MAP3K1 Proteine (MAP3K1)

Mitogen-Activated Protein Kinase Kinase Kinase 1 Proteine (MAP3K1)
Auf finden Sie aktuell 9 Mitogen-Activated Protein Kinase Kinase Kinase 1 (MAP3K1) Proteine von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MAP3K1 Antikörper (138) und MAP3K1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 161 MAP3K1 Produkte verfügbar.
ARAKIN, ATMEKK1, MAP3K1, MAPK/ERK kinase kinase 1, MAPKKK1, MAPKKK8, MEKK, MEKK1, MEKK 1, SRXY6, T15F16.5, T15F16_5
alle Proteine anzeigen Gen GeneID UniProt
Ratte MAP3K1 MAP3K1 116667 Q62925
MAP3K1 26401  
MAP3K1 4214 Q13233

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Weitere Proteine zu MAP3K1 Interaktionspartnern

Pig (Porcine) Mitogen-Activated Protein Kinase Kinase Kinase 1 (MAP3K1) Interaktionspartner

  1. let-7g induces porcine granulosa cells apoptosis by inhibiting the MAP3K1 gene, which promotes FoxO1 (zeige FOXO1 Proteine) expression and dephosphorylation with nuclear accumulation.

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase 1 (MAP3K1) Interaktionspartner

  1. These results reveal the importance of the MEKK1 (zeige MAP2K1 Proteine)-calponin-3 (zeige CNN3 Proteine) signaling pathway to cell contractility.

  2. Map3k1 regulates iNKT cell proliferative expansion in response to glycolipid antigen

  3. goya and kinase-deficient Map3k1 homozygotes initially develop supernumerary cochlear outer hair cells (OHCs) that subsequently degenerate.

  4. These data highlight the crucial role of MAP3K1 in the development and function of the mouse inner ear and hearing.

  5. Dioxin exposure markedly inhibited c-Jun (zeige JUN Proteine) phosphorylation in Map3k1-deficient embryonic eyelid epithelium, suggesting that dioxin-induced AHR (zeige AHR Proteine) pathways can synergize with gene mutations to inhibit MAP3K1 signaling.

  6. Both the MEKK1 (zeige MAP2K1 Proteine) PHD (zeige PDC Proteine) and TAB1 (zeige TAB1 Proteine) are critical for ES-cell differentiation

  7. Results suggest that proto-oncogene (zeige RAB1A Proteine) protiins c-Jun (zeige JUN Proteine) and mitogen-activated protein 3 (zeige HSPB3 Proteine) kinase 1 (MAP3K1) represent parallel pathways in the control of eyelid closure.

  8. Aberrant expression of Map3k1 enabled growth factor-autonomous proliferation and drove BRAF (zeige BRAF Proteine)-independent ERK (zeige EPHB2 Proteine) signaling, thus shedding light on alternative means of activating this prominent signaling pathway in melanoma.

  9. analysis of the gene expression program of MAP3K1 in mouse eyelid morphogenesis

  10. Proximal to the RING domain is a SWIM (SWI2/SNF2 (zeige SMARCA4 Proteine) and MuDR) domain. The MEKK1 (zeige MAP2K1 Proteine) SWIM domain, but not the RING domain, directly associates with the c-Jun (zeige JUN Proteine) DNA-binding domain, and the SWIM domain is required for MEKK1 (zeige MAP2K1 Proteine)-dependent c-Jun (zeige JUN Proteine) ubiquitylation.

Arabidopsis thaliana Mitogen-Activated Protein Kinase Kinase Kinase 1 (MAP3K1) Interaktionspartner

  1. double mekk1/camta3 mutant positioned CAMTA3 downstream of MEKK1 and verified their distinct roles in GSR (zeige GSR Proteine) regulation. mekk1-5 displays programmed cell death and overaccumulates reactive oxygen species and salicylic acid

  2. Treatment of Arabidopsis with a membrane rigidifier, DMSO, causes MPK4 (zeige MAPK4 Proteine) activation concomitantly with MEKK1 and MKK2 (zeige MAP2K2 Proteine) phosphorylation.

  3. Ca(2 (zeige CA2 Proteine)+) signaling occurred upstream of the MEKK1-MKK2 (zeige MAP2K2 Proteine) pathway. MEKK1 was phosphorylated by calcium/calmodulin (zeige CALM Proteine)-regulated receptor-like kinase (CRLK1), which suggested that CRLK1 is one of candidates located upstream of MEKK1.

  4. MEKK1 plays a key role in transducing the l-Glu (zeige DCTN1 Proteine) signal that elicits large-scale changes in root architecture, and provide genetic evidence for the existence in plants of an external glutamate (zeige GRIN2A Proteine) (l-Glu (zeige DCTN1 Proteine)) signalling pathway analogous to that found in animals.

  5. Data indicate that MEKK2 (zeige MAP3K2 Proteine) is required for the mekk1, mkk1 (zeige MAP2K1 Proteine) mkk2 (zeige MAP2K2 Proteine), and mpk4 (zeige MAPK4 Proteine) autoimmune phenotypes.

