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Collectively, these data show that beta-arrestin2 phosphorylation at Thr(383) underlies beta-arrestin-dependent Erk1/2 activation by G protein-coupled receptors.
The results of this study suggest for the first time that cadmium induces MUC8 expression via TLR4 (zeige TLR4 Proteine)-mediated ERK1/2 and p38 MAPK (zeige MAPK14 Proteine) signaling pathway in human airway epithelial cells
Lysophosphatidylcholine induced nNOS uncoupling and nNOS(Ser852) phosphorylation, reduced NO and H2O2 production and improved superoxide production by modulating ERK1/2 activity in endothelial cells.
the D domain of LRRC4 (zeige LRRC4 Proteine) anchors ERK1/2 in the cytoplasm and competitively inhibits MEK (zeige MAP2K1 Proteine)/ERK (zeige EPHB2 Proteine) activation in glioma cells.
GLUL (zeige GLUL Proteine) knockdown markedly inhibited the p38 MAPK (zeige MAPK14 Proteine) and ERK1/ERK2 (zeige MAPK1 Proteine) signaling pathways in cultured breast cancer cells and reduces their proliferation.
These results suggested that HOXB7 (zeige HOXB7 Proteine) stimulates ERK1/2 phosphorylation and provided evidence that HOXB7 (zeige HOXB7 Proteine), besides its role in transcriptional regulation, also promotes cell motility and invasiveness.
High ERK1 expression is associated with castration-resistant prostate cancer.
combined use of butyrate and highly specific Syk inhibitor BAY61-3606 does not enhance differentiation and apoptosis of colonocytes. Instead, BAY completely abolishes butyrate-induced differentiation and apoptosis in a Syk- and ERK1/2-dependent manner.
new findings indicating that canonical FGFR-ERK1/2 signaling entrapped hBMSCs in a pre-committed state and arrested further maturation of committed precursors.
mutually exclusive transcriptional regulation by AP-1 (cjun (zeige JUN Proteine)/cfos) and non-canonical NF-kappaB (zeige NFKB1 Proteine) (RelB (zeige RELB Proteine)/p52 (zeige FKBP4 Proteine)) downstream of MEK (zeige MAP2K1 Proteine)-ERK (zeige EPHB2 Proteine) and NIK (zeige MAP3K14 Proteine)-IKK-alpha (zeige CHUK Proteine)-NF-kappaB2 (p100 (zeige CUX1 Proteine)) phosphorylation, respectively was responsible for persistent Ccl20 (zeige CCL20 Proteine) expression in the colonic cells.
Cortical neuron-specific deletion of extracellular signal-regulated kinases Erk1 or Erk2 (zeige MAPK1 Proteine) significantly increased the duration of wakefulness.
pERK1/2 is a regulator of CD44 (zeige CD44 Proteine) expression, and increased CD44 (zeige CD44 Proteine) expression leads to a pro-sclerotic and migratory parietal epithelial cell phenotype in focal segmental glomerulosclerosis.
mmLDL increased the serum concentrations and expression of ICAM-1 (zeige ICAM1 Proteine) and VCAM-1 (zeige VCAM1 Proteine) by activating the ERK1/2 pathway, resulting in the expression of ETB (zeige EDNRB Proteine) receptors and the enhancement of contractile function in vascular smooth muscle.
Angiotensin II regulates dendritic cells through activation of p65 NF-kappaB (zeige NFkBP65 Proteine), ERK1, ERK2 (zeige MAPK1 Proteine) and STAT1 (zeige STAT1 Proteine) pathways.
MAPK3/1 participates in primordial follicle activation through mTORC1-KITL (zeige KITLG Proteine) signaling.
At low oxLDL levels LOX-1 activates the protective Oct-1/SIRT1 pathway, while at higher levels of the lipoprotein switches to the thrombogenic ERK1/2 pathway.
Studies indicate that progesterone receptor transgenic (Pgrcre/+) mitogen inducible gene 6 (Mig-6over) phosphatase and tensin homolog protein (Ptenf/f) knockout mice exhibited an increase of phospho-ERK1/2 and its target genes.
Gpr182 reduction led to increased activation of ERK1/2 in basal and challenge models, demonstrating a potential role for this orphan GPCR in regulating the proliferative capacity of the intestine.
