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anti-Human MAPK14 Antikörper:
anti-Mouse (Murine) MAPK14 Antikörper:
anti-Rat (Rattus) MAPK14 Antikörper:
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Human Polyclonal MAPK14 Primary Antibody für FACS, IF - ABIN1882176
Cheung, Campbell, Nebreda, Cohen: Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha. in The EMBO journal 2003
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Dog (Canine) Monoclonal MAPK14 Primary Antibody für IF, WB - ABIN968769
Brunet, Pouysségur: Identification of MAP kinase domains by redirecting stress signals into growth factor responses. in Science (New York, N.Y.) 1996
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Dog (Canine) Monoclonal MAPK14 Primary Antibody für IF, WB - ABIN968770
Han, Lee, Bibbs, Ulevitch: A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. in Science (New York, N.Y.) 1994
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Human Monoclonal MAPK14 Primary Antibody für ICC, FACS - ABIN1724830
Li, Zheng, Li, Ma: Unfractionated heparin inhibits lipopolysaccharide-induced inflammatory response through blocking p38 MAPK and NF-?B activation on endothelial cell. in Cytokine 2012
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Human Monoclonal MAPK14 Primary Antibody für IHC, ELISA - ABIN1724904
Chung, Tang, Sun, Chou, Yeh, Yu, Sun: Galectin-1 promotes lung cancer progression and chemoresistance by upregulating p38 MAPK, ERK, and cyclooxygenase-2. in Clinical cancer research : an official journal of the American Association for Cancer Research 2012
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results suggest that ET-1 (zeige EDN1 Antikörper)-induced activation of proMMP-2 is mediated via cross-talk between NADPH oxidase (zeige NOX1 Antikörper)-PKCalpha (zeige PKCa Antikörper)-p(38)MAPK (zeige MAPK1 Antikörper) and NFkappaB-MT1MMP (zeige MMP14 Antikörper) signaling pathways along with a marked decrease in TIMP-2 (zeige TIMP2 Antikörper) expression in the cells
cross-talk between p(38)MAPK (zeige MAPK1 Antikörper) and Gialpha play a pivotal role for full activation of cPLA2 (zeige PLA2G4A Antikörper) during ET-1 (zeige EDN1 Antikörper) stimulation of pulmonary artery smooth muscle cells.
MAPK14 signalling pathway is largely involved in heat-induced sperm damage.
p38 MAPK is an early redox sensor in the laminar shear stress with hydrogen peroxide being a signaling mediator.
Blockade of p38 enhances chondrocyte phenotype in monolayer culture and may promote more efficient cartilage tissue regeneration for cell-based therapies.
p38 phosphorylation and MMP13 (zeige MMP13 Antikörper) expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.
These data suggest that the p38 and JNK (zeige MAPK8 Antikörper) signaling pathways play pivotal roles in PRRSV replication and may regulate immune responses during virus infection.
findings support the hypothesis that ischemic factor stimulation of the blood-brain barrier Na-K-Cl cotransporter (zeige SLC12A1 Antikörper) involves activation of p38 and JNK (zeige MAPK8 Antikörper) MAPKs
These data suggest a differential requirement of JNK1 (zeige MAPK8 Antikörper) and p38 MAPK in TNF (zeige TNF Antikörper) regulation of E2F1 (zeige E2F1 Antikörper). Targeted inactivation of JNK1 (zeige MAPK8 Antikörper) at arterial injury sites may represent a potential therapeutic intervention for ameliorating TNF (zeige TNF Antikörper)-mediated EC dysfunction.
p38 MAPK (MAPK14) is redox-regulated in reactive oxygen species-dependent endothelial barrier dysfunction.
These results illustrate a novel pro-tumourigenic crosstalk between the p38 MAPK pathway and JAK (zeige JAK3 Antikörper) signalling in a Drosophila model of Myeloproliferative neoplasms.
ROS (zeige ROS1 Antikörper)/JNK (zeige MAPK8 Antikörper)/p38/Upd (zeige UROD Antikörper) stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.
Taken together, our findings indicate that the p38 MAP Kinase is an integral component of the core circadian clock of Drosophila in addition to playing a role in stress-input pathways.
Data show that the genetic interaction between p38b MAPK (zeige MAPK1 Antikörper) and Rack1 (zeige GNB2L1 Antikörper) controls muscle aggregate formation, locomotor function, and longevity.
The interaction of any of several Drosophila Delta class glutathione transferases and p38b mitogen-activated protein kinase (zeige MAPK1 Antikörper) can affect the substrate specificity of either enzyme, which suggests induced conformational changes affecting catalysis.
found a correlation between the depth of integration of individual p38 kinases into the protein interaction network and their functional significance; propose a central role of p38b in the p38 signaling module with p38a and p38c playing more peripheral auxiliary roles
Loss of p38 MAPK causes early lethality and precipitates age-related motor dysfunction and stress sensitivity.
