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Data suggest that UBR5 down-regulates levels of TRAF3 (zeige TRAF3 Proteine), a key component of Toll (zeige TLR4 Proteine)-like receptor signaling, via the miRNA pathway; p90RSK is an upstream regulator of UBR5; p90RSK phosphorylates UBR5 as required for translational repression of TRAF3 (zeige TRAF3 Proteine) mRNA. (UBR5 = ubiquitin protein ligase E3 component n-recognin 5 protein; TRAF3 (zeige TRAF3 Proteine) = TNF receptor-associated factor 3 (zeige TRAF3 Proteine); p90RSK = 90 kDa ribosomal protein S6 (zeige RPS6 Proteine) kinase (zeige RPS6KB1 Proteine))
Data indicate that BTG2 (zeige BTG2 Proteine), MAP3K11 (zeige MAP3K11 Proteine), RPS6KA1 and PRDM1 (zeige PRDM1 Proteine) as putative targets of microRNA miR (zeige MLXIP Proteine)-125b.
VEGF-A (zeige VEGFA Proteine) driven Mdm2 (zeige MDM2 Proteine) phosphorylation on Ser166 is dependent on the ERK1/2/p90RSK signaling pathway in primary human endothelial cells.
The p90RSK has an essential role in promoting tumor growth and proliferation in non-small cell lung cancer (NSCLC). BID (zeige BID Proteine) may serve as an alternative cancer treatment in NSCLC.
RSK1 binds to EBP50 (zeige SLC9A3R1 Proteine) at its first PDZ domain, and mitogen activated RSK1 phosphorylates EBP50 (zeige SLC9A3R1 Proteine) at T156, an event that is crucial for its nuclear localization
Data show that the 90 kDa ribosomal protein S6 (zeige RPS6 Proteine) kinases RSK1 and RSK2 (zeige RPS6KA3 Proteine) play a key role in the homing of ovarian cancer cells in metastatic sites by regulating cell adhesion and invasion.
RSK1 and 3 but not RSK2 (zeige RPS6KA3 Proteine) are down-regulated in breast tumour and are associated with disease progression. RSK may be a key component in the progression and metastasis of breast cancer.
PKD2 (zeige PKD2 Proteine) and RSK1 regulate integrin beta4 phosphorylation at threonine 1736 to stabilize keratinocyte cell adhesion and its hemidesmosomes.
Results indicate that the phosphorylation of EphA2 (zeige EPHA2 Proteine) at Ser (zeige SIGLEC1 Proteine)-897 is controlled by RSK and the RSK-EphA2 (zeige EPHA2 Proteine) axis might contribute to cell motility and promote tumour malignant progression.
SL0101 and BI-D1870 induce distinct off-target effects in mTORC1-p70S6K (zeige RPS6KB1 Proteine) signaling, and thus, the functions previously ascribed to RSK1/2 based on these inhibitors should be reassessed.
In hippocampal neurons of wild-type mice, pP90RSK translocates into the nucleus upon stimulation with forskolin (left), whereas in Period1-knockout (Per1 (zeige PER1 Proteine)(-/-) ) mice (right) the kinase is trapped at the nuclear periphery
Data show that the phosphoinositide-dependent kinase 1 (PDK1 (zeige PDPK1 Proteine))-p90 (zeige GPAM Proteine) kDa ribosomal S6 kinases (Rsks) Rsk1/2 pathway is critical for establishment and maintenance of a normal Langerhans cells (LC) network.
IL-6 (zeige IL6 Proteine) induces the activation of the Stat3 (zeige STAT3 Proteine) signaling and promotes the downmodulation of the p90RSK/eEF2 (zeige EEF2 Proteine) and mTOR (zeige FRAP1 Proteine)/p70S6K (zeige RPS6KB1 Proteine) axes, while it does not affect the activation of AKT (zeige AKT1 Proteine).
analysis of p38 (zeige CRK Proteine)-MK2 (zeige KCNA2 Proteine)-activated Rsk signaling in toll (zeige TLR4 Proteine)-like receptor-stimulated dendritic cells
These data indicate that aripiprazole and quetiapine signal to specific nuclear targets of ERK (zeige EPHB2 Proteine), which for quetiapine occurs via an EGFR (zeige EGFR Proteine)-linked mechanism, possibly indicating involvement of this system in its action.
hypoxia/reoxygenation (H/R)-mediated decrease in PKARIalpha protein levels leads to activation of RSK1, which via phosphorylation of NHE1 (zeige SLC9A1 Proteine) induces cardiomyocyte apoptosis.
RSK1 Cys223 glutathionylation may contribute to regulate the levels of nitric in the brain.
Our study highlights the importance of the p90RSK/ERK5 (zeige MAPK7 Proteine) module as a critical mediator of endothelial dysfunction in diabetes mellitus and atherosclerosis formation.
Results show increased protein levels of Rsk1 and Rsk2 (zeige RPS6KA3 Proteine) in the striatum of Huntington disease (zeige HTT Proteine) mice and and striatal cells transfected with full-length mutant Huntingtin (zeige HTT Proteine).
Type I keratin (zeige KRT12 Proteine) 17 (zeige KRT17 Proteine) protein is phosphorylated on serine 44 by p90 (zeige GPAM Proteine) ribosomal protein S6 kinase 1 (RSK1) in a growth- and stress-dependent fashion
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
90 kDa ribosomal protein S6 kinase 1
, MAP kinase-activated protein kinase 1a
, MAPK-activated protein kinase 1a
, MAPKAP kinase 1a
, S6K-alpha 1
, dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1)
, p90-RSK 1
, ribosomal S6 kinase 1
, ribosomal protein S6 kinase alpha 1
, ribosomal protein S6 kinase alpha-1
, ribosomal protein S6 kinase, 90kD, polypeptide 1; Ribosomal protein S6 kinase, 90kD, 1
, MAP kinase-activated protein kinase 1
, MAPK-activated protein kinase 1
, MAPKAP kinase 1
, ribosomal protein S6 kinase 2 alpha
, ribosomal protein S6 kinase II alpha
, S6 protein kinase (Rsk-1)
, S6 kinase II beta
, ribosomal protein S6 kinase 2 beta
, ribosomal protein S6 kinase II beta
, ribosomal protein S6 kinase a, polypeptide 1