ERK1 underexpression is associated with obesity.
retinoschisin (zeige RS1 Proteine) is a novel regulator of MAP kinase (zeige MAPK1 Proteine) signalling and exerts an anti-apoptotic effect on retinal cells.
ERK1/2-Akt1 (zeige AKT1 Proteine) crosstalk regulates arteriogenesis in mice and zebrafish.
eena (zeige SH3GL1 Proteine) plays an important role in the development of the myeloid cell through activation of the ERK1/ERK2 (zeige MAPK1 Proteine) pathway
ERK1 and ERK2 (zeige MAPK1 Proteine) target common and distinct gene sets, confirming diverse roles for these kinases during embryogenesis; for ERK1 different specific genes involved in dorsal-ventral patterning and subsequent embryonic cell migration were identified.
These results demonstrate that induction of Hsp70 (zeige HSPA1A Proteine) in response to heat stress is dependent on ERK (zeige MAPK1 Proteine) activation in Pac2 (zeige PSMG2 Proteine) cells.
Data define distinct roles for ERK1 and ERK2 (zeige MAPK1 Proteine) in developmental cell migration processes during zebrafish embryogenesis.
MAPK3/1 is involved in luteinizing hormone-mediated decrease of C-type natriuretic peptide (zeige NPPC Proteine) and this process is related to the EGFR (zeige EGFR Proteine) and MAPK3/1 signal pathways
Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling.
ER Ca(2+) release enhances eNOS Ser-635 phosphorylation and function via ERK1/2 activation.
Thrombospondin 1 (zeige THBS1 Proteine), fibronectin (zeige FN1 Proteine), and vitronectin (zeige VTN Proteine) are differentially dependent upon RAS, ERK1/2, and p38 (zeige MAPK14 Proteine) for induction of vascular smooth muscle cell chemotaxis.
results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
These data suggest that Gab1-ERK1/2 binding and their nuclear translocation play a crucial role in Egr-1 (zeige EGR1 Proteine) nuclear accumulation.
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.
This study demonstrates for the first time that cyclic mechanical stretch induces the proliferation of bovine satellite cells and suppresses their myogenic differentiation through the activation of ERK (zeige MAPK1 Proteine).
findings indicate that exposure to DHEA, at concentrations found in human blood, causes vascular endothelial proliferation by a plasma membrane-initiated activity that is Gi/o and ERK1/2 dependent.
Results suggest that estrogen receptors and the ERK1/2 signaling pathway are involved in the anti-apoptotic action of LY117018 in vascular endothelial cells.
Early activation of MAPK p44/42 is involved in deoxynivalenol -induced disruption of intestinal barrier function and tight junction network signaling.
Pseudorabies virus glycoprotein gE-mediated ERK 1/2 phosphorylation also occurs in epithelial cells and in these cells, gE-mediated ERK 1/2 signaling is associated with degradation of the pro-apoptotic protein Bim (zeige BCL2L11 Proteine).
Treatment with ERK inhibitors or ERK1/2 knockdown significantly suppressed porcine epidemic diarrhea virus progeny production.
This study reveals a new function of the gE glycoprotein of pseudorabies virus and suggests that pseudorabies virus, through activation of ERK1/2 signaling, has a substantial impact on T cell behavior.
CSF2 (zeige CSF2 Proteine) stimulates proliferation of trophectoderm cells by activation of the PI3K-and ERK1/2 MAPK (zeige MAPK1 Proteine)-dependent MTOR (zeige FRAP1 Proteine) signal transduction cascades.
PGRN (zeige GRN Proteine) inhibits adipogenesis in porcine preadipocytes partially through ERK (zeige MAPK1 Proteine) activation mediated PPARgamma (zeige PPARG Proteine) phosphorylation.
Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK (zeige PRKAA1 Proteine)/ERK (zeige MAPK1 Proteine)/TSC2/mTOR (zeige FRAP1 Proteine) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis
Data show that proinflammatory cytokines induction was ERK1/2 and JNK1 (zeige MAPK8 Proteine)/2 dependent.
