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The ADD1 Gly460Trp gene polymorphism is significantly and independently associated with Essential Hypertension risk in a Caucasian population from Madeira Island.
ZNF322A (zeige ZNF322A Proteine) overexpression transcriptionally dysregulates genes involved in cell growth and motility therefore contributes to lung tumorigenesis and poor prognosis
ADD1 rs4963 polymorphism showed an increased hypertension risk.
This indicates that ADD1 G460W polymorphism could be an important factor in the pathophysiology of tinnitus.
Study shows that ADD1-rs4963 conferred susceptibility to colorectal cancer (CRC (zeige CALR Proteine)) suggesting an association between ADD1 and CRC (zeige CALR Proteine) risk.
The T allele of ADD1 is associated with essential hypertension in Asians.
study of potential effects of interaction between DNA methylation (zeige HELLS Proteine) of ADD1 promoter and ADD1 tagSNPs and environmental factors on essential hypertension (EH); results indicate ADD1 SNP rs4961 has a protective role in development of EH; interactions between alcohol consumption and DNA methylation (zeige HELLS Proteine) of ADD1 gene promoter have a significant role in modifying EH susceptibility
There were significant differences between the control group and pediatric hypertensive group in terms of ACE (zeige ACE Proteine) I/D (P<0.05) and AGT (zeige AGXT Proteine) M235T (P<0.05) polymorphisms, but there were no differences in ADD Gly460Trp (P>0.05) polymorphism.
A significant association was found between ADD1 gene G614T polymorphism and essential hypertension in Chinese patients. Further studies need to be done to confirm these findings in a large sample.
When alpha-adducin complexes with sodium potassium ATPase in astrocytes, non-cell autonomous neurodegeneration is triggered.
The expression of hHL promoted hepatic triglyceride accumulation and de novo lipogenesis without affecting triglyceride secretion, and this was associated with an upregulation of Srebf1 (zeige TOM1L2 Proteine) as well as the main genes controlling the synthesis of fatty acids. Transgenic mice also exhibited more adiposity and an increased LPL (zeige LPL Proteine)-mediated FFA influx into the WAT without affecting glucose tolerance
Data show that miR (zeige MLXIP Proteine)-200b and miR (zeige MLXIP Proteine)-200c could directly bind the 3' UTR of JUN (zeige JUN Proteine), and JUN (zeige JUN Proteine) activated the transcription of srebp1 (zeige SREBF1 Proteine) to increase lipid accumulation.
a novel role for SREBP-1 (zeige SREBF1 Proteine) as a cell surface retention factor for TbetaRI (zeige TGFBR1 Proteine) in mesangial cells, is reported.
Srebp1c (zeige SREBF1 Proteine) is a key regulator of metabolic remodeling leading to the beneficial effects of caloric restriction.
The present study indicates a requirement for C/EBPbeta (zeige CEBPB Proteine) in the insulin (zeige INS Proteine)-mediated induction of SREBP-1c (zeige SREBF1 Proteine) mRNA expression in rodent liver. Coupled with previous data showing that this induction requires LXRalpha (zeige NR1H3 Proteine), our data reported herein indicate a requirement for both transcription factors.
Sez6l2 (zeige SEZ6L2 Proteine) is one of the auxiliary subunits of the AMPA (zeige GRIA3 Proteine) receptor and acts as a scaffolding protein to link GluR1 (zeige GRIA1 Proteine) to ADD. Furthermore, Sez6l2 (zeige SEZ6L2 Proteine) overexpression upregulates ADD phosphorylation, whereas siRNA-mediated downregulation of Sez612 prevents ADD phosphorylation, suggesting that Sez6l2 (zeige SEZ6L2 Proteine) modulates AMPA (zeige GRIA3 Proteine)-ADD signal transduction.
The deletion of Srebf-2 (zeige SREBF2 Proteine) and subsequent lower sterol synthesis in hepatocytes eliminated the production of an endogenous sterol ligand required for LXR (zeige NR1H3 Proteine) activity and SREBP-1c (zeige SREBF1 Proteine) expression.
The fasting-induced (zeige C10orf10 Proteine) transcription factor KLF15, a key regulator of gluconeogenesis, forms a complex with LXR (zeige NR1H3 Proteine)/RXR, specifically on the Srebf1 (zeige TOM1L2 Proteine) promoter.
Exposure to a xenobiotic during early development induced persistent fat accumulation via hypomethylation of lipogenic genes. Moreover, increased Nrf2 (zeige NFE2L2 Proteine) recruitment to the Srebp-1c (zeige SREBF1 Proteine) promoter in livers of BPA (zeige DST Proteine)-exposed mice was observed.
Reduction in ADD1 protein in NEK1 mutant mice is associated with hyperphosphorylation of ADD1, thereby preventing the interaction with MYO10 during meiotic spindle formation
Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms\; however, not all variants have been fully described.
adducin 1 (alpha)
, adducin 2 (beta)
, erythrocyte adducin alpha subunit
, erythrocyte adducin subunit alpha
, adipocyte determination- and differentiation-dependent factor 1
, sterol regulatory element-binding protein 1