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The expression of UCN, CRHR1, CRHR2 and CRHBP by immunohistochemistry, Western blot and reverse transcription with the polymerase chain reaction (RT-PCR) in the horse thyroid gland, was investigated
Data show that corticotropin releasing hormone receptor 2 (Crhr2) protein is abundantly expressed in the heart, and plasma Ucn2 levels were higher in patients with heart failure compared to healthy controls, indicating that endogenous Crhr2 is associated with heart failure.
Taken together, our data indicate that sex shows significant interaction with genotype and Ucn1 during colitis. Human duodenal and colonic biopsies revealed that sex-specific differences exist in levels of CRF receptors and Ucn1 expression in patients with CD compared with the matched non-IBD subjects. To conclude, Ucn1 mediates sex-specific immune and cellular signaling responses via CRF2, emphasizing the need for inclus
In deep infiltrating endometriotic lesions, CRH (zeige CRH ELISA Kits), Ucn (zeige UCN ELISA Kits) and CRH-R2 mRNA levels were significantly higher than in ovarian endometrioma.
Endogenous CRF (zeige CRH ELISA Kits) may be involved in the pathogenesis of ischemia/reperfusion-induced enteritis, possibly via the activation of peripheral CRF (zeige CRH ELISA Kits) receptor 2
This study showed that two CRHR2 variants (rs4722999-C and rs12701020-C) in BPD subjects with sexual and physical abuse.
found associations between CRHR2 genotypes and haplotypes and negative emotion in IBS patients and controls
Wound healing and signal transducer and activator of transcription 3 activity were elevated in CRHR2-overexpressing cells after urocortin 2 and IL-6 treatment, suggesting advanced healing progression
This study demonstrated that CRF2 Receptor Deficiency Eliminates the Long-Lasting Vulnerability of Motivational States Induced by Opiate Withdrawal.
D1 and CRF2 alpha receptors are capable of heterodimerization in living cells. D1 /CRF2 alpha receptor heteromerization might account, at least in part, for the complex physiological interactions established between dopamine and CRH (zeige CRH ELISA Kits).
HSF2 element confers estrogen up-regulation of CRHR2 transcription and estrogen increases CRHR2 transcription via induction of HSF2 demethylation.
Results indicate that corticotropin releasing hormone receptor 2 (Crhr2) is highly expressed in cardiomyocytes, and cardiomyocyte-specific deletion of Crhr2 protected mice from pressure overload-induced cardiac dysfunction.
findings collectively suggest that the MeA (zeige MEA1 ELISA Kits) Ucn3 (zeige UCN3 ELISA Kits)-CRF-R2 system modulates the ability of mice to cope with social challenges
Study suggests that selective CRF2 receptor agonists urocortin 2 (zeige UTS2 ELISA Kits) and 3 could be used as a therapy in nicotine addiction.
Study demonstrated that CRF1 receptor (zeige CRHR1 ELISA Kits)-deficiency prolongs whereas CRF2 receptor-deficiency shortens the duration of recognition memory deficits induced by morphine discontinuation, unraveling opposite roles for the two known CRF (zeige CRH ELISA Kits) receptor subtypes in cognitive dysfunction associated with opiate withdrawal.
results indicate that long-term UVA eye irradiation led to increased gp91phox (zeige CYBB ELISA Kits)-derived ROS (zeige ROS1 ELISA Kits) in the brain and the increased expression of urocortin 2 (zeige UTS2 ELISA Kits) and CRHR (zeige CRHR1 ELISA Kits) type 2, resulting in photoaging; however, further studies are needed to confirm these findings
Crhr2(-/-) mice showed increased mortality in the dextran sodium sulfate healing protocol
the inhibitory effect of CRFR2 signaling on insulin (zeige INS ELISA Kits) action is mediated by cAMP in a mammalian target of rapamycin (zeige FRAP1 ELISA Kits)-dependent manner.
This study aims to investigate the cellular localization of CRF (zeige CRH ELISA Kits) and UCNs in the ileum and to explore whether and how this cellular expression is altered in conditions of intestinal Schistosoma mansoni-induced inflammation.
cPLA2 (zeige PLA2G4A ELISA Kits) participates in CRHR1 (zeige CRHR1 ELISA Kits)-induced apoptosis and CRHR2-inhibited apoptosis.
Data suggest that signal transduction via ghrelin (zeige GHRL ELISA Kits) and Crhr2 plays role in regulation of muscle glucose metabolism; Ghsr1a (ghrelin receptor (zeige GHSR ELISA Kits) type 1A) was not detected in mouse myoblast cell line (C2C12) investigated.
These results suggest that a regulatory system exists in the bovine thyroid gland based on UCN (zeige UCN ELISA Kits), CRHR1 (zeige CRHR1 ELISA Kits) and CRHR2 and that UCN (zeige UCN ELISA Kits) plays a role in the regulation of thyroid physiological functions through an autocrine/paracrine mechanism.
CRHR1 (zeige CRHR1 ELISA Kits) and CRHR2 are expressed in the bovine adrenal gland.
CRFr1 (zeige CRHR1 ELISA Kits) activation mediates intestinal mucosa barrier dysfunction and hypersecretion in early-weaned piglets, whereas CRFr2 activation may be responsible for novel protective properties in the porcine intestine in response to early life stress.
The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
corticotropin releasing hormone receptor 2
, corticotropin-releasing factor receptor 2-like
, CRF2 receptor, beta isoform
, corticotropin-releasing factor receptor 2
, CRF 2 receptor
, corticotropin releasing factor receptor type 2 beta
, corticotropin-releasing factor 2
, corticotropin-releasing hormone receptor 2
, CRF-R 2
, CRH-R 2
, corticotrophin releasing hormone receptor 2
, corticotropin-releasing factor receptor subtype 2
, putative corticotropin-releasing hormone receptor type 2