ROCK1 Proteine (ROCK1)

Bezeichnung:
rho-Associated, Coiled-Coil Containing Protein Kinase 1 Proteine (ROCK1)
Auf www.antikoerper-online.de finden Sie aktuell 9 rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) Proteine von 7 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen ROCK1 Antikörper (152) und ROCK1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 170 ROCK1 Produkte verfügbar.
Synonyme:
1110055K06Rik, CG9774, Dmel\\CG9774, DRhk, drok, LOC100229794, p160ROCK, Rhk, RhoK, Rock, ROCK-1, ROCK-I, ROCK1, Rok, ROKalpha/beta
alle Proteine anzeigen Gen GeneID UniProt
ROCK1 19877 P70335
ROCK1 81762 Q63644
ROCK1 6093 Q13464

Weitere Synonyme anzeigen

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Weitere Proteine zu ROCK1 Interaktionspartnern

Fruit Fly (Drosophila melanogaster) rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) Interaktionspartner

  1. polarity-induced spatiotemporal control of Rok and Pkn (zeige PKN1 Proteine) is important for unequal cortical expansion, ensuring correct cleavage furrow positioning and the establishment of physical asymmetry.

  2. Loss of DRok function in tendon cells results in mis (zeige AMH Proteine)-orientation of tendon cell extensions and abnormal accumulation of Thrombospondin and betaPS-integrin, which may cause abnormal myotendinous (zeige TNC Proteine) junction formation and muscle morphogenesis.

  3. model in which Rok-induced phosphorylation of residues within the basic region mediates the activation of FHOD1 (zeige FHOD1 Proteine) homolog Knittrig in controlling macrophage migration

  4. Atonal and EGFR (zeige EGFR Proteine) signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis.

  5. The structure of Shrm domain 2 (SD2), which mediates the interaction with Rock and is required for Shrm function, is reported.

  6. Data show that that Drak broadly promotes proper morphogenesis of epithelial tissues during development, and Drak activity is largely redundant with that of the Drosophila ROCK orthologue, Rok.

  7. CD44 (zeige CD44 Proteine) interaction with p115RhoGEF (zeige ARHGEF1 Proteine) and ROK plays a pivotal role in promoting Gab-1 phosphorylation leading to Gab-1.PI 3 (zeige PI3 Proteine)-kinase membrane localization, AKT (zeige AKT1 Proteine) signaling, and cytokine (M-CSF (zeige CSF1R Proteine)) production during HA-mediated breast cancer progression

  8. Drok and Drosophila Lim (zeige ZYX Proteine)-kinase interact in the developing nervous system

  9. DRok is required for tissue morphogenesis in diverse compartments of the egg chamber during oogenesis

  10. activation of RhoA/ROCK and PI3K/Akt plays a pivotal role in leptin signaling, leading to the development of VSMC hypertrophy through a mechanism involving altered actin dynamics

Mouse (Murine) rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) Interaktionspartner

  1. that reduction of ROCK1 diminishes amyloid-beta levels by enhancing Amyloid beta-Protein Precursor protein degradation

  2. ANXA1 (zeige ANXA1 Proteine) restores Abeta42-induced blood brain barrier disruption through inhibition of RhoA (zeige RHOA Proteine)-ROCK signaling pathway

  3. the cross-talk between canonical and non-canonical signaling pathways of Wnt3A (zeige WNT3A Proteine), which induces GSK-3beta phosphorylation and beta-catenin (zeige CTNNB1 Proteine) accumulation through RhoA (zeige RHOA Proteine) and ROCK activation.

  4. Inhibition of ROCK1 largely blocked Endothelial-to-mesenchymal transition and the increase in endothelial permeability under this high-glucose condition, but overexpression of ROCK1 induced these changes.

  5. While the loss of either Rock1 or Rock2 (zeige ROCK2 Proteine) had no negative impact on tumorigenesis in mouse models of non-small cell lung cancer and melanoma, loss of both blocked tumor formation, as no tumors arise in which both Rock1 and Rock2 (zeige ROCK2 Proteine) have been genetically deleted.

  6. Fyn (zeige FYN Proteine) mediates high glucose-induced actin cytoskeleton remodeling of podocytes via promoting ROCK activation and paxillin (zeige PXN Proteine) phosphorylation

  7. YQFM ameliorates the OGD-induced brain microvascular endothelial cell barrier disruption associated with the NF-kappaB/p65 and ROCK1/MLC signaling pathways.

  8. Extracellular vesicle-encapsulated caspase-3 (zeige CASP3 Proteine) was largely responsible for the alveolar macrophage activation via the ROCK1 pathway.

  9. In experimental autoimmune encephalomyelitis (EAE), ROCK activity was also increased in serum, spleen, brain and spinal cord. Neuron injury with scratch and TNF-alpha (zeige TNF Proteine) stimulation induced the up-regulation of ROCK activity.

  10. indicates that the up-regulation of ROCK1 activity in RhoA (zeige RHOA Proteine)-deleted macrophages and macrophage phenotype/polarity are dependent on non-apoptotic Caspase-3 (zeige CASP3 Proteine)

Human rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) Interaktionspartner

  1. Despite sharing the catalytic domain with ROCK2 (zeige ROCK2 Proteine), ROCK1 appears to be the dominant kinase essential for junctional integrity and contractile tension at epithelial ZA.

  2. RhoA (zeige RHOA Proteine)/ROCK and Raf-1 (zeige RAF1 Proteine)/CK2 (zeige CSNK2A1 Proteine) pathway are responsible for TNF-alpha (zeige TNF Proteine)-mediated endothelial cytotoxicity via regulation of the vimentin (zeige VIM Proteine) cytoskeleton.

