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disruption of this hippocampal POMC (zeige POMC Proteine)/MC4R (zeige MC4R Proteine) circuit might contribute to synaptic dysfunction observed in Alzheimer's disease.
The data show that somatic MORs in POMC (zeige POMC Proteine) neurons couple to multiple effectors that have differential sensitivity to desensitization of the receptor.
These findings indicate that the relevance of AgRP (zeige AGRP Proteine) to POMC (zeige POMC Proteine) neuron GABA connectivity depends on the state of AgRP (zeige AGRP Proteine) neuron activity and suggest that different types of transmitter release should be considered when circuit mapping.
these data unmasked a role for mitochondrial fission in leptin (zeige LEP Proteine) sensitivity and glucose sensing of POMC (zeige POMC Proteine) neurons.
it is suggested that the suppression of NeuroD1 (zeige NEUROD1 Proteine) expression and the inhibition of NeuroD1 (zeige NEUROD1 Proteine)/E-box interaction may play an important role in the Gc-mediated negative regulation of Pomc (zeige POMC Proteine).
To clarify the functional roles of the AKT-mTOR pathway in the hippocampal neurons, we generated conditional knockout mice harboring the deletion of Pten (Pten-cKO) in Proopiomelanocortin-expressing neurons.
Epo (zeige EPO Proteine) regulates hypothalamus POMC (zeige POMC Proteine) expression via STAT3 (zeige STAT3 Proteine) activation.
Data suggest that the solitary tract pro-opiomelanocortin (zeige POMC Proteine) (NTSPOMC) neurons were involved in cardiorespiratory control and endogenous analgesia.
hypothalamic arcuate nucleus (Arc (zeige NOL3 Proteine))POMC (zeige POMC Proteine)-deficient mice, which develop severe obesity and insulin (zeige INS Proteine) resistance, unexpectedly exhibit improved glucose tolerance and remain protected from hyperglycemia via decreased renal GLUT2 (zeige SLC2A2 Proteine) expression and glycosuria.
Hypomethylation of POMC (zeige POMC Proteine) promoter occurred in the hypothalamus of the high sucrose diet offspring compared with controls.
Elevated ACTH (zeige POMC Proteine) secretion is associated with Cushing's syndrome.
a novel p53 (zeige TP53 Proteine)/POMC (zeige POMC Proteine)/Galphas (zeige GNAS Proteine)/SASH1 (zeige SASH1 Proteine) autoregulatory positive feedback loop is regulated by SASH1 (zeige SASH1 Proteine) mutations to induce pathological hyperpigmentation phenotype.
Data suggest that alpha-MSH enhances cell adhesion to fibronectin (zeige FN1 Proteine) in primary mixed synoviocytes obtained from osteoarthritis patients; alpha-MSH reduces secretion of cytokines (TNF (zeige TNF Proteine), IL-6 (zeige IL6 Proteine) and IL-8 (zeige IL8 Proteine)) in such synoviocyte cultures.
Data suggest that the first screening step diagnosis for pituitary adenoma was determined based upon immunohistochemical (IHC) scores for Pit-1 (zeige POU1F1 Proteine), SF-1 (zeige NR5A1 Proteine), and ACTH (zeige POMC Proteine).
The aim of this survey is to evaluate the association of genetic variants of melanocortin-4-receptor (MC4R (zeige MC4R Proteine)), pro-opiomelanocortin (POMC (zeige POMC Proteine)), apolipoprotein E (APOE (zeige APOE Proteine)) and agouti-related protein (AGRP (zeige AGRP Proteine)) with obesity in the North Indian population.
The expression of Pomc (zeige POMC Proteine) mRNA was stimulated in the arcuate nucleus after skin exposure to UVB.
hsa (zeige CD24 Proteine)-miR (zeige MLXIP Proteine)-34a can regulate the CRH (zeige CRH Proteine)/CRHR1 (zeige CRHR1 Proteine)/POMC (zeige POMC Proteine) axis and may influence body mass index.
these common variants in PCSK1 (zeige PCSK1 Proteine) and POMC (zeige POMC Proteine) were not the major cause of obesity in the Thai subjects sampled. However, variants in PCSK1 (zeige PCSK1 Proteine) did affect cholesterol level, LDL-C level, and waist circumference.
ACTH (zeige POMC Proteine) was readily detected at significantly higher levels in regions of ACTH (zeige POMC Proteine)-secreting adenomas and in normal anterior adenohypophysis compared with non-secreting adenoma and neurohypophysis.
CSF (zeige CSF2 Proteine) POMC (zeige POMC Proteine) was higher in lean vs. overweight/obese subjects.
The association has been reported between polymorphisms of the CRH (zeige CRH Proteine) and POMC (zeige POMC Proteine) genes with economic traits in Korean cattle.
Expression of the hepatic endocannabinoid system and proopiomelanocortin (zeige POMC Proteine) was altered by plane of dietary energy prepartum particularly during the first 2-week postpartum.
Significant associations were observed between POMC (zeige POMC Proteine) c.288C>T with start-of-finishing weight (SOF (zeige GJA1 Proteine) WT; P = 0.04), hot carcass weight (HCW; P = 0.02), average fat and grade fat (both P = 0.05), carcass rib-eye area (REA (zeige PHB2 Proteine); P = 0.03) and marbling
The polymorphism of POMC (zeige POMC Proteine) gene is associated with the growth traits of Nanyang cattle.
The expression of the genes coding for proopiomelanocortin (POMC (zeige POMC Proteine)), proenkephalin (PENK (zeige PENK Proteine)) and prodynorphin (PDYN (zeige PDYN Proteine)) in porcine luteal cells isolated from corpora lutea (CL) collected on days 3-6, 8-10 and 13-16 of the oestrous cycle is reported.
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used\; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.
adrenal corticotropic hormone
, adrenocorticotropic hormone
, alpha-melanocyte stimulating hormone
, corticotropin-like intermediary peptide
, melanotropin gamma
, alpha-melanocyte-stimulating hormone
, beta-melanocyte-stimulating hormone
, lipotropin beta
, lipotropin gamma
, melanotropin alpha
, melanotropin beta
, opiomelanocortin prepropeptide
, proopiomelanocortin preproprotein
, proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)
, beta-melanocyte stimulating hormone