anti-ABCC8 (ABCC8) Antikörper

anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 Antikörper (ABCC8)
Auf finden Sie aktuell 87 ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) Antikörper von 19 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen ABCC8 Proteine (8) und ABCC8 Kits (5) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 104 ABCC8 Produkte verfügbar.
ABC36, D930031B21Rik, HHF1, HI, HRINS, MRP8, PHHI, Sur, Sur1, SUR1delta2, TNDM2
Alle Antikörper anzeigen Gen GeneID UniProt
ABCC8 6833 Q09428
ABCC8 20927  
ABCC8 25559 Q09429

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Meistgesuchte Reaktivitäten zu anti-ABCC8 (ABCC8) Antikörper

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anti-Human ABCC8 Antikörper:

anti-Mouse (Murine) ABCC8 Antikörper:

anti-Rat (Rattus) ABCC8 Antikörper:

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Am meisten referenzierte anti-ABCC8 Antikörper

  1. Human Monoclonal ABCC8 Primary Antibody für ELISA, WB - ABIN4948191 : Jablonski, McAteer, de Bakker, Franks, Pollin, Hanson, Saxena, Fowler, Shuldiner, Knowler, Altshuler, Florez: Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program. in Diabetes 2010 (PubMed)
    Zeige alle 5 Referenzen für 4948191

  2. Human Polyclonal ABCC8 Primary Antibody für DB, EIA - ABIN493480 : Thomas, Cote, Wohllk, Haddad, Mathew, Rabl, Aguilar-Bryan, Gagel, Bryan: Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy. in Science (New York, N.Y.) 1995 (PubMed)
    Zeige alle 3 Referenzen für 493480

  3. Hamster Monoclonal ABCC8 Primary Antibody für ICC, IF - ABIN1027723 : Campbell, Sansom, Ashcroft: Potassium channel regulation. in EMBO reports 2003 (PubMed)
    Zeige alle 2 Referenzen für 1027723

  4. Cow (Bovine) Polyclonal ABCC8 Primary Antibody für IHC, WB - ABIN2781496 : Babenko: A novel ABCC8 (SUR1)-dependent mechanism of metabolism-excitation uncoupling. in The Journal of biological chemistry 2008 (PubMed)
    Zeige alle 2 Referenzen für 2781496

  5. Human Polyclonal ABCC8 Primary Antibody für ELISA, WB - ABIN334499 : de Wet, Rees, Shimomura, Aittoniemi, Patch, Flanagan, Ellard, Hattersley, Sansom, Ashcroft: Increased ATPase activity produced by mutations at arginine-1380 in nucleotide-binding domain 2 of ABCC8 causes neonatal diabetes. in Proceedings of the National Academy of Sciences of the United States of America 2007 (PubMed)

Weitere Antikörper gegen ABCC8 Interaktionspartner

Human ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) Interaktionspartner

  1. Mutation in ABCC8 gene is associated with congenital hyperinsulinism.

  2. ABCC8 mutation causing loss of function of beta-cell KATP channels lead to congenital hyperinsulinism, higher basal [Ca(2 (zeige CA2 Antikörper)+)] i and insulin (zeige INS Antikörper) secretion, increased insulin (zeige INS Antikörper) secretion in response to amino acids but not to glucose, increased basal rate of oxygen consumption and mitochondrial mass, increased rates of glycolysis, increased serine/glycine and glutamine (zeige GFPT1 Antikörper) biosynthesis, and low gamma-aminobutyric acid (GABA) levels.

  3. Hyperinsulinism-causing mutations cause multiple molecular defects in SUR1 nucleotide-binding domains.

  4. Genes ABCC7 (zeige CFTR Antikörper), A3, A8, A12 (zeige UGT1A9 Antikörper), and C8 prevailed among the most upregulated or downregulated ones. In conclusion, the results supported our theory about general adenosine triphosphate-binding cassette gene expression profiles and their importance for cancer on clinical as well as research levels.

  5. Cross-linking experiments showed that KATP channel inhibitors promoted interactions between the N terminus of Kir6.2 and SUR1, whereas channel openers did not, suggesting the inhibitors enhance intersubunit interactions to overcome channel biogenesis and trafficking defects.

  6. Mutations of the ABCC8 gene is associated with congenital hyperinsulinism.

  7. ABCC8 mutation is associated with neonatal diabetes mellitus and iDEND syndrome.

  8. The most frequently seen mutations in Turkish patients with congenital hyperinsulinism (CHI) were ATP binding cassette subfamily C (zeige CYP Antikörper) member 8 (ABCC8) gene, followed by 3-hydroxyacyl CoA dehydrogenase (HADH (zeige HADH Antikörper)) and kcnj11 (zeige KCNJ11 Antikörper) channel (KCNJ11 (zeige KCNJ11 Antikörper)) genes.

