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Spastin Proteine (SPAST)

Bezeichnung:
Spastin Proteine (SPAST)
Auf www.antikoerper-online.de finden Sie aktuell 7 Spastin (SPAST) Proteine von 3 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Spastin Antikörper (60) und Spastin Kits (6) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 74 Spastin Produkte verfügbar.
Synonyme:
ADPSP, CG5977, D-spastin, Dmel\\CG5977, Dspastin, FSP2, LOC100224472, mKIAA1083, Spas, SPAST, Spg4, zgc:85952
alle Proteine anzeigen Gen GeneID UniProt
SPAST 6683 Q9UBP0
SPAST 50850 Q9QYY8
Ratte SPAST SPAST 362700 B2RYN7

Weitere Synonyme anzeigen

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Weitere Proteine zu Spastin Interaktionspartnern

Fruit Fly (Drosophila melanogaster) Spastin (SPAST) Interaktionspartner

  1. targeting sequence directs spastin to the surface of lipid droplets. Depletion of the homologous spastin proteins in both flies and worms affects lipid droplet number and triacylglycerol content.

  2. The spastin is a key regulator of axon regeneration, and initiation of regeneration is extremely sensitive to the spastin copy number.

  3. Dendritic growth is regulated by Kruppel-like factor dendritic arbor reduction protein 1 (Dar1) suppressing the expression of microtubule-severing protein (zeige KATNA1 Proteine) spastin.

  4. spastin is essential for apical domain biogenesis during rhabdomere elongation in Drosophila photoreceptor morphogenesis

  5. Exogenous expression of wild-type Drosophila or human spastin rescues behavioral and cellular defects in spastin null flies equivalently.

  6. Here we identify the predicted gene product CG5977 as the Drosophila homolog of the human spastin gene, with much higher sequence similarities than any other related AAA (zeige AAAS Proteine) domain protein in the fly.

  7. D-spastin displays ATPase activity and uses energy from ATP hydrolysis to sever and disassemble microtubules; disease mutations abolish or partially interfere with these activities.

  8. Spastin and Fidgetin are utilized to stimulate microtubule minus-end depolymerization and flux; they concentrate at centrosomes, where they catalyze the turnover of gamma-tubulin (zeige TUBG1 Proteine).

  9. X ray structure; data support a model in which spastin pulls the C terminus of tubulin (zeige TUBB Proteine) through its central pore, generating a mechanical force that destabilizes tubulin-tubulin (zeige TUBB Proteine) interactions within the microtubule lattice

Zebrafish Spastin (SPAST) Interaktionspartner

  1. The results suggest that the spinal cord motor neuron axon outgrowth of zebrafish is regulated by the interaction between spastin and protrudin (zeige ZFYVE27 Proteine).

  2. Simultaneous knockdown of spastin and katanin caused a more severe phenotype than did individual knockdown of either gene, suggesting that they have different but related functions in supporting axon outgrowth.

  3. Reduced spg4 function caused dramatic defects in motor axon outgrowth without affecting the events driving the initial specification of motor neurones.

Human Spastin (SPAST) Interaktionspartner

  1. The data of this study confirmed the genetic heterogeneity of childhood-onset pure HSP, with SPG4/SPAST and SPG3A/ATL1 (zeige ATL1 Proteine) being the most frequent forms.

  2. We report the first genetic study of uncomplicated HSP patients from the Czech Republic. We found broad mutation spectrum in 13 from the 17 coding exons and adjacent regions of the SPAST gene. We detected 21 novel presumably pathogenic mutations. The high frequency of SPAST mutations was found only in familial patients.

  3. This study demonstrted that the most frequently affected gene was SPAST with pathogenic or likely pathogenic mutations in hereditary spastic paraplegia.

  4. This study demonstrated that SPAST gene mutation associated with hereditary spastic paraplegias in group of Polish patients

  5. We identified two novel mutations and two previously reported mutations in SPAST and ATL1 (zeige ATL1 Proteine), respectively. The family with the ATL1 (zeige ATL1 Proteine) c.1204T>G mutation exhibited male-lethality, female infancy-onset, and pseudo- X-linked dominant transmission

  6. Using human-engineered and differentially modified microtubules study finds that glutamylation is the main regulator of the hereditary spastic paraplegia microtubule severing enzyme spastin.

