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cloning and expression analysis of a protein kinase C gene, PKCmu, and its regulation of the promoter region (PKCmu)
PKD1 (zeige PKD1 Proteine) contributes to the regulation of physiological angiogenesis and lymphangiogenesis during zebrafish development and is essential for tumor angiogenesis.
None of the Polymorphous low-grade adenocarcinoma (PLGA) lacking PRKD1 somatic mutations or PRKD gene family rearrangements harboured somatic mutations in the kinase domains of the PRKD2 (zeige PKD2 Proteine) or PRKD3 (zeige PRKD3 Proteine) genes.
A single nucleotide polymorphism located within the fourth intron of PRKD1 (rs57803087) was strongly associated with DPP-4 (zeige DPP4 Proteine) inhibitor response in patients with type 2 diabetes
Mutation in PRKD1 gene is associated with congenital heart defects.
Bradykinin stimulates myofibroblast migration through protein kinase D-mediated activation of COX-2 and Hsp27 (zeige HSPB1 Proteine).
Lysophosphatidic acid/PKD-1 (zeige PKD1 Proteine) signaling leads to nuclear accumulation of histone deacetylase 7 (zeige HDAC7 Proteine), where it interacts with forkhead box protein O1 (zeige FOXO1 Proteine) to suppress endothelial CD36 (zeige CD36 Proteine) transcription and mediates silencing of antiangiogenic switch, resulting in proangiogenic and proarteriogenic reprogramming.
This study discovered and characterized a novel, highly conserved N-terminal domain, comprising 92 amino acids, which mediates dimerization of Protein Kinase D (PKD) isoforms, PKD1 (zeige PKD1 Proteine), PKD2 (zeige PKD2 Proteine), and PKD3 (zeige PRKD3 Proteine) monomers.
MC stimulation by physical contact with T cells results in PKD activation, leading to the phosphorylation of p38 (zeige CRK Proteine), degranulation and release of cytokines. Understanding the molecular events associated with T cell-induced MC activation might lead to therapeutic approaches for controlling T cell-mediated inflammatory processes in which MC participate.
Data suggest the role of the phospholipase C epsilon-Protein kinase D-PEA15 (zeige PEA15 Proteine) protein-ribosomal S6 kinase (zeige RPS6KB1 Proteine)-IkappaB-NF-kappa B (zeige NFKB1 Proteine) pathway in facilitating inflammation and inflammation-associated carcinogenesis in the colon.
PRKD1 Mutation is not associated with Solid Tumors and Leukemias.
Knockdown of PKD1 (zeige PKD1 Proteine) did not affect NMDAR (zeige GRIN1 Proteine) internalization but prevented the phosphorylation and inhibition of remaining surface NMDARs and NMDAR (zeige GRIN1 Proteine)-mediated synaptic functions.
These findings imply that PKD1 (zeige PKD1 Proteine) plays a critical regulatory role in Group B streptococci (GBS (zeige GNB5 Proteine))-induced proinflammatory reactions and sepsis, and inhibition of PKD1 (zeige PKD1 Proteine) activation together with antibiotic treatment in GBS (zeige GNB5 Proteine)-infected neonates could be an effective way to control GBS (zeige GNB5 Proteine) diseases.
Our studies demonstrate that PKD1 (zeige PKD1 Proteine)/2 is a key regulator of MVB maturation and exosome secretion, and constitutes a mediator of the DGK alpha (zeige DGKA Proteine) effect on MVB secretory traffic.
Our results show that AKAP13-PKD1 (zeige PKD1 Proteine) signaling is critical for transcriptional regulation of key contractile, cell death, and metabolic pathways during the development of compensatory hypertrophy in vivo.
PKD1 (zeige PKD1 Proteine) acts downstream of TGFalpha and Kras, to mediate formation of ductal structures through activation of the Notch (zeige NOTCH1 Proteine) pathway.
Results reveal that whereas protein kinase D1 and protein kinase D2 (zeige PKD2 Proteine) are essential for neuronal polarity, there exists a functional redundancy between the two proteins.
PKD controls synaptic plasticity and learning by regulating actin stability in dendritic spines.
regulatory kinase of eNOS (zeige NOS3 Proteine) in endothelial cells whose activity orchestrates mammalian vascular tone
Overexpression of constitutively active PKD1 (zeige PKD1 Proteine) in rodent heart results in dilated cardiomyopathy.
PKD1 (zeige PKD1 Proteine)-deficient keratinocytes showed an increase in transglutaminase expression and activity, indicating an anti-differentiative role of PKD1 (zeige PKD1 Proteine). Furthermore, the PKD1 (zeige PKD1 Proteine)-deficient keratinocytes exhibited decreased proliferation.
AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
Data indicate that Ser738/742-to-glutamate (zeige GRIN2A Proteine) protein kinase D mutant increased AngII-induced CREB (zeige CREB1 Proteine) protein and activating transcription factor 2 (zeige ATF2 Proteine) phosphorylation, and phospho-CREB (zeige CREB1 Proteine) binding to the steroidogenic acute regulatory protein (zeige STAR Proteine) promoter.
These results indicate that PKD is downstream of PLD and suggest that PKD is one of the mechanisms through which PLD promotes aldosterone production in response to AngII in adrenal glomerulosa cells.
PKD mediates acute AngII-induced aldosterone secretion.
Protein kinase D-HDAC5 pathway plays an important role in VEGF regulation of gene transcription and angiogenesis
PRKD1 is a serine/threonine kinase that regulates a variety of cellular functions, including membrane receptor signaling, transport at the Golgi, protection from oxidative stress at the mitochondria, gene transcription, and regulation of cell shape, motility, and adhesion (summary by Eiseler et al., 2009
protein kinase D1
, protein kinase C, mu
, serine/threonine-protein kinase D1-like
, protein kinase C mu type
, protein kinase D
, serine/threonine-protein kinase D1
, protein kinase C mu