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Study indicates that chga may play an important role in nervous system development during the early embryonic stages.
Increased myocardial CgA (zeige CGA Proteine) glycosylation and impaired CgA (zeige CGA Proteine) processing to catestatin in heart failure be considered detrimental because CST (zeige CORT Proteine) reduces diastolic Ca2 (zeige CA2 Proteine)+ leak via direct CaMKIIdelta inhibition.
performance of CgA (zeige CGA Proteine)-deficient Chga-KO mice in treadmill exercise was impaired. CgA (zeige CGA Proteine) deficiency renders the muscle energy deficient, impairs performance in treadmill exercise and prevents regeneration after exercise-induced tissue damage.
dilated mitochondrial cristae, endoplasmic reticulum and Golgi complex, as well as increased synaptic mitochondria, synaptic vesicles and glycogen (zeige GYS1 Proteine) granules in Chga-knockout mice compared to WT mice.
the presence of ChgA and subsequent activation of ChgA-reactive T cells are essential for the initiation and development of autoimmune diabetes in NOD mice.
Studied leptin (zeige LEP Proteine) and CST (zeige CORT Proteine) modulation of SGLT1 (zeige SLC5A1 Proteine) expression in hyperleptinemic type 2 diabetic mice.
N-terminal additions to the WE14 peptide of chromogranin A create strong autoantigen agonists in type 1 diabetes.
Data indicate that T-cell receptors that react to chromogranin A (ChgA) and islet amyloid polypeptide (zeige IAPP Proteine) precursor (IAPP (zeige IAPP Proteine)) autoantigens were impaired when the thymic stromal cells lacked thymus-specific serine protease (TSSP (zeige PRSS16 Proteine)).
the important roles of CgA and CgB in glucose and cardiovascular homeostasis. This study also unveils the existence of direct implications of Cgs in the control of behaviour and mood.
Chromogranin A (10-19) and chromogranin A (43-52) were identified as antigens for autoreactive CD8 (zeige CD8A Proteine)(+) T cells in NOD.beta2m(null).HHD (zeige ATP2C1 Proteine) mice.
Report QT/heart rate variability in a genomically "humanized" chromogranin a monogenic mouse model with hyperadrenergic hypertension.
Results show that chronic lymphocytic leukemia (CLL) patients had increased plasma levels of chromogranin A (CgA), compared to normal subjects, particularly those >70-year-old or those treated with proton pump inhibitors.
The authors show that CHGA-415 T/C polymorphism is an independent risk factor of poor prognosis in critically ill patients
Concurrent increases in plasma BNP (B-type natriuretic peptide (zeige BNP Proteine)) and CST (zeige GAL3ST1 Proteine) levels predicted the highest risk for both all-cause and cardiac deaths in chronic heart failure patients.
Full-length CgA (zeige CGA Proteine) is an independent indicator of atherosclerotic plaques in carotid artery stenosis.
Even a single baseline measurement of CgA (zeige CGA Proteine) can be useful in establishing prognosis in this group, if this parameter exceeds its upper normal limit more than tenfold.
Compared with chromogranin A, chromogranin B (zeige CHGB Proteine) may be more useful during proton pump inhibitor treatment and can detect tumors without liver metastases.
Salivary impairments and high levels of CHGA are associated with T2DM patients. In addition, CGHA polymorphisms might be associated with salivary gland hypofunction and higher salivary CHGA production in T2DM patients. This could be a significant insight to establish a role for salivary CHGA as a potential clinical biomarker to T2DM.
we could provide evidence that established stress-related biomarkers ET-1 (zeige EDN1 Proteine), MCP-1 (zeige CCL2 Proteine), CGA (zeige CGA Proteine) were differentially regulated among patients with AF compared to healthy controls.
Combined plasma CgA (zeige CGA Proteine) concentrations and World Health Organization grading may assist in better stratification of PNET patients in terms of the risk of recurrence.
Metastatic castration-resistant prostate cancer patients with an early high CGA (zeige CGA Proteine) rise may demonstrate a subgroup with poor outcome due to underlying small cell/neuroendocrine cell transformation.
High pancreastatin levels are significantly associated with neuroendocrine tumors.
No circadian pattern was detected for salivary CgA in either spring or autumn, and there were no significant effects of gender or age. However, mean salivary CgA concentrations were significantly higher in the pigs sampled in autumn, compared to spring.
expression and localization of chromogranin A (CgA), chromogranin B (CgB (zeige CHGB Proteine)), synaptophysin (zeige SYP Proteine), and insulin (zeige INS Proteine) were ultrastructurally studied with the immunogold technique in porcine and human pancreatic islet neuroendocrine cells
Vasoconstriction-Inhibiting Factor (VIF (zeige BTG1 Proteine)), a degradation product of chromogranin A, is a vasoregulatory peptide that modulates the vasoconstrictive effects of angiotensin II by acting on the angiotensin II type 2 receptor (zeige AGTR2 Proteine).
chromogranin A has a role in the IP(3)-mediated Ca(2 (zeige CA2 Proteine)+) release mechanism of secretory granules
chromogranin A has a specific site in the N-terminal domain that can bind membrane lipids from different species
role of coupling with the inositol 1,4,5-trisphosphate receptor/Ca2 (zeige CA2 Proteine)+ channel (InsP3R (zeige ITPR1 Proteine))in the Ca2 (zeige CA2 Proteine)+-dependent ciliary movement
involvement of CGA (zeige CGA Proteine) with other components of the senile plaque
significant species differences in vasoactivity of the N-terminal domain of ChgA
determination of the subcellular distribution of chromogranins A and B in chromaffin cells; results suggest that chromogranins are at the center of intracellular Ca(2 (zeige CA2 Proteine)+) homeostasis in secretory cells
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides\; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown.
, chromogranin A
, betagranin (N-terminal fragment of chromogranin A)
, parathyroid secretory protein 1
, pituitary secretory protein I