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MEK2 (zeige MAP2K2 Proteine) was essential for the phosphorylation of MKK3 (zeige MAP2K3 Proteine)/MKK6 and p38 MAPK (zeige MAPK14 Proteine) that directly impacted on cyclin D1 (zeige CCND1 Proteine) expression.
Data indicate that mitogen-activated protein kinase kinase 6 (MKK6) levels were substantially higher in monocytes than in neutrophils.
Data show significant increase in the expression of MKK6 in Esophageal, Stomach, and Colon cancers as compared to controls.
uncover a new mechanism of deactivation of MKK6-p38 (zeige CRK Proteine) and substantiate a novel regulatory role of FBXO31 (zeige FBXO5 Proteine) in stress response
Serine phosphorylation of p66shc (zeige SHC1 Proteine) is carried out by active MKK6. beta-Amyloid-induced ROS (zeige ROS1 Proteine) production and apoptosis increased in the presence of MKK6 and p66shc (zeige SHC1 Proteine), which directly associate.
The models confirmed the reaction order, revealed processivity in the phosphorylation of MEK6 by ASK1 (zeige MAP3K5 Proteine), and suggested that the order of phosphorylation is dictated by both binding and catalysis rates.
crystal structure of human non-phosphorylated MAP2K6 (npMAP2K6) complexed with an ATP analogue was determined at 2.6 A resolution and represents an auto-inhibition state of MAP2K6
Data suggest aberrant MAP2K protein (MKK3 (zeige MAP2K3 Proteine), MKK4 (zeige MAP2K4 Proteine), MKK6, and MKK7 (zeige MAP2K7 Proteine)) expression indicates that altered cellular signal transduction mediated via JNK (zeige MAPK8 Proteine) and p38 (zeige CRK Proteine) may be common in bladder cancer.
the balance between MKK6 and MKK3 (zeige MAP2K3 Proteine) mediates p38 MAPK (zeige MAPK14 Proteine) associated resistance to cisplatin in NSCLC
activation by mechanical stretch induces HMGB1 (zeige HMGB1 Proteine) and cytokine expression in A549 cells
MAP2K6 functions in mouse testis determination, via positive effects on Sry (zeige SRY Proteine), and a minor role for MAP2K3 (zeige MAP2K3 Proteine).
MKK3 (zeige MAP2K3 Proteine) and MKK6 differentially regulate bone loss due to estrogen withdrawal. MKK3 (zeige MAP2K3 Proteine) directly mediates osteoclastogenesis while MKK6 likely contributes to pro-inflammatory cytokine production that promotes osteoclast formation.
Activation of distinct p38MAPK (zeige MAPK14 Proteine) isoforms is regulated by the selective and synchronized action of two kinases, MKK3 (zeige MAP2K3 Proteine) and MKK6, in response to cell stress.
MKK6 is downreglated in peripheral CD4 (zeige CD4 Proteine)(+)T cells
p38alpha (zeige MAPK14 Proteine) can negatively regulate the stability of the MKK6 mRNA and thus control the steady-state concentration of one of its upstream activators
Involvement of MKK6 in apoptotic cell death in thymocytes.
MKK6 is one of three different protein kinases which activate p38 MAPK (zeige MAPK14 Proteine) in vitro.
MKK3 (zeige MAP2K3 Proteine) and MKK6 are rapidly activated during engagement of the Type I IFN receptor and play important roles in Type I IFN signaling and the generation of IFN responses
increased activity of Sox9 (zeige SOX9 Proteine) accounts at least in part for the phenotype caused by constitutive activation of MKK6 in chondrocytes
These results indicate that TAK1 (zeige NR2C2 Proteine) and MKK6 constitute the p38 (zeige CRK Proteine) signalling pathway to participate to Oc differentiation by RANKL (zeige TNFSF11 Proteine) through p65 (zeige NFkBP65 Proteine) phosphorylation and NFATc1 (zeige NFATC1 Proteine) induction.
Arabidopsis MPK4 (zeige MAPK4 Proteine) can interact with and be phosphorylated by the cytokinesis-related MAP kinase (zeige MAPK1 Proteine) kinase, AtMKK6.
AtMKK6-AtMPK13 module positively regulates lateral root formation.
Plants with mutations in the MKK6/ANQ gene exhibit severe defects in cytokinesis.
This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.
MAPK/ERK kinase 6
, MAPKK 6
, MEK 6
, SAPK kinase 3
, dual specificity mitogen-activated protein kinase kinase 6
, protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6)
, stress-activated protein kinase kinase 3
, MAP kinase kinase 6
, mitogen activated protein kinase kinase 6
, protein kinase, mitogen activated, kinase 6
, mitogen-activated protein kinase kinase 3