  6. Data suggest that the MEKK1-MKK1 (zeige MAP2K1 Proteine)/MKK2 (zeige MAP2K2 Proteine)-MPK4 (zeige MAPK4 Proteine) kinase cascade negatively regulates MEKK2 (zeige MAP3K2 Proteine) and activation of MEKK2 (zeige MAP3K2 Proteine) triggers SUMM2-mediated immune responses.

  7. CRLK1 interacts with MEKK1 in vitro and in planta during cold treatment.

  8. An analysis of the interation of MEKK1 and MEK1 (zeige MAP2K1 Proteine) in response to wounding stress in A. thaliana seedlings is presented.

  9. MEKK1 is essential for activation of MPK4 and negatively regulates temperature-sensitive and tissue-specific cell death and H(2)O(2) accumulation that are dependent on both RAR1 (resistance protein function) and SID2 (isochorismate synthase)

  10. This study demonstrated that analysis of plants carrying T-DNA knockout alleles indicated that MEKK1 is required for flg22-induced activation of MPK4 (zeige MAPK4 Proteine).

Human Mitogen-Activated Protein Kinase Kinase Kinase 1 (MAP3K1) Interaktionspartner

  1. SNP variants at the MAP3K1/SETD9 gene boundary associate with somatic PIK3CA (zeige PIK3CA Proteine) variants in breast cancers.

  2. CSN6 (zeige COPS6 Proteine) positively regulates c-Jun (zeige JUN Proteine) in a MEKK1-dependent manner

  3. Mekk1 mediates p53 protein stability in the presence of Mdm2 and reduces p53 ubiquitination, suggesting an interference with Mdm2-mediated degradation of p53 by the ubiquitin-proteasome pathway.

  4. BAALC (zeige BAALC Proteine) conferred chemoresistance in acute myeloid leukemia (zeige BCL11A Proteine) cells by upregulating ATP-binding cassette proteins in an ERK (zeige EPHB2 Proteine)-dependent manner, which can be therapeutically targeted by MEK (zeige MAP2K1 Proteine) inhibitor

  5. MiR (zeige MLXIP Proteine)-451 inhibited the proliferation of esophageal squamous cell carcinoma cells by targeting CDKN2D (zeige CDKN2D Proteine) and MAP3K1 expression.

  6. There were 3 specimens with mutations in MAP3K1 (MEKK1), including two truncation mutants, T779fs and T1481fs; T1481fs encoded an unstable and nonfunctional protein when expressed in vitro.

  7. Single nucleotide polymorphisms in ALDOB (zeige ALDOB Proteine), MAP3K1, and MEF2C (zeige MEF2C Proteine) are associated with cataract.

  8. Results demonstrate that MAP3K1 rs889312 is closely correlated with outcome among diffuse-type gastric cancer in a Chinese population.

  9. We propose that the cancer risk alleles act to increase MAP3K1 expression in vivo and might promote breast cancer cell survival.

  10. The present meta-analysis suggests that MAPKKK1 rs889312-C allele and rs16886165-G allele might be risk factors for breast cancer, especially in Europeans and Asians.

MAP3K1 Protein Überblick

Protein Überblick

The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus.

Alternative names and synonyms associated with MAP3K1

  • mitogen-activated protein kinase kinase kinase 1 (MAP3K1)
  • similar to MEK kinase 1 (MAP3K1)
  • mitogen-activated protein kinase kinase kinase 1 (map3k1)
  • mitogen activated protein kinase kinase kinase 1 (Map3k1)
  • mitogen-activated protein kinase kinase kinase 1 (Map3k1)
  • mitogen-activated protein kinase kinase kinase 1 (MEKK1)
  • mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase (MAP3K1)
  • ARAKIN Protein
  • ATMEKK1 Protein
  • MAP3K1 Protein
  • MAPK/ERK kinase kinase 1 Protein
  • MAPKKK1 Protein
  • MAPKKK8 Protein
  • MEKK Protein
  • MEKK1 Protein
  • MEKK 1 Protein
  • SRXY6 Protein
  • T15F16.5 Protein
  • T15F16_5 Protein

Bezeichner auf Proteinebene für MAP3K1

mitogen-activated protein kinase kinase kinase 1 , MAPK/ERK kinase kinase 1 , MEK kinase 1 , MEKK 1 , mitogen activated protein kinase kinase kinase 1 , MAP/ERK kinase kinase 1

396617 Sus scrofa
427144 Gallus gallus
471543 Pan troglodytes
478061 Canis lupus familiaris
710979 Macaca mulatta
100061688 Equus caballus
100137396 Papio anubis
100466442 Ailuropoda melanoleuca
100490504 Xenopus (Silurana) tropicalis
100550623 Meleagris gallopavo
100561745 Anolis carolinensis
116667 Rattus norvegicus
26401 Mus musculus
523962 Bos taurus
826409 Arabidopsis thaliana
4214 Homo sapiens
100328655 Oryctolagus cuniculus
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