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The rxfp1 expression pattern in Danio rerio embryos is very similar to that reported in the adult mammalian brain, suggesting a pivotal role of this receptor in the neurophysiology processes already at very early developmental stages.
Binding of relaxin (zeige 0 ELISA Kits) to RXFP1 recruits G proteins with subsequent activation of adenylyl cyclase and elevation of cAMP.
The decreased expression of the endometrial RLX (zeige RLN1 ELISA Kits) receptor in women with implantation failures, both in vitro fertilization failure and recurrent pregnancy loss, suggests that RLX (zeige RLN1 ELISA Kits) may play a crucial role in the structural and functional changes of the endometrium during the window of implantation.
Hormone receptor (zeige NR4A1 ELISA Kits) expression was concentrated in the fibroblasts, and RXFP1 was also evident in blood vessels and nerves
The complex binding mode of the peptide hormone H2 relaxin (zeige 0 ELISA Kits) to its receptor RXFP1 has been deciphered.
RXFP1 gene expression was dysregulated in the anterior cingulate of bipolar patients.
H2 relaxin (zeige 0 ELISA Kits) amide is fully active at the relaxin (zeige 0 ELISA Kits) receptor RXFP1 and thus dimerization is not required for biological activity.
Synthetic covalently linked dimeric form of H2 relaxin (zeige 0 ELISA Kits) retains native RXFP1 activity and has improved in vitro serum stability.
Using cells stably expressing RXFP1, we found that relaxin regulation of PPARgamma activity requires accumulation of cAMP and subsequent activation of cAMP-dependent protein kinase (PKA).
RXFP-1 receptors are present at the ligament, cartilage, and synovium of the TM joint, indicating that it is a potential target for relaxin (zeige 0 ELISA Kits). This suggests that circulating relaxin (zeige 0 ELISA Kits) may impact joint stability.
To create a tool to investigate the low-affinity interaction, a protein scaffold system displaying exoloops 1 and 2 from RXFP1 was designed.
No differences were found in RXFP1 expression related to aging.
Colonic tissue expresses RXFP1 in smooth muscle cells of the muscular wall and in neurons of the myenteric plexus.
relaxin (zeige 0 ELISA Kits)/RXFP1 signaling in smooth muscle cells is important for normal collagen turnover and relaxation of the pubic symphysis during pregnancy
Rxfp1, Rxfp2 (zeige RXFP2 ELISA Kits), and Nr3c1 (zeige NR3C1 ELISA Kits) mRNAs were expressed on the developing maxilla and mandible, Meckel's cartilage, tongue, and tooth primordia between mouse embryonic days 13.5-18.5.
maternal exposure to simazine causes disturbed relaxin (zeige 0 ELISA Kits) signaling pathway and testicular dysfunction
H3 relaxin (zeige 0 ELISA Kits) exerts antifibrotic actions via RXFP1 receptor
The downregulation of RXFP1 resulted in significant decrease in metastasis rate in PC3 (zeige BTG2 ELISA Kits) tumors.
Rxfp1 acts in an autocrine and/or paracrine fashion upstream of PCDHY in regulating increased canonical Wnt (zeige WNT2 ELISA Kits) signaling in prostate cancer.
neither Insl3 (zeige INSL3 ELISA Kits) nor Lgr8 (zeige RXFP2 ELISA Kits) contribute to the RLN (zeige RLN1 ELISA Kits) signaling pathway; Insl3 (zeige INSL3 ELISA Kits)/Lgr8 (zeige RXFP2 ELISA Kits) and Rln1 (zeige RLN1 ELISA Kits)/Lgr7 actions do not overlap in vivo
mouse and rat LGR7 are the relaxin (zeige 0 ELISA Kits) receptors in these species
This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
leucine-rich repeat-containing G protein-coupled receptor 7
, relaxin/insulin-like family peptide receptor 1
, relaxin receptor 1-like
, relaxin receptor 1
, leucine-rich repeat-containing 7
, leucine-rich repeat-containing G-protein coupled receptor 7
, relaxin family peptide receptor 1
, relaxin/insulin-like family peptide receptor 2