anti-MAP3K4 (MAP3K4) Antikörper

anti-Mitogen-Activated Protein Kinase Kinase Kinase 4 Antikörper (MAP3K4)
Auf finden Sie aktuell 81 Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) Antikörper von 16 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MAP3K4 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 90 MAP3K4 Produkte verfügbar.
D17Rp17, D17Rp17e, MAPKKK4, Mek4b, MEKK 4, Mekk4, mKIAA0213, MTK1, PRO0412, RP17, Rp17a, Tas
Alle Antikörper anzeigen Gen GeneID UniProt
MAP3K4 308106  
MAP3K4 4216 Q9Y6R4
MAP3K4 26407 O08648

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anti-Rat (Rattus) MAP3K4 Antikörper:

anti-Human MAP3K4 Antikörper:

anti-Mouse (Murine) MAP3K4 Antikörper:

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Am meisten referenzierte anti-MAP3K4 Antikörper

  1. Human Polyclonal MAP3K4 Primary Antibody für EIA, IHC (p) - ABIN953298 : Grucza, Johnson, Krueger, Breslau, Saccone, Chen, Derringer, Agrawal, Lynskey, Bierut: Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes. in Addiction biology 2010 (PubMed)
    Zeige alle 5 Referenzen für 953298

  2. Human Monoclonal MAP3K4 Primary Antibody für WB - ABIN393852 : Whitmarsh, Davis: Role of mitogen-activated protein kinase kinase 4 in cancer. in Oncogene 2007 (PubMed)
    Zeige alle 5 Referenzen für 393852

Weitere Antikörper gegen MAP3K4 Interaktionspartner

Human Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) Interaktionspartner

  1. IL-21 (zeige IL17C Antikörper) expression is promoted by MEKK4 in malignant T cells and is associated with progression risk in cutaneous T-cell lymphoma

  2. Mutations in genes such as AKT2 (zeige AKT2 Antikörper), CCNA1 (zeige CCNA1 Antikörper), MAP3K4, and TGFBR1 (zeige TGFBR1 Antikörper), were associated significantly with Epstein-Barr-positive gastric tumors, compared with EBV-negative tumors.

  3. Map3k4 haploinsufficiency is the cause of T-associated sex reversal.

  4. MTK1 was identified in the HER2 (zeige ERBB2 Antikörper)/HER3 (zeige ERBB3 Antikörper)-HRG (zeige NRG1 Antikörper) mediated extracellular acidification and cell migration pathway in breast cancer cells.

  5. MAP3K4 is sufficiently mediate the TGFbeta (zeige TGFB1 Antikörper)-induced phosphorylation of p38 MAPK (zeige MAPK14 Antikörper) in MEFs and HaCaT cells.

  6. we have identified a reduced IL-1A (zeige IL1A Antikörper) response, related to a low MAP3K4 expression and high expression of its inhibitor GSK3beta (zeige GSK3b Antikörper), identifying a novel key player in Crohn's disease.

  7. For the first time we report a significant association between nicotine dependence and DRD5 (zeige DRD5 Antikörper), NPY1R (zeige NPY1R Antikörper) MAP3K4 single nucleotide polymorphism.

  8. The upstream molecule of the TRAIL-induced MAPK (zeige MAPK1 Antikörper) activation is MEKK (zeige MAP3K1 Antikörper), as opposed to ASK1 (zeige MAP3K5 Antikörper), via the mediation of its signal through JNK (zeige MAPK8 Antikörper)/p38 (zeige CRK Antikörper) in a caspase-8 (zeige CASP8 Antikörper)-dependent manner.

  9. CIN85 (zeige SH3KBP1 Antikörper) binding to a C-terminal motif within hTTP leads to the increased phosphorylation of hTTP, possibly through enhanced association with MEKK4

  10. Axin (zeige AXIN1 Antikörper) utilizes distinct regions for competitive MEKK1 (zeige MAP3K1 Antikörper) and MEKK4 binding and JNK (zeige MAPK8 Antikörper) activation.

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) Interaktionspartner

  1. by forming a complex with MEKK4 in skeletal muscle fibers, Gadd45a (zeige GADD45A Antikörper) increases MEKK4 protein kinase (zeige CDK7 Antikörper) activity, which is both sufficient to induce skeletal muscle fiber atrophy and required for Gadd45a (zeige GADD45A Antikörper)-mediated skeletal muscle fiber atrophy.

  2. Map3k4 haploinsufficiency is the cause of T-associated sex reversal.

  3. suggest a requirement for GADD45gamma (zeige GADD45G Antikörper) in promoting MAP3K4-mediated activation of p38 MAPK (zeige MAPK14 Antikörper) signaling in embryonic gonadal somatic cells for testis determination

  4. MTK1 plays an important role in the regulation of cell death and is also involved in the pathogenesis of heart failure.

  5. During Th1 (zeige HAND1 Antikörper) differentiation, the GADD45beta (zeige GADD45B Antikörper)/GADD45gamma (zeige GADD45G Antikörper)/MEKK4 pathway integrates upstream signals transduced by both T cell receptor and IL12 (zeige IL12A Antikörper)/STAT4 (zeige STAT4 Antikörper), leading to augmented interferon-gamma (zeige IFNG Antikörper) production in a process independent of STAT4 (zeige STAT4 Antikörper).

  6. MEKK4 plays a critical role in regulating MKK4 (zeige MAP2K4 Antikörper) activity and apoptotic cell death during neural tube development.

  7. MEKK4 is the MAPK (zeige MAPK1 Antikörper) kinase kinase for TRAF4 (zeige TRAF4 Antikörper) regulation of the JNK (zeige MAPK8 Antikörper) pathway

  8. Hindbrains of exencephalic MEKK4(K1361R) embryos show a striking increase in neuroepithelial cell apoptosis and a dramatic loss of phosphorylation of MKK3 (zeige MAP2K3 Antikörper) and -6, mitogen-activated protein kinase (zeige MAPK1 Antikörper) kinases (MKKs (zeige MKKS Antikörper)) regulated by MEKK4 in the p38 (zeige CRK Antikörper) pathway.

  9. MEKK4 regulates epithelial-to-mesenchymal transition in the endocardial cushions of the developing heart.

  10. our results demonstrate a link between MEKK4 and filamin-a (zeige FLNA Antikörper) that impacts neuronal migration initiation

MAP3K4 Antigen-Profil

Beschreibung des Gens

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described.

Alternative names and synonyms associated with MAP3K4

  • mitogen activated protein kinase kinase kinase 4 (Map3k4) Antikörper
  • mitogen-activated protein kinase kinase kinase 4 (MAP3K4) Antikörper
  • mitogen-activated protein kinase kinase kinase 4 (Map3k4) Antikörper
  • D17Rp17 Antikörper
  • D17Rp17e Antikörper
  • MAPKKK4 Antikörper
  • Mek4b Antikörper
  • MEKK 4 Antikörper
  • Mekk4 Antikörper
  • mKIAA0213 Antikörper
  • MTK1 Antikörper
  • PRO0412 Antikörper
  • RP17 Antikörper
  • Rp17a Antikörper
  • Tas Antikörper

Bezeichner auf Proteinebene für MAP3K4

mitogen-activated protein kinase kinase kinase 4 , MAP three kinase 1 , MAP/ERK kinase kinase 4 , MAPK/ERK kinase kinase 4 , MEK kinase 4 , MEKK 4 , SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of , dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4) , predicted protein of HQ0412 , T-associated sex reversal , mitogen activated protein kinase kinase kinase 4

308106 Rattus norvegicus
4216 Homo sapiens
26407 Mus musculus
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