therapeutic target for cancer treatment.

  7. SIRT4 behaves as a tumor suppressor at the human tissue protein level.

  8. Overexpression of SIRT4 attenuated inflammation mediators in umbilical vein endothelial cells.

  9. Results show that mitochondrial sirtuins SIRT3 (zeige SIRT3 Proteine), SIRT4, and SIRT5 (zeige SIRT5 Proteine) can promote increased mitochondrial respiration and cellular metabolism and respond to excess glucose by inducing a coordinated increase of glycolysis and respiration.

  10. SIRT4 has a tumour-suppressive function and may serve as a novel therapeutic target in colorectal cancer.

Mouse (Murine) Sirtuin 4 (SIRT4) Interaktionspartner

  1. These findings identify a robust enzymatic activity for SIRT4, uncover a mechanism controlling branched-chain amino acid flux, and position SIRT4 as a crucial player maintaining insulin (zeige INS Proteine) secretion and glucose homeostasis during aging.

  2. miR (zeige MLXIP Proteine)-497 modulates cardiac hypertrophy by targeting Sirt4 and may serve as a potential therapeutic substance in the course.

  3. Until now, a mammalian cellular lipoamidase has not been characterized; this study discovered that SIRT4 can function with this enzymatic capacity in the mitochondria, and that PDH (zeige PDP Proteine) is a biological substrate; compared to its catalytic efficiency for deacetylation, SIRT4 exhibits far superior enzymatic activity for lipoyl- and biotinyl-lysine modifications.

  4. The results of this study indicated a critical and novel stress response role for SIRT4 in promoting proper glutamate (zeige GRIN1 Proteine) transport capacity and protecting against excitotoxicity

  5. regulates ATP levels via ANT2 (zeige SLC25A5 Proteine) and a feedback loop involving AMPK (zeige PRKAA1 Proteine)

  6. these results highlight the tumor-suppressive role of SIRT4 in Myc-induced B cell lymphoma and suggest that SIRT4 may be a potential target against Myc-induced and/or glutamine-dependent cancers.

  7. The enhanced fatty acid oxidation observed in SIRT4 knockout hepatocytes requires functional SIRT1 (zeige SIRT1 Proteine), demonstrating a clear cross talk between mitochondrial and nuclear sirtuins.

  8. Data uncover SIRT4 as an important component of the DNA damage response pathway that orchestrates a metabolic block in glutamine metabolism, cell cycle arrest, and tumor suppression.

  9. SIRT4 represses fatty acid oxidation and stimulates lipogenesis. SIRT4 deacetylates and represses malonyl CoA decarboxylase, regulating malonyl coA levels.

  10. Data demonstrate that SIRT4 inhibition increases fat oxidative capacity in liver and mitochondrial function in muscle.

SIRT4 Protein Überblick

Protein Überblick

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.

Alternative names and synonyms associated with SIRT4

  • sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae) (SIRT4)
  • zgc:103539 (zgc:103539)
  • sirtuin 4 (SIRT4)
  • sirtuin 4 (Sirt4)
  • 4930596O17Rik Protein
  • im:7139453 Protein
  • SIR2L4 Protein
  • SIRT4 Protein

Bezeichner auf Proteinebene für Sirtuin 4 Proteine (SIRT4)

sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae) , sirtuin 4 , NAD-dependent ADP-ribosyltransferase sirtuin-4 , NAD-dependent protein deacetylase sirtuin-4 , SIR2-like protein 4 , regulatory protein SIR2 homolog 4 , sir2-like 4 , sirtuin type 4 , NAD-dependent deacetylase sirtuin-4

742235 Pan troglodytes
791628 Danio rerio
100586803 Nomascus leucogenys
23409 Homo sapiens
75387 Mus musculus
304539 Rattus norvegicus
477507 Canis lupus familiaris
100125349 Sus scrofa
519328 Bos taurus
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