RPS6KA1 Proteine (RPS6KA1)

Bezeichnung:
Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 Proteine (RPS6KA1)
Auf www.antikoerper-online.de finden Sie aktuell 12 Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1) Proteine von 8 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen RPS6KA1 Antikörper (392) und RPS6KA1 Kits (10) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 425 RPS6KA1 Produkte verfügbar.
Synonyme:
CLS, hu-1, HU-3, ISPK-1, mapkapk1a, MAPKAPK1B, MRX19, p90-RSK2, p90rsk, pp90RSK2, RPS6KA, RSK, rsk1, RSK2, S6K-alpha3
alle Proteine anzeigen Gen GeneID UniProt
RPS6KA1 20111  
Ratte RPS6KA1 RPS6KA1 81771 Q63531
RPS6KA1 6195 Q15418

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Weitere Proteine zu RPS6KA1 Interaktionspartnern

Mouse (Murine) Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1) Interaktionspartner

  1. In hippocampal neurons of wild-type mice, pP90RSK translocates into the nucleus upon stimulation with forskolin (left), whereas in Period1-knockout (Per1 (zeige PER1 Proteine)(-/-) ) mice (right) the kinase is trapped at the nuclear periphery

  2. Data show that the phosphoinositide-dependent kinase 1 (PDK1 (zeige PDPK1 Proteine))-p90 (zeige GPAM Proteine) kDa ribosomal S6 kinases (Rsks) Rsk1/2 pathway is critical for establishment and maintenance of a normal Langerhans cells (LC) network.

  3. IL-6 (zeige IL6 Proteine) induces the activation of the Stat3 (zeige STAT3 Proteine) signaling and promotes the downmodulation of the p90RSK/eEF2 (zeige EEF2 Proteine) and mTOR (zeige FRAP1 Proteine)/p70S6K (zeige RPS6KB1 Proteine) axes, while it does not affect the activation of AKT (zeige AKT1 Proteine).

  4. analysis of p38 (zeige CRK Proteine)-MK2 (zeige KCNA2 Proteine)-activated Rsk signaling in toll (zeige TLR4 Proteine)-like receptor-stimulated dendritic cells

  5. These data indicate that aripiprazole and quetiapine signal to specific nuclear targets of ERK (zeige EPHB2 Proteine), which for quetiapine occurs via an EGFR (zeige EGFR Proteine)-linked mechanism, possibly indicating involvement of this system in its action.

  6. hypoxia/reoxygenation (H/R)-mediated decrease in PKARIalpha protein levels leads to activation of RSK1, which via phosphorylation of NHE1 (zeige SLC9A1 Proteine) induces cardiomyocyte apoptosis.

  7. RSK1 Cys223 glutathionylation may contribute to regulate the levels of nitric in the brain.

  8. Our study highlights the importance of the p90RSK/ERK5 (zeige MAPK7 Proteine) module as a critical mediator of endothelial dysfunction in diabetes mellitus and atherosclerosis formation.

  9. Results show increased protein levels of Rsk1 and Rsk2 (zeige RPS6KA3 Proteine) in the striatum of Huntington disease (zeige HTT Proteine) mice and and striatal cells transfected with full-length mutant Huntingtin (zeige HTT Proteine).

  10. Type I keratin (zeige KRT12 Proteine) 17 (zeige KRT17 Proteine) protein is phosphorylated on serine 44 by p90 (zeige GPAM Proteine) ribosomal protein S6 kinase 1 (RSK1) in a growth- and stress-dependent fashion

Human Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1) Interaktionspartner

  1. Inhibition of RSK2 (zeige RPS6KA3 Proteine) was used to investigate the function of RSK2 (zeige RPS6KA3 Proteine) on PDK1 (zeige PDK1 Proteine)-induced inflammation. The phosphorylation of RSK2 (zeige RPS6KA3 Proteine) was detected when PDK1 (zeige PDK1 Proteine) was inhibited. Inhibition of RSK2 (zeige RPS6KA3 Proteine) reduced the PDK1 (zeige PDK1 Proteine)-induced cell invasion and cytokines secretion in human rheumatoid arthritis synovial MH7A cells. In response to TNF-alpha (zeige TNF Proteine), PDK1 (zeige PDK1 Proteine) could phosphorylate RSK2 (zeige RPS6KA3 Proteine) and activated RSK2 (zeige RPS6KA3 Proteine), then promoting the activation of NF-kappaB (zeige NFKB1 Proteine).

  2. Our finding demonstrates that RSK2 (zeige RPS6KA3 Proteine) directly phosphorylates stathmin (zeige STMN1 Proteine) and regulates microtubule polymerization to provide a pro-invasive and pro-metastatic advantage to cancer cells. Therefore, the RSK2 (zeige RPS6KA3 Proteine)-stathmin (zeige STMN1 Proteine) pathway represents a promising therapeutic target and a prognostic marker for metastatic human cancers.