The p38 pathway-mediated stress response contribute to Drosophila host defense against microbial infection.
p38b MAPK (zeige MAPK1 Antikörper) plays a crucial role in the balance between intestinal stem cell proliferation and proper differentiation in the adult Drosophila midgut.
the D-p38b gene is regulated by the DREF (zeige ZBED1 Antikörper) pathway and DREF (zeige ZBED1 Antikörper) is involved in the regulation of proliferation and differentiation of Drosophila ISCs (zeige NFS1 Antikörper) and progenitors
p38 mitogen-activated protein kinase is crucial for bovine papillomavirus type-1 transformation of equine fibroblasts.
p38 Mitogen-activated protein kinase (MAPK (zeige MAPK1 Antikörper)) is essential for drug-induced COX-2 (zeige PTGS2 Antikörper) expression in leukocytes, suggesting that p38 MAPK is a potential target for anti-inflammatory therapy.
These findings support a function for p38 MAPK in equine neutrophil migration and suggest the potential for the ability of p38 MAPK inhibition to limit neutrophilic inflammation in the laminae during acute laminitis.
Cultured equine digital vein endothelial cells were exposed to lipopolysaccharide and phosphorylation of p38 MAPK was assessed by Western blotting using phospho-specific antibodies.
Data suggest that in vitro-induction of CD8 (zeige CD8A Antikörper)+ Tregs depended in part on transforming growth factor beta 1 (TGF-beta1 (zeige TGFB1 Antikörper)) activation of p38 MAPK signaling, and that p38 MAPK could be a therapeutic target in ovarian cancer (OC) anti-tumor immunotherapy.
present study provides evidence that variations in GADD45B (zeige GADD45B Antikörper) rs2024144T, MAPK14 rs3804451A and GADD45A (zeige GADD45A Antikörper) rs581000C may predict platinum-based chemotherapy toxicity outcomes in patients with advanced non-small cell lung cancer
Gab1 (zeige GAB1 Antikörper)/SHP2 (zeige PTPN11 Antikörper)/p38MAPK signaling pathway and Ang-2 (zeige ANGPT2 Antikörper) have an essential role in regulating thrombin (zeige F2 Antikörper)-induced monocyte adhesion and vascular leakage
Studies suugest Wip1 (zeige PPM1D Antikörper) role in tumorigenesis through regulation of p53 (zeige TP53 Antikörper) and p38MAPK pathways.
Data show that Cx43 (zeige GJA1 Antikörper) was inhibited predominantly via IL-1beta (zeige IL1B Antikörper)-activated ERK1/2 (zeige MAPK1/3 Antikörper) and p38 MAP kinase cascades.
cyclophilin (zeige PPIA Antikörper)-dependent isomerisation of p38MAPK is an important novel mechanism in regulating p38MAPK phosphorylation and functions.
MEK2 (zeige MAP2K2 Antikörper) was essential for the phosphorylation of MKK3 (zeige MAP2K3 Antikörper)/MKK6 (zeige MAP2K6 Antikörper) and p38 MAPK that directly impacted on cyclin D1 (zeige CCND1 Antikörper) expression.
stress-induced activation of p38 MAPK and apoptosis in endothelial cells and established the link between the acid sphingomyelinase (zeige SMPD1 Antikörper)/ceramide and p38 MAPK pathways.
The results of this study suggest for the first time that cadmium induces MUC8 expression via TLR4 (zeige TLR4 Antikörper)-mediated ERK1/2 (zeige MAPK1/3 Antikörper) and p38 MAPK signaling pathway in human airway epithelial cells
These data suggested that t-BHP induced both apoptosis and necroptosis in endothelial cells which was mediated by ROS (zeige ROS1 Antikörper) and p38MAPK. ROS (zeige ROS1 Antikörper) derived from NADPH oxidase (zeige NOX1 Antikörper) and mitochondria contributed to t-BHPL and t-BHPH-induced apoptosis and necroptosis, respectively
results suggest that the TLR2 (zeige TLR2 Antikörper)-p38 (zeige CRK Antikörper)-CD86 (zeige CD86 Antikörper) signaling pathway plays a vital role in inflammation associated with burn injury
Overall, our results provide the first evidence that HDAC6 (zeige HDAC6 Antikörper) is capable of inducing expression of pro-inflammatory genes by regulating the ROS (zeige ROS1 Antikörper)-MAPK (zeige MAPK1 Antikörper)-NF-kappaB (zeige NFKB1 Antikörper)/AP-1 (zeige JUN Antikörper) pathways and serves as a molecular target for inflammation.
YZH-106 induced p38 MAPK and ERK1/2 (zeige MAPK1/3 Antikörper) phosphorylation, which led to the activation of erythroid 2-related factor 2 (Nrf2 (zeige NFE2L2 Antikörper)) that up-regulated heme oxygenase-1 (HO-1 (zeige HMOX1 Antikörper)) expression in addition to other genes.
