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A three-way interaction among maternal and fetal variants in BHMT2, GSTP1 (zeige GSTP1 ELISA Kits) and GPX3 (zeige GPX3 ELISA Kits) contribute to congenital heart defects
The faster evolutionary rate of BHMT2 overall suggests that selective constraints were reduced relative to BHMT (zeige BHMT ELISA Kits).
Multiple SNPs in BHMT (zeige BHMT ELISA Kits) and BHMT2 were identified to be associated with the occurrence of infant obstructive heart defects and interaction effects with maternal use of folic acid supplements.
No significant level of association was found with cleft lip with or without cleft palate and BHMT2 variants.
gene-gene interaction analysis revealed a significant epistatic interaction of BHMT2 (rs673752), PEMT (zeige PEMT ELISA Kits) (rs12325817), and PCYT1A (zeige PCYT1A ELISA Kits) (rs712012) with maternal NCL (zeige CLN5 ELISA Kits)/P susceptibility.
Hyperhomocysteinemia, a risk factor for coronary diseases, can be caused by genetic mutations in BHMT2 metabolism.
Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase.
Common genetic variation in BHMT (zeige BHMT ELISA Kits) and BHMT2 and functionally characterized BHMT (zeige BHMT ELISA Kits) SNPs.
the mouse liver extracts, containing the BHMT-2 homocysteine methyltransferase candidate for a similar activity, recognizes (S,S)-AdoMet (zeige MAT1A ELISA Kits) but not (R,S)-AdoMet (zeige MAT1A ELISA Kits).
Betaine-homocysteine methyltransferase 2 (Bhmt2) was identified as a diet-dependent genetic factor that affected susceptibility to acetaminophen-induced liver toxicity in mice.
Homocysteine is a sulfur-containing amino acid that plays a crucial role in methylation reactions. Transfer of the methyl group from betaine to homocysteine creates methionine, which donates the methyl group to methylate DNA, proteins, lipids, and other intracellular metabolites. The protein encoded by this gene is one of two methyl transferases that can catalyze the transfer of the methyl group from betaine to homocysteine. Anomalies in homocysteine metabolism have been implicated in disorders ranging from vascular disease to neural tube birth defects such as spina bifida. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
betaine-homocysteine methyltransferase 2
, Betaine--homocysteine S-methyltransferase 2
, betaine--homocysteine S-methyltransferase 2
, betaine--homocysteine S-methyltransferase 2-like
, S-methylmethionine--homocysteine S-methyltransferase BHMT2
, SMM-hcy methyltransferase