  3. Data suggest that UBR5 down-regulates levels of TRAF3 (zeige TRAF3 Proteine), a key component of Toll (zeige TLR4 Proteine)-like receptor signaling, via the miRNA pathway; p90RSK is an upstream regulator of UBR5; p90RSK phosphorylates UBR5 as required for translational repression of TRAF3 (zeige TRAF3 Proteine) mRNA. (UBR5 = ubiquitin protein ligase E3 component n-recognin 5 protein; TRAF3 (zeige TRAF3 Proteine) = TNF receptor-associated factor 3 (zeige TRAF3 Proteine); p90RSK = 90 kDa ribosomal protein S6 (zeige RPS6 Proteine) kinase (zeige RPS6KB1 Proteine))

  4. Data indicate that BTG2 (zeige BTG2 Proteine), MAP3K11 (zeige MAP3K11 Proteine), RPS6KA1 and PRDM1 (zeige PRDM1 Proteine) as putative targets of microRNA miR (zeige MLXIP Proteine)-125b.

  5. VEGF-A (zeige VEGFA Proteine) driven Mdm2 (zeige MDM2 Proteine) phosphorylation on Ser166 is dependent on the ERK1/2/p90RSK signaling pathway in primary human endothelial cells.

  6. we discuss the function of the RSK2 (zeige RPS6KA3 Proteine) signaling axis by interactions with binding partners in cancer development--{REVIEW}

  7. Results showed that RSK2 (zeige RPS6KA3 Proteine) gene was overexpressed in osteosarcoma patients cells and its knockdown increased cell apoptosis, enhanced cell chemosensitivity, inhibits proliferation and migration, and weakened tumor formation.

  8. Upregulated expression of RSK2 (zeige RPS6KA3 Proteine) is associated with breast cancer.

  9. The p90RSK has an essential role in promoting tumor growth and proliferation in non-small cell lung cancer (NSCLC). BID (zeige BID Proteine) may serve as an alternative cancer treatment in NSCLC.

  10. RSK1 binds to EBP50 (zeige SLC9A3R1 Proteine) at its first PDZ domain, and mitogen activated RSK1 phosphorylates EBP50 (zeige SLC9A3R1 Proteine) at T156, an event that is crucial for its nuclear localization

RPS6KA1 Protein Überblick

Protein Überblick

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS).

Alternative names and synonyms associated with RPS6KA1

  • ribosomal protein S6 kinase polypeptide 1 (Rps6ka1)
  • ribosomal protein S6 kinase, 90kDa, polypeptide 1 (RPS6KA1)
  • ribosomal protein S6 kinase, 90kDa, polypeptide 1 (rps6ka1)
  • ribosomal protein S6 kinase, 90kDa, polypeptide 3 (RPS6KA3)
  • CLS Protein
  • hu-1 Protein
  • HU-3 Protein
  • ISPK-1 Protein
  • mapkapk1a Protein
  • MAPKAPK1B Protein
  • MRX19 Protein
  • p90-RSK2 Protein
  • p90rsk Protein
  • pp90RSK2 Protein
  • RPS6KA Protein
  • RSK Protein
  • rsk1 Protein
  • RSK2 Protein
  • S6K-alpha3 Protein

Bezeichner auf Proteinebene für RPS6KA1

90 kDa ribosomal protein S6 kinase 1 , MAP kinase-activated protein kinase 1a , MAPK-activated protein kinase 1a , MAPKAP kinase 1a , MAPKAPK-1a , RSK-1 , S6K-alpha-1 , p90-RSK 1 , p90RSK1 , p90S6K , ribosomal S6 kinase 1 , ribosomal protein S6 kinase alpha-1 , ribosomal protein S6 kinase, 90kD, polypeptide 1; Ribosomal protein S6 kinase, 90kD, 1 , MAPKAPK1A , S6 protein kinase (Rsk-1) , S6K-alpha 1 , pp90RSK1 , dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1) , ribosomal protein S6 kinase alpha 1 , MAP kinase-activated protein kinase 1 , MAPK-activated protein kinase 1 , MAPKAP kinase 1 , MAPKAPK-1 , S6KII-alpha , p90-RSK , ribosomal protein S6 kinase 2 alpha , ribosomal protein S6 kinase II alpha , P90-RSK , S6 kinase II beta , S6KII-beta , ribosomal protein S6 kinase 2 beta , ribosomal protein S6 kinase II beta , MAP kinase-activated protein kinase 1b , MAPK-activated protein kinase 1b , MAPKAP kinase 1b , MAPKAPK-1b , RSK-2 , S6K-alpha-3 , insulin-stimulated protein kinase 1 , p90-RSK 3 , ribosomal S6 kinase 2 , ribosomal protein S6 kinase alpha-3

GENE ID SPEZIES
20111 Mus musculus
81771 Rattus norvegicus
533908 Bos taurus
6195 Homo sapiens
386579 Gallus gallus
487353 Canis lupus familiaris
100057166 Equus caballus
100523972 Sus scrofa
445821 Xenopus laevis
6197 Homo sapiens
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