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Data show that the locomotion and blebbing of the primordial germ cells (PGCs) required F-actin, myosin II activity and RhoA/Rho-associated protein kinase (ROCK) signaling.
Data demonstrate a direct relationship between SHP-2(N308D) and ROCK activation in the developing heart.
Morphogenesis of the primitive gut tube is generated by Rho/ROCK/myosin II-mediated endoderm rearrangements.
The findings of the present study indicate that miR (zeige MYLIP Proteine)-142-3p plays a critical role in hematopoiesis, cardiogenesis, and somitegenesis in the early stage of mesoderm formation via regulation of Rock2a.
Data show that Rock2 acts as a negative regulator of the TGFbeta (zeige TGFB1 Proteine) signaling pathway.
Dexamethasone up-regulates ROCK1 (zeige ROCK1 Proteine)/2 activity promoting migration, invasion and metastasis of melanoma cells.
these data suggest that ROCK2 signaling plays a critical role in controlling the development of TFH cells induced by autoimmune conditions through reciprocal regulation of STAT3 (zeige STAT3 Proteine) and STAT5 (zeige STAT5A Proteine) activation.
Data indicate that oxidative stress in diabetes causes a decrease in miR (zeige MLXIP Proteine)-133a expression leading to an increase in RhoA (zeige RHOA Proteine)/Rho kinase pathway and muscle contraction.
Results strongly support the hypothesis that spinal RhoA (zeige RHOA Proteine)/ROCK2 signaling plays a central role in the neuropathic pain. In addition, simvastatin might exert its antihyperalgesic and antiallodynic effects through the attenuation of sensitization of spinal nociceptive transmission that is modulated by mechanisms dependent on the RhoA (zeige RHOA Proteine)/ROCK2 signaling.
p21-associated inhibition of early-stage malignant progression and the intense expression in papilloma outgrowths, identifies a novel, significant antagonism between p21 and ras(Ha)/ROCK2/NF-kappaB (zeige NFKB1 Proteine) signalling in skin carcinogenesis.these data show that ROCK2 activation induces malignancy in ras(Ha)-initiated/promoted papillomas in the context of p53 (zeige TP53 Proteine) loss and novel NF-kappaB (zeige NFKB1 Proteine) expression
The effect of Smad4 (zeige SMAD4 Proteine) was at least partially mediated by the downstream effectors Syk (zeige SYK Proteine) and ROCK2 transcription in megakaryocytes.
Here we describe the generation of a gene-targeted mouse line that enables CRE-inducible expression of a conditionally-active fusion between the ROCK2 kinase domain and the hormone-binding domain of a mutated estrogen receptor (zeige ESR1 Proteine) (ROCK2:ER). This two-stage system of regulation allows for tissue-selective expression of the ROCK2:ER fusion protein, which then requires administration of estrogen analogues
The results of the present study verify that ROCKII participates in the loss of DA neurons induced by MPTP (zeige PTPN2 Proteine) and suggest that ROCKII inhibition may be a promising therapeutic target for PD.
These results indicate that tensile force induces in vivo gene expression associated with vascularization early in tensile-force-induced sutural bone formation. Moreover, the early induction of Vegf (zeige VEGFA Proteine) gene expression is regulated by CTGF (zeige CTGF Proteine) and ROCK2.
While the loss of either Rock1 (zeige ROCK1 Proteine) or Rock2 had no negative impact on tumorigenesis in mouse models of non-small cell lung cancer and melanoma, loss of both blocked tumor formation, as no tumors arise in which both Rock1 (zeige ROCK1 Proteine) and Rock2 have been genetically deleted.
Results showed that ROCK1 (zeige ROCK1 Proteine) gene rs2271255 (Lys222Glu), rs35996865, and ROCK2 gene rs726843, rs2290156, rs10178332, rs35768389 (Asp601Val) polymorphisms were significantly associated with respiratory distress syndrome (RDS (zeige PRPH2 Proteine)), and that they could be a risk factor for development of neonatal RDS (zeige PRPH2 Proteine).
Despite sharing the catalytic domain with ROCK2, ROCK1 (zeige ROCK1 Proteine) appears to be the dominant kinase essential for junctional integrity and contractile tension at epithelial ZA.
Studies showed that ROCK isoforms, ROCK1 (zeige ROCK1 Proteine) and ROCK2, have been found in various types of neuron-like cell lines and neurons, and function as different regulators in axon outgrowth, neurite retraction, cell survival, autophagy, energy balance, and generation of endogenous beta amyloid. [review]
ICAP-1 (zeige ITGB1BP1 Proteine) monoubiquitylation helps in switching from ROCK2-mediated to MRCKalpha-mediated cell contractility.
BCR-ABL-dependent ROCK, but not TK, is involved in CD1d downregulation. We propose that ROCK, which is most likely activated by the DH/PH domain of BCR-ABL, mediates iNKT-cell immune subversion in chronic myeloid leukaemia (CML) patients by downregulating CD1d expression on CML mDCs.
this study shows that ulinastatin (zeige AMBP Proteine) inhibites the hyperpermeability of vascular endothelial cells induced by TNF-alpha (zeige TNF Proteine), and that this inhibitory effect may be related to the RhoA (zeige RHOA Proteine)/ROCK2 signaling pathway
Taken together, these results suggest that this newly identified Rock2-beta-catenin (zeige CTNNB1 Proteine)/TCF4 (zeige TCF4 Proteine)-SCARA5 (zeige SCARA5 Proteine) axis will provide novel insight into the understanding of the regulatory mechanisms of proliferation in human RCC (zeige XRCC1 Proteine).
Panax notoginseng saponins provide neuroprotective effects in a rat model of cerebral ischemia and SH-SY5Y cells exposed to oxygen/glucose deprivation injury by inhibiting the overexpression of NgR1 (zeige NEUROG1 Proteine), RhoA (zeige RHOA Proteine), and ROCK2.
Results indicate that ROCK1 (zeige ROCK1 Proteine) and ROCK2 may exert different biological functions during the regulation of compaction and in ensuring development of porcine preimplantation embryos to the blastocyst stage.
ROCK2 plays a pivotal role in generating the intrinsic circadian rhythm of vascular contractility by receiving a cue from RORalpha.
It is highly possible that Rho-kinase (zeige ROCK1 Proteine) plays an important role in the pathogenesis of in-stent restenosis. Rho-kinase (zeige ROCK1 Proteine) is not involved in endothelial regeneration after vascular injury.
Rho-kinase (zeige ROCK1 Proteine) analysis of coiled-coil association of the RhoA (zeige RHOA Proteine)-binding domain
RhoA/Rho-kinase pathway is an important component of TGF-beta-induced effects on endothelial myosin light chain phosphorylation, cytoskeletal reorganization, and barrier integrity.
nucleus-localized ROCK2 targets p300 for phosphorylation to regulate its acetyltransferase activity
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.
Rho-associated kinase alpha
, rho-associated protein kinase 2
, rho-associated, coiled-coil containing protein kinase 2
, Rho-associated, coiled-coil containing protein kinase 2
, rho-associated protein kinase 2-like
, Rho-associated coiled-coil forming kinage 2
, p164 ROCK-2
, rho-associated, coiled-coil-containing protein kinase 2
, rho-associated, coiled-coil-containing protein kinase II
, Rho-associated coiled-coil forming kinase 2
, RhoA - binding serine/threosine kinase alpha (ROK - alpha)
, p150 ROK-alpha
, rhoA-binding kinase 2
, Rho-kinase alpha