Trehalose may rescue against insulin (zeige INS Antikörper) resistance-induced myocardial contractile defect and apoptosis, via autophagy associated with dephosphorylation of p38 MAPK and Foxo1 (zeige FOXO1 Antikörper) without affecting phosphorylation of Akt (zeige AKT1 Antikörper).
SPAK (zeige STK39 Antikörper) plays a pathogenic role in IgA nephropathy through the activation of NF-kappaB (zeige NFKB1 Antikörper)/MAPK (zeige MAPK1 Antikörper) signaling pathway.
cyclophilin (zeige PPIE Antikörper)-dependent isomerisation of p38MAPK is an important novel mechanism in regulating p38MAPK phosphorylation and functions.
findings identify p38alpha MAPK (zeige MAPK1 Antikörper) as a key component of PTH (zeige PTH Antikörper) signaling in osteoblast lineage cells and highlight its requirement in iPTH osteoanabolic activity
p38alpha serves as a critical regulator of platelet activation and potential indicator of highly thrombotic lesions and no-reflow in ST-elevation myocardial infarction.
Blockade of TRPV1 (zeige TRPV1 Antikörper), through genetic deletion or systemic or intra-nucleus accumbens (NAc (zeige NLRP1 Antikörper)) pharmacological means, inhibited morphine-induced CPP in mice. In addition, p38 MAPK inhibition blocked development of morphine conditioned place preference (CPP) as well. Moreover, blockade of either NAc (zeige NLRP1 Antikörper) p38 MAPK or TRPV1 (zeige TRPV1 Antikörper) dampened protein expression levels of p-p38 MAPK, AC1 (zeige HRASLS Antikörper), and p-NF-kappaB (zeige NFKB1 Antikörper) which are normally induced by morphine ...
Results demonstrate that in vivo attenuation of p38alpha activity slows age-associated decline in dentate gyrus neurogenesis and associated cognitive function. Aged DN-p38alphaAF/+ mice produce more adult-born neurons than wildtype littermates, suggesting that p38alpha negatively contributes to age-dependent decline in neurogenesis that underlies the age-dependent decline in context discrimination.
These findings suggest that the TQ-induced production of ROS (zeige ROS1 Antikörper) causes dedifferentiation through the ERK (zeige MAPK1 Antikörper) pathway and inflammation through the PI3K and p38 pathways in rabbit articular chondrocytes.
These results suggest that p38 MAPK signal transduction pathway is critical to NO-induced chondrocyte apoptosis, and p38 plays a role by way of stimulating NF-kappaB (zeige NFKB1 Antikörper), p53 (zeige TP53 Antikörper) and caspase-3 (zeige CASP3 Antikörper) activation.
Porcine reproductive and respiratory syndrome virus strain CH-1a could significantly up-regulate IL-10 (zeige IL10 Antikörper) production through p38 MAPK activation.
JNK (zeige MAPK8 Antikörper) plays an active role in fragmentation of pig oocytes and p38 MAPK is not involved in this process.[p38MAPK]
Retinal ischemia-reperfusion alters expression of mitogen-activated protein kinases, particularly ERK1/2 (zeige MAPK1/3 Antikörper), in the neuroretina and retinal arteries.
cytochrome c (zeige CYCS Antikörper) microinjection induces p38 phosphorylation through caspase-3 (zeige CASP3 Antikörper) activation, and caspase (zeige CASP3 Antikörper) inhibition reduces p38 activation induced by osmostress, indicating that a positive feedback loop is engaged by hyperosmotic shock
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
MAP kinase 14
, MAP kinase p38 alpha
, MAPK 14
, mitogen-activated protein kinase p38 alpha
, p38 mitogen activated protein kinase
, p38 mitogen-activated protein kinase
, stress-activated p38b MAP kinase
, p38 mitogen-activated kinase
, cytokine suppressive anti-inflammatory drug binding protein 1
, mitogen activated protein kinase 14
, p38 MAP kinase alpha
, p38 MAPK
, p38 alpha
, tRNA synthetase cofactor p38
, CSAIDS-binding protein 1
, mitogen-activated protein kinase 14A
, stress-activated protein kinase 2a
, Csaids binding protein
, MAP kinase 2
, MAP kinase Mxi2
, MAX-interacting protein 2
, cytokine suppressive anti-inflammatory drug binding protein
, cytokine-supressive anti-inflammatory drug binding protein
, mitogen-activated protein kinase 14
, p38 MAP kinase
, p38alpha Exip
, reactive kinase
, stress-activated protein kinase 2A
, MAPK p38
, Mitogen-activated protein kinase 2
, mitogen-activated Mitogen-activated protein kinase 2