Saccharomyces cerevisiae inhibits the Enterotoxigenic Escherichia coli-induced expression of pro-inflammatory transcripts and this inhibition was associated to a decrease of ERK1/2 and p38 MAPK (zeige MAPK14 Proteine) phosphorylation
ERK1 phosphorylation in response to Insulin-like Growth Factor-1 (zeige IGF1 Proteine) does not require activation of the Insulin-like Growth Factor-1 receptor tyrosine kinase (zeige IGF1R Proteine)
The results suggest that the MPK-1 (zeige MAPK1 Proteine)/ERK (zeige MAPK1 Proteine) regulatory network, including FBF-1, FBF-2, and LIP-1 (zeige CENPJ Proteine), controls the number of sperm by regulating the timing of the sperm-oocyte switch in C. elegans.
Cek2 (zeige FGFR3 Proteine) has a cryptic role in cell-wall biogenesis and its role is not entirely redundant to Cek1.
knockdown of SUV420H1 (zeige SUV420H1 Proteine) reduced phosphorylated ERK1 and total ERK1 proteins, and interestingly suppressed ERK1 at the transcriptional level
Secreted aspartic protease-mediated proteolytic cleavage of Msb2 is required for activation of the Cek1 mitogen activated protein kinase (zeige MAPK1 Proteine) pathway in response to environmental cues.
The authors propose that a Msb2, Cek1 and Ace2 signalling pathway addresses PMT genes as downstream targets and that different modes of regulation have evolved for PMT1 and PMT2/PMT4 genes.
Msb2 is involved in the transmission of the signal toward Cek1 mediated by the Cdc42 (zeige CDC42 Proteine) GTPase (zeige RACGAP1 Proteine).
MPK3 role in ultraviolet induced stomatal closure
Study propose that the pathogen-responsive MPK3/MPK6 (zeige MAPK6 Proteine) cascade and ABA are two essential signaling pathways that control, respectively, the organic acid metabolism and ion channels, two main branches of osmotic regulation in guard cells that function interdependently to control stomatal opening/closure.
Data report that MPK3/MPK6 and their substrate ERF6 promote the biosynthesis of IGSs and the conversion of I3G to 4MI3G, a target of PEN2/PEN3-dependent chemical defenses in plant immunity.
Data show that the protein kinases MPK3 and MPK6 (zeige MAPK6 Proteine) can both interact with SPOROCYTELESS/NOZZLE (SPL (zeige SGPL1 Proteine)) in vitro and in vivo and can phosphorylate the SPL (zeige SGPL1 Proteine) protein in vitro.
MKK4 (zeige MAP2K4 Proteine), MKK5 (zeige MAP2K5 Proteine), MKK7 (zeige MAP2K7 Proteine), and MKK9, are responsible for the activation of MPK3 and MPK6 (zeige MAPK6 Proteine) by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK (zeige MAPK1 Proteine) signaling through MKK4 (zeige MAP2K4 Proteine)/5/7/9-MPK3/6 cascades.
Phosphatase AP2C1, as well as AP2C1-targeted MPK3 and MPK6 (zeige MAPK6 Proteine), are important regulators of plant-nematode interaction, where the co-ordinated action of these signalling components ensures the timely activation of plant defence.
Results demonstrated the contribution of MPK3 and MPK6 (zeige MAPK6 Proteine) to riboflavin-induced resistance.
These results indicate that the MVB pathway is positively regulated by pathogen-responsive MPK3/6 through LIP5 phosphorylation and plays a critical role in plant immune system
MKK3-MPK6 is activated by blue light in a MYC2-dependent manner.
MPK3 and MPK6 (zeige MAPK6 Proteine) target a subclass of 'VQ-motif'-containing proteins to regulate immune responses.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.
MAP kinase isoform p44
, MAPK 1
, extracellular signal-regulated kinase 1
, extracellular signal-related kinase 1
, insulin-stimulated MAP2 kinase
, microtubule-associated protein 2 kinase
, MAP kinase 3
, p44 MAP kinase
, pp42/MAP kinase
, mitogen-activated protein kinase 3
, MAP kinase 12
, MAPK 12
, extracellular signal-regulated kinase 6
, mitogen-activated protein kinase 12
, stress-activated protein kinase 3
, MAP kinase 1
, MAPK 3
, mitogen-activated 3
, mitogen-activated protein kinase 1
, extracellular signal-regulated kinase-1
, likely protein kinase