  9. Mutations in the ABCC8 gene were the most common cause of congenital hyperinsulinism in our cohort.

  10. ABCC8 mutation is associated with persistently elevated insulin (zeige INS Antikörper) concentrations.

Mouse (Murine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) Interaktionspartner

  1. Despite its importance in central nervous system (CNS) injuries, sulfonylurea receptor 1 (SUR1) upregulation appears to play no part in rodent anterior ischemic optic neuropathy (rAION) injury.

  2. study provides evidence for a role of Abcc8(ATP-binding cassette sub-family C) in early-phase glucose-mediated insulin (zeige INS Antikörper) secretion and validates this gene as a contributor to beta-cell dysfunction in type 2 diabetes

  3. We conclude that the gradual development of glucose intolerance in patients with the SUR1-E1506K mutation might, as in the mouse model, result from impaired insulin (zeige INS Antikörper) secretion due a failure of insulin (zeige INS Antikörper) content to increase with age.

  4. The results confirm that Kir6.2 (zeige KCNJ11 Antikörper) contributes to APD shortening in both atria and ventricle during metabolic stress, and that SUR1 is required for atrial APD shortening while SUR2A (zeige ABCC9 Antikörper) is required for ventricular APD shortening.

  5. EPAC (zeige RAPGEF3 Antikörper) interaction with SUR1 controls seizure susceptibility and possibly acts via regulation of glutamate (zeige GRIN1 Antikörper) release.

  6. the role of CpG methylation in regulating SUR1 and SUR2 (zeige ABCC9 Antikörper) expression

  7. SUR1 controls K(ATP) channel activity but not TRPM4 (zeige TRPM4 Antikörper) channels.

  8. Conserved intramolecular disulfide bond is critical to trafficking and fate of ATP-binding cassette (ABC (zeige ABCB6 Antikörper)) transporters ABCB6 (zeige ABCB6 Antikörper) and sulfonylurea receptor 1 (SUR1)/ABCC8.

  9. ATP regulates pancreatic beta-cell K(ATP) channel activity, not only by its direct actions on Kir6.2 pore subunit, but also via ATP modulation of Syn-1A binding to SUR1.

  10. Diazoxide does not open the ventricular sarcolemmal adenosine triphosphate-sensitive potassium channel but provides volume homeostasis via an SUR1-dependent pathway in mouse ventricular myocytes.

Pig (Porcine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) Interaktionspartner

  1. islets express mRNA transcripts for sulfonylurea receptor 1 (Sur1), inward rectifying potassium channel (zeige KCNAB2 Antikörper) (Kir6.2 (zeige KCNJ11 Antikörper), associated with Sur1), glucagon-like peptide 1 receptor (GLP1R (zeige GLP1R Antikörper)), and adrenergic receptor alpha 2A (zeige ADRA2A Antikörper) (ADRalpha2A)

ABCC8 Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed\; however, the transcript variants have not been fully described.

Alternative names and synonyms associated with ABCC8

  • ATP-binding cassette, sub-family C (CFTR/MRP), member 8 (ABCC8) Antikörper
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 8 (Abcc8) Antikörper
  • ATP-binding cassette, subfamily C (CFTR/MRP), member 8 (Abcc8) Antikörper
  • ABC36 Antikörper
  • D930031B21Rik Antikörper
  • HHF1 Antikörper
  • HI Antikörper
  • HRINS Antikörper
  • MRP8 Antikörper
  • PHHI Antikörper
  • Sur Antikörper
  • Sur1 Antikörper
  • SUR1delta2 Antikörper
  • TNDM2 Antikörper

Bezeichner auf Proteinebene für ABCC8

ATP-binding cassette, sub-family C (CFTR/MRP), member 8 , ATP-binding cassette, sub-family C, member 8 , ATP-binding cassette sub-family C member 8 , ATP-binding cassette transporter sub-family C member 8 , sulfonylurea receptor (hyperinsulinemia) , sulfonylurea receptor 1 , sulfonylurea receptor , sulphonylurea receptor 1

423072 Gallus gallus
451056 Pan troglodytes
654490 Macaca mulatta
6833 Homo sapiens
20927 Mus musculus
485402 Canis lupus familiaris
538996 Bos taurus
100158245 Sus scrofa
100722700 Cavia porcellus
25559 Rattus norvegicus
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