  3. High ROCK1 expression is associated with Clear cell renal cell carcinoma (zeige MOK Proteine).

  4. Studies showed that ROCK isoforms, ROCK1 and ROCK2 (zeige ROCK2 Proteine), have been found in various types of neuron-like cell lines and neurons, and function as different regulators in axon outgrowth, neurite retraction, cell survival, autophagy, energy balance, and generation of endogenous beta amyloid. [review]

  5. BCR-ABL-dependent ROCK, but not TK, is involved in CD1d downregulation. We propose that ROCK, which is most likely activated by the DH/PH domain of BCR-ABL, mediates iNKT-cell immune subversion in chronic myeloid leukaemia (CML) patients by downregulating CD1d expression on CML mDCs.

  6. that reduction of ROCK1 diminishes amyloid-beta levels by enhancing Amyloid beta-Protein Precursor protein degradation

  7. Silencing Drp1 (zeige CRMP1 Proteine) inhibits glioma cells proliferation and invasion by RHOA (zeige RHOA Proteine)/ ROCK1 pathway.

  8. RhoB and ROCK play a key role in preeclampsia.

  9. We successfully identified a novel pathway via which SIN (zeige EFS Proteine) exerted antioxidative and renal protective functions, and provided a molecular basis for potential SIN (zeige EFS Proteine) applications in treating DN vascular disorders.

  10. The results of the present study indicate that miR126 inhibits RCC (zeige XRCC1 Proteine) cell proliferation, migration and invasion by downregulating ROCK1.

Rabbit rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) Interaktionspartner

Pig (Porcine) rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) Interaktionspartner

  1. Results indicate that ROCK1 and ROCK2 (zeige ROCK2 Proteine) may exert different biological functions during the regulation of compaction and in ensuring development of porcine preimplantation embryos to the blastocyst stage.

  2. It is highly possible that Rho-kinase plays an important role in the pathogenesis of in-stent restenosis. Rho-kinase is not involved in endothelial regeneration after vascular injury.

Cow (Bovine) rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) Interaktionspartner

  1. results suggest that the ROCK/MLC/actomyosin as well as ROCK/LIMK (zeige LIMK1 Proteine)/cofilin (zeige CFL1 Proteine) pathways regulate meiotic spindle migration and cytokinesis during bovine oocyte maturation.

  2. In airway smooth muscle, muscle contraction involves the translocation of ROCK1 from non-caveolar to caveolar regions.

  3. p38 (zeige MAPK14 Proteine) phosphorylation and MMP13 (zeige MMP13 Proteine) expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.

  4. The RhoA (zeige RHOA Proteine)/ROCK signaling pathway is an important negative regulator of vascular calcification.

  5. caveolar and cholesterol integrity are indispensable for the proper functionality of the H(1) and 5-HT(2A) receptors through their Rho/ROCK signaling.

  6. A functional contribution of PI3K, Rho, and ROCK to both the autocrine mechanism of ATP release and ATP-mediated angiogenic activation of vasa (zeige DDX4 Proteine) vasorum endothelial cells, is reported.

ROCK1 Protein Überblick

Protein Überblick

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.

Alternative names and synonyms associated with ROCK1

  • Rho-associated, coiled-coil containing protein kinase 1 (ROCK1)
  • Rho-associated, coiled-coil containing protein kinase 1 (LOC100229794)
  • Rho-kinase (rok)
  • Rho-associated coiled-coil containing protein kinase 1 (Rock1)
  • Rho-associated, coiled-coil containing protein kinase 1 (rock1)
  • 1110055K06Rik Protein
  • CG9774 Protein
  • Dmel\\CG9774 Protein
  • DRhk Protein
  • drok Protein
  • LOC100229794 Protein
  • p160ROCK Protein
  • Rhk Protein
  • RhoK Protein
  • Rock Protein
  • ROCK-1 Protein
  • ROCK-I Protein
  • ROCK1 Protein
  • Rok Protein
  • ROKalpha/beta Protein

Bezeichner auf Proteinebene für ROCK1

Rho-associated coiled coil containing protein kinase 1 , rho-associated protein kinase 1 , Rho-associated, coiled-coil containing protein kinase 1 , CG9774-PA , DRho-kinase , ROCK , Rho-associated kinase , RhoA kinase , drosophila rho-associated kinase , rho kinase , rok-PA , Rho-associated coiled-coil forming kinase 1 , p160 ROCK-1 , p160ROCK , rho-associated, coiled-coil-containing protein kinase 1 , rho-associated, coiled-coil-containing protein kinase I , Rho-associated kinase beta , liver regeneration-related protein LRRG199 , p150 RhoA-binding kinase ROK beta , Rho kinase , p160-ROCK , renal carcinoma antigen NY-REN-35 , HEBM1 , cAMP-dependent protein kinase ROCK-I , cePKA , corneal epithelial Rho-associated-Ser/Thr kinase 1 , Rho-kinase beta , Rho-associated protein kinase 1 , rho-associated coiled-coil domain-containing protein kinase 1

GENE ID SPEZIES
100034056 Equus caballus
100229794 Taeniopygia guttata
43916 Drosophila melanogaster
19877 Mus musculus
81762 Rattus norvegicus
6093 Homo sapiens
480181 Canis lupus familiaris
100009220 Oryctolagus cuniculus
397447 Sus scrofa
785911 Bos taurus
455326 Pan troglodytes
100329779 Danio rerio
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