  7. Patients with deletions of exons in the SPAST gene showed pure hereditary spastic paraplegia.

  8. Novel SPAST pathogenic variants were identified in Korean patients with hereditary spastic paraplegia.

  9. The coexistence of mutations in SPAST and FSHD was confirmed in our proband and in two siblings

  10. The spastin as a microtubule-severing protein (zeige KATNA1 Proteine) was an important mechanistic breakthrough, it seems certain that insufficient microtubule severing alone is not an adequate explanation for HSP-SPG4.

Mouse (Murine) Spastin (SPAST) Interaktionspartner

  1. Spastin is recruited by microtubules polyglutamylation, induced by Tau missorting triggered translocalization of TTLL6 (zeige TTLL6 Proteine) (Tubulin-Tyrosine-Ligase (zeige TTL Proteine)-Like-6) into dendrites

  2. early and marked impairment of microtubule dynamics all along the axons of spastin-deficient cortical neurons, which is likely to be responsible for the occurrence of axonal swellings and cargo stalling

  3. we aimed to identify the critical promoter regions of SPG4 gene and effects of Elk1 (zeige ELK1 Proteine) on SPG4 gene expression

  4. Sequence analysis of the SPG4 (spastin) gene identified a novel 1593 C > T (GLN490Stop) mutation in hereditary spastic paraplegia with cerebellar ataxia (zeige USP14 Proteine).

  5. two modes by which microtubule severing occurs during axonal branch formation, based on the concentration of spastin at branch sites and on local detachment from microtubules of molecules such as tau that regulate the severing properties of P60-katanin (zeige KATNA1 Proteine)

  6. These results strongly support a direct role for defective axonal transport in the pathogenesis of HSP because of spastin mutation.

Cow (Bovine) Spastin (SPAST) Interaktionspartner

  1. A defective SPAST gene in cattle is associated with a recessive, congenital neurodegenerative disease, which is characterized by pathological changes of the myelin sheaths in the spinal cord.

Spastin (SPAST) Protein Überblick

Protein Überblick

This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The encoded ATPase may be involved in the assembly or function of nuclear protein complexes. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequences have not been determined. Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4.

Alternative names and synonyms associated with Spastin (SPAST)

  • spastin (spas)
  • spastin (spast)
  • spastin (SPAST)
  • spastin (LOC100224472)
  • spastin (LOC100345919)
  • spastin (Spast)
  • ADPSP Protein
  • CG5977 Protein
  • D-spastin Protein
  • Dmel\\CG5977 Protein
  • Dspastin Protein
  • FSP2 Protein
  • LOC100224472 Protein
  • mKIAA1083 Protein
  • Spas Protein
  • SPAST Protein
  • Spg4 Protein
  • zgc:85952 Protein

Bezeichner auf Proteinebene für Spastin Proteine (SPAST)

CG5977-PA , CG5977-PB , CG5977-PC , D-spastin , Dm-Spastin , dspastin , spas-PA , spas-PB , spas-PC , spasin , spg4 , spastin , spastic paraplegia 4 (autosomal dominant; spastin) , spastin-like , spastic paraplegia 4 protein , spastic paraplegia 4 homolog , spastic paraplegia 4 (autosomal dominant , neuronal spastin

GENE ID SPEZIES
42846 Drosophila melanogaster
405851 Danio rerio
459133 Pan troglodytes
549207 Xenopus (Silurana) tropicalis
608582 Canis lupus familiaris
706264 Macaca mulatta
100224472 Taeniopygia guttata
100345919 Oryctolagus cuniculus
100408469 Callithrix jacchus
100599689 Nomascus leucogenys
6683 Homo sapiens
50850 Mus musculus
362700 Rattus norvegicus
521442 Bos taurus
421481 Gallus gallus
396584 Sus scrofa
446560 Xenopus laevis
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