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results indicate that PKIB promotes cell proliferation and tumorigenesis by activating the PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) pathway in non-small cell lung cancer (NSCLC), implying that this is an important underlying mechanism that affects the progression of NSCLC
mutation of the pseudosubstrate domain abolished the inhibitory activity of PKIB on protein kinase A activity, but had no effect on the interaction with GPR39 (zeige GPR39 Proteine), cell protection and induction of SRE-dependent transcription
PKIB overexpression was strongly correlated with pAkt (zeige AKT1 Proteine) expression and triple-negative breast cancer, suggesting that PKIB overexpression might contribute to the tumor behavior and development of breast cancers.
human PKIbeta gene (clone 436F11, GenBank with accession number: AF225513) was over-expressed in normal brain tissues
PKIbeta may be a novel full-length gene related to human glioma and may provide a new way to gene therapy of glioma.
Findings show that PKIB and PKA-C kinase can have critical functions of aggressive phenotype of PCs through Akt (zeige AKT1 Proteine) phosphorylation and that they should be a promising molecular target for PC treatment.
This gene encodes a member of the cAMP-dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of this gene may play a role in prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, cAMP-dependent protein kinase (catalytic subunit binding) inhibtor 2
, cAMP-dependent protein kinase inhibitor beta
, cAMP-dependent protein kinase inhibitor, testis isoform
, protein kinase (cAMP dependent, catalytic) inhibitor beta
, protein kinase inhibitor beta, (cAMP-dependent, catalytic) inhibitor beta
, protein kinase inhibitor beta, cAMP dependent, catalytic
, protein kinase inhibitor beta, cAMP dependent, testis specific
, protein kinase inhibitor, beta
, cAMP-dependent protein kinase inhibitor 2
, protein kinase, cAMP-dependent, catalytic